公开(公告)号：US07783006B2

公开(公告)日：2010-08-24

申请号：US10962247

申请日：2004-10-08

申请人： Daren L. Stewart ,  Paul A. Lovoi ,  Thomas W. Rusch ,  Alex Lim ,  Darius Francescatti

发明人： Daren L. Stewart ,  Paul A. Lovoi ,  Thomas W. Rusch ,  Alex Lim ,  Darius Francescatti

IPC分类号： G21K5/00

CPC分类号： A61N5/1015 ,  A61B90/39 ,  A61B2017/22051 ,  A61B2090/3933 ,  A61N2005/1003 ,  A61N2005/1061

摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.

摘要翻译： 描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。 在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。 在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。 描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

公开(公告)号：US07771340B2

公开(公告)日：2010-08-10

申请号：US11881835

申请日：2007-07-28

申请人： Steve Axelrod ,  James E. Jervis ,  Paul A. Lovoi

发明人： Steve Axelrod ,  James E. Jervis ,  Paul A. Lovoi

IPC分类号： A61N5/00

CPC分类号： A61M25/1011 ,  A61B2017/22069 ,  A61M25/1002 ,  A61M2025/1061 ,  A61N5/1015

摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue farther away from a radiation source within a source guide inside the balloon. In one case a secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape, and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.

摘要翻译： 气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。 这对于使敏感组织更远离辐射源在气囊内的源引导件内是有用的。 在一种情况下，次级隔室形成在主气囊上，并且可分开地充气，以便在需要时允许起泡。 在另一种形式中，球囊包括单个腔室，但是具有“窗口”或其中球囊壁具有弹性的区域或者比主气囊壁基本上更有弹性的区域，使得球囊到达某一点的膨胀形成基本上规则的 气球形状，并且增加进一步的压力将使弹性区域膨胀，从而在气球的期望取向上增加轴与敏感组织之间的距离。

公开(公告)号：US20090209803A1

公开(公告)日：2009-08-20

申请号：US12070176

申请日：2008-02-14

申请人： Paul A. Lovoi

发明人： Paul A. Lovoi

IPC分类号： A61M36/06

CPC分类号： A61M25/10 ,  A61B17/8855 ,  A61N5/1014

摘要： In a kyphoplasty procedure to expand and repair a damaged vertebra, diseased bone around the vertebral fraction zone is irradiated by use of a small radiation source inserted through the cannula used in the kyphoplasty procedure.

摘要翻译： 在用于扩展和修复受损的椎骨的椎体后凸成形术中，通过使用插入通过用于椎体后凸成形术的插管的小的辐射源来照射椎骨部分区周围的患病骨。

公开(公告)号：US20090112046A1

公开(公告)日：2009-04-30

申请号：US11925200

申请日：2007-10-26

申请人： Paul A. Lovoi ,  Joseph A. Heanue

发明人： Paul A. Lovoi ,  Joseph A. Heanue

IPC分类号： A61N5/00

CPC分类号： A61N5/1001 ,  A61N5/1014 ,  A61N5/1015

摘要： A brachytherapy applicator and method of use involve a source guide that assumes a desired curving, non-linear configuration when inserted into an inflated balloon of the applicator. A flexible source catheter follows the shape of the source guide when inserted into the balloon. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With rotation of the curving source guide coupled with translation of the source via longitudinal movement of the catheter, the applicator can approximate a spherical source, through either stepped or continuous movement of the source and source guide.

摘要翻译： 近距离放射治疗施放器和使用方法涉及当将插入到施放器的充气气球中时呈现期望的弯曲非线性构造的源引导件。 当插入气球时，柔性源导管遵循源引导件的形状。 可以使用本发明更好地控制在各组织区域中接收的辐射剂量，并且可以降低腔表面剂量与处方深度剂量的比例。 随着通过导管的纵向移动与源的平移耦合的弯曲源引导件的旋转，施加器可以通过源和引导件的阶梯式或连续移动近似球形源。

公开(公告)号：US20090012430A1

公开(公告)日：2009-01-08

申请号：US11894052

申请日：2007-08-17

申请人： Paul A. Lovoi ,  Kieran Murphy ,  Jeff Jarvela ,  Pete Neild ,  John Thomas ,  Ray Schumacher

发明人： Paul A. Lovoi ,  Kieran Murphy ,  Jeff Jarvela ,  Pete Neild ,  John Thomas ,  Ray Schumacher

IPC分类号： A61B7/00 ,  G06K9/00

CPC分类号： A61B7/04 ,  A61B5/02007 ,  A61B5/4076 ,  A61B5/6814 ,  A61B5/7267 ,  G06F19/00 ,  G06F19/324 ,  G16H50/20 ,  G16H50/50

摘要： Vascular conditions are detected non-invasively in the human body using a collection of acoustic information from small local regions of the vasculature. An array of accelerometers or other sensors are attached to the head or other points of interest of a patient and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a library for further processing. The signature library is used to localize the origin of the recognized vascular feature, and the localized feature is presented to the physician in a clinically relevant manner.

摘要翻译： 使用从脉管系统的小的局部区域的声学信息的集合，在人体内非侵入性地检测血管状态。 一组加速度计或其他传感器附着在患者的头部或其他感兴趣点上，并记录血流声音。 使用随机，周期，带限或瞬态分析的血管结构如分支，动脉瘤，狭窄等的振动特征提供了进一步处理的文库。 签名库用于定位识别的血管特征的起源，并且以临床相关的方式向局部特征提供局部特征。

公开(公告)号：US20080154085A1

公开(公告)日：2008-06-26

申请号：US11932974

申请日：2007-10-31

申请人： James E. Jervis ,  Paul A. Lovoi

发明人： James E. Jervis ,  Paul A. Lovoi

IPC分类号： A61N5/10

CPC分类号： A61N5/1015 ,  A61N5/103 ,  A61N5/1048

摘要： Radiation treatment methods for breast cancer following resection, both intraoperative and post operative, involve mapping preferably using an electronic x-ray source, and can include rotation of a direction source. By using a very rapid, near-instantaneous method of pathology of tissue margins following resection, the invention carries out intraoperative radiation treatment, preferably with the patient remaining anesthetized. Whether or not radiation is intraoperative, the invention preferably includes a mapping procedure using an electronic source that is progressed through the resection cavity while radiation dose is sensed at one or more points, to determine the shape of the resection cavity.

摘要翻译： 切除术后，术中和术后两者的乳腺癌的放射治疗方法都涉及优选使用电子X射线源进行测绘，并且可包括方向源的旋转。 通过使用切除术后组织边缘的非常快速，近瞬时的病理学方法，本发明进行术中放射治疗，优选在患者保持麻醉的情况下进行。 无论辐射是否在术中，本发明优选地包括使用电子源的映射程序，该电子源在一个或多个点处感测放射剂量时进入切除腔，以确定切除腔的形状。

公开(公告)号：US07338430B2

公开(公告)日：2008-03-04

申请号：US11323346

申请日：2005-12-30

申请人： Alex Lim ,  Paul A. Lovoi ,  Heike Hausen ,  Daren L. Stewart

发明人： Alex Lim ,  Paul A. Lovoi ,  Heike Hausen ,  Daren L. Stewart

IPC分类号： A61M36/00

CPC分类号： A61N5/1016 ,  A61N5/1048 ,  A61N2005/1005

摘要： A vaginal brachytherapy applicator is versatile to different anatomies and more comfortable to the patient than prior applicators. An inflatable balloon on a shaft may be inelastic or elastic. In one embodiment the shaft is rotatable relative to the balloon for enabling a ring or band of dose delivery, for versatility in radiation placement. Alternatively, the source can be rotated and pulled back within a stationary shaft. An adjustment is provided for reducing the length of balloon that inflates, to accommodate different anatomies and positions. Although isotope radiation sources can be used in the applicator, an electronic source is preferred, and the system and method include procedures for using the applicator with an electronic source.

公开(公告)号：US07317378B2

公开(公告)日：2008-01-08

申请号：US10919800

申请日：2004-08-17

申请人： Neil Jarvis ,  Paul A. Lovoi ,  Warren Fay ,  Christopher J. Lee ,  Jarie G. Bolander ,  Bernard Baron ,  Anthony G. Jennetti ,  Forrest Wunderlich ,  Oscar Ayzenberg

发明人： Neil Jarvis ,  Paul A. Lovoi ,  Warren Fay ,  Christopher J. Lee ,  Jarie G. Bolander ,  Bernard Baron ,  Anthony G. Jennetti ,  Forrest Wunderlich ,  Oscar Ayzenberg

IPC分类号： H04Q1/00

CPC分类号： G06K19/0701 ,  G06K7/0008

摘要： An electronic identification tag, usually in very small size, responds to a reader with an identification code unique to the object to which the tag is attached. The stand-alone device responds to a reader signal by storing energy received from the signal, then using the stored energy to generate another signal that is encoded with identification information. In operation, a reader generates RF energy which can reach a multiplicity of such tags over a distance of several meters. The system minimizes power requirements for the tag by minimizing intelligence in the IC. Use of a transmit frequency which is different from the reader's power frequency reduces interference between the power pulse and information pulse, eliminates the need for filters and enables the multiplied clock reference frequency as the transmit carrier frequency.

摘要翻译： 通常尺寸非常小的电子识别标签用读写器对标签附着的对象特有的识别代码进行响应。 独立设备通过存储从信号接收的能量来响应读取器信号，然后使用所存储的能量来生成另外的用识别信息编码的信号。 在操作中，读取器产生RF能量，其可以在几米的距离上达到多个这样的标签。 该系统通过最小化IC中的智能来最小化标签的电源要求。 使用不同于读取器功率频率的发射频率可以减少功率脉冲与信号脉冲之间的干扰，消除了对滤波器的需要，并使倍频时钟参考频率成为发射载波频率。

公开(公告)号：US07257504B2

公开(公告)日：2007-08-14

申请号：US11145016

申请日：2005-06-03

申请人： Jarie G. Bolander ,  Forrest Wunderlich ,  Neil Jarvis ,  Christopher J. Lee ,  Bernard Baron ,  Paul A. Lovoi

发明人： Jarie G. Bolander ,  Forrest Wunderlich ,  Neil Jarvis ,  Christopher J. Lee ,  Bernard Baron ,  Paul A. Lovoi

IPC分类号： H04B1/59 ,  H04Q5/22

CPC分类号： G06K19/0723 ,  G06K7/10059 ,  G06K19/0726

摘要： A radio frequency ID tag, very small in size and with an onboard antenna, is manufactured, tested and applied cost-efficiently. The transmit frequency for the tag is set during manufacture approximately, within a selected range, in a gross tuning step. A second tuning step fine tunes each tag by RF communication to set values of capacitance, resistance, etc., and this can be at the point of application of the tags. Other aspects include burning a randomly-selected value in the RF ID chip during manufacture to impose a random time delay for tag response (rather than having a random generator on the chip itself); structural testing of a large number of tags on a wafer using on-wafer interconnects and a special onboard sequencer test die; and production of the tag so as to be tunable to different frequency ranges.

摘要翻译： 射频识别标签尺寸非常小，带有板载天线，经过高效制造，测试和应用。 标签的发送频率在制造过程中大致在一个选定的范围内，在总体调整步骤中设置。 第二调谐步骤通过RF通信精细调谐每个标签以设置电容值，电阻值等，这可以在标签的应用点。 其他方面包括在制造期间在RF ID芯片中烧制随机选择的值以对标签响应施加随机时间延迟（而不是在芯片本身上具有随机发生器）; 使用晶片间互连和特殊的板载定序器测试晶片对晶片上的大量标签进行结构测试; 以及标签的生产以便可调谐到不同的频率范围。

公开(公告)号：US07253716B2

公开(公告)日：2007-08-07

申请号：US10993199

申请日：2004-11-19

申请人： Paul A. Lovoi ,  Teri E. Judelson ,  Anthony G. Jennetti ,  Bernard Baron

发明人： Paul A. Lovoi ,  Teri E. Judelson ,  Anthony G. Jennetti ,  Bernard Baron

IPC分类号： H04Q1/00

CPC分类号： A61J3/007 ,  A61J2205/60 ,  A61K9/0024 ,  A61K9/2072 ,  A61K9/7023 ,  G06K7/0008 ,  G06K19/0701 ,  G06K19/07345

摘要： A medical pill intended for human or animal consumption includes an RF ID tag in or on the pill. The tag will respond to a nearby reader, the tag itself being without a battery or other constant power supply, capturing power from the reader's transmitted signal and storing a portion of that power in a power supply. An antenna for the RF ID tag may be integral with the tag or it may be transferred to the pill using conductive materials in the pill's coating, filler or binding agents, embedded within the pill, or printed onto the pill. If separate from the tag the antenna is electromagnetically coupled to the tag which has a small onboard antenna. The RF ID tag of each pill has data that are transmitted when the tag is interrogated by a signal from a reader. Incorporation of an ingestable ID tag is possible because of the tag's very small size compatible with ingestion and because the tag can contain an antenna within the pill that allows the tag to be read at a substantial distance. Several different methods for deactivating the RF ID tag after ingestion or use of the pill are disclosed. Medicaments other than oral pills can also have the ID tags.

摘要翻译： 用于人或动物消费的药丸包括药片中或丸上的RF ID标签。 标签将响应附近的读卡器，标签本身没有电池或其他恒定的电源，从读取器的发送信号中捕获电力并将该电力的一部分存储在电源中。 用于RF ID标签的天线可以与标签一体，或者可以使用胶囊的涂层，填充剂或粘合剂中的导电材料转移到丸剂中，或者印在丸上。 如果与标签分开，则天线与具有小型板载天线的标签电磁耦合。 每个药片的RF ID标签具有当标签被读取器的信号询问时发送的数据。 由于标签的尺寸非常小，因为标签可以包含药片内的天线，允许在相当长的距离读取标签，因此可以加入可吸收的ID标签。 公开了在摄取或使用药丸之后停用RF ID标签的几种不同方法。 药物以外的口服药片也可以有ID标签。