公开(公告)号：US20100016400A1

公开(公告)日：2010-01-21

申请号：US11719687

申请日：2005-11-18

Applicant: Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Mehta ,  Sudershan K. Arora ,  Anita Chugh

Inventor： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Mehta ,  Sudershan K. Arora ,  Anita Chugh

IPC: A61K31/403 ,  C07D209/52 ,  C07D409/06 ,  A61P11/00

CPC classification number: C07D209/52 ,  C07D409/06

Abstract: The present invention generally relates to muscarinic receptor antagonists, which are useful for treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to processes for preparing compounds described herein, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备本文所述化合物的方法，含有所公开化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US07488748B2

公开(公告)日：2009-02-10

申请号：US10543585

申请日：2003-01-23

Applicant: Anita Mehta ,  Arundutt V. Silamkoti ,  Naresh Kumar ,  Jang Bahadur Gupta

Inventor： Anita Mehta ,  Arundutt V. Silamkoti ,  Naresh Kumar ,  Jang Bahadur Gupta

IPC: A61K31/403 ,  C07D209/52

CPC classification number: C07D401/04 ,  C07D209/52 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04

Abstract: This invention generally relates to derivatives of 3,6 disubstituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及3,6-二取代的氮杂双环己烷的衍生物。 本发明的化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US07446123B2

公开(公告)日：2008-11-04

申请号：US10552455

申请日：2004-01-07

Applicant: Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

Inventor： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

IPC: A61K31/40 ,  A61K31/4035 ,  C07D209/52

CPC classification number: C07D209/52 ,  C07D403/06

Abstract: This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080255188A1

公开(公告)日：2008-10-16

申请号：US11995433

申请日：2006-07-11

Applicant: Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

Inventor： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

IPC: A61K31/472 ,  C07D217/26

CPC classification number: C07D471/08

Abstract: This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20070292477A1

公开(公告)日：2007-12-20

申请号：US10581710

申请日：2004-12-06

Applicant: Naresh Kumar

Inventor： Naresh Kumar

IPC: A61K31/765 ,  A61K31/787 ,  A61K9/00 ,  A61L15/20 ,  A61M25/00 ,  A61P31/00 ,  C07D207/24 ,  C07D307/26

CPC classification number: C07D307/58 ,  A61K31/341 ,  A61K31/4015 ,  A61K47/59 ,  A61K47/60 ,  C07B2200/11 ,  C07D207/44 ,  C07F7/1804 ,  C08G77/38 ,  C08G77/388 ,  G02B1/043

Abstract: The invention describes antimicrobial silicone oligomers or polymers comprising a silicone oligomer or polymer associated with at least one compound of formula (I). Also described are methods of associating compounds of formula (I) to surfaces and products thereof.

Abstract translation: 本发明描述了抗微生物聚硅氧烷低聚物或包含与至少一种式（I）化合物缔合的聚硅氧烷低聚物或聚合物的聚合物。 还描述了将式（I）化合物与其表面及其产物缔合的方法。

公开(公告)号：US20070106078A1

公开(公告)日：2007-05-10

申请号：US10543517

申请日：2004-01-30

Applicant: Mukesh Sharma ,  Chandra Khanduri ,  Naresh Kumar ,  Yatendra Kumar

Inventor： Mukesh Sharma ,  Chandra Khanduri ,  Naresh Kumar ,  Yatendra Kumar

IPC: C07D211/34

CPC classification number: C07D211/22

Abstract: The invention relates to highly pure fexofenadine and a process for preparing highly pure fexofenadine. The invention also relates to pharmaceutical compositions that include the highly pure fexofenadine and use of said compositions for treating a patient for allergic reactions.

Abstract translation: 本发明涉及高纯度非索非那定和制备高纯度非索非那定的方法。 本发明还涉及包含高纯度非索非那定的药物组合物和所述组合物用于治疗患者过敏反应的用途。

公开(公告)号：US20070021487A1

公开(公告)日：2007-01-25

申请号：US10552503

申请日：2004-01-06

Applicant: Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

Inventor： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

IPC: A61K31/403 ,  C07D209/02

CPC classification number: C07D209/52 ,  C07D403/06

Abstract: This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0]hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 具体地，本发明涉及氮杂二环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷，以及含有这些化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20060111425A1

公开(公告)日：2006-05-25

申请号：US10520572

申请日：2003-04-11

Applicant: Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Sarma ,  Shankar Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Silamkoti ,  Anita Chugh

Inventor： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Sarma ,  Shankar Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Silamkoti ,  Anita Chugh

IPC: A61K31/403 ,  C07D403/02 ,  C07D209/02

CPC classification number: C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

公开(公告)号：US06932300B2

公开(公告)日：2005-08-23

申请号：US10481868

申请日：2002-06-21

Applicant: Naresh Kumar

Inventor： Naresh Kumar

IPC: B64D17/46

CPC classification number: B64D17/46

Abstract: The invention provides a device for closing parachute packs, each of which has a plurality of flaps and a closing cord (36), the device (10) being characterised by a base (12) for bearing on a flap in one direction during the packing operation, and by a mechanism (18, 22) adapted to draw a pull cord (34) connectable to the closing cord (36) in substantially an opposite direction to allow the flaps to be secured relative to the closing cord (36) by a pin.

Abstract translation: 本发明提供了一种用于关闭降落伞包装件的装置，每个装置具有多个翼片和闭合绳索（36），该装置（10）的特征在于在包装期间沿一个方向承载在翼片上的底座（12） 操作，以及适于沿大致相反的方向拉出可连接到关闭绳索（36）的拉绳（34）的机构（18,22），以允许翼片相对于关闭绳索（36）被固定 销。

公开(公告)号：US06835848B1

公开(公告)日：2004-12-28

申请号：US10221113

申请日：2003-01-06

Applicant: Prosenjit Bose ,  Naresh Kumar ,  Taro Kiyoto

Inventor： Prosenjit Bose ,  Naresh Kumar ,  Taro Kiyoto

IPC: C07C22900

CPC classification number: C07C227/16 ,  C07C229/34 ,  C07C2601/02

Abstract: The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates for the production of highly active antibacterial quinolone medicaments.

Abstract translation: 本发明涉及用于制备3-环丙基氨基-2- [2,4-二溴-3-（二氟甲氧基）苯甲酰基] -2-丙烯酸烷基酯的新的和工业上有利的一锅法，其中R代表甲基或 乙基，它们是生产高活性抗菌喹诺酮药物的有价值的中间体。