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91 条记录 (耗时 0.032 秒)

    Sensor for microscopy
    72.
    发明授权
    Sensor for microscopy 有权

    公开(公告)号：US10353190B2

    公开(公告)日：2019-07-16

    申请号：US13519360

    申请日：2010-12-22

    申请人： Bas Hulsken ,  Sjoerd Stallinga

    发明人： Bas Hulsken ,  Sjoerd Stallinga

    IPC分类号： H04N7/18 ,  G02B21/36 ,  G02B21/24

    摘要： This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.

    Microdissection method and information processing system
    73.
    发明授权
    Microdissection method and information processing system 有权
    显微解剖方法和信息处理系统

    公开(公告)号：US08995733B2

    公开(公告)日：2015-03-31

    申请号：US13266552

    申请日：2010-04-20

    申请人： Erik Martinus H. P. Van Dijk ,  Sjoerd Stallinga

    发明人： Erik Martinus H. P. Van Dijk ,  Sjoerd Stallinga

    IPC分类号： G06K9/00 ,  G06T7/00

    CPC分类号： G06T7/0014 ,  G01N1/04 ,  G01N1/06 ,  G06T2207/10056 ,  G06T2207/20104 ,  G06T2207/30024

    摘要： A method for use in biology, histology, and pathology includes providing a digital first image of a first slice of an object having biological material; generating a digital second image of a second slice of the object; determining a region of interest in the second image based on a region of interest in the first image; determining a region of interest in the second slice based on the region of interest in the second image; and extracting material from the region of interest in the second slice.

    摘要翻译： 用于生物学，组织学和病理学的方法包括提供具有生物材料的物体的第一切片的数字第一图像; 产生所述对象的第二片的数字第二图像; 基于所述第一图像中的感兴趣区域来确定所述第二图像中的感兴趣区域; 基于所述第二图像中的感兴趣区域来确定所述第二切片中的感兴趣区域; 以及从第二切片中的感兴趣区域提取材料。

    AUTOFOCUS IMAGING
    74.
    发明申请
    AUTOFOCUS IMAGING 审中-公开
    自动成像

    公开(公告)号：US20130057674A1

    公开(公告)日：2013-03-07

    申请号：US13697681

    申请日：2011-05-04

    申请人： Bas Hulsken ,  Sjoerd Stallinga

    发明人： Bas Hulsken ,  Sjoerd Stallinga

    IPC分类号： G03B13/00 ,  H04N7/18

    CPC分类号： G02B21/245 ,  G02B21/36 ,  H04N3/1581 ,  H04N5/23212

    摘要： The present invention relates to the field of digital pathology and in particular to whole slide scanners. Autofocus imaging can be performed by sampling a first number of pixels of a primary image sensor and sampling a second number of pixels of an autofocus image sensor, wherein the second number is between one quarter and three quarters of the first number. Thus, continuous autofocus for rapid light scanning may be provided based on an additional image sensor that is tilted with respect to the optical axis.

    摘要翻译： 本发明涉及数字病理学领域，特别涉及整个幻灯片扫描器。 可以通过对主图像传感器的第一数量的像素进行采样并对自动聚焦图像传感器的第二数量的像素进行采样来执行自动聚焦成像，其中第二数量在第一数量的四分之一到四分之三之间。 因此，可以基于相对于光轴倾斜的附加图像传感器来提供用于快速光扫描的连续自动对焦。

    Optical illumination apparatus for illuminating a sample with a line beam
    75.
    发明授权
    Optical illumination apparatus for illuminating a sample with a line beam 有权
    用于用线束照射样品的光学照明装置

    公开(公告)号：US08314407B2

    公开(公告)日：2012-11-20

    申请号：US12743824

    申请日：2008-11-19

    申请人： Erik Martinus Hubertus Petrus Van Dijk ,  Sjoerd Stallinga

    发明人： Erik Martinus Hubertus Petrus Van Dijk ,  Sjoerd Stallinga

    IPC分类号： G21K5/00

    CPC分类号： G01N19/08 ,  G02B27/0911 ,  G02B27/095

    摘要： An optical system for illuminating a sample with a line beam includes a light source, a beam shaper for transforming the beam of light emitted by the light source into an intermediate astigmatic image, and an imaging system for transforming the intermediate astigmatic image into a final astigmatic image and for illuminating the sample. The beam shaper provides different non-unity magnifications in a lateral plane and in a transversal plane, and comprises a toroidal entrance surface for implementing the angular magnification and angular reduction and a toroidal exit surface with finite radii of curvature.

    摘要翻译： 用于用线束照射样品的光学系统包括光源，用于将由光源发射的光束变换为中间散光图像的光束整形器，以及用于将中间散光图像转换成最终散光的成像系统 图像和照亮样品。 光束整形器在横向平面和横向平面中提供不同的非单位放大倍数，并且包括用于实现角放大率和角度减小的环形入射面和具有有限曲率半径的环形出射面。

    SENSOR FOR MICROSCOPY
    76.
    发明申请
    SENSOR FOR MICROSCOPY 审中-公开
    传感器用于显微镜

    公开(公告)号：US20120287256A1

    公开(公告)日：2012-11-15

    申请号：US13519360

    申请日：2010-12-22

    申请人： Bas Hulsken ,  Sjoerd Stallinga

    发明人： Bas Hulsken ,  Sjoerd Stallinga

    IPC分类号： H04N7/18

    CPC分类号： G02B21/367 ,  G02B21/241 ,  G02B21/361

    摘要： This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.

    摘要翻译： 本发明涉及一种用于对样品进行微观成像的方法，数字扫描器包括包含2D阵列像素的传感器和执行该方法的数字扫描显微镜。 特别提供了一种用于使用扫描仪对样品进行显微成像的方法，所述扫描器包括在XY坐标系中包括像素的2D阵列的传感器，所述轴线Y基本上垂直于扫描方向，其中扫描器被布置成使得传感器可 对样本的倾斜横截面进行成像，并且其中所述方法包括以下步骤：•激活所述2D阵列的第一子阵列，所述第一子阵列主要沿着所述Y轴在第一X坐标（X1 ），•通过借助于第一像素子阵列对样本的第一区域进行成像来创建第一图像。 根据本发明的方面，进一步提出扫描器执行该方法并使用相同的2D阵列传感器用于成像和自动聚焦目的。

    MULTI-FOCAL SPOT GENERATOR AND MULTI-FOCAL MULTI-SPOT SCANNING MICROSCOPE
    77.
    发明申请
    MULTI-FOCAL SPOT GENERATOR AND MULTI-FOCAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
    多焦点发生器和多焦点多点扫描显微镜

    公开(公告)号：US20100264294A1

    公开(公告)日：2010-10-21

    申请号：US12742985

    申请日：2008-11-19

    申请人： Sjoerd Stallinga ,  Levinus P. Bakker ,  Dirk L.J. Vossen

    发明人： Sjoerd Stallinga ,  Levinus P. Bakker ,  Dirk L.J. Vossen

    IPC分类号： G02B27/64 ,  G02B26/08 ,  H01L27/14

    CPC分类号： G02B27/0087 ,  G02B3/0006 ,  G02B21/004

    摘要： The invention relates to a spot-generator (10) having: an entrance surface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entrance surface defining an entrance side (16) and the exit surface defining an exit side (18), wherein the spot generator is designed to modulate the incident light beam to generate on the exit side a plurality of separate light spots. According to the invention, the plurality of light spots comprises a first light spot (22) generated in a first focal plane (24) and a second light spot (26) generated in a second focal plane (28), the first focal plane and the second focal plane being essentially perpendicular to the mean propagation direction of the exit light beam, and wherein the first light spot (22) differs from every other light spot generated on the exit side by the spot generator in the projection of its position on a plane essentially perpendicular to the mean propagation direction of the exit light beam. Advantageously, the light spots of the plurality of separate light spots have identical spectra. The invention further relates to a multi-spot scanning microscope and to a method of generating an image of a microscopic sample. Advantageously, the method comprises the step of generating a three-dimensional image of the sample.

    摘要翻译： 本发明涉及点光发生器（10），其具有：用于接收入射光束（20）的入射表面（12）和用于透射光束的出射表面（14），入射面限定入射侧（16 ）和所述出射表面限定出射侧（18），其中所述光斑发生器被设计成调制所述入射光束，以在所述出射侧产生多个单独的光斑。 根据本发明，多个光点包括在第一焦平面（24）中产生的第一光点（22）和在第二焦平面（28）中产生的第二光点（26），第一焦平面和 所述第二焦平面基本上垂直于所述出射光束的平均传播方向，并且其中所述第一光点（22）在其位置的投影中由所述光点发生器在出射侧产生的每隔一个光点不同 平面基本上垂直于出射光束的平均传播方向。 有利地，多个分开的光点中的光点具有相同的光谱。 本发明还涉及多点扫描显微镜和产生微观样品图像的方法。 有利地，该方法包括产生样本的三维图像的步骤。

    OPTICAL DATA STORAGE SYSTEM FOR RECORDING AND/OR READING AN OPTICAL DATA STORAGE MEDIUM FOR USE IN SUCH SYSTEM
    78.
    发明申请
    OPTICAL DATA STORAGE SYSTEM FOR RECORDING AND/OR READING AN OPTICAL DATA STORAGE MEDIUM FOR USE IN SUCH SYSTEM 审中-公开
    用于记录和/或读取在这种系统中使用的光学数据存储介质的光学数据存储系统

    公开(公告)号：US20090190461A1

    公开(公告)日：2009-07-30

    申请号：US10599997

    申请日：2005-04-15

    申请人： Martinus Bernardus Van Der Mark ,  Ferry Zijp ,  Sjoerd Stallinga

    发明人： Martinus Bernardus Van Der Mark ,  Ferry Zijp ,  Sjoerd Stallinga

    IPC分类号： G11B7/135 ,  G11B7/26

    CPC分类号： G11B7/24038 ,  G11B7/1374 ,  G11B7/1387 ,  G11B2007/13727

    摘要： Multi layer near-field optical recording using a moderate numerical aperture (NA) is superior to the high-NA (NA=2.0) first-surface single-layer technique. The use of very flat and thin spacer layers limits spherical aberration due to difference in layer depth. The thin spacer layers may have a high refractive index because their thickness allow for a relatively high absorption constant. This makes possible in principle an m-layer system, e.g. m=4, with NA=1.6 which may include a flat, protective cover layer. Further a medium for use in such a system is described.

    摘要翻译： 使用中等数值孔径（NA）的多层近场光学记录优于高NA（NA = 2.0）第一表面单层技术。 使用非常平坦和薄的间隔层由于层深度的差异而限制了球面像差。 薄间隔层可以具有高折射率，因为它们的厚度允许相对较高的吸收常数。 这在原理上使得m层系统成为可能。 m = 4，其中NA = 1.6，其可以包括平坦的保护性覆盖层。 此外，还描述了用于这种系统的介质。

    Method and apparatus for detection of a speckle based physically unclonable function
    79.
    发明授权
    Method and apparatus for detection of a speckle based physically unclonable function 失效
    用于检测基于散斑的物理不可克隆功能的方法和装置

    公开(公告)号：US07432485B2

    公开(公告)日：2008-10-07

    申请号：US10582383

    申请日：2004-11-24

    申请人： Sjoerd Stallinga ,  Boris Skoric ,  Pim Theo Tuyls ,  Willem Gerard Ophey ,  Antonius Hermanus Maria Akkermans

    发明人： Sjoerd Stallinga ,  Boris Skoric ,  Pim Theo Tuyls ,  Willem Gerard Ophey ,  Antonius Hermanus Maria Akkermans

    IPC分类号： G02B7/04 ,  H01L27/00

    CPC分类号： G02B27/48 ,  H04L9/3278

    摘要： An optical arrangement of at least a coherent light source (1), a strongly scattering object (5) (the PUF), and a pixe-lated photo-detector (6), wherein the pixels are comparable in size with the bright and dark patches of the speckle pattern produced by coherent radiation traversing the scattering object (5). Quantitively, the pixel size should be roughly λ/NA, where λ is the wave-length, and (i) NA=a/z for free-space geometry, with a being the beam radius and z being the distance between the exit surface of the PUF (5) and the pixelated detector (6), or (ii) NA is the numerical aperture of a lens (7) in an imaging geometry. In a preferred embodiment of the invention, there are tentative requirements that the pixels should be at least smaller than ηmaxλNA and preferably larger than ηmaxλ/NA, where (in an exemplary embodiment) ηmax=5 and ηmin=0.05, say. It will be understood by a person skilled in the art that the present invention is concerned with the optical arrangement of the PUF (5) and the photo-detector (6), rather than the photo -detector (6) per se.

    摘要翻译： 至少相干光源（1），强散射物体（5）（PUF）和像素照片检测器（6）的光学布置，其中像素在尺寸上与明暗相当 通过穿过散射物体（5）的相干辐射产生的斑点图案的斑块。 数量上，像素尺寸应该大致为λ/ NA，其中λ是波长，和（i）NA =自由空间几何的a / z，其中光束半径和z是出射表面之间的距离 的PUF（5）和像素化检测器（6），或者（ii）NA是成像几何形状中的透镜（7）的数值孔径。 在本发明的优选实施例中，暂时要求像素应该至少小于λmaxλNA，并且优选地大于等于λmax /λ，其中（ 在一个示例性实施例中），例如，max = 5和eta分钟= 0.05。 本领域技术人员将理解，本发明涉及PUF（5）和光电检测器（6）的光学布置，而不是光电检测器（6）本身。