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71.发明授权Method for screening for cancer using binders for MAGE related peptides and complexes of the peptide and HLA molecules 失效使用MAGE相关肽的结合物和肽和HLA分子的复合物筛选癌症的方法公开(公告)号：US06379901B1
公开(公告)日：2002-04-30
申请号：US08443580
申请日：1995-05-17
申请人： Thierry Boon-Falleur , Pierre van der Bruggen , Etienne De Plaen , Christophe Lurguin , Catia Traversari , Beatrice Gaugler , Benoit Van den Eynde
发明人： Thierry Boon-Falleur , Pierre van der Bruggen , Etienne De Plaen , Christophe Lurguin , Catia Traversari , Beatrice Gaugler , Benoit Van den Eynde
IPC分类号： G01N3353
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention involves a nonapeptide derived from the tumor rejection antigen precursor encoded by gene MAGE-3. This nonapeptide is presented by the HLA molecule HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.
摘要翻译： 本发明涉及衍生自由MAGE-3基因编码的肿瘤排斥抗原前体的非肽。 这种非肽由HLA分子HLA-A1呈递。 所得复合物通过溶细胞T细胞鉴定。 这种识别可用于诊断或治疗。
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公开(公告)号：US06323028B1
公开(公告)日：2001-11-27
申请号：US09241268
申请日：1999-02-01
IPC分类号： C12N508
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and therapeutic uses are described.
摘要翻译： 本发明涉及鉴定与HLA-Cw * 16分子复合的肽，然后可以通过溶细胞T细胞引起它们结合的细胞的裂解。 描述诊断和治疗用途。
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公开(公告)号：US06245525B1
公开(公告)日：2001-06-12
申请号：US09183706
申请日：1998-10-30
IPC分类号： C12N1500
CPC分类号： C07K14/4748
摘要： The invention describes sdp3.8 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdp3.8 gene product.
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74.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-3的分离的核酸分子及其用途公开(公告)号：US06235525B1
公开(公告)日：2001-05-22
申请号：US08037230
申请日：1993-03-26
IPC分类号： C12N510
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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公开(公告)号：US06222012B1
公开(公告)日：2001-04-24
申请号：US08393273
申请日：1995-02-23
申请人： Thierry Boon-Falleur , Pierre Van der Bruggen , Etienne De Plaen , Christoph Lurquin , Catia Traversari , Beatrice Gaugler , Benoit Van den Eynde , Pedro Romero
发明人： Thierry Boon-Falleur , Pierre Van der Bruggen , Etienne De Plaen , Christoph Lurquin , Catia Traversari , Beatrice Gaugler , Benoit Van den Eynde , Pedro Romero
IPC分类号： C07K700
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention involves nonapeptides bound by HLA molecules such as HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.
摘要翻译： 本发明涉及由HLA分子如HLA-A1结合的非肽。 所得复合物通过溶细胞T细胞鉴定。 这种识别可用于诊断或治疗。
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公开(公告)号：US06171806B2
公开(公告)日：2001-01-09
申请号：US09266294
申请日：1999-03-11
IPC分类号： G01N33574
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/112 , G01N33/56977
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are not derived from tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.
摘要翻译： 描述了由HLA-B44分子呈递的肿瘤排斥抗原。 这些肽可用于诊断和治疗方法。 肿瘤排斥抗原不是源自酪氨酸酶，酪氨酸酶先前被鉴定为被HLA-B44呈递的抗原加工的肿瘤排斥抗原前体。
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77.发明授权Methods for determining complexes of tumor rejection antigens and HLA-Cw*160/molecules 失效确定肿瘤排斥抗原与HLA-Cw * 1601分子复合物的方法
公开(公告)号：US6110694A
公开(公告)日：2000-08-29
申请号：US38328
申请日：1998-03-11
申请人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/574
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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78.发明授权Method for diagnosing a disorder characterized by expression of a BAGE tumor rejection antigen precursor 失效用于诊断以BAGE肿瘤排斥抗原前体的表达为特征的病症的方法
公开(公告)号：US6093540A
公开(公告)日：2000-07-25
申请号：US573186
申请日：1995-12-15
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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79.发明授权Isolated tumor rejection antigen precursor MAGE-2 derived peptides, and uses thereof 失效分离的肿瘤排斥抗原前体MAGE-2衍生肽及其用途
公开(公告)号：US6063900A
公开(公告)日：2000-05-16
申请号：US667725
申请日：1996-06-21
申请人： Cornelis J. M. Melief , Marjan J. W. Visseren , W. Martin Kast , Pierre van der Bruggen , Thierry Boon-Falleur
发明人： Cornelis J. M. Melief , Marjan J. W. Visseren , W. Martin Kast , Pierre van der Bruggen , Thierry Boon-Falleur
IPC分类号： C12P21/08 , A61K35/26 , A61K38/00 , A61K38/04 , A61K39/00 , A61K39/395 , A61P35/00 , A61P37/00 , C07K5/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/705 , C07K14/74 , C07K16/28 , C12N5/00 , A61K38/08 , C12N5/06
CPC分类号： C07K14/4748 , C07K14/705 , A61K2039/5158 , A61K38/00 , A61K39/00 , Y10S530/828 , Y10S530/868
摘要： The invention describes peptides derived from tumor rejection antigen precursor MAGE-2. These peptides bind with HLA-A2 molecules, thus presenting complexes which provoke cytolytic T cell production. The resulting "CTLs" are specific for complexes of HLA-A2 and the peptide. The complexes can be used to generate monoclonal antibodies. The cytolytic T cells produced may be used in the context of immunotherapy, such as adoptive transfer.
摘要翻译： 本发明描述了衍生自肿瘤排斥抗原前体MAGE-2的肽。 这些肽与HLA-A2分子结合，因此呈现引起溶细胞T细胞产生的复合物。 所得的“CTL”对HLA-A2和肽的复合物是特异性的。 该复合物可用于产生单克隆抗体。 所产生的细胞溶解性T细胞可以用于免疫治疗的上下文，例如过继转移。
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80.发明授权Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof 失效与HLA-A2分子复合的分离的MAGE-3衍生的肽及其用途
公开(公告)号：US6019987A
公开(公告)日：2000-02-01
申请号：US668560
申请日：1996-06-21
IPC分类号： G01N33/53 , A61K35/26 , A61K38/00 , A61K39/395 , A61P35/00 , C07K7/06 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/44 , C12N5/06 , C12P21/08 , G01N33/577 , A61K39/00 , C07K16/00 , C12N15/85
CPC分类号： C07K16/30 , C07K14/4748 , A61K38/00 , Y10S530/828
摘要： Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
摘要翻译： 已经鉴定了源于肿瘤排斥前体MAGE-3的肿瘤排斥抗原。 这些“TRAS”与MHC-I类分子HLA-A2结合，并且所得复合物刺激裂解呈递细胞的溶细胞T细胞克隆的产生。 肽和复合物可以用于诊断，治疗和用作产生抗体的免疫原，或用作产生溶细胞T细胞克隆的靶标。
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