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    Tissue culture process for producing a large number of viable mint plants in vitro
    72.
    发明授权
    Tissue culture process for producing a large number of viable mint plants in vitro 失效
    用于在体外生产大量活的薄荷植物的组织培养方法

    公开(公告)号：US06323394B1

    公开(公告)日：2001-11-27

    申请号：US09263485

    申请日：1999-03-08

    申请人： Sushil Kumar ,  Shiv Kumar Gupta ,  Savithri Bhat ,  Rakesh Tuli

    发明人： Sushil Kumar ,  Shiv Kumar Gupta ,  Savithri Bhat ,  Rakesh Tuli

    IPC分类号： A01H100

    CPC分类号： C12N15/8201 ,  A01H4/005 ,  A01H4/008

    摘要： The present invention relates to a tissue culture process for producing a large number of genetically transformed viable mint plants in vitro. The process of the present invention employs specified pieces of an internodal segment of the stem of the mint plant as the starting material and identifies medium, culture and transformation conditions for producing a large number of genetically transformed plants. Such plants can be selected for desirable characteristics.

    摘要翻译： 本发明涉及用于在体外生产大量遗传转化的活的薄荷植物的组织培养方法。 本发明的方法使用薄荷植物茎的节间段的指定片段作为起始材料，并鉴定用于生产大量遗传转化植物的培养和转化条件。 可以选择这样的植物用于期望的特征。

    Process for preparing novel biologically active synthetic molecule 4-(p-methoxyphenyl)-2-amino-butane
    75.
    发明授权
    Process for preparing novel biologically active synthetic molecule 4-(p-methoxyphenyl)-2-amino-butane 失效
    制备新型生物活性合成分子4-（对甲氧基苯基）-2-氨基 - 丁烷的方法

    公开(公告)号：US06252114B1

    公开(公告)日：2001-06-26

    申请号：US09535121

    申请日：2000-03-24

    申请人： Sunil Kumar Chattopadhyay ,  Koneni Venkata Sashidhara ,  Vinayak Tripathi ,  Arun Kumar Tripathi ,  Veena Prajapati ,  Sushil Kumar

    发明人： Sunil Kumar Chattopadhyay ,  Koneni Venkata Sashidhara ,  Vinayak Tripathi ,  Arun Kumar Tripathi ,  Veena Prajapati ,  Sushil Kumar

    IPC分类号： C07C20700

    CPC分类号： C07C43/225 ,  C07C217/62

    摘要： The invention provides a process for the preparation of 4-(p-methoxyphenyl)-2-aminobutane represented by structural formula (1) as shown herein below: [C11H17ON=4-(p-methoxy phenyl)-2-amino butane] said process comprising the steps of, (a) isolating a phenolic compound 4-hydroxyphenyl)-butan-2-ol from the leaves of Taxus wallichiana by known methods, (b) treating the phenolic compound in aqueous mineral acid to obtain a phenolic halide derivative, (c) converting the phenolic halide derivative into its methyl ether by treating it with a methating agent, (d) reacting the methyl ether halide with azide to obtain an azido derivative, and (e) hydrogenating the azido compound to obtain 4-(p-methoxyphenyl)-2-aminobutane.

    摘要翻译： 本发明提供了制备由结构式（1）表示的4-（对甲氧基苯基）-2-氨基丁烷的方法，如下所示：[C 11 H 17 ON = 4-（对甲氧基苯基）-2-氨基丁烷]所述 方法包括以下步骤：（a）通过已知方法从紫杉属的叶子中分离酚类化合物4-羟基苯基 - 丁-2-醇，（b）在无机酸水溶液中处理酚类化合物以获得酚卤化物衍生物 （c）通过用甲基化剂处理酚卤化物衍生物转化成甲基醚，（d）使甲基醚卤化物与叠氮化物反应得到叠氮基衍生物，和（e）氢化叠氮化合物得到4-（ 对甲氧基苯基）-2-氨基丁烷。

    Process for the production of taxol
    76.
    发明授权
    Process for the production of taxol 失效
    紫杉醇生产工艺

    公开(公告)号：US5856532A

    公开(公告)日：1999-01-05

    申请号：US909810

    申请日：1997-08-12

    申请人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar ,  Kunnath Padmanabhan Madhusudanan

    发明人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar ,  Kunnath Padmanabhan Madhusudanan

    IPC分类号： A61K31/335 ,  A61K31/337 ,  A61K36/18 ,  A61P35/00 ,  C07C13/26 ,  C07D305/14

    CPC分类号： C07D305/14

    摘要： A process has been developed for production of taxols A, B, C with high yields from 7-xylosyl-10-deacetyl taxol A (taxol analogue A or, xyloside A), 7-xylosyl-10-deacetyl-taxol B (taxol analogue B or xyloside B), 7-xylosyl-10-deacetyl--taxol C (taxol analogue C or xyloside C), which comprises (i) isolating the taxol analogues A, B, C form the stembark of Taxus wallichiana by an improved process devoiding of solvent partitioning step, (ii) treating the isolated taxol analogues A, B, C with periodates in an acid free polar solvent medium to cleave the diol into dialdehyde at ambient temperature, (iii) reducing the dialdehyde solution with borohydride in a polar solvent--acetic acid medium at 0.degree.-40.degree. C. into an acetal, (iv) acidifying the resultant acetal with a mixture of mineral acid-polar solvent at 0.degree.-40.degree. C. into intermediate product 10-deacetyl taxols A, B, C, (V) reacting 10-deacetyl taxols A or B or C with a silane in presence of a base at 20.degree.-40.degree. C. to protect 2', 7-hydroxyl groups, of 10-deacetyl taxols A, B, C (vi) acetylating the 10-hydroxyl group in situ with an acetylating agent at 10.degree.-40.degree. C., (vii) deprotecting the 2', 7-hydroxyl groups with a mixture of mineral acid-polar solvent at 0.degree.-10.degree. C. (viii) isolating taxols A or B or C by chromatography over silica.

    摘要翻译： 已经开发了用于从7-木糖基-10-脱乙酰紫杉醇A（紫杉醇类似物A或木糖苷A），7-木糖基-10-脱乙酰基紫杉醇B（紫杉醇类似物）的高收率生产紫杉醇A，B，C的方法 B或木糖苷B），7-木糖基-10-脱乙酰基紫杉醇C（紫杉醇类似物C或木糖苷C），其包括（i）通过改进的方法脱除紫杉醇类似物A，B，C形成紫杉属 的溶剂分配步骤，（ii）在酸性极性溶剂介质中用高碘酸盐处理分离的紫杉酚类似物A，B，C，以在环境温度下将二醇切割成二醛，（iii）用极性溶剂中的硼氢化物还原二醛溶液 - 乙酸培养基在0°-40℃进入缩醛，（iv）在0-40℃下用无机酸 - 极性溶剂的混合物将所得缩醛酸化成中间产物10-脱乙酰基紫杉醇A，B C，（Ⅴ）在20℃-40℃下，使10-脱乙酰基的紫杉醇A或B或C与硅烷反应，保护2' ，10-脱乙酰基紫杉醇A，B，C（vi）的7-羟基，（vi）在10°-40℃用乙酰化剂原位乙酰化10-羟基，（vii）使2'，7- 羟基与无机酸极性溶剂的混合物在0-10℃下进行。（viii）通过硅胶色谱分离紫杉醇A或B或C。

    Mean time to recover (MTTR) advisory
    79.
    发明授权
    Mean time to recover (MTTR) advisory 有权
    平均恢复时间（MTTR）咨询

    公开(公告)号：US07020599B1

    公开(公告)日：2006-03-28

    申请号：US10017337

    申请日：2001-12-13

    申请人： Qiang Cao ,  Sushil Kumar ,  Tirthankar Lahiri ,  Yunrui Li ,  Gianfranco Putzolu

    发明人： Qiang Cao ,  Sushil Kumar ,  Tirthankar Lahiri ,  Yunrui Li ,  Gianfranco Putzolu

    IPC分类号： G06F9/45

    CPC分类号： G06F11/3457 ,  G06F17/30306 ,  G06F2201/86 ,  Y10S707/99943 ,  Y10S707/99953

    摘要： A method for simulating different MTTR settings includes determining a simulated MTTR setting and providing a simulated checkpoint queue. The simulated checkpoint queue is associated with the simulated MTTR setting and is an ordered list of one or more elements. Each element represents a buffer, and the ordered list has a head and a tail. The method also includes providing a simulated write counter associated with the simulated MTTR setting. The method further includes, in response to detecting a change to a first buffer, checking if the first buffer is represented in the simulated checkpoint queue. If the first buffer is not represented in the simulated checkpoint queue, an element that represents the first buffer is linked to the tail of the simulated checkpoint queue. An MTTR advisory system includes a memory, one or more processors coupled to the memory, a simulated MTTR setting, a simulated checkpoint queue, and a simulated write counter. The simulated MTTR setting is maintained in the memory. The simulated checkpoint queue is maintained in the memory and associated with the simulated MTTR setting. The simulated write counter is also maintained in the memory, and is associated with the simulated MTTR setting. The simulated write counter provides a count of the number of times an element is removed from the simulated checkpoint queue, wherein the element is removed from the simulated checkpoint queue in response to a write out of a buffer from volatile memory and storing in nonvolatile memory.

    摘要翻译： 用于模拟不同MTTR设置的方法包括确定模拟MTTR设置并提供模拟检查点队列。 模拟的检查点队列与模拟的MTTR设置相关联，并且是一个或多个元素的有序列表。 每个元素表示一个缓冲区，有序列表有一个头和尾。 该方法还包括提供与模拟的MTTR设置相关联的模拟写入计数器。 该方法还包括响应于检测到对第一缓冲器的改变，检查在模拟检查点队列中是否表示第一缓冲器。 如果模拟检查点队列中没有表示第一个缓冲区，则表示第一个缓冲区的元素链接到模拟检查点队列的尾部。 MTTR咨询系统包括存储器，耦合到存储器的一个或多个处理器，模拟MTTR设置，模拟检查点队列和模拟写入计数器。 模拟的MTTR设置保留在内存中。 模拟检查点队列保存在存储器中并与模拟的MTTR设置相关联。 模拟写计数器也保存在存储器中，并与模拟的MTTR设置相关联。 仿真写入计数器提供从模拟检查点队列中删除元素的次数的计数，其中响应于从易失性存储器写入缓冲器并存储在非易失性存储器中，将元件从模拟检查点队列中移除。

    Self-managing performance statistics repository for databases
    80.
    发明申请
    Self-managing performance statistics repository for databases 有权
    数据库的自我管理性能统计信息库

    公开(公告)号：US20050086263A1

    公开(公告)日：2005-04-21

    申请号：US10934771

    申请日：2004-09-03

    申请人： Gary Ngai ,  Michael Feng ,  Alex Tsukerman ,  Benoit Dageville ,  Mark Ramacher ,  Karl Dias ,  Graham Wood ,  Leng Leng Tan ,  Richard Sarwal ,  Sushil Kumar

    发明人： Gary Ngai ,  Michael Feng ,  Alex Tsukerman ,  Benoit Dageville ,  Mark Ramacher ,  Karl Dias ,  Graham Wood ,  Leng Leng Tan ,  Richard Sarwal ,  Sushil Kumar

    IPC分类号： G06F7/00

    CPC分类号： G06F17/30306

    摘要： A self-managing workload repository (AWR) infrastructure useful for a database server to collect and manage selected sets of important system performance statistics. Based on a schedule, the AWR runs automatically to collect data about the operation of the database system, and stores the data that it captures into the database. The AWR is advantageously designed to be lightweight and to self manage its use of storage space so as to avoid ending up with a repository of performance data that is larger than the database that it is capturing data about. The AWR is configured to automatically capture snapshots of statistics data on a periodic basis as well as purge stale data on a periodic basis. Both the frequency of the statistics data capture and length of time for which data is kept is adjustable. Manual snapshots and purging may also be performed. The AWR captured data allows for both system level and user level analysis to be automatically performed without unduly impacting system performance, e.g., by eliminating or reducing the requirement to repeat the workload in order to diagnose problems.

    摘要翻译： 自管理工作负载存储库（AWR）基础架构可用于数据库服务器收集和管理所选的重要系统性能统计信息。 根据计划，AWR自动运行以收集有关数据库系统操作的数据，并将其捕获的数据存储到数据库中。 AWR有利地被设计为轻量级并且自我管理其对存储空间的使用，以避免最终获得比它正在捕获数据的数据库更大的性能数据库。 AWR配置为定期自动捕获统计数据的快照，并定期清除过期数据。 统计数据捕获的频率和保存数据的时间长短都是可调的。 也可以执行手动快照和清除。 AWR捕获的数据允许自动执行系统级别和用户级别分析，而不会不必要地影响系统性能，例如通过消除或减少重复工作负载以便诊断问题的要求。