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公开(公告)号：US08518105B2
公开(公告)日：2013-08-27
申请号：US11726647
申请日：2007-03-21
申请人： Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Thierry Glauser , Yiwen Eveleen Tang , Eugene T. Michal
发明人： Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Thierry Glauser , Yiwen Eveleen Tang , Eugene T. Michal
CPC分类号： A61L31/043 , A61L2430/36
摘要： A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.
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公开(公告)号：US20120328770A1
公开(公告)日：2012-12-27
申请号：US13605795
申请日：2012-09-06
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
IPC分类号： B05D7/00
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译： 公开了调节药物涂层支架释放速率的方法。
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公开(公告)号：US08293318B1
公开(公告)日：2012-10-23
申请号：US11847222
申请日：2007-08-29
申请人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Ni Ding , Yiwen Tang , Fuh-Wei Tang , Lothar Walter Kleiner , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61L31/10 , A61F2240/001 , A61F2250/0056 , A61F2250/0068 , A61L31/16 , A61L2300/416 , A61L2300/60 , C08L33/10 , C08L27/16 , C08L27/20 , C08L29/04
摘要： Methods for modulating the release rate of a drug coated stent are disclosed.
摘要翻译： 公开了调节药物涂层支架释放速率的方法。
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公开(公告)号：US20110274734A1
公开(公告)日：2011-11-10
申请号：US13186207
申请日：2011-07-19
CPC分类号： A61L31/10 , A61L31/14 , C08F8/00 , C08F8/04 , C08F8/40 , C08F8/48 , Y10T428/1393 , C08L101/04 , C08F214/22
摘要： Provided herein are methods for functionalizing an polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.
摘要翻译： 本文提供了用于官能化用于形成涂层的聚合物和由其形成的涂层和装置或用于官能化包括聚合物的涂层或装置表面的方法。
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75.发明授权Medical device coated with a coating containing elastin pentapeptide VGVPG 有权涂有含有弹性蛋白五肽VGVPG的涂层的医疗器械公开(公告)号：US08029816B2
公开(公告)日：2011-10-04
申请号：US11803031
申请日：2007-05-10
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
摘要翻译： 本发明涉及包括涂层在内的医疗装置。 涂层包括面漆，其包括包含弹性蛋白五肽嵌段的共聚物。 面漆在疏水涂层上方的多层（聚乙烯醇）层上或包含孔或包含生物活性剂的贮槽的多孔涂层上方。
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公开(公告)号：US20110169197A1
公开(公告)日：2011-07-14
申请号：US13072658
申请日：2011-03-25
IPC分类号： B29C35/08
CPC分类号： B29C45/7207 , A61F2/86 , B29C45/0001 , B29L2031/7532
摘要： A stent can be made by injecting a molten reaction mixture into a mold. The mold being in the shape of a radially expandable stent. The reaction mixture can have a reactive species capable of causing polymerization or crosslinking in the reaction mixture upon exposure to radiation. The method can include exposing the reaction mixture to radiation to cause polymerization or crosslinking in the reaction mixture.
摘要翻译： 可以通过将熔融反应混合物注入模具中来制造支架。 模具是可扩张支架的形状。 反应混合物可以具有能够在暴露于辐射时在反应混合物中引起聚合或交联的反应性物质。 该方法可以包括将反应混合物暴露于辐射以引起反应混合物中的聚合或交联。
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公开(公告)号：US20110098803A1
公开(公告)日：2011-04-28
申请号：US12872166
申请日：2010-08-31
IPC分类号： A61F2/82
CPC分类号： A61L31/148 , A61L31/06 , C08L67/04
摘要： Stents fabricated from hydrolytically degradable polymers with accelerated degradation rates and methods of fabricating stents with accelerated degradation rates are disclosed.
摘要翻译： 公开了由具有加速降解速率的水解可降解聚合物制备的支架和具有加速降解速率的制造支架的方法。
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78.发明授权Stereocomplex-forming composition and implantable medical device comprising same 有权形成立体络合物的组合物和包括其的可植入医疗装置公开(公告)号：US07862830B2
公开(公告)日：2011-01-04
申请号：US11827912
申请日：2007-07-12
CPC分类号： C08L67/04 , A61L31/10 , C08L101/00 , C08L2203/02 , C08L2205/02 , C08L2205/03 , C08L2666/18 , C08L2666/02
摘要： The present invention relates to a composition of a first single enantiomer homopolymer and a separate stereocomplex formed of a second single enantiomer homopolymer and it mirror image enantiomer, wherein the first and second single enantiomer homopolymers can be the same or different.
摘要翻译： 本发明涉及第一单一对映异构体均聚物和由第二单一对映异构体均聚物及其镜像对映异构体形成的单独立体络合物的组合物，其中第一和第二单一对映异构体均聚物可以相同或不同。
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公开(公告)号：US07794495B2
公开(公告)日：2010-09-14
申请号：US11488928
申请日：2006-07-17
CPC分类号： A61L31/148 , A61L31/06 , C08L67/04
摘要： Stents fabricated from hydrolytically degradable polymers with accelerated degradation rates and methods of fabricating stents with accelerated degradation rates are disclosed.
摘要翻译： 公开了由具有加速降解速率的水解可降解聚合物制备的支架和具有加速降解速率的制造支架的方法。
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公开(公告)号：US20100209476A1
公开(公告)日：2010-08-19
申请号：US12466317
申请日：2009-05-14
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/604 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a terpolymer comprising caprolactone and glycolide and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译： 本发明提供一种包含储层的涂层，其包含含有己内酯和乙交酯的三元共聚物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用的方法。
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