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公开(公告)号:US20060122184A1
公开(公告)日:2006-06-08
申请号:US10536889
申请日:2003-11-26
申请人: Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
发明人: Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
IPC分类号: A61K31/53 , A61K31/50 , A61K31/4965 , A61K31/421 , A61K31/381 , A61K31/277 , A61K31/415
CPC分类号: C07C255/25 , A61K38/00 , C07D211/66 , C07D213/82 , C07D277/30 , C07D333/40 , C07K5/06139
摘要: The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译: 本发明涉及作为半胱氨酸蛋白酶,特别是组织蛋白酶B,K,F和S的抑制剂的氰甲基衍生物,因此可用于治疗由这些蛋白酶介导的疾病。 本发明涉及包含这些化合物的药物组合物及其制备方法。
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72.
公开(公告)号:US20050204414A1
公开(公告)日:2005-09-15
申请号:US11128496
申请日:2005-05-13
申请人: Yang Liu , Pan Zheng , Xuefeng Bai , Xingluo Liu
发明人: Yang Liu , Pan Zheng , Xuefeng Bai , Xingluo Liu
IPC分类号: A61K38/00 , A61K38/095 , A61K39/00 , C07K14/705 , C07K16/28 , A01K67/027 , C07H21/04 , A61K39/395 , C07K14/74
CPC分类号: A61K38/177 , A61K38/00 , A61K39/0008 , C07K14/70596 , C07K16/2896 , C07K2319/00 , C07K2319/30
摘要: Methods of reducing autoreactive T cell-initiated destruction of tissues in a mammal, comprising: administering to a mammal a CD24 antisense molecule or a polynucleotide coding for the same, wherein the CD24 antisense molecule or polynucleotide is administered to the mammal by an ex vivo or in vivo procedure.
摘要翻译: 减少哺乳动物组织中自身反应性T细胞起始破坏的方法,包括:向哺乳动物施用CD24反义分子或编码其的多核苷酸,其中所述CD24反义分子或多核苷酸通过离体或 体内程序。
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73.
公开(公告)号:US20050204413A1
公开(公告)日:2005-09-15
申请号:US11128495
申请日:2005-05-13
申请人: Yang Liu , Pan Zheng , Xuefeng Bai , Xingluo Liu
发明人: Yang Liu , Pan Zheng , Xuefeng Bai , Xingluo Liu
IPC分类号: A61K38/00 , A61K38/095 , A61K39/00 , C07K14/705 , C07K16/28 , A01K67/027 , C07H21/04 , A61K39/395 , C12N15/09 , C07K14/74
CPC分类号: A61K38/177 , A61K38/00 , A61K39/0008 , C07K14/70596 , C07K16/2896 , C07K2319/00 , C07K2319/30
摘要: Methods of reducing autoreactive T cell-initiated destruction of tissues in a mammal, comprising administering to the mammal a CD24 dsRNAi molecule or a polynucleotide that encodes a CD24 dsRNAi molecule, wherein said molecule or polynucleotide is administered to the mammal by an ex vivo or in vivo procedure.
摘要翻译: 减少哺乳动物组织自身反应性T细胞破坏的方法,包括向哺乳动物施用CD24 dsRNAi分子或编码CD24 dsRNAi分子的多核苷酸,其中所述分子或多核苷酸通过离体或 体内过程。
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公开(公告)号:US11039090B2
公开(公告)日:2021-06-15
申请号:US16599850
申请日:2019-10-11
申请人: Yang Liu
发明人: Yang Liu
IPC分类号: H04N5/33 , H04N13/204 , A61B5/00 , A61B5/0205 , A61B5/1455 , G02B27/01 , H04N7/15
摘要: A multi-purpose imaging and display system includes a display; a detector coupled to the display and having a field of view; and a filter communicating with the detector. The field of view is imaged by the detector through the filter, the filter configured to be sensitive to a first frequency spectrum, so the detector displays only objects within the field of view on the detector that emit one or more frequencies within the first frequency spectrum. The detector and filter can work together in different operational states or modes for acquiring image data of a target object under investigation. A computing device can be included to process acquired image data, and communication interfaces can be employed to achieve networking of multiple systems. A peripheral interface allows a plurality of peripheral devices to be selectively added to tailor the data acquisition and display capabilities of the imaging and display system.
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75.
公开(公告)号:US10924670B2
公开(公告)日:2021-02-16
申请号:US15952909
申请日:2018-04-13
IPC分类号: H04N5/232 , G06T7/33 , H04N13/25 , H04N5/225 , H04N13/246 , H04N17/00 , H04N13/271 , G06T7/38 , H04N5/33 , H04N5/235 , G06T7/593
摘要: The present disclosure provides an image capturing device that captures images of a first sensor that includes a first imaging modality, a second sensor that includes a first imaging modality and a third sensor that includes a second imaging modality. A controller connected with the first sensor, the second sensor and the third sensor, wherein the controller registers an image captured by the first sensor or the second sensor to an image captured by the third sensor.
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公开(公告)号:US20210038189A1
公开(公告)日:2021-02-11
申请号:US16987999
申请日:2020-08-07
申请人: Yang Liu , Cristina Shin , Nathan Silberman , Audrey Howell , Daniel Hertz , Swaminathan Sankaranarayanan
发明人: Yang Liu , Cristina Shin , Nathan Silberman , Audrey Howell , Daniel Hertz , Swaminathan Sankaranarayanan
摘要: Aspects of the technology described herein include determining, during ultrasound imaging, that an anatomical region is clipped by a field of view of an ultrasound image, and providing a notification, during the ultrasound imaging, that the anatomical region is clipped by the field of view of the ultrasound image. Aspects of the technology described herein also include determining that an anatomical region is clipped by a field of view of at least one ultrasound image collected during a three-dimensional ultrasound imaging sweep, and providing a notification that the anatomical region is clipped by the field of view of the at least one ultrasound image collected during the three-dimensional ultrasound imaging sweep.
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公开(公告)号:US10849710B2
公开(公告)日:2020-12-01
申请号:US15118139
申请日:2014-10-27
申请人: Yang Liu
发明人: Yang Liu
摘要: An imaging and display system for guiding medical interventions includes a wearable display, such as a goggle display, for viewing by a user. The display presents a composite, or combined image that includes pre-operative surgical navigation images, intraoperative images, and in-vivo microscopy images or sensing data. The pre-operative images are acquired from scanners, such as MRI and CT scanners, while the intra-operative images are acquired in real-time from a camera system carried by the goggle display for imaging the patient being treated so as to acquire intraoperative images, such as fluorescence images. A probe, such as a microscopy probe or a sensing probe, is used to acquire in-vivo imaging/sensing data from the patient. Additionally, the intra-operative and in-vivo images are acquired using tracking and registration techniques to align them with the pre-operative image and the patient to form a composite image for display by the goggle display.
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公开(公告)号:US20200320695A1
公开(公告)日:2020-10-08
申请号:US16839020
申请日:2020-04-02
申请人: Yang Liu
发明人: Yang Liu
摘要: Aspects of the technology described herein relate to receiving an ultrasound image, automatically determining a location of a specific point on an anatomical structure depicted in the ultrasound image, and displaying an indicator of the location of the specific point on the anatomical structure on the ultrasound image. In some embodiments, the anatomical structure is a bladder. In some embodiments, the specific point is the centroid. In some embodiments, a statistical model determines the specific point. The indicator may be, for example, a symbol located at the specific point, a horizontal line extending through the specific point from one edge of the anatomical structure to another, and/or a vertical line extending through the specific point from one edge of the anatomical structure to another.
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公开(公告)号:US10723965B1
公开(公告)日:2020-07-28
申请号:US15792372
申请日:2017-10-24
申请人: Mingming Lu , Yang Liu
发明人: Mingming Lu , Yang Liu
IPC分类号: C10L5/44
摘要: A system and process for producing biofuel from spent coffee grounds (SCGs) comprises the steps of performing a first operation comprising the steps of obtaining spent SCGs from a source, washing the SCGs, mixing the washed SCGs with an inorganic acid and heating and stirring the washed SCGs to form a SCG slurry without separating coffee oil, drying the SCG slurry, mixing the dried slurry with a solvent and heating the dried slurry and solvent mixture to create a reaction to produce biofuel and residual grounds, and separating the biofuel from the solvent and the residual grounds. The process further includes the step of using an activation agent and heating the residual grounds and the activation agent to create activated residual grounds. Biochar is also produced without activation and heating de-oiled SCGs at lower temperatures without oxygen.
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公开(公告)号:US10541523B2
公开(公告)日:2020-01-21
申请号:US15514690
申请日:2014-10-03
申请人: GENERAL ELECTRIC COMPANY , Jiahong Wang , Craig Dement , Jiemin Fu , Jay Leonard , Yang Liu , Roman Kolar , Edward Wayne Hardwicke , Andre Langel
发明人: Jiahong Wang , Craig Dement , Jiemin Fu , Jay Leonard , Yang Liu , Roman Kolar , Edward Wayne Hardwicke , Andre Langel
摘要: The present disclosure is directed to a cable securement assembly for protecting cables and/or cable bundles within a wind turbine. The cable securement assembly includes a cable spacer having an inner surface and an outer surface separated by a thickness and one or more fastening components. The inner surface defines an open center configured to receive the plurality of cables therein. The inner surface defines a plurality of cable locations defined by one or more through holes configured through the thickness. The one or more fastening components are configured to secure one or more of the plurality of cables at each cable location via the through holes.
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