公开(公告)号：US20060065836A1

公开(公告)日：2006-03-30

申请号：US11199262

申请日：2005-08-09

申请人： Katsutoshi Tsuchiya ,  Hiroshi Kitaguchi ,  Yuichi Morimoto ,  Shinya Kominami ,  Kazuma Yokoi ,  Tsuneaki Kawaguchi ,  Masatoshi Tanaka ,  Takafumi Ishitsu

发明人： Katsutoshi Tsuchiya ,  Hiroshi Kitaguchi ,  Yuichi Morimoto ,  Shinya Kominami ,  Kazuma Yokoi ,  Tsuneaki Kawaguchi ,  Masatoshi Tanaka ,  Takafumi Ishitsu

IPC分类号： G21K1/02

CPC分类号： G01T1/1648 ,  A61B6/037

摘要： Disclosed herein is a radiation imaging apparatus and radiation-imaging-apparatus-based nuclear medicine diagnosis apparatus having a collimator in which a plurality of rectangular through-holes are arranged in a grid pattern and separated by septa is rotated through a predetermined angle as viewed from above in relation to the layout of a plurality of rectangular detectors that are arranged in a grid pattern. The predetermined angle ranges from 20 to 70 degree and more preferably from 30 deg to 60 deg. With this configuration, the influence of sensitivity variations (moire patterns) that are included in an image picked up due to interference with a collimator when pixel type detectors are used is eliminated.

摘要翻译： 本发明公开了一种辐射成像装置和基于放射成像装置的核医学诊断装置，其具有准直仪，其中多个矩形通孔以网格图案排列并且由隔片隔开，从而从其观察时旋转预定角度 相对于以网格图案排列的多个矩形检测器的布局。 预定角度为20至70度，更优选为30度至60度。 利用这种配置，消除了当使用像素型检测器时由于与准直器的干涉而拾取的图像中包括的灵敏度变化（莫尔图案）的影响。

公开(公告)号：US20090084947A1

公开(公告)日：2009-04-02

申请号：US12039413

申请日：2008-02-28

申请人： Norihito YANAGITA ,  Shinichi Inoue ,  Katsutoshi Tsuchiya

发明人： Norihito YANAGITA ,  Shinichi Inoue ,  Katsutoshi Tsuchiya

IPC分类号： G12B13/00

CPC分类号： G01T1/1648

摘要： A nuclear medicine diagnosis apparatus, which rotates a rod-shaped radiation source or a point radiation source while changing the radius thereof and carries out a calibration work, is provided to resolve the following problems. If detector calibration is carried out using a cylindrical phantom whose interior is filled with a 18F solution, for example, there is a risk that a γ-ray is scattered by the aqueous solution itself inside the cylindrical phantom. Although there is a method for correcting the scattered radiation, the method has a disadvantage that the correction results in poor calibration. Moreover, if a rod-shaped radiation source is rotated inside a tunnel, there is an extremely low risk of causing the above-described scattering because it is rod-shaped. However, this rod-shaped radiation source only rotates on an orbit of a certain radius, resulting in a ring-shaped radiation source having a hollow portion thereinside.

摘要翻译： 提供了一种在改变其半径并执行校准工作的同时旋转棒状辐射源或点辐射源的核医学诊断装置，以解决以下问题。 如果使用其内部填充有18F溶液的圆柱形幻影进行检测器校准，例如，存在伽马射线在水平溶液本身在圆柱体模体内散射的风险。 虽然存在用于校正散射辐射的方法，但是该方法具有校正导致校准差的缺点。 此外，如果杆状辐射源在隧道内旋转，则由于它是棒状，所以导致上述散射的风险极低。 然而，该棒状辐射源仅在某个半径的轨道上旋转，导致环形辐射源在其内部具有中空部分。

公开(公告)号：US07038039B2

公开(公告)日：2006-05-02

申请号：US09958305

申请日：2001-02-13

申请人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

发明人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

IPC分类号： A61K31/665 ,  A61K31/7024 ,  C07F9/6544

CPC分类号： C07H19/10 ,  C07H19/00 ,  C07H19/20

摘要： A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.

公开(公告)号：US06875860B2

公开(公告)日：2005-04-05

申请号：US10144802

申请日：2002-05-15

申请人： Hironori Komatsu ,  Toshiyuki Kouno ,  Katsutoshi Tsuchiya ,  Hiroharu Tanikawa ,  Hiroki Ishibashi

发明人： Hironori Komatsu ,  Toshiyuki Kouno ,  Katsutoshi Tsuchiya ,  Hiroharu Tanikawa ,  Hiroki Ishibashi

IPC分类号： C07H19/067 ,  C07H19/06 ,  C07H19/073 ,  B01D9/02

CPC分类号： C07H19/06

摘要： This invention provides a method for efficiently purifying 5′-protected thymidines which cannot be efficiently purified by the prior art. Impurities can be separated by obtaining crystals including a carbonyl-containing solvent to provide a highly pure 5′-protected thymidine. Thus, this invention allows 5′-protected thymidines, which cannot be purified in an industrial scale by the prior art, to be easily provided with a high purity in a large scale.

摘要翻译： 本发明提供了一种有效提纯现有技术无法有效纯化的5'保护的胸腺嘧啶的方法。 可以通过获得包含含羰基溶剂的晶体来分离杂质，以提供高度纯的5'-保护的胸苷。 因此，本发明允许通过现有技术不能以工业规模纯化的5受保护的胸苷以容易的大规模提供高纯度。

公开(公告)号：US06794392B1

公开(公告)日：2004-09-21

申请号：US09417216

申请日：1999-10-13

申请人： Tsuneji Suzuki ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Osamu Nakanishi ,  Akiko Saito ,  Takashi Yamashita ,  Yoshinori Shiraishi ,  Eishi Tanaka

发明人： Tsuneji Suzuki ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Osamu Nakanishi ,  Akiko Saito ,  Takashi Yamashita ,  Yoshinori Shiraishi ,  Eishi Tanaka

IPC分类号： A61K31505

CPC分类号： C07D213/30 ,  C07C233/80 ,  C07C237/42 ,  C07C255/57 ,  C07C271/20 ,  C07C275/24 ,  C07C275/40 ,  C07C335/16 ,  C07C335/20 ,  C07D207/34 ,  C07D211/22 ,  C07D213/38 ,  C07D213/40 ,  C07D213/50 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/48 ,  C07D215/54 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D233/90 ,  C07D241/12 ,  C07D241/24 ,  C07D249/08 ,  C07D261/08 ,  C07D261/18 ,  C07D263/24 ,  C07D275/03 ,  C07D277/24 ,  C07D277/40 ,  C07D295/088 ,  C07D307/12 ,  C07D307/68 ,  C07D333/16 ,  C07D333/70 ,  C07D401/06 ,  C07D405/12 ,  C07D413/12 ,  C07D453/02 ,  C07D491/04

摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。

公开(公告)号：US20110233412A1

公开(公告)日：2011-09-29

申请号：US12019269

申请日：2008-01-24

申请人： Tsuneaki Kawaguchi ,  Masatoshi Tanaka ,  Shigeru Kimura ,  Katsutoshi Tsuchiya ,  Masami Murayama ,  Junichi Katogi

发明人： Tsuneaki Kawaguchi ,  Masatoshi Tanaka ,  Shigeru Kimura ,  Katsutoshi Tsuchiya ,  Masami Murayama ,  Junichi Katogi

IPC分类号： G21K1/02 ,  G01T1/00

CPC分类号： G21K1/025 ,  G01T1/1648

摘要： A collimator, a radiological imaging apparatus and a nuclear medicine diagnosis apparatus which are able to improve the sensitivity are provided. The radiological imaging apparatus has a collimator 11 disposed to oppose a radiological detection device 12 and having through-holes 11a for passing to the radiological detection device 12 gamma rays in a specified direction out of those radiated from an object to be examined. The collimator 11 is produced by mutually coupling a plurality of metal tubular members 11A each having the through-hole 11a with the help of a bonding agent S in alignment with a plurality of detectors 12a constituting the radiological detection device 12.

摘要翻译： 提供了能够提高灵敏度的准直仪，放射学成像装置和核医学诊断装置。 放射线成像装置具有与放射线检测装置12相对设置的准直仪11，具有通过通孔11a使得放射线检测装置12沿从规定方向射出的伽马射线从被检体的辐射状态射出。 准直仪11是借助于与构成放射线检测装置12的多个检测器12a对准的接合剂S，使具有贯通孔11a的多个金属管状构件11A相互连接而制造的。

公开(公告)号：US20080310580A1

公开(公告)日：2008-12-18

申请号：US12039270

申请日：2008-02-28

申请人： Isao Takahashi ,  Kazuma Yokoi ,  Tsuneaki Kawaguchi ,  Katsutoshi Tsuchiya

发明人： Isao Takahashi ,  Kazuma Yokoi ,  Tsuneaki Kawaguchi ,  Katsutoshi Tsuchiya

IPC分类号： G01N23/00

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： A nuclear medial diagnosis apparatus is used for performing diagnosis by administering a medicine marked with a radioactive isotope into an examinee and by using an image obtained by detecting gamma rays emitted from a particular organ or tumor where the medicine is accumulated. An image (an image created by an image creation unit) is created by a signal (a signal as an output from a radiation detector) corresponding to the energy of the gamma ray detected by a radiation detector. The image includes a contamination component attributed to gamma scattering in the radiation detector. An image correction operation unit performs a convolution operation to obtain a contamination image. The contamination image is subtracted by a corrected image creation unit. Thus, it is possible to prevent image degradation by the gamma ray scattering in the radiation detector.

摘要翻译： 核内诊断装置用于通过将标有放射性同位素的药物给予受检者并使用通过检测从药物积聚的特定器官或肿瘤发射的γ射线获得的图像进行诊断。 图像（由图像创建单元创建的图像）由对应于由辐射检测器检测的伽马射线的能量的信号（作为来自辐射检测器的输出的信号）产生。 图像包括归因于辐射检测器中的伽马散射的污染成分。 图像校正操作单元执行卷积操作以获得污染图像。 污染图像由校正图像创建单元减去。 因此，可以防止辐射检测器中的伽马射线散射引起的图像劣化。

公开(公告)号：US07317028B2

公开(公告)日：2008-01-08

申请号：US10753365

申请日：2004-01-09

申请人： Tsuneji Suzuki ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Osamu Nakanishi ,  Akiko Saito ,  Takashi Yamashita ,  Yoshinori Shiraishi ,  Eishi Tanaka

发明人： Tsuneji Suzuki ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Osamu Nakanishi ,  Akiko Saito ,  Takashi Yamashita ,  Yoshinori Shiraishi ,  Eishi Tanaka

IPC分类号： A61K31/44

CPC分类号： C07D213/30 ,  C07C233/80 ,  C07C237/42 ,  C07C255/57 ,  C07C271/20 ,  C07C275/24 ,  C07C275/40 ,  C07C335/16 ,  C07C335/20 ,  C07D207/34 ,  C07D211/22 ,  C07D213/38 ,  C07D213/40 ,  C07D213/50 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/48 ,  C07D215/54 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D233/90 ,  C07D241/12 ,  C07D241/24 ,  C07D249/08 ,  C07D261/08 ,  C07D261/18 ,  C07D263/24 ,  C07D275/03 ,  C07D277/24 ,  C07D277/40 ,  C07D295/088 ,  C07D307/12 ,  C07D307/68 ,  C07D333/16 ,  C07D333/70 ,  C07D401/06 ,  C07D405/12 ,  C07D413/12 ,  C07D453/02 ,  C07D491/04

摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。

公开(公告)号：US07074917B2

公开(公告)日：2006-07-11

申请号：US11204009

申请日：2005-08-16

申请人： Hironori Komatsu ,  Toshiyuki Kouno ,  Katsutoshi Tsuchiya

发明人： Hironori Komatsu ,  Toshiyuki Kouno ,  Katsutoshi Tsuchiya

IPC分类号： C07H19/00

CPC分类号： C07H19/16 ,  C07H1/06

摘要： A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

公开(公告)号：US08330113B2

公开(公告)日：2012-12-11

申请号：US12019269

申请日：2008-01-24

申请人： Tsuneaki Kawaguchi ,  Masatoshi Tanaka ,  Shigeru Kimura ,  Katsutoshi Tsuchiya ,  Masami Murayama ,  Junichi Katogi

发明人： Tsuneaki Kawaguchi ,  Masatoshi Tanaka ,  Shigeru Kimura ,  Katsutoshi Tsuchiya ,  Masami Murayama ,  Junichi Katogi

IPC分类号： G01T1/00

CPC分类号： G21K1/025 ,  G01T1/1648

摘要： A collimator, a radiological imaging apparatus and a nuclear medicine diagnosis apparatus which are able to improve the sensitivity are provided. The radiological imaging apparatus has a collimator 11 disposed to oppose a radiological detection device 12 and having through-holes 11a for passing to the radiological detection device 12 gamma rays in a specified direction out of those radiated from an object to be examined. The collimator 11 is produced by mutually coupling a plurality of metal tubular members 11A each having the through-hole 11a with the help of a bonding agent S in alignment with a plurality of detectors 12a constituting the radiological detection device 12.

摘要翻译： 提供了能够提高灵敏度的准直仪，放射学成像装置和核医学诊断装置。 放射线成像装置具有与放射线检测装置12相对设置的准直仪11，具有通过通孔11a使得放射线检测装置12沿从规定方向射出的伽马射线从被检体的辐射状态射出。 准直仪11是借助于与构成放射线检测装置12的多个检测器12a对准的接合剂S，使具有贯通孔11a的多个金属管状构件11A相互连接而制造的。