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公开(公告)号：US07687525B2
公开(公告)日：2010-03-30
申请号：US11984206
申请日：2007-11-14
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/44 , A61K31/16 , A61K31/50 , C07D239/42 , A61K31/40
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：US06174905B1
公开(公告)日：2001-01-16
申请号：US08935087
申请日：1997-09-26
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K3144
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：US20100256201A1
公开(公告)日：2010-10-07
申请号：US12721843
申请日：2010-03-11
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/4406 , A61K31/167 , A61K31/4965 , A61K31/381 , A61K31/341 , A61K31/40 , A61K31/42 , A61K31/426 , A61K31/4164 , A61K31/47 , A61K31/4355 , A61K31/444 , A61K31/445 , A61K31/495 , A61K31/27 , A61K31/439 , A61K31/17
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化的作用，因此可用于恶性肿瘤，自身免疫性疾病，皮肤病， 寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：US20080188489A1
公开(公告)日：2008-08-07
申请号：US11984206
申请日：2007-11-14
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/4965 , A61P29/00 , A61K31/164 , A61K31/4406 , A61K31/4402
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
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公开(公告)号：US07317028B2
公开(公告)日：2008-01-08
申请号：US10753365
申请日：2004-01-09
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/44
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：US08026239B2
公开(公告)日：2011-09-27
申请号：US12721843
申请日：2010-03-11
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/497 , A61K31/44 , A61K31/47 , A61K31/445 , C07D211/72 , C07D213/46 , C07D213/55
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： A method of treating a malignant tumor selected from the group consisting of leukemia, colorectal cancer, ovarian cancer, oral cancer, lung carcinoma, breast carcinoma, prostate carcinoma, and melanoma by administering to a patient in need thereof an effective amount of at least one compound represented by formula (1) wherein A, X, Q, R1-3, and n are defined herein.
摘要翻译： 一种治疗选自白血病，结肠直肠癌，卵巢癌，口腔癌，肺癌，乳腺癌，前列腺癌和黑素瘤的恶性肿瘤的方法，通过向有需要的患者施用有效量的至少一种 由式（1）表示的化合物，其中A，X，Q，R1-3和n如本文所定义。
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公开(公告)号：USRE40703E1
公开(公告)日：2009-04-28
申请号：US11542043
申请日：2006-10-03
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/44 , C07D211/70 , C07D211/72 , C07D211/84
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：USRE39754E1
公开(公告)日：2007-07-31
申请号：US10640278
申请日：2003-08-14
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31/44 , A01N43/08 , A01N43/32 , C07D211/70 , C07D327/04 , C07D327/06
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：US06794392B1
公开(公告)日：2004-09-21
申请号：US09417216
申请日：1999-10-13
申请人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人： Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号： A61K31505
CPC分类号： C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译： 由式（1）表示的新型苯甲酰胺衍生物和本发明式（13）表示的新型酰苯胺衍生物具有诱导分化作用，因此可用于恶性肿瘤，自身免疫疾病，皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物，特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号：US08716943B2
公开(公告)日：2014-05-06
申请号：US13027788
申请日：2011-02-15
申请人： Tsuyoshi Oyaizu , Seiko Kawashima , Haruki Takei , Akiko Saito
发明人： Tsuyoshi Oyaizu , Seiko Kawashima , Haruki Takei , Akiko Saito
CPC分类号： H05B33/0884 , H01L2224/45144 , H01L2224/48091 , H01L2224/48137 , H01L2224/73265 , H01L2924/181 , H05B33/0803 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： According to one embodiment, a light-emitting device includes a substrate including an insulating surface, a plurality of light-emitting elements mounted on the surface of the substrate and electrically connected to each other, a positive power feeding conductor and a negative power feeding conductor mounted on the surface of the substrate to feed power to the light-emitting elements, lead-out terminals leading from the power feeding conductors, to the outside of an mounting area of the light-emitting elements, and an anti-noise part connected to the lead-out terminals and arranged outside the mounting area.
摘要翻译： 根据一个实施例，一种发光装置包括：基板，包括绝缘表面;多个发光元件，安装在基板的表面上并彼此电连接，正电力馈送导体和负电力供电导体 安装在基板的表面上，以将功率馈送到发光元件，从馈电导体引出的引出端到发光元件的安装区域的外部，以及连接到 引出端子并布置在安装区域外部。
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