公开(公告)号：US11453931B2

公开(公告)日：2022-09-27

申请号：US17607397

申请日：2020-09-24

Applicant: TANAKA KIKINZOKU KOGYO K.K. ,  TOKUSHIMA UNIVERSITY

Inventor： Michimasa Okubo ,  Kenji Goto ,  Kunihiro Tanaka ,  Kojiro Shiraishi ,  Kunihiro Shima ,  Yuya Kato ,  Kenichi Hamada ,  Eiichi Honda ,  Emi Takegawa

IPC: C22C5/02 ,  C22C1/02

Abstract: The present invention relates to a medical Au—Pt—Pd alloy including Au, Pt, Pd, and inevitable impurities. The alloy has an alloy composition inside a polygon (A1-A2-A3-A4-A5-A6) surrounded by straight lines connected at point A1 (Au: 37.9 atom %, Pt: 0.1 atom %, and Pd: 62 atom %), point A2 (Au: 79.9 atom %, Pt: 0.1 atom %, and Pd: 20 atom %), point A3 (Au: 79.9 atom %, Pt: 20 atom %, and Pd: 0.1 atom %), point A4 (Au: 69.9 atom %, Pt: 30 atom %, and Pd: 0.1 atom %), point A5 (Au: 49 atom %, Pt: 30 atom %, and Pd: 21 atom %), and point A6 (Au: 39 atom %, Pt: 40 atom %, and Pd: 21 atom %) in a Au—Pt—Pd ternary state diagram. The metal structure of the alloy is optimized, and the metal structure is close to a single-phase structure, and has little precipitation of a Au-rich phase and a Pt-rich phase different in composition from a mother phase.

公开(公告)号：US20220257676A1

公开(公告)日：2022-08-18

申请号：US17626622

申请日：2020-07-17

Applicant: Asahi Group Holdings, Ltd. ,  Tokushima University

Inventor： Daisuke SAWADA ,  Shigeru FUJIWARA ,  Tomonori SUGAWARA ,  Kazuhito ROKUTAN ,  Kensei NISHIDA ,  Yuki KUWANO

IPC: A61K35/747 ,  A61P15/00 ,  A61P17/10 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24

Abstract: [Problem] The purpose of the present invention is to provide a novel technology capable of regulating female hormone secretion. [Solution] Provided is an agent for regulating female hormone secretion, which contains the lactobacillus strain Lactobacillus gasseri strain CP2305 (accession No.: FERM PB-11331), a treated product of said lactobacillus strain, or extracts thereof.

公开(公告)号：US20220220234A1

公开(公告)日：2022-07-14

申请号：US17608591

申请日：2020-05-08

Applicant: SEKISUI CHEMICAL CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Yohei NISHIMURA ,  Risa YAMAZAKI ,  Koichi UTE ,  Miyuki OSHIMURA ,  Tomohiro HIRANO ,  Ryo KAGITANI

IPC: C08F16/06 ,  C08F16/38 ,  C08F8/30

Abstract: The present invention provides a vinyl alcohol-amino acid ester copolymer that is excellent in properties such as cell culture properties, biocompatibility, antibacterial properties, and solubility in organic solvents, and is applicable to the medical field, the biomaterial field, and the agricultural field (medical and life science fields). Provided is a vinyl alcohol-amino acid ester copolymer including a unit represented by the following formula (1) and a unit represented by the following formula (2): where, in the formula (2), R1 represents a hydrocarbon group that may optionally have a substituent, R2 and R3 each independently represent a hydrogen atom or a hydrocarbon group, and R1 and R2, or R2 and R3, may optionally be bonded together to form a cyclic structure.

公开(公告)号：US20210253522A1

公开(公告)日：2021-08-19

申请号：US17270334

申请日：2019-08-22

Applicant: TOKUSHIMA UNIVERSITY ,  AICHI STEEL CORPORATION

Inventor： Kosuke NAMBA ,  Motofumi SUZUKI ,  Akane MERA

IPC: C07D207/16 ,  C05C11/00 ,  A01N59/16 ,  A01N43/36 ,  C07F15/02

Abstract: The present invention is a heterocycle-containing amino acid compound represented by a general formula (1): wherein R1 and R2 are identical with or different from each other, and each represent a hydrogen atom or a carboxy-protecting group; R3 represents a carboxyl group or a hydroxyl group; and n is 1 or 2, or a salt thereof.

公开(公告)号：US10732099B2

公开(公告)日：2020-08-04

申请号：US16068087

申请日：2016-12-20

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Yoshihiro Deguchi

IPC: G01N21/27 ,  G01N21/39 ,  G01N21/3504 ,  G01N21/03

Abstract: A gas analysis device includes a laser light source configured to output a laser beam, an irradiation unit configured to irradiate a measurement region including measurement target gas with the laser beams in plural directions, plural photoreceivers each configured to receive a laser beam having passed through the measurement region and output an electric signal according to intensity of the received laser beam, and an analyzer configured to analyze the physical state of the measurement target gas based on the electric signal output from each photoreceiver. The analyzer sets a function (e.g. two-dimensional polynomial f(X,Y)) representing the physical state (e.g. concentration, temperature) of the target gas at least in the measurement region, and measures the physical state of the target gas by determining a coefficient of each of terms included in the function based on a measured value obtained from the electric signal output from the photoreceiver.

公开(公告)号：US20200181579A1

公开(公告)日：2020-06-11

申请号：US16341175

申请日：2017-10-06

Applicant: Tokushima University

Inventor： Hideharu ABE

IPC: C12N5/071 ,  G01N33/50

Abstract: A novel tissue usable for a kidney tissue model is provided. A method for producing a kidney-like tissue includes co-culturing a cell group containing mesenchymal stem cells, vascular endothelial cells, and clonal embryonic kidney cells.

公开(公告)号：US10400226B2

公开(公告)日：2019-09-03

申请号：US14436833

申请日：2013-10-17

Applicant: TOKUSHIMA UNIVERSITY ,  MEIJI PHARMACEUTICAL UNIVERSITY

Inventor： Koji Ito ,  Hitoshi Sakuraba ,  Daisuke Tsuji

IPC: C12N9/24 ,  A61K38/47 ,  A61K38/00

Abstract: Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.

公开(公告)号：US20190153136A1

公开(公告)日：2019-05-23

申请号：US16098478

申请日：2017-05-08

Applicant: TOKUSHIMA UNIVERSITY ,  SEKISUI CHEMICAL CO., LTD.

Inventor： Koichi UTE ,  Tomohiro HIRANO ,  Miyuki OSHIMURA ,  Yasunari KUSAKA

IPC: C08F216/38 ,  C08F216/06 ,  B01J31/12

Abstract: The present invention provides a vinyl alcohol-vinyl acetate copolymer having excellent solubility and a method for producing a vinyl alcohol-vinyl acetate copolymer. Provided is a vinyl alcohol-vinyl acetate copolymer including a unit of vinyl alcohol and a unit of vinyl acetate, the vinyl alcohol-vinyl acetate copolymer having a randomness value R of 0.5 or higher, the randomness value R being obtained using the following equation (1): R = 1 L A + 1 L O ( 1 ) where LO represents a mean chain length of the unit of vinyl alcohol and LA represents a mean chain length of the unit of vinyl acetate.

公开(公告)号：US20180303093A1

公开(公告)日：2018-10-25

申请号：US15767660

申请日：2016-11-01

Applicant: AICHI STEEL CORPORATION ,  TOKUSHIMA UNIVERSITY

Inventor： Kosuke NAMBA ,  Yoshiko MURATA

IPC: A01N43/36 ,  A01N59/16

CPC classification number: A01N43/36 ,  A01N59/16 ,  C05D9/02 ,  C05F11/10 ,  C07D207/16 ,  Y02P20/55

Abstract: Provided is a novel heterocycle-containing amino acid compound that has a metal uptake ability equivalent to mugineic acids and can be less expensively produced than mugineic acids. Also provided are a fertilizer and a plant growth regulating agent each comprising the novel heterocycle-containing amino acid compound. The present invention is a heterocycle-containing amino acid compound represented by general formula (1): (wherein: R1, R2 and R3 are the same or different and represent a hydrogen atom or a carboxyl-protecting group; R4 represents a hydrogen atom or a hydroxy-protecting group; R5 represents a hydrogen atom or an amino-protecting group; and n is an integer of 1-3) or a salt thereof and use of the same.

公开(公告)号：US20180217053A1

公开(公告)日：2018-08-02

申请号：US15748261

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Michio YAMAJI ,  Nobukazu IKEDA ,  Kouji NISHINO ,  Masayoshi KAWASHIMA ,  Kazuteru TANAKA

IPC: G01N21/31 ,  G01N21/59 ,  G01J3/42

CPC classification number: G01N21/3103 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J3/433 ,  G01J2001/4242 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/59 ,  G01N2021/3133 ,  G01N2201/0625 ,  G01N2201/0627

Abstract: A concentration measurement device including at least one light source; a measurement cell for containing a fluid to be measured; a splitter for dividing light from the light source into incident light being incident into the measurement cell and non-incident light not being incident into the measurement cell; a transmitted-light detector for detecting transmitted light that is the incident light having passed through the measurement cell; a non-incident light detector for detecting the non-incident light; and an arithmetic part for correcting a detection signal of the transmitted-light detector using a detection signal of the non-incident light detector.