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公开(公告)号：US20220130031A1
公开(公告)日：2022-04-28
申请号：US17491150
申请日：2021-09-30
发明人： Damon Woodard , Mark M. Tehranipoor , Navid Asadi-Zanjani , Ronald Wilson , Hangwei Lu , Nidish Vashistha
摘要： Embodiments of the present disclosure provide methods, apparatus, systems, and computer program products for using an image of an integrated circuit (IC) including a plurality of cells to locate one or more target cells within the IC. Accordingly, in various embodiments, a footprint for each cell of the plurality of cells is encoded to transform the image of the IC into a two-dimensional string matrix. A string search algorithm is then applied on each encoded dopant region found in the two-dimensional string matrix using an encoded target layout cell to identify one or more candidate regions of interest within the image. Finally, a mask window is slid over each candidate region of interest while performing matching using match criteria to identify any target cells in the one or more target cells that are located within the candidate region of interest.
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公开(公告)号：US20220127337A1
公开(公告)日：2022-04-28
申请号：US17512027
申请日：2021-10-27
IPC分类号： C07K16/10 , A61P31/14 , G01N33/569
摘要： Described are methods for generating human antibodies capable of blocking one or more functions of coronavirus viroporins. The methods can be used to generate therapeutic antibodies to treat or prevent coronavirus infection, including SARS-CoV-2 infection.
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公开(公告)号：US20220125908A1
公开(公告)日：2022-04-28
申请号：US17431281
申请日：2020-02-14
IPC分类号： A61K39/095 , A61P31/04 , A61K45/06
摘要： Embodiments herein include an attenuated live vaccine composition for protection against Neisseria spp. infection, the vaccine composition comprising an effective amount of Snodgras sella alvi (S. alvi), or an antigen component thereof, and methods for treating or preventing disease related to or aggravated by Neisseria gonorrhoea is provided.
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公开(公告)号：US20220105078A1
公开(公告)日：2022-04-07
申请号：US17321210
申请日：2021-05-14
IPC分类号： A61K31/426 , C07D277/10
摘要： Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a poly ether moiety at the 4′-position of the phenyl ring of the compound.
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75.发明授权公开(公告)号：US11270439B2
公开(公告)日：2022-03-08
申请号：US17250947
申请日：2019-10-09
摘要： A histogram-based method for auto segmentation of integrated circuit structures is disclosed. The method includes an auto-segmentation process/algorithm, which works on the histogram of the SEM image and does not try to model the noise sources or the features. The auto-segmentation process/algorithm extracts the number of peaks in the histogram from low magnification SEM images or SEM images not necessarily having high quality images, significantly simplifies the traditionally lengthy and expensive IC reverse engineering efforts. Hence, the size of the image does not affect the final segmentation. The auto-segmentation process/algorithm performs the steps of: extract a first histogram from the first SEM image; identifying boundaries of the plurality of structural elements in the IC based at least in part on an output of the first histogram; and auto-segmenting the first SEM image into the plurality of structural elements.
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公开(公告)号：US11248058B2
公开(公告)日：2022-02-15
申请号：US15552071
申请日：2016-02-19
发明人： Lung-Ji Chang
IPC分类号： C07K16/30 , C07K14/705 , C07K14/715 , C07K16/28 , A61K39/00 , A61P35/00 , C07K14/725 , C12N15/85
摘要： Provided herein are chimeric antigen receptors (CARs) comprising an antigen binding domain (e.g., CD19, CD30, GD2, etc.), transmembrane domain (e.g., CD28), and a cytoplasmic domain (e.g., CD27, 4-1BB, etc.). In some aspects, the disclosure relates to use of the CARs in T cells, compositions, kits and methods.
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公开(公告)号：US20220028086A1
公开(公告)日：2022-01-27
申请号：US17378438
申请日：2021-07-16
摘要： Various embodiments of the present disclosure provide for accelerated segmentation for reverse engineering of integrated circuits. In one example, an embodiment provides for receiving an SEM image for an integrated circuit, performing filtering and binarization with respect to the SEM image, extracting information associated with filter sizes for the filtering, extracting signatures related to a distribution for background pixels and foreground pixels of the SEM image, extracting respective distance to mean signatures for the background pixels and the foreground pixels, and segmenting the SEM image based at least in part on the filter sizes and the respective distance to mean signatures to generate a segmented image for the integrated circuit.
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公开(公告)号：US20210406384A1
公开(公告)日：2021-12-30
申请号：US17357265
申请日：2021-06-24
发明人： Yier Jin , Yichen Jiang , Xuan Zhang , Huifeng Zhu , Xiaolong Guo
IPC分类号： G06F21/57 , G11C11/406 , G11C11/4096 , G11C11/4076
摘要： Embodiments provide for predicting rowhammer attack vulnerability of one or more memory cells of a direct random access memory (DRAM) chip, the DRAM chip including a plurality of memory cells. An example method, determines, for each memory cell of a subset of memory cells of the plurality of memory cells, a leakage time t, a resistance of intrinsic leakage RL based at least in part on the leakage time t, an activation time of an adjacent aggressor row to flip a bit in the memory cell, a resistance of coupling leaking RSW based at least in part on the activation time, and a toggling count. The method identifies, based at least in part on one or more of the RSW, RL, or toggling count, whether the direct random memory access (DRAM) chip is vulnerable to a rowhammer attack.
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79.发明授权公开(公告)号：US11207382B2
公开(公告)日：2021-12-28
申请号：US16326488
申请日：2017-08-18
发明人： Steven C. Ghivizzani
IPC分类号： A61K38/20 , A61K35/761 , A61K9/00 , A61K35/32 , A61K45/06
摘要： Methods and compositions for treating symptoms of conditions such as but not limited to osteoarthritis and rheumatoid arthritis. The methods may feature direct intraarticular injection of a recombinant self-complementary adeno-associated virus (sc-rAAV) with a vector adapted to express a modified IL-1Ra peptide. The methods of the present invention may express a therapeutically effective amount of the modified IL-1Ra peptide so as to ameliorating symptoms associated with the condition being treated.
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公开(公告)号：US20210390883A1
公开(公告)日：2021-12-16
申请号：US17303988
申请日：2021-06-11
发明人： Sean P. KILEY , Anthony DESTEPHENS
摘要： Described is an open chest cardiac massage (OCCM) task trainer. The OCCM task trainer includes a simulated chest cavity and a simulated heart having a form factor, feel, dimensions, mechanical properties, deformability, and other characteristics that are substantially equivalent to a human heart. The OCCM task trainer includes componentry for structural support of other components and for facilitating navigation of the chest cavity by a trainee prior to simulating OCCM. The OCCM task trainer includes a simulated skin and sternum configured to be surgically separated and reformed for repeated anterior access to the chest cavity. The task trainer includes one or more sensors placed on, about, and/or within the simulated heart in order to determine the effectiveness of OCCM as simulated by a trainee. Computing circuitry and methods are described for providing real-time feedback to a trainee about the effectiveness of simulated OCCM relative to best practices for OCCM procedures.
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