公开(公告)号：US11986536B2

公开(公告)日：2024-05-21

申请号：US17393626

申请日：2021-08-04

Applicant: ABLEVIA BIOTECH GMBH

Inventor： Oskar Smrzka ,  Bettina Wanko

IPC: A61K47/68 ,  A61K38/00 ,  A61K47/64 ,  C07K5/04 ,  C07K7/06 ,  C07K16/18

CPC classification number: A61K47/6811 ,  A61K47/643 ,  A61K47/644 ,  C07K5/04 ,  C07K7/06 ,  A61K38/00 ,  C07K16/18

Abstract: The present invention provides a compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P(—S—P)(n-1) and a second peptide n-mer of the general formula P(—S—P)(n-1); wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent.

公开(公告)号：US20240158481A1

公开(公告)日：2024-05-16

申请号：US18328960

申请日：2023-06-05

Applicant: Teva Pharmaceuticals International GmbH

Inventor： Joerg Zeller ,  Kristian T. Poulsen ,  Yasmina Noubia Abdiche ,  Jaume Pons ,  Sierra Jones Collier ,  Arnon Rosenthal

IPC: C07K16/18 ,  A61K31/4045 ,  A61K39/395 ,  C07K16/26

CPC classification number: C07K16/18 ,  A61K31/4045 ,  A61K39/3955 ,  C07K16/26 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/70

Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

公开(公告)号：US20240156977A1

公开(公告)日：2024-05-16

申请号：US18492348

申请日：2023-10-23

Applicant: Pfizer Inc.

Inventor： Andrea Therese HOOPER ,  Kimberly Ann MARQUETTE ,  Chakrapani SUBRAMANYAM ,  Hans-Peter GERBER ,  Chad Michael MAY

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/18

CPC classification number: A61K47/6803 ,  A61K47/6843 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08 ,  A61K47/6811

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

公开(公告)号：US11981729B2

公开(公告)日：2024-05-14

申请号：US18449190

申请日：2023-08-14

Applicant: Agency for Science, Technology and Research

Inventor： Frederic Bard ,  Anh Tuan Nguyen ,  Ros Manon

IPC: A61K39/395 ,  C07K16/18

CPC classification number: C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622

Abstract: We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

公开(公告)号：US20240151722A1

公开(公告)日：2024-05-09

申请号：US18547075

申请日：2022-02-21

Applicant: The University of Tokyo ,  Tsuzuki Educational Institute

Inventor： Takahisa Murata ,  Tatsuro Nakamura ,  Nanae Nagata ,  Kosuke Aritake ,  Sakura Masuko

IPC: G01N33/573 ,  C07K16/18 ,  G01N33/531

CPC classification number: G01N33/573 ,  C07K16/18 ,  G01N33/531 ,  C07K2317/24 ,  G01N2333/99 ,  G01N2800/24

Abstract: The present invention relates to a monoclonal antibody or a fragment thereof that specifically binds to tetranor-PGDM.

公开(公告)号：US20240150449A1

公开(公告)日：2024-05-09

申请号：US18549629

申请日：2022-03-10

Applicant: MABYLON AG ,  UNIVERSITY OF ZURICH

Inventor： Dimitri BIELI ,  Natascha WUILLEMIN ,  Niccolo PENGO ,  Tiziana Maria SONATI ,  Pierre DE ROSSI ,  Magdalini POLYMENIDOU ,  Marc EMMENEGGER ,  Adriano AGUZZI

IPC: C07K16/18 ,  A61K39/00 ,  A61K49/00 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K49/0002 ,  A61P25/28 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622

Abstract: The present invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to the pathological form of TDP-43, which characterizes various TDP-43 proteinopathies. The antibodies, and antigen binding fragments thereof, decrease TDP-43 aggregation observed under pathological conditions. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the diagnosis, treatment and prevention of TDP-43 proteinopathies.

公开(公告)号：US20240150448A1

公开(公告)日：2024-05-09

申请号：US18545688

申请日：2023-12-19

Applicant: AMGEN INC.

Inventor： Neeraj Jagdish AGRAWAL ,  Irwin CHEN ,  Su CHONG ,  Bryna FUCHSLOCHER ,  Kevin GRAHAM ,  Agnes Eva HAMBURGER ,  Mark Leo MICHAELS ,  Christopher MOHR ,  Derek E. PIPER ,  Kenneth William WALKER ,  Zhulun WANG ,  Cen XU

IPC: C07K16/18 ,  A61K38/22 ,  A61P25/06 ,  C07K16/28

CPC classification number: C07K16/18 ,  A61K38/2278 ,  A61P25/06 ,  C07K16/2869 ,  A61K2039/545 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

公开(公告)号：US20240150447A1

公开(公告)日：2024-05-09

申请号：US18501780

申请日：2023-11-03

Applicant: Cephalon, LLC

Inventor： Jason TIEN ,  Jennifer STRATTON ,  David S. WILSON

IPC: C07K16/18 ,  C07K16/28 ,  C12N9/24

CPC classification number: C07K16/18 ,  C07K16/2863 ,  C12N9/2402 ,  C12Y302/0105 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/75 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/30

Abstract: The present disclosure generally relates to compositions and methods for enhancing transport of molecules into the brain using modified IgG Fc regions, and methods of producing and using molecules comprising such modified Fc regions.

公开(公告)号：US11976384B2

公开(公告)日：2024-05-07

申请号：US17518221

申请日：2021-11-03

Applicant: Manifold Biotechnologies, Inc.

Inventor： Pierce Ogden ,  Gleb Kuznetsov ,  Shane Lofgren ,  Kathleen Nudel ,  Hoong Chuin Lim ,  Karen Duffy ,  Jeffrey Chang

IPC: C40B40/08 ,  C07K16/00 ,  C07K16/18 ,  C07K17/02 ,  C12N15/10

CPC classification number: C40B40/08 ,  C07K16/005 ,  C07K16/18 ,  C07K17/02 ,  C12N15/1037 ,  C07K2317/55

Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.

公开(公告)号：US11976125B2

公开(公告)日：2024-05-07

申请号：US17150272

申请日：2021-01-15

Applicant: Harpoon Therapeutics, Inc.

Inventor： Holger Wesche ,  Bryan D. Lemon ,  Richard J. Austin

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K47/6849 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07K16/18 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94

Abstract: Disclosed herein are B cell maturation antigen binding proteins with improved binding affinities and improved ability to mediate killing of cancer cells expressing B cell maturation antigen (BCMA). Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of treatment of a cancer or a metastasis thereof using such formulations are further provided.