公开(公告)号：US20040109878A1

公开(公告)日：2004-06-10

申请号：US10717101

申请日：2003-11-19

发明人： Harold L. Atkins ,  John C. Bell ,  Conrad J. Heilman JR. ,  Brian D. Lichty ,  Robert M. Lorence ,  Michael S. Roberts ,  David F. Stojdl

IPC分类号： A01N063/00 ,  A61K039/15

CPC分类号： C12N5/0093 ,  A61K35/14 ,  A61K35/28 ,  A61K35/765 ,  A61K35/766 ,  A61K35/768 ,  C12N2501/24 ,  A61K2300/00

摘要： The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating graft-versus host diseases, and autoimmune cells. The subject invention also relates to the purging of undesirable cells from bone marrow or peripheral blood cell harvests in the treatment of mammals including cancer patients, transplant recipients, and patients with autoimmune disease.

摘要翻译： 本发明涉及能够清除（减少或消除）细胞混合物中的不需要的细胞的病毒。 不想要的细胞可以包括肿瘤细胞，介导移植物抗宿主病的细胞和自身免疫细胞。 本发明还涉及在治疗包括癌症患者，移植受体和患有自身免疫疾病的患者的哺乳动物中从骨髓或外周血细胞收获中清除不期望的细胞。

公开(公告)号：US20040076615A1

公开(公告)日：2004-04-22

申请号：US10432565

申请日：2003-05-22

发明人： Reiner Grabowski ,  Manuela Braunschweiger ,  Alexander Gasch ,  Kornelia Berghof

IPC分类号： A01N063/00 ,  A01N063/04 ,  A01N065/00

CPC分类号： C12N1/18 ,  C12Q1/6895

摘要： The invention relates to the use of a yeast strain for human and animal consumption. It may be dispensed as a fermented drink, drink suspension, medicine or component in a baked mixture. Extracts from cells of the strain may also be consumed.

摘要翻译： 本发明涉及酵母菌株用于人和动物消费的用途。 它可以作为发酵饮料，饮料悬浮液，药物或组分在焙烧混合物中分配。 菌株细胞的提取物也可能被消耗。

公开(公告)号：US20040038825A1

公开(公告)日：2004-02-26

申请号：US10344374

申请日：2003-06-09

发明人： Jarrod Ethan Leland ,  Donald E Mullins ,  Larry Jay Vaughn

IPC分类号： A01N063/00

CPC分类号： A01N63/00 ,  A01N25/22 ,  A01N63/04 ,  A01N2300/00

摘要： The invention provides a formulation for the protection of a bioactive agent, a method of producing the formulation, and methods for using the formulation. In the formulation, the bioactive agent is coated with a water-soluble protective material, dried, and suspended in a hydrophobic carrier such as an oil. The formulation is used to deliver the bioactive to a target substrate. The bioactive agent may be a biopesticidal microbe, the protective material may be a lignin, and the target substrate may be an insect pest or plant.

摘要翻译： 本发明提供了用于保护生物活性剂的制剂，制备该制剂的方法和使用该制剂的方法。 在制剂中，生物活性剂涂覆有水溶性保护材料，干燥并悬浮在疏水载体如油中。 该制剂用于将生物活性递送至靶基质。 生物活性剂可以是生物杀虫微生物，保护性材料可以是木质素，靶基质可以是害虫或植物。

公开(公告)号：US20030211082A1

公开(公告)日：2003-11-13

申请号：US10296158

申请日：2002-11-22

发明人： Mark A. Holland

IPC分类号： A01N063/00 ,  A01H005/00

CPC分类号： A01N63/00 ,  A01C1/00 ,  A01H1/00 ,  A01H1/02 ,  A01H3/00 ,  A01H5/02

摘要： A method for altering fertility of a plant or modifying its structure is described. The method comprises, in any order, contacting the seed of the plant with Pink-Pigmented Facultative Methylotroph (PPFM) that in the aggregate produces more or less amount of cytokinin than the PPFM that was previously associated with the plant, and then planting the seed.

摘要翻译： 描述了改变植物生育力或改变其结构的方法。 该方法以任何顺序包含与植物的种子接触的粉红色 - 色素兼性甲养殖（PPFM），其总共产生比先前与植物相关的PPFM更多或更少量的细胞分裂素，然后种植种子 。

公开(公告)号：US20030211081A1

公开(公告)日：2003-11-13

申请号：US10459513

申请日：2003-06-12

申请人： Empresa Brasileira De Pesquisa Agropecuaria - Embrapa

发明人： Wilmar Corio da Luz

IPC分类号： A01N063/00 ,  C12N001/20

CPC分类号： A01N63/00

摘要： Microbiological agents are provided for control of certain diseases of wheat and other cereals caused by Fusarium species, including Fusarium head blight of wheat and other cereals. These agents can also improve yield of wheat plants and cereals. The agents are novel isolates of Pantoea agglomerans and of Bacillus megaterium that exhibit the property of inhibiting fungal pathogens, particularly those produced by Fusarium species. Biocontrol compositions, and methods of using them to control plant pathogen development on wheat and cereal plants and for increasing plant yield, are also provided. The biocontrol compositions comprise a mixture of at least one microorganism selected from the group consisting of Pantoea agglomerans and Bacillus megaterium.

摘要翻译： 提供微生物用于控制由镰孢属物种引起的小麦和其他谷物的某些疾病，包括小麦和其他谷类的镰刀菌病。 这些药剂也可以提高小麦植物和谷类的产量。 这些试剂是组合泛菌和巨大芽孢杆菌的新型分离物，其表现出抑制真菌病原体的特性，特别是由镰刀菌属物种产生的菌体。 还提供了生物防治组合物，以及使用它们来控制小麦和谷类植物上的植物病原体发育以及提高植物产量的方法。 生物防治组合物包含至少一种选自组氨球菌和巨大芽孢杆菌的微生物的混合物。

公开(公告)号：US20030207252A1

公开(公告)日：2003-11-06

申请号：US09935100

申请日：2001-08-22

发明人： David B. Weiner ,  David Nathan Levy ,  Yosef Refaeli

IPC分类号： A61K048/00 ,  C12N015/63 ,  A61K038/17 ,  C12Q001/70 ,  A01N063/00 ,  A61K038/00 ,  C07K014/00 ,  C12N015/85 ,  C07H021/04 ,  C07K017/00 ,  C12P021/08 ,  G01N033/564 ,  C07K001/00 ,  C07K016/00 ,  C12N015/87 ,  G01N033/53

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6921 ,  C12N2740/16322 ,  G01N33/56988

摘要： Pharmaceutical compositions comprising the HIV protein vpr or nucleic acid molecule encoding vpr are disclosed. Also disclosed are methods of treating patients suffering from diseases characterized by hyperproliferating undifferentiated cells such as cancer by administering such compositions. Methods of identifying compounds which have anti-HIV activity are disclosed, in particular, methods of identifying compounds which modulate the activity of vpr and of identifying compounds which inhibit vpr binding to the HIV protein gag.

摘要翻译： 公开了包含HIV蛋白质vpr或编码vpr的核酸分子的药物组合物。 还公开了通过施用这样的组合物治疗患有特征在于通过过度增殖未分化细胞例如癌症的患者的方法。 公开了鉴定具有抗HIV活性的化合物的方法，特别是鉴定调节vpr活性的化合物和鉴定抑制vpr与HIV蛋白质凝胶结合的化合物的方法。

公开(公告)号：US20030195117A1

公开(公告)日：2003-10-16

申请号：US10139063

申请日：2002-05-02

发明人： Takahiro Imada ,  Naoya Hiruma ,  Tsuyoshi Isawa ,  Munehiro Noda ,  Yohsuke Kurihara ,  Madoka Kon

IPC分类号： A01N063/00 ,  A01N025/26

CPC分类号： A01N63/00

摘要： The objective of the present invention is to confer pest resistance to plants of Poaceae without using any chemically synthesized pesticides. The pest resistance can be conferred to plants of Poaceae by isolating from a natural plant an endophytic bacterium capable of expressing pest resistance, artificially culturing the endophytic baterium, and introducing the bacteria to a Poaceae plant of interest.

摘要翻译： 本发明的目的是在不使用任何化学合成的农药的情况下赋予禾本科植物抗病虫害性。 通过从天然植物中分离出能够表达害虫抗性的内生细菌，人工培养内生菌，并将细菌引入感兴趣的禾本科植物，可以将抗病性赋予禾本科植物。

公开(公告)号：US20030186813A1

公开(公告)日：2003-10-02

申请号：US10394929

申请日：2003-03-19

发明人： Jay C. Pershing ,  Eric S. Sachs ,  Ernest F. Sanders

IPC分类号： A01C001/00 ,  A01G001/00 ,  A01N063/00 ,  A01H001/00

CPC分类号： A01N51/00 ,  A01N63/00 ,  A01N63/02 ,  Y02A50/356 ,  A01N53/00 ,  A01N61/00 ,  A01N2300/00

摘要： A method to protect corn against feeding damage by one or more pests includes the treatment of corn seed having a transgenic event that is targeted against at least one of the pests with a pesticide in an amount that is effective against the same or another of the one or more pests. Seeds having such protection are also disclosed, as well as a means for deploying a non-transgenic refuge crop into a field of transgenic crops.

摘要翻译： 一种保护玉米免受一种或多种害虫侵害的方法包括：处理具有转基因事件的玉米种子，所述转基因事件针对至少一种害虫，其中杀虫剂的量对一种或多种害虫的相同或另一种有效 或更多的害虫。 还披露了具有这种保护的种子，以及用于将非转基因避难作物部署到转基因作物领域的手段。

公开(公告)号：US20030186812A1

公开(公告)日：2003-10-02

申请号：US10102948

申请日：2002-03-22

发明人： Amitabha Chattopadhyay ,  Neeru Gupta ,  Mahendra Pandurang Darokar ,  Suman Preet Singh Khanuja

IPC分类号： A01N063/00 ,  A01N025/00

CPC分类号： C05F11/10 ,  A01N61/00 ,  A01N65/00 ,  A01N65/22 ,  C05F5/006 ,  Y02A40/19 ,  Y02A40/211 ,  A01N59/02 ,  A01N59/16

摘要： The present invention relates to a mint spent compost based synergistic formulation useful as plant growth regulator comprising bioactive extracts from mint spent compost such as composted distilled crop residue of Menthol mint; Mentha arvensis etc., and nutrient mixtures exhibiting synergistic effect in enhancing plant growth also this invention provides a unique process for the preparation of the said formulation and the methods of its application.

摘要翻译： 本发明涉及用作植物生长调节剂的薄荷废弃堆肥基协同配方，其包括薄荷废堆肥如薄荷醇薄荷的堆肥蒸馏作物残余物的生物活性提取物; Mentha arvensis等，以及在增强植物生长中表现出协同效应的营养混合物，本发明也提供了制备所述制剂的独特方法及其应用方法。

公开(公告)号：US20030185806A1

公开(公告)日：2003-10-02

申请号：US09751373

申请日：2000-12-29

申请人： John Wayne Cancer Institute

发明人： Donald L. Morton

IPC分类号： C07H021/04 ,  A61K048/00 ,  A01N063/00 ,  C12N015/09 ,  C12N015/63 ,  C12N015/74 ,  A61K039/00 ,  A61K039/385 ,  A61K039/12 ,  C12N015/00 ,  C12N015/70

CPC分类号： A61K39/0011

摘要： The present invention is directed to compositions and methods for the induction of immune responses in mammals against enveloped animal viruses. More particularly, the invention provides vaccine compositions containing multiple MHC allotypes. By generating an immune response against these MHC molecules, virus or virus-infected cells expressing foreign MHC molecules can be attacked prior to infection of cells in the immunized host. In some embodiments, the vaccine compositions contain viral antigens and adjuvants as well. The vaccine compositions may comprise intact cells, cell-derived membrane preparations or recombinantly or chemically produced MHC molecules or fragments thereof.

摘要翻译： 本发明涉及用于诱导哺乳动物针对包膜动物病毒的免疫应答的组合物和方法。 更具体地，本发明提供了含有多种MHC同种异型的疫苗组合物。 通过产生针对这些MHC分子的免疫应答，可以在免疫宿主中感染细胞之前攻击表达外源MHC分子的病毒或病毒感染细胞。 在一些实施方案中，疫苗组合物也含有病毒抗原和佐剂。 疫苗组合物可以包含完整细胞，细胞衍生的膜制备物或重组或化学产生的MHC分子或其片段。