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    Processes for the recovery of optically active diacyltartaric acids
    72.
    发明授权
    Processes for the recovery of optically active diacyltartaric acids 有权
    回收光学活性二酰基酒石酸的方法

    公开(公告)号：US07358384B2

    公开(公告)日：2008-04-15

    申请号：US10542498

    申请日：2003-12-22

    申请人： Seiji Morii ,  Toshihiro Fujino ,  Haruyo Sato

    发明人： Seiji Morii ,  Toshihiro Fujino ,  Haruyo Sato

    IPC分类号： C07C69/76 ,  C07C69/66 ,  C07C51/42 ,  C07C59/255

    CPC分类号： C07C67/52 ,  C07B2200/07 ,  Y02P20/582 ,  C07C69/76

    摘要： When a salt of an amine and an optically active diacyltartaric acid, or a diastereomer salt of an optically active amine and an optically active diacyltartaric acid, obtained by optically resolving a racemic amine using the optically active diacyltartaric acid, is salt-exchanged with an acid aqueous solution, the optically active diacyltartaric acid is added in the acid aqueous solution beforehand.Furthermore, a raw material containing a racemic amine and an optically active diacyltartaric acid is optically resolved, and the diastereomer salt of the optically active amine and the optically active diacyltartaric acid respectively of one isomer type, is separated. The obtained diastereomer salt is dissociated using an acid aqueous solution containing the optically active diacyltartaric acid, for recovering the optically active diacyltartaric acid, and the obtained optically active diacyltartaric acid is recycled into an optical resolution step as a raw material of the optical resolution step.

    摘要翻译： 当通过光学拆分外消旋胺使用光学活性的二酰基酒石酸获得的胺和光学活性二酰基酒石酸盐或光学活性胺和光学活性二酰基酒石酸的非对映体盐与酸盐交换时， 水溶液中，将光学活性的二酰基酒石酸预先加入到酸性水溶液中。 此外，含有外消旋胺和光学活性二酰基酒石酸的原料被光学拆分，分离出一种异构体类型的光学活性胺和光学活性二酰基酒石的非对映异构体盐。 使用含有光学活性二酰基酒石酸的酸性水溶液使得到的非对映异构体盐解离，回收光学活性的二酰基酒石酸，将得到的光学活性二酰基酒石再循环至作为光学拆分工序的原料的光学拆分工序。

    Production of hydroxy fatty acids and estolide intermediates
    75.
    发明授权
    Production of hydroxy fatty acids and estolide intermediates 失效
    羟基脂肪酸和内酯中间体的生产

    公开(公告)号：US5380894A

    公开(公告)日：1995-01-10

    申请号：US662606

    申请日：1991-03-01

    申请人： Douglas A. Burg ,  Robert Kleiman ,  Selim M. Erhan

    发明人： Douglas A. Burg ,  Robert Kleiman ,  Selim M. Erhan

    IPC分类号： C07C69/675 ,  C07C69/732 ,  C07C59/255

    CPC分类号： C07C69/675 ,  C07C69/732

    摘要： A process for the production of hydroxy fatty acids and novel estolide compounds, each of which may be used as lubricants, greases, plasticizers and printing inks, as well as in cosmetics. The estolides are of the formula (I): ##STR1## wherein R.sub.1 is selected from C.sub.6 -C.sub.16 hydrocarbons which may be saturated or unsaturated, and branched or straight chain, and optionally substituted, such as with one or more hydroxy groups; R.sub.2 is independently selected from C.sub.2 -C.sub.17 hydrocarbons which may be saturated or unsaturated, and branched or straight chain, and optionally substituted, such as with one or more hydroxy groups; A is selected from C.sub.3 -C.sub.14 hydrocarbons which may be saturated or unsaturated, and branched or straight chain, and optionally substituted; n is greater than or equal to 1; y is an integer from 3-13; x is 1 or 2; and . . . designates a single or double carbon/carbon bond. Formation of these estolides is by catalytic reaction of unsaturated fatty acids, especially .DELTA..sup.5 and .DELTA..sup.6 unsaturated fatty acids. Following their formation, the estolides may be recovered for subsequent use, or in the alternative, they may be hydrolyzed to produce hydroxy fatty acids.

    摘要翻译： 用于生产羟基脂肪酸和新颖的炔雌醇化合物的方法，每种可以用作润滑剂，润滑脂，增塑剂和印刷油墨，以及在化妆品中。 所述耳塞体具有式（I）：其中R 1选自可以是饱和或不饱和的，支链或直链的C6-C16烃，并且任选地被取代，例如与一个或多个羟基 ; R2独立地选自可以是饱和或不饱和的支链或直链的C2-C17烃，并且任选被取代，例如与一个或多个羟基; A选自可以是饱和或不饱和的，分支或直链的，可选地被取代的C 3 -C 14烃; n大于或等于1; y是3-13的整数; x为1或2; 和。 。 。 表示单或双碳/碳键。 这些儿茶素的形成是通过不饱和脂肪酸，特别是DELTA 5和DELTA 6不饱和脂肪酸的催化反应。 形成后，可以回收耳内酯用于随后的使用，或者作为替代方案，它们可被水解生成羟基脂肪酸。

    Carboxylic acid derivatives
    76.
    发明授权
    Carboxylic acid derivatives 失效
    羧酸衍生物

    公开(公告)号：US5229418A

    公开(公告)日：1993-07-20

    申请号：US691399

    申请日：1991-04-25

    申请人： Eric W. Collington ,  John W. Clitherow ,  David E. Bays

    发明人： Eric W. Collington ,  John W. Clitherow ,  David E. Bays

    IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/555 ,  A61P1/00 ,  A61P1/04 ,  A61P31/04 ,  C07C59/255 ,  C07C59/265 ,  C07D307/52 ,  C07D405/06 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D307/52

    摘要： The invention relates to a salt of a basic histamine H.sub.2 -receptor antagonist of formula (I) ##STR1## and a complex of bismuth with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, or a solvate of such a salt, whereinR.sup.1 represents a group of formula ##STR2## where R.sup.3 represents methyl or the group (CH.sub.2).sub.2 CONR.sup.4 R.sup.5 in which R.sup.4 and R.sup.5 both represent ethyl groups;R.sup.2 represents a hydrogen atom or, when R.sup.1 is the group --C(.dbd.CHNO.sub.2)NHCH.sub.3, R.sup.2 may also represent a methyl group; andn is 3 and X is oxygen, or n is 2 and X is CH.sub.2 or sulphur;with the provisos that(i) when R.sup.1 represents ##STR3## then X is sulphur and n is 2: (ii) when R.sup.1 represents --C(.dbd.CHNO.sub.2)NHCH.sub.3 and R.sup.2 is hydrogen, then X is oxygen and n is 3 or X is CH.sub.2 and n is 2; and(iii) when R.sup.1 represents --C(.dbd.CHNO.sub.2)NHCH.sub.3 and R.sup.2 is methyl, then X is oxygen and n is 3 or X is sulphur and n is 2.The salts and solvates thereof are useful in the treatment of gastro-intestinal disorders, such as peptic ulcer disease, gastritis and non-ulcer dyspepsia.