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    Crystalline polyglycolic acid, polyglycolic acid composition and production process thereof
    71.
    发明授权
    Crystalline polyglycolic acid, polyglycolic acid composition and production process thereof 有权
    结晶聚乙醇酸，聚乙醇酸组合物及其制备方法

    公开(公告)号：US06951956B2

    公开(公告)日：2005-10-04

    申请号：US10132578

    申请日：2002-04-25

    申请人： Kazuyuki Yamane ,  Hiromitsu Miura ,  Toshihiko Ono ,  Junji Nakajima ,  Daisuki Itoh

    发明人： Kazuyuki Yamane ,  Hiromitsu Miura ,  Toshihiko Ono ,  Junji Nakajima ,  Daisuki Itoh

    IPC分类号： B29C49/00 ,  B65D1/02 ,  C07C59/10 ,  C08G63/08 ,  C08G63/80 ,  C08G63/88 ,  C08K5/49 ,  C08K5/527

    CPC分类号： C08G63/08 ,  C08G63/80 ,  C08G63/88 ,  C08K5/527 ,  C08L67/04

    摘要： Crystalline polyglycolic acid wherein a difference between the melting point Tm and the crystallization temperature Tc2 is not lower than 35° C., and a difference between the crystallization temperature Tc1 and the glass transition temperature Tg is not lower than 40° C. A production process of polyglycolic acid modified in crystallinity, comprising applying heat history to crystalline polyglycolic acid at a temperature of not lower than (the melting point Tm of the crystalline polyglycolic acid+38° C.). A polyglycolic acid composition comprising crystalline polyglycolic acid and a heat stabilizer, wherein a difference (T2−T1) between the temperature T2 at 3%-weight loss on heating of the polyglycolic acid composition and the temperature T1 at 3%-weight loss on heating of the crystalline polyglycolic acid is not lower than 5° C.

    摘要翻译： 其中熔点Tm和结晶温度Tc 2之差的结晶聚乙醇酸不低于35℃，结晶温度Tc 1和 玻璃化转变温度Tg不低于40℃。结晶度改性的聚乙醇酸的制备方法包括在不低于（结晶聚乙醇酸+ 38的熔点Tm）的温度下对结晶聚乙醇酸施加热历史 C。）。 一种包含结晶聚乙醇酸和热稳定剂的聚乙醇酸组合物，其中温度T 2℃之间的差异（T 2 2 -T 1 H 2）在 聚乙醇酸组合物加热时3％重量损失和结晶聚乙醇酸加热时3％重量损失温度T 1不低于5℃。

    Process for producing 2,2'-Bis(hydroxymethyl) alkanoic acid
    72.
    发明授权
    Process for producing 2,2'-Bis(hydroxymethyl) alkanoic acid 失效
    制备2,2'-双（羟甲基）链烷酸的方法

    公开(公告)号：US6072082A

    公开(公告)日：2000-06-06

    申请号：US246964

    申请日：1999-02-09

    申请人： Hideshi Saito ,  Mikio Suzuki ,  Shoji Sakamoto ,  Toshiharu Yokoyama ,  Kouji Maeda

    发明人： Hideshi Saito ,  Mikio Suzuki ,  Shoji Sakamoto ,  Toshiharu Yokoyama ,  Kouji Maeda

    IPC分类号： C07C51/235 ,  C07C45/75 ,  C07C51/285 ,  C07C51/43 ,  C07C51/48 ,  C07C59/105 ,  C07C51/16 ,  C07C59/10

    CPC分类号： C07C51/285 ,  C07C45/75 ,  C07C51/48

    摘要： A process for producing 2,2'-bis(hydroxymethyl)alkanoic acid of the present invention, comprises:a 2,2'-bis(hydroxymethyl)alkanal production step (A1) of reacting aliphatic aldehyde having two hydrogen atoms bonded to .alpha.-carbon atom thereof, with formaldehyde in the presence of a water-soluble base;a 2,2'-bis(hydroxymethyl)alkanoic acid production step (B) of subjecting the thus obtained aqueous solution (a) containing 2,2'-bis(hydroxymethyl)alkanal and the base to oxidation treatment; andan alkanoic acid recovery step (C) of separating 2,2'-bis(hydroxymethyl)alkanoic acid from the thus obtained aqueous solution (b) containing the 2,2'-bis(hydroxymethyl)alkanoic acid and the base,in the alkanoic acid recovery step (C), a mineral acid being added to the aqueous solution (b) in an amount of not more than one equivalent based on the base in the aqueous solution (b) to convert the base into a salt thereof,water in the aqueous solution (b) being replaced with an organic solvent to form an organic solvent solution, and after removing the mineral acid salt precipitated from the organic solvent solution, 2,2'-bis(hydroxymethyl)alkanoic acid being crystallized from the organic solvent solution.

    摘要翻译： 制备本发明的2,2'-双（羟甲基）链烷酸的方法包括：使具有两个氢原子的脂族醛键合到α - （羟甲基）链烷酸的2,2'-双（羟甲基）链烷醛生产步骤（A1） 碳原子与甲醛在水溶性碱存在下反应; 将由此得到的含有2,2'-双（羟甲基）链烷醛和碱的水溶液（a）进行氧化处理的2,2'-双（羟甲基）链烷酸制备步骤（B） 和从这样得到的含有2,2'-双（羟甲基）链烷酸和碱的水溶液（b）中分离出2,2'-双（羟甲基）链烷酸的链烷酸回收步骤（C） 链烷酸回收步骤（C），将无机酸以水溶液（b）中的碱为基准添加到水溶液（b）中的量不超过1当量，将碱转化成其盐，将水 在水溶液（b）被有机溶剂代替以形成有机溶剂溶液后，从有机溶剂溶液中除去沉淀的无机酸盐后，从有机溶剂中结晶出2,2'-双（羟甲基）链烷酸 溶剂溶液。

    Process for the preparation of ethercarboxylic acids
    74.
    发明授权
    Process for the preparation of ethercarboxylic acids 失效
    制备醚羧酸的方法

    公开(公告)号：US5523479A

    公开(公告)日：1996-06-04

    申请号：US230282

    申请日：1994-04-20

    申请人： Josef Sanders ,  Klaus Konig

    发明人： Josef Sanders ,  Klaus Konig

    IPC分类号： C07C51/367 ,  C07C67/31 ,  C07C59/10 ,  C07C59/125 ,  C07C59/245

    CPC分类号： C07C67/31 ,  C07C51/367

    摘要： A process for the preparation of carboxylic acids which contain ether groups by the catalytically accelerated addition of alcoholic hydroxyl groups from mono- or polyhydric alcohols to tertiary-alkyl esters of .alpha.,.beta.-unsaturated carboxylic acids, and followed with acid hydrolysis of the tertiary-alkyl .beta.-ethercarboxylate obtained as intermediates in this way.

    摘要翻译： 通过催化加速将醇羟基从一元醇或多元醇加成加成α，β-不饱和羧酸的叔烷基酯，然后酸性水解叔丁醇，制备含有醚基团的羧酸的方法， 以此方式获得的作为中间体的β-羧酸叔丁酯。

    Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof
    75.
    发明授权
    Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof 失效
    3,4-二羟基丁酸及其盐的制备方法

    公开(公告)号：US5374773A

    公开(公告)日：1994-12-20

    申请号：US141635

    申请日：1993-10-27

    申请人： Rawle I. Hollingsworth

    发明人： Rawle I. Hollingsworth

    IPC分类号： C07C51/285 ,  C07C59/06 ,  C07C59/10 ,  C07D307/33

    CPC分类号： C07C51/285

    摘要： A process for the preparation of 3,4-dihydroxybutanoic acid (1) and salts thereof from a glucose source containing 1,4-1inked glucose as a substituent is described. The process uses an alkali metal hdyroxide and hydrogen peroxide to convert the glucose source to (1). The compound (1) is useful as a chemical intermediate to naturally occurring fatty acids and is used to prepare 3,4-dihydroxybutanoic acid-gamma-lactone (2) and furanone (3), particularly stereoisomers of these compounds.

    摘要翻译： 描述了从含有1,4-丁二葡萄糖作为取代基的葡萄糖源制备3,4-二羟基丁酸（1）及其盐的方法。 该方法使用碱金属氢氧化物和过氧化氢将葡萄糖源转化为（1）。 化合物（1）可用作天然存在的脂肪酸的化学中间体，并用于制备3,4-二羟基丁酸-γ-内酯（2）和呋喃酮（3），特别是这些化合物的立体异构体。

    Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof
    76.
    发明授权
    Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof 失效
    3,4-二羟基丁酸及其盐的制备方法

    公开(公告)号：US5292939A

    公开(公告)日：1994-03-08

    申请号：US966571

    申请日：1992-10-26

    申请人： Rawle I. Hollingsworth

    发明人： Rawle I. Hollingsworth

    IPC分类号： C07C51/285 ,  C07C59/06 ,  C07C59/10 ,  C07D307/33

    CPC分类号： C07C51/285

    摘要： A process for the preparation of 3,4-dihydroxybutanoic acid (1) and salts thereof from a glucose source containing 1,4-linked glucose as a substituent is described. The process uses an alkali metal hdyroxide and hydrogen peroxide to convert the glucose source to (1). The compound (1) is useful as a chemical intermediate to naturally occurring fatty acids and is used to prepare 3,4-dihydroxybutanoic acid-gamma-lactone (2) and furanone (3), particularly stereoisomers of these compounds.

    摘要翻译： 描述了从含有1,4-连接葡萄糖作为取代基的葡萄糖源制备3,4-二羟基丁酸（1）及其盐的方法。 该方法使用碱金属氢氧化物和过氧化氢将葡萄糖源转化为（1）。 化合物（1）可用作天然存在的脂肪酸的化学中间体，并用于制备3,4-二羟基丁酸-γ-内酯（2）和呋喃酮（3），特别是这些化合物的立体异构体。

    Novel liquid iodophors
    77.
    发明授权
    Novel liquid iodophors 失效
    新型液体碘伏

    公开(公告)号：US4759931A

    公开(公告)日：1988-07-26

    申请号：US598809

    申请日：1984-04-10

    申请人： Nicolaas A. I. van Paassen

    发明人： Nicolaas A. I. van Paassen

    IPC分类号： A01N59/12 ,  C11D1/06 ,  C11D3/48 ,  C07C59/10 ,  C07C59/48

    CPC分类号： C11D3/485 ,  A01N59/12 ,  C11D1/06

    摘要： Liquid iodophors are provided containing as surface-active agent a product of the formula RO--(C.sub.3 H.sub.6 O).sub.m --(C.sub.2 H.sub.4 O).sub.n --CH.sub.2 COOM, wherein RO is the residue of an alcohol of at least 8 carbon atoms or of an alkylphenol of at least 10 carbon atoms which is substantially free of olefinic unsaturation, m is a number having an average value of 0-10, n is a number having an average value of 2-20 and M is hydrogen or a monovalent cation. Preferably the iodophors contain at least 20% of iodine. The novel iodophors are prepared by dissolving at room temperature the desired amount of iodine in the surface-active agent.

    摘要翻译： 提供液体碘剂，其含有式RO-（C 3 H 6 O）m - （C 2 H 4 O）n -CH 2 COOM的产物作为表面活性剂，其中RO是至少8个碳原子的醇的残基或至少至少 10个基本上不含烯属不饱和度的碳原子，m是平均值为0-10的数，n是平均值为2-20的数，M为氢或一价阳离子。 碘伏剂优选含有至少20％的碘。 通过在室温下将所需量的碘溶解在表面活性剂中来制备新的碘伏剂。

    Preparation of optically active 1,3-dioxolane-4-methanol compounds
    79.
    发明授权
    Preparation of optically active 1,3-dioxolane-4-methanol compounds 失效
    光学活性1,3-二氧戊环-4-甲醇化合物的制备

    公开(公告)号：US4575558A

    公开(公告)日：1986-03-11

    申请号：US580492

    申请日：1984-02-15

    申请人： Khuong H. X. Mai ,  Ghanshyam Patil

    发明人： Khuong H. X. Mai ,  Ghanshyam Patil

    IPC分类号： C07C69/675 ,  B01J31/00 ,  B01J31/04 ,  C07C51/00 ,  C07C51/367 ,  C07C59/10 ,  C07C67/00 ,  C07C67/08 ,  C07D317/20 ,  C07D317/72 ,  C07D317/00 ,  C07C59/285

    CPC分类号： C07D317/72 ,  C07C59/10 ,  C07D317/20

    摘要： Described is a process for preparing 2,2'-disubstituted-1,3-dioxolane-4-methanol compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, cycloalkyl or R.sub.1 and R.sub.2 together with the carbon atom form a 3 to 6 member cycloalkyl group, or aryl, the process comprising: reacting D- or L-serine with a nitrosating agent in an aqueous solution in the presence of formic acid, acetic acid, or propanoic acid to prepare 2,3-dihydroxypropanoic acid (D- or L-glyceric acid), the aqueous solution comprising from about 0.1 to 0.5 liter of water per mole of the serine starting material; reacting the glyceric acid so formed with 2,2-dimethoxypropane in the presence of a loweralkyl alcohol to prepare the D- or L-glyceric acid alkyl ester which is reacted with a selected aldehyde or ketone or the acetal or ketal derivative to prepare the corresponding 1,3-dioxolane derivative. Reacting the 1,3-dioxolane derivative with lithium aluminum hydride provides the desired 2,2'-disubstituted-1,3-dioxolane-4-methanol derivative.If an alcohol is not used as described above, then the 2,3-dihydroxypropanoic acid is reacted with a selected aldehyde or ketone or the acetal or ketal derivative to prepare the 1,3-dioxolane derivative. The dioxolane derivative is then reacted with lithium aluminum hydride to provide the desired 2,2'-disubstituted-1,3-dioxolane-4-methanol derivative.The compounds so prepared are intermediates in the preparation of optically active beta-agonists or antagonists.

    摘要翻译： 描述了一种制备具有式“IMAGE”的2,2'-二取代-1,3-二氧戊环-4-甲醇化合物的方法，其中R 1和R 2各自独立地为氢，烷基，环烷基或R 1和R 2与碳原子一起 形成3至6元环烷基或芳基，该方法包括：在甲酸，乙酸或丙酸存在下，使D-或L-丝氨酸与亚硝化剂在水溶液中反应，制备2,3- 二羟基丙酸（D-或L-甘油酸），该水溶液每摩尔丝氨酸起始物质含有约0.1至0.5升水; 使如此形成的甘油与2,2-二甲氧基丙烷在低级烷基醇的存在下反应，以制备与所选择的醛或酮或缩醛或缩酮衍生物反应的D-或L-甘油酸烷基酯，以制备相应的 1,3-二氧戊环衍生物。 用氢化铝锂反应1,3-二氧戊环衍生物，得到所需的2,2'-二取代-1,3-二氧戊环-4-甲醇衍生物。 如果不如上所述使用醇，则将2,3-二羟基丙酸与选择的醛或酮或缩醛或缩酮衍生物反应以制备1,3-二氧戊环衍生物。 然后将二氧戊环衍生物与氢化铝锂反应，得到所需的2,2'-二取代-1,3-二氧戊环-4-甲醇衍生物。 如此制备的化合物是制备光学活性β-激动剂或拮抗剂的中间体。