公开(公告)号：US07504109B2

公开(公告)日：2009-03-17

申请号：US11133346

申请日：2005-05-20

申请人： Chin-Fen Yang ,  George Kemble ,  Kanta Subbarao ,  Brian Murphy

发明人： Chin-Fen Yang ,  George Kemble ,  Kanta Subbarao ,  Brian Murphy

IPC分类号： A61K39/145 ,  C12N7/01 ,  C12N7/02

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/58 ,  C07K14/005 ,  C12N2501/70 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16161 ,  C12N2760/16162 ,  C12N2760/16171 ,  C12Q1/701

摘要： Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.

摘要翻译： 提供了包含（禽流感）流感血凝素和神经氨酸酶变体的多肽，多核苷酸，方法，组合物和疫苗。

公开(公告)号：US20240327454A1

公开(公告)日：2024-10-03

申请号：US18001637

申请日：2021-06-29

申请人： MEDIMMUNE, LLC

发明人： Alan HUNTER ,  Matthew ASPELUND ,  Dhanesh GADRE ,  Thomas LINKE ,  Kamiyar REZVANI ,  Guoling XI

IPC分类号： C07K1/36

CPC分类号： C07K1/36

摘要： Provided herein is an environmentally compatible detergent for use in purification of a recombinantly produced bio-therapeutic. The environmentally compatible detergent includes Laureth-9 and can be used for viral clearance, cell lysis, and removal of impurities such as host cell proteins an endotoxins. Advantageously, Laureth-9 does not adversely impact product quality.

公开(公告)号：US20240123081A1

公开(公告)日：2024-04-18

申请号：US17769041

申请日：2019-10-25

申请人： MEDIMMUNE, LLC

发明人： Nazzareno DIMASI ,  Amit KUMAR

IPC分类号： A61K47/68 ,  A61K47/54 ,  C07D207/452

CPC分类号： A61K47/6889 ,  A61K47/545 ,  A61K47/6803 ,  A61K47/68031 ,  A61K47/68033 ,  A61K47/68035 ,  A61K47/68037 ,  A61K47/6831 ,  A61K47/6851 ,  C07D207/452

摘要： A tri-functional linker moiety: formula (I), where X and Y are linking chains, and its use for preparing dual-mechanistic drug conjugates, preferably in a site-specific manner.

公开(公告)号：US11939382B2

公开(公告)日：2024-03-26

申请号：US17661307

申请日：2022-04-29

申请人： MedImmune, LLC

发明人： Yariv Mazor ,  Yue Wang ,  Gordon Moody ,  Deepali Malhotra ,  Michael Overstreet ,  Eleanor Clancy-Thompson ,  Karin Lee ,  Stacy Pryts ,  Scott Hammond

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2803 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure relates to binding proteins, including antibodies, that bind to Programmed Death-1 (“PD-1”) and T cell immunoreceptor with Ig and ITIM domains (“TIGIT”). The disclosure also provides compositions comprising such binding proteins and nucleic acid molecules encoding such binding proteins. The disclosure further relates to methods of treating a disorder or condition using such binding proteins.

公开(公告)号：US11845791B2

公开(公告)日：2023-12-19

申请号：US17653681

申请日：2022-03-07

申请人： MedImmune, LLC

发明人： Claire Dobson ,  Fiona Cusdin ,  Darren Schofield ,  Peter Cariuk ,  Elaine Hurt ,  Margareta Ek ,  Carina Johansson ,  Jenny Sandmark

IPC分类号： C07K16/22 ,  A61P35/00 ,  A61P21/00 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61P21/00 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure is directed to human GDF-15-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect human GDF-15 and/or in methods of treating cancer or body weight loss, including cachexia, associated with over-expression of human GDF-15.

公开(公告)号：US20230165974A1

公开(公告)日：2023-06-01

申请号：US17997376

申请日：2021-04-28

申请人： MEDIMMUNE, LLC

发明人： Ronald James CHRISTIE ,  Morgan Audrey URELLO

IPC分类号： A61K48/00 ,  C07D213/82 ,  C07D279/12 ,  C07D295/15 ,  A61K47/69 ,  A61K47/64

CPC分类号： A61K48/0041 ,  C07D213/82 ,  C07D279/12 ,  C07D295/15 ,  A61K47/6935 ,  A61K47/6455

摘要： The invention relates to modified lysines of the formula (I). The invention further relates to polypeptides comprising one or more modified lysine residues, pharmaceutical delivery systems comprising these polypeptides, pharmaceutical compositions containing them, and to their use in therapy.

公开(公告)号：US20230145764A1

公开(公告)日：2023-05-11

申请号：US17961827

申请日：2022-10-07

申请人： MEDIMMUNE, LLC

发明人： Koustubh RANADE ,  Brandon W. HIGGS ,  Rajiv G. RAJA ,  Philip Z. BROHAWN ,  Han SI ,  Michael A. KUZIORA

IPC分类号： C12Q1/6886 ,  A61K39/395 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K39/3955 ,  A61P35/00 ,  C12Q2600/156 ,  C12Q2600/106

摘要： The disclosure generally relates to methods for treating non-small cell lung cancer patients based on use of blood-based tumor mutation burden to predict overall survival in patients treated with durvalumab, tremelimumab, and/or a chemotherapy agent. The disclosure also relates to methods for treating non-small cell lung cancer patients based on identification of mutations in circulating tumor DNA associated with sensitivity or resistance to immunotherapy.

公开(公告)号：US20230079661A1

公开(公告)日：2023-03-16

申请号：US17819199

申请日：2022-08-11

申请人： MedImmune LLC ,  Humabs BioMed SA

发明人： Qun WANG ,  Meghan PENNINI ,  Xiaodong XIAO ,  Davide CORTI ,  Elisabetta CAMERONI ,  Martina BELTRAMELLO ,  Gilad KAPLAN ,  Anna DeMARCO ,  Charles K. Stover

IPC分类号： C07K16/12 ,  A61P31/04 ,  A61K31/407 ,  A61K39/40

摘要： The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to Klebsiella pneumoniae O2 and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae) and/or protects mice from a lethal Klebsiella challenge. The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering the Klebsiella pneumoniae O2 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.

公开(公告)号：US20230045712A1

公开(公告)日：2023-02-09

申请号：US17775143

申请日：2020-11-06

申请人： MEDIMMUNE, LLC

发明人： Joseph Samuel GRIMSBY ,  Chao-Yu JIN ,  Judith FALLOON ,  Judith Ann HSIA ,  Sotirios K. KARATHANASIS ,  Richard Thomas GEORGE, Jr. ,  John Edward LE LAY ,  Brian Timothy HUMMER ,  Yue HUANG ,  Anton I. ROSENBAUM

IPC分类号： C07K16/40 ,  A61K9/00 ,  A61P9/10

摘要： The present disclosure provides methods of administering antibodies and antigen-binding fragments thereof that specifically bind to human endothelial lipase (EL) to a subject in need thereof, for example, a subject with cardiovascular disease.

公开(公告)号：US11548933B2

公开(公告)日：2023-01-10

申请号：US16901812

申请日：2020-06-15

申请人： MedImmune, LLC

发明人： Timothy Pabst ,  Mariko Fonseca ,  Christopher Thompson ,  Alan Hunter ,  Xiangyang Wang ,  Liu Tie ,  Yiming Li

IPC分类号： C07K14/00 ,  C07K14/765 ,  A61K47/64 ,  C07K1/18 ,  C07K1/22 ,  C07K14/78 ,  A61K38/00

摘要： The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion protein comprises a scaffold, such as human Tenascin C scaffold. Compositions comprising the albumin-fusion protein are further disclosed.