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公开(公告)号:US20220162335A1
公开(公告)日:2022-05-26
申请号:US17441519
申请日:2020-03-22
发明人: Cheng-I WANG , Bei WANG , Zi Xian Eve NGOH , Wen-Hsin LEE , Ching-Wen HUANG , Yee Chin, Yvonne YEAP
IPC分类号: C07K16/30 , C07K16/28 , C07K14/725 , A61K39/395 , A61K38/17 , A61K47/68 , A61P35/00
摘要: We describe an antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) sequence and a light chain variable region (VL) sequence of a clone selected from: 5C4, 4H1, 1D2, 1C4, 2B5, 1F1, 1H1, 4A5, 1D8, 1D3, 2F1, 3C6, 3D12, 3A9, 1F4, 1H10, 3C12, 4G11, 4A12, 1A12, 3G12, 4F9, 4G4 and 1E1 which is capable of specifically binding to glypican-3 (GPC-3) (GenBank Accession Number: NP_004475.1), or a sequence having at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity thereto.
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公开(公告)号:US20220146252A1
公开(公告)日:2022-05-12
申请号:US17436685
申请日:2020-03-26
发明人: Lei Zhang , Weng Heng Liew , Huajun Liu
IPC分类号: G01B11/16
摘要: A non-contact non-destructive testing method includes spatially and/or temporally controlling a laser excitation light based on a predetermined pattern. The laser excitation light is projected onto a surface of a test object to generate acoustic waves on the test object. The acoustic waves apply stress loading to the test object. The method also includes imaging the test object with and without stress loading using shearography imaging, and analyzing shearography imaging data to determine a presence of a defect in the test object.
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公开(公告)号:US20220137040A1
公开(公告)日:2022-05-05
申请号:US17574169
申请日:2022-01-12
发明人: Jackie Y. Ying , Yong Yeow Lee , Jianhao Bai
IPC分类号: G01N33/543 , G01N33/558
摘要: A test strip for paper based assay, the test strip comprising a substrate addition zone for receiving a substrate and a test zone, the test zone comprising a capture agent, wherein the substrate addition zone is located upstream of the test zone. The invention also relates to a paper-based enzyme assay comprising a test strip of the invention and methods of detecting the presence of an analyte in a sample using a test strip of the invention.
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公开(公告)号:US20220134721A1
公开(公告)日:2022-05-05
申请号:US17435237
申请日:2020-03-05
发明人: Warintorn THITSARTARN , Siok Wei TAY , Qi Feng LIM , Chaobin HE
摘要: A conductive carbon fiber reinforced composite comprising: a metal-coated carbon fiber fabric laminated with a nanocomposite resin, the nanocomposite resin comprising a mixture of: a polymerizable thermosetting polymer, a conductive filler, and a carbonaceous fiber-like filler. A method of forming a conductive carbon fiber reinforced composite, the composite comprising a metal-coated carbon fiber fabric laminated with a nanocomposite resin, the nanocomposite resin comprising a mixture of: a polymerizable thermosetting polymer, a conductive filler, and a carbonaceous fiber-like filler, the method comprising the steps of: a) forming the nanocomposite resin; b) forming the metal-coated carbon fiber fabric; and c) laminating the metal-coated carbon fiber fabric with the nanocomposite resin using one of: a wet lay-up process followed by hot-press curing under vacuum, a vacuum infusion process, a prepreg fabrication process, and a resin transfer molding process.
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公开(公告)号:US20220133883A1
公开(公告)日:2022-05-05
申请号:US17576800
申请日:2022-01-14
发明人: Madhavan NALLANI , Fabien DECAILLOT , Zhikang FU , Xingfang SU
IPC分类号: A61K39/385 , A61K9/127 , A61K9/00 , A61K47/34 , A61K39/12
摘要: The invention relates to methods for eliciting an immune response to an immunogen, and in particular, to such methods using polymersomes as carriers for the immunogen.
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公开(公告)号:US20220096604A1
公开(公告)日:2022-03-31
申请号:US17426756
申请日:2020-01-30
发明人: Wenn-Chyau LEE , Laurent RENIA
IPC分类号: A61K38/36 , A61K38/18 , A61K31/366 , A61K31/357 , A61K31/4706 , A61K31/4709 , A61K31/506 , A61K31/635 , A61K31/65 , A61K31/137 , A61K31/155 , A61P33/06
摘要: The invention relates to a composition comprising insulin growth factor binding protein 7 (IGFBP7) for treating malaria or reducing the phenomenon of IRB C-endothelial cytoadherence. The composition can further comprise Von Willebrand Factor (VWF) and/or thrombospondin-1 (TSP-1). The composition can also be used as an adjunct therapeutic agent alongside other anti-malarial drugs.
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公开(公告)号:US11249081B2
公开(公告)日:2022-02-15
申请号:US16329751
申请日:2017-08-31
发明人: Florent Ginhoux , Chi Ee Peter See
IPC分类号: G01N33/569 , A61K35/15 , C07K16/28
摘要: Biomarkers for the detection and identification of a precursor of conventional dendritic cell (cDC) (pre-DC) and its cell subsets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also disclosed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer.
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公开(公告)号:US11248106B2
公开(公告)日:2022-02-15
申请号:US16499028
申请日:2018-03-28
摘要: According to the present disclosure, a method of forming an exfoliated or intercalated filler material is provided, wherein the said method comprises the steps of mixing particles of filler material such as montmorillonite (MMT), mica, layered double hydroxide (LDH), and attapulgite (AT) dispersed in an aqueous medium with cationic acrylate monomers to form modified particles comprising positively charged ions, dispersing the modified particles in organic medium to form a dispersion, contacting said dispersion with an organo-silicate such as tetraethyl orthosilicate (TEOS) and a functionalizing agent comprising an organo-silane such as aminopropyltrimethoxysilane (APTMS), in the presence of a basic catalyst to form a layer of silica on the modified particles. The present disclosure also relates to an exfoliated or intercalated filler material obtained by the said method as well as a method of forming a resin/clay nanocomposite.
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公开(公告)号:US11248088B2
公开(公告)日:2022-02-15
申请号:US16166017
申请日:2018-10-19
发明人: Xin Ting Zheng , Yen Nee Tan , Victor Hesheng Xu
IPC分类号: A01N37/44 , A61K31/787 , A61K9/51 , B82Y15/00 , B82Y40/00 , C08G73/02 , G01N1/30 , B82Y5/00 , C08L101/00 , A01N37/50 , A61K9/14 , B82Y30/00
摘要: The present invention relates to a hybrid nanodot made by a process comprising a step of reacting a mixture of an amino acid and a polymer selected from polycationic polymers or any copolymers or derivatives of these polymers under hydrothermal reaction conditions. The present invention also relates to a process for synthesizing said hybrid nanodots.
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公开(公告)号:US11241494B2
公开(公告)日:2022-02-08
申请号:US15939232
申请日:2018-03-28
发明人: Madhavan Nallani , Fabien Decaillot , Zhikang Fu , Xingfang Su
摘要: The invention relates to methods for eliciting an immune response to an immunogen, and in particular, to such methods using polymersomes as carriers for immunogen.
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