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公开(公告)号：US10752902B2
公开(公告)日：2020-08-25
申请号：US15513660
申请日：2015-09-22
IPC分类号： C07K19/00 , C07K14/47 , C12N15/117 , C07K14/705 , A61K38/02 , A61K38/17 , A61K39/00
摘要： The disclosure relates to, among other things, agents that modulate the homophilic interaction between two CRACC polypeptides, methods for making such agents, and therapeutic applications in which the agents are useful. For example, the agents described herein are useful for modulating an immune response in a mammal. Also featured are screening methods for identifying additional agents capable of modulating the activation of an immune cell exposed to an antigen.
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82.发明申请公开(公告)号：US20200261559A1
公开(公告)日：2020-08-20
申请号：US16642690
申请日：2018-04-23
发明人： Xuefei Huang , Suttipun Sungsuwan
摘要： Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.
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公开(公告)号：US10745707B2
公开(公告)日：2020-08-18
申请号：US16221838
申请日：2018-12-17
IPC分类号： C12N15/82 , C12N9/18 , C12N15/52 , C12N15/113
摘要： Plants described herein have increased biomass and are more readily digested into fermentable sugars when the plants express increased levels of one or more types of CGR2 and/or CGR3 enzymes.
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公开(公告)号：US10713540B2
公开(公告)日：2020-07-14
申请号：US15913498
申请日：2018-03-06
IPC分类号： G06K9/62
摘要： A system and method is provided that utilizes deep learning, including convolutional neural networks, to identify subject objects in unconstrained user images such as unknown pills. An image of, e.g., a pill, may be captured and subsequently processed using deep learning models to identify the pill. The deep learning models may be optimized to have a small footprint (in terms of computational and memory resources) suitable for a resource-limited device such as a smartphone while retaining a high object recognition accuracy. Each such model may also be run on modified versions of the unconstrained image, for example on color, greyscale, and gradient images, to focus the models on different distinguishing features of the object.
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公开(公告)号：US20200181628A1
公开(公告)日：2020-06-11
申请号：US16783380
申请日：2020-02-06
IPC分类号： C12N15/74 , C07K14/195
摘要： Described herein are mutant cyanobacterial cell populations that have a smaller mean cell length than wild type cyanobacterial cell populations of the same species.
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86.发明申请公开(公告)号：US20200173891A1
公开(公告)日：2020-06-04
申请号：US16697417
申请日：2019-11-27
发明人： Thomas Schuelke , Cory A. Rusinek , Michael Becker , Mary Ensch
IPC分类号： G01N1/40 , G01N33/487 , B01L3/00
摘要： The disclosure relates to a method for pretreating a sample for metals determination. The method includes: providing an aqueous sample mixture comprising a sample containing or suspected of containing one or more metals for detection; contacting the aqueous sample mixture with a first electrode (anode) comprising electrically conducting boron-doped diamond (BDD); electrically contacting the aqueous sample mixture with a second electrode (cathode); applying an electrical potential between the first electrode and the second electrode (i) to provide an electrical current therebetween and through the aqueous sample mixture, (ii) to generate hydroxyl ion (OH−) species at the first electrode, (iii) to oxidize and free the one or more metals for detection in the sample, thereby forming a pretreated aqueous sample comprising free metal ions in aqueous solution and corresponding to the one or more metals in the original sample; and withdrawing the pretreated aqueous sample comprising the free metal ions in aqueous solution. The pretreated aqueous sample can be analyzed for metal content using any desired conventional analysis technique.
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公开(公告)号：US20200169275A1
公开(公告)日：2020-05-28
申请号：US16695758
申请日：2019-11-26
摘要： A multiband sensing system includes an active multiband sensing unit configured to transmit a radio frequency (RF) signal in multiple bands and communicate with a network. The active multiband sensing unit includes at least one transmitting antenna configured to transmit the RF signal. The multiband sensing system includes a passive multiband sensing unit including at least one receiving antenna configured to receive the RF signal, an acoustic actuator powered by the received RF signal including an actuating sensor element configured to actuate in response to receiving extracted modulated information of the RF signal, and an acoustic detector. The acoustic detector includes a detector transmitting antenna configured to backscatter a new frequency band signal to the active multiband sensing unit and a detector sensor element configured to sense data. The sensed data is modulated over the received RF signal to produce the new frequency band signal.
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公开(公告)号：US10662183B2
公开(公告)日：2020-05-26
申请号：US14934769
申请日：2015-11-06
发明人： Scott D. Larsen , Richard Neubig , Andrew Haak , Kim Hutchings , Walajapet Rajeswaran , Dinesh Khanna , Erika Mathes Lisabeth
IPC分类号： C07D211/06 , C07D211/60 , C07D417/14 , C07D405/10 , C07D409/10 , C07D405/14 , C07D401/10 , C07D401/06 , C07D417/06 , C07D413/14 , C07D417/10 , C07D413/06 , C07D405/06
摘要： Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
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公开(公告)号：US10645886B2
公开(公告)日：2020-05-12
申请号：US15417522
申请日：2017-01-27
发明人： James Kremer , James M. Tiedje , Sheng-Yang He
摘要： The disclosure relates to a plant growth apparatus and related system to grow and maintain plants under controlled biotic conditions, for example to grow axenic (microbe-free) plants, gnotobiotic (defined microbiota) plants, and holoxenic (complex, or undefined microbiota) plants. This system allows aseptic bottom irrigation with water, soluble nutrients, chemicals, and/or microbiota. Plants can be inverted for dipping and/or vacuum infiltration. The system also allows for passive (gravity) drainage, thereby allowing for gas exchange and preventing root anoxia. A variety of plant growth substrates can be used within the plant growth apparatus as a plant growth medium. The plant growth apparatus, containing the growth substrate medium, can be completely flushed via the drainage port to remove potential toxic byproducts of the sterilization processes. The entire system is suitably constructed using autoclavable material.
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公开(公告)号：US10607807B2
公开(公告)日：2020-03-31
申请号：US16096938
申请日：2017-02-28
发明人： Chong-Yu Ruan
IPC分类号： H01J37/075 , H01J37/26 , H01J37/21 , H01J37/244 , H01J37/073 , H01J37/147 , H01J49/48
摘要： An electron spectroscopy system and method are disclosed. In another aspect, an ultrabright and ultrafast angle-resolved electron spectroscopy system is provided. A further aspect of the present system employs an electron gun, a radio frequency cavity and multiple spectrometers. Yet another aspect uses spectrometers in an aligned manner to deflect and focus electrons emitted by the electron gun. Moreover, an ultrafast laser is coupled to an electron spectroscopy system. A bunch of monochromatic electrons have their energy compressed and reoriented in an additional aspect of the present system. A further aspect of the present electron spectroscopy system employs adaptive and/or adjustable optics to optimize both time and energy compression. Another aspect provides at least two RF lenses or cavities, one before a specimen and one after the specimen.
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