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81.发明申请公开(公告)号：US20210277130A1
公开(公告)日：2021-09-09
申请号：US17173886
申请日：2021-02-11
发明人： Brian Wong , Emma Masteller , Justin Wong , Haishan Lin
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis and associated conditions, methods of treating systemic lupus erythematosus and associated conditions, and methods of treating multiple sclerosis.
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公开(公告)号：US11098103B2
公开(公告)日：2021-08-24
申请号：US16354689
申请日：2019-03-15
发明人： Thomas Brennan , David Bellovin , David Busha , Barbara Sennino
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395 , A61K45/06 , C07K16/00 , C07K16/28 , A61K38/00
摘要： This application relates to CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in treatment of cancer, both alone and in combination with other therapeutic agents, such as immune stimulating agents such as PD-1/PD-L1 inhibitors.
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83.发明授权公开(公告)号：US11091555B2
公开(公告)日：2021-08-17
申请号：US16613579
申请日：2018-05-15
发明人： Helen L. Collins , James Hnatyszyn , Hong Xiang , Xiang Zhang
IPC分类号： C07K16/28 , A61P35/04 , A61P35/00 , A61K9/00 , A61K31/282 , A61K31/513 , A61K31/519 , A61K39/395 , A61K39/00
摘要： This application relates to uses of antibodies against fibroblast growth factor receptor 2 (FGFR2), including antibodies against the FGFR2 isoform FGFR2-IIIb (also known as FGFR2b), in treatment of certain cancers in combinations with mFOLFOX6 chemotherapy.
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公开(公告)号：US20210070861A1
公开(公告)日：2021-03-11
申请号：US16997577
申请日：2020-08-19
发明人： Yong QUAN , Chin-Yi HUANG , Harjeet Singh GANDA
摘要： The present disclosure provides pharmaceutical compositions comprising antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4). The present disclosure also prides methods for treating disorders, such as cancer, by administering such pharmaceutical compositions.
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公开(公告)号：US20210017283A1
公开(公告)日：2021-01-21
申请号：US16982277
申请日：2019-03-19
发明人： Robert J. Johnston , Arvind Rajpal , Paul O. Sheppard , Luis Borges , Andrew Rankin , Keith Sadoon Bahjat , Alan J. Korman , Xiaodi Deng , Lin Hui Su , Ginger Rakestraw , Jason R. Pinckney , David A. Critton , Guodong Chen , Richard Y. Huang , Ekaterina G. Deyanova
摘要： The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
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公开(公告)号：US20210009700A1
公开(公告)日：2021-01-14
申请号：US16911806
申请日：2020-06-25
IPC分类号： C07K16/28
摘要： Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
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公开(公告)号：US20210009697A1
公开(公告)日：2021-01-14
申请号：US16646690
申请日：2018-09-12
发明人： Katherine E. Lewis , Serena Kimi Perna , Michael Carleton , Ke Xu , Penny Phillips , Dimple Pandya , Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Janine Powers , Ernestine Lee
IPC分类号： C07K16/28 , A61K31/7068 , A61K31/513 , A61K39/395 , A61K31/337 , A61K47/69 , A61K47/64 , C12Q1/6886 , A61P35/00
摘要： The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).
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88.发明授权公开(公告)号：US10822421B2
公开(公告)日：2020-11-03
申请号：US16256311
申请日：2019-01-24
发明人： Brian Wong , Emma Masteller , Kris Reedquist
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , A61K39/00
摘要： Methods of reducing cytokine levels and methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating inflammatory conditions, such as rheumatoid arthritis.
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公开(公告)号：US20200255528A1
公开(公告)日：2020-08-13
申请号：US16814627
申请日：2020-03-10
发明人： Charles KAPLAN , Derrick HOUSER , Luis BORGES , Gloria BRATTICH , David BELLOVIN , Felicia KEMP , Majid GHODDUSI , Nels P. NIELSON , Kathy MILLER , Maike SCHMIDT
IPC分类号： C07K16/28 , G01N33/574 , A61P35/00
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.
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公开(公告)号：US20200055936A1
公开(公告)日：2020-02-20
申请号：US16493712
申请日：2018-03-13
发明人： Robert J. Johnston , Arvind Rajpal , Paul O. Sheppard , Luis Borges , Andrew Rankin , Keith Sadoon Bahjat , Alan J. Korman , Andy X. Deng , Lin Hui Su , Ginger Rakestraw
IPC分类号： C07K16/28
摘要： The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
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