公开(公告)号：US10744032B2

公开(公告)日：2020-08-18

申请号：US15775515

申请日：2016-11-10

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Eliyahu Bsharim ,  Tova Lifshitz ,  Nadav Yaakov Belfair

IPC: A61F9/007

Abstract: An ophthalmic surgical instrument for fragmenting the lens nucleus of an eye, and method of use thereof. The instrument includes an elongated handle portion, a tubular head portion at the handle portion distal end, at least three prongs with cutting tips, and a holding ring. The prongs are selectively retractable into and deployable from the head portion. The holding ring selectively contracts and expands to adjust the deployment width of the prongs. The instrument is inserted toward the eye lens through a corneal incision, while the head portion is opened to deploy the prongs to slide over and grasp onto the lens nucleus at a posterior position thereof. The instrument is then withdrawn toward the eye lens anterior while the head portion is closed to retract the prongs, such that the prong cutting tips cut along the lens nucleus, so as to fragment the lens nucleus into multiple segments.

公开(公告)号：US10557173B2

公开(公告)日：2020-02-11

申请号：US15014074

申请日：2016-02-03

Applicant: Mor Research Applications Ltd.

Inventor： Smadar Avigad ,  Isaac Yaniv

IPC: C12Q1/68 ,  C12Q1/6886

Abstract: The present invention relates to prognostic methods and kits for the assessment and monitoring of relapse-free or disease-free survival of ALL patients. The detection is based on the use of detecting nucleic acids, specific for determination of the expression of at least one of miR-151-5p and miR-451 in a test sample. The invention thereby also provides methods and kits for monitoring and early diagnosis of cancerous disorders associated with low miR-151-5p and/or miR-451 expression, specifically ALL, and appropriate associated treatments thereof.

公开(公告)号：US20190383815A1

公开(公告)日：2019-12-19

申请号：US16480342

申请日：2018-01-25

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Esther RABIZADEH ,  Izchak CHERNY ,  Aida INBAL

IPC: G01N33/574 ,  G01N33/86

Abstract: A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.

公开(公告)号：US20190142448A1

公开(公告)日：2019-05-16

申请号：US16098474

申请日：2017-05-04

Applicant: MOR Research Applications Ltd.

Inventor： Igor Igov

IPC: A61B17/29

Abstract: The subject matter discloses a grasper, comprising a grasping element at a distal end of the grasper; wherein the grasping element is configurable to at least a narrow state having a narrow cross-section, and at least an expanded state having an expanded cross-section; wherein the grasping element configured in the narrow state is insertable through an incision or narrow orifice into a body; wherein the grasping element configured in the expanded state has an increased grasping surface; and wherein the grasping element is configurable from the narrow state to the expanded state after insertion into the body.

公开(公告)号：US10206900B2

公开(公告)日：2019-02-19

申请号：US15083370

申请日：2016-03-29

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ayala Pollack ,  Zeev Dvashi

IPC: A61K31/335 ,  C07K16/40

Abstract: Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.

公开(公告)号：US20180235644A1

公开(公告)日：2018-08-23

申请号：US15962285

申请日：2018-04-25

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ronen JAFFE ,  Eytan JAFFE

IPC: A61B17/221

CPC classification number: A61B17/221 ,  A61B17/22032 ,  A61B2017/22034 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2017/22079 ,  A61B2017/2215 ,  A61B2217/005 ,  A61M2025/1059

Abstract: A catheter for removable insertion into a body vasculature has at least one inflatable member. The catheter has at least in part an expandable body that forms an internal axially extending lumen in at least the expanded state of the body. The inflatable member is adjacent a distal axial end of the body and is configured to at least partially obstruct the lumen.

公开(公告)号：US09988690B2

公开(公告)日：2018-06-05

申请号：US15363822

申请日：2016-11-29

Applicant: ROSETTA GENOMICS LTD. ,  MOR RESEARCH APPLICATIONS

Inventor： Moshe Hoshen ,  Gila Lithwick Yanai ,  Ram Eitan

IPC: C12Q1/68 ,  A61K31/713 ,  A61K45/00

CPC classification number: C12Q1/6886 ,  A61K31/713 ,  A61K45/00 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention further provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions for the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.

公开(公告)号：US20180147157A1

公开(公告)日：2018-05-31

申请号：US15877665

申请日：2018-01-23

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Moshe YESHURUN

IPC: A61K31/05 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/05 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0095 ,  A61K45/06

Abstract: The invention provides methods for preventing, ameliorating and treating the acute and chronic forms of graft-versus-host disease (GVHD) by using Cannabidiol compositions.

公开(公告)号：US09956182B2

公开(公告)日：2018-05-01

申请号：US14787515

申请日：2014-04-29

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Moshe Yeshurun

IPC: A61K31/05 ,  A61K9/00 ,  A61K38/13 ,  A61K45/06 ,  A61K31/436 ,  A61K31/519 ,  A61K31/573

CPC classification number: A61K31/05 ,  A61K9/0053 ,  A61K31/436 ,  A61K31/519 ,  A61K31/573 ,  A61K38/13 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods for preventing, ameliorating and treating the acute and chronic forms of graft-versus-host disease (GVHD) by using Cannabidiol compositions.

公开(公告)号：US20180042501A1

公开(公告)日：2018-02-15

申请号：US15552469

申请日：2016-02-25

Applicant: Mor Research Applications Ltd.

Inventor： Nimrod ADI ,  Gil ZOIZNER ,  Jonathan RUBIN

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/0205

CPC classification number: A61B5/02416 ,  A61B5/0004 ,  A61B5/02055 ,  A61B5/0295 ,  A61B5/6806

Abstract: A system for vital sign measuring of a patient, comprising: a first sensor removably attachable with a first body portion of the patient and configured to measure, when in operable position, a vital sign of the patient; at least one additional sensor removably attachable with a second body portion of the patient and configured to measure, when in operable position, a vital sign of the patient; and a processor configured to provide data descriptive of a level of correspondence between measurements of the vital signs provided by the first sensor and the at least one additional sensor.