公开(公告)号：US10954300B2

公开(公告)日：2021-03-23

申请号：US15763995

申请日：2016-09-28

Applicant: Sankar Ghosh ,  Yenkel Grinberg-Bleyer

Inventor： Sankar Ghosh ,  Yenkel Grinberg-Bleyer

IPC: A61K31/522 ,  A61P35/00 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00

Abstract: Methods of treating a PD-1-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a PD-1 inhibitor. A pharmaceutical combination comprising a therapeutically effective amount of a c-Rel inhibitor, and a therapeutically effective amount of a PD-1 inhibitor is also provided. Finally, methods of treating a cancer such as a CTLA-4-resistant cancer, a CD137-resistant cancer, and an OX-4-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a CLTA-4, CD137 or OX-4 inhibitor, respectively.

公开(公告)号：US20140296154A1

公开(公告)日：2014-10-02

申请号：US14115036

申请日：2012-05-07

Applicant: Brian Poligone ,  Sankar Ghosh

Inventor： Brian Poligone ,  Sankar Ghosh

IPC: C07K14/435 ,  C07K14/47 ,  A61K45/06 ,  A61K38/17

CPC classification number: C07K14/435 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0368 ,  A61K38/1709 ,  A61K45/06 ,  A61K48/005 ,  C07K14/47 ,  C07K14/4703 ,  C07K2319/10 ,  C12N15/8509

Abstract: The present invention relates to a method of inhibiting onset of or preventing development of a psoriatic lesion in a patient having psoriasis. The method comprises administering to a patient having psoriasis an effective amount of an agent that inhibits NF-κB activity under conditions effective to inhibit onset of or prevent development of psoriatic lesions. Another aspect of the invention relates to a method of treating an early stage psoriatic lesion on a patient by contacting the early stage psoriatic lesion of a patient with an effective amount of an agent that inhibits NF-κB activity, whereby said contacting inhibits development of the early stage psoriatic lesion. Both transgenic and nontransgenic approaches are contemplated.

Abstract translation: 本发明涉及一种抑制银屑病患者银屑病病变发病或预防发展的方法。 所述方法包括向有银屑病患者施用有效量的抑制NF-κB活性的药物，所述药物有效抑制银屑病病变的发生或预防发展。 本发明的另一方面涉及通过使患者的早期银屑病病变与有效量的抑制NF-κB活性的药物接触来治疗患者的早期牛皮癣病变的方法，由此所述接触抑制发育 的早期银屑病病变。 考虑转基因和非转基因方法。

公开(公告)号：US08242240B2

公开(公告)日：2012-08-14

申请号：US12869962

申请日：2010-08-27

Applicant: Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

Inventor： Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

IPC: C07K14/00

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

Abstract translation: 本发明提供抗炎化合物，其药物组合物及其用于治疗炎症性疾病的方法。 本发明还提供鉴定抗炎化合物的方法和抑制细胞中NF-和κ-依赖性靶基因表达的方法。

公开(公告)号：US20090286748A1

公开(公告)日：2009-11-19

申请号：US12421488

申请日：2009-04-09

Applicant: Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

Inventor： Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

IPC: A61K38/08 ,  C12N5/06

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

Abstract translation: 本发明提供抗炎化合物，其药物组合物及其用于治疗炎症性疾病的方法。 本发明还提供鉴定抗炎化合物的方法和抑制细胞中NF-κB依赖性靶基因表达的方法。

公开(公告)号：US07604175B2

公开(公告)日：2009-10-20

申请号：US11801747

申请日：2007-05-10

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G06K7/10

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: A method of reading bar code symbols using a digital-imaging based code symbol reading system employing an event-driven multi-tier modular software architecture and supporting automatic operating system login and loading of a bar code symbol reading application.

Abstract translation: 一种使用基于数字成像的代码符号读取系统来读取条形码符号的方法，该系统采用事件驱动的多层模块化软件架构并支持自动操作系统登录和加载条形码符号读取应用。

公开(公告)号：US07490774B2

公开(公告)日：2009-02-17

申请号：US10989220

申请日：2004-11-15

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G02B26/00

CPC classification number: G06F9/44526 ,  G06K7/10712 ,  G06K7/10732 ,  G06K7/10831 ,  G06K7/10851 ,  G06K7/10881 ,  G06K7/14 ,  G06K2207/1012

Abstract: A hand-supportable digital imaging-based bar code symbol reading device comprises: an IR-based object presence and range detection subsystem; a area-type image formation and detection subsystem having an image capture modes of operation; a multi-mode led-based illumination subsystem for providing a narrow-band field of illumination; an automatic light exposure measurement and illumination control subsystem; an image capturing and buffering subsystem; a image-processing bar code symbol reading subsystem; an input/output subsystem; and a system control subsystem integrated with each of the above-described subsystems. The automatic light exposure measurement and illumination control subsystem has a light collecting element and a photodiode arranged within the hand-supportable housing, wherein incident illumination is collected from the predetermined portion of the FOV using the light collecting element, and then focused upon the photodiode for detection of the intensity of incident illumination and subsequent processing by the automatic light exposure measurement and illumination control subsystem.

Abstract translation: 一种基于手持式数字成像的条形码符号读取装置，包括：基于IR的对象存在和范围检测子系统; 具有图像拍摄模式的区域型图像形成和检测子系统; 用于提供窄带场照明的多模式LED基照明子系统; 自动曝光测量和照明控制子系统; 图像捕获和缓冲子系统; 图像处理条形码符号读取子系统; 输入/输出子系统; 以及与上述每个子系统集成的系统控制子系统。 自动曝光测量和照明控制子系统具有布置在手持式外壳内的光收集元件和光电二极管，其中使用光收集元件从FOV的预定部分收集入射照明，然后聚焦在光电二极管上 通过自动曝光测量和照明控制子系统检测入射照明强度和后续处理。

公开(公告)号：US20070290044A1

公开(公告)日：2007-12-20

申请号：US11801748

申请日：2007-05-10

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Knowles

IPC: G06K7/10

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: Digital-imaging based code symbol reading system employing an event-driven multi-tier modular software architecture and supporting automatic operating system login and loading of a bar code symbol reading application.

Abstract translation: 基于数字成像的代码符号读取系统采用事件驱动的多层模块化软件架构，并支持自动操作系统登录和加载条形码符号读取应用程序。

公开(公告)号：US20070145148A1

公开(公告)日：2007-06-28

申请号：US11635435

申请日：2006-12-07

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Knowles

IPC: G06K7/10

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: A digital-imaging based code symbol reading system having a hands-on mode operation and a hands-free presentation mode of operation, and supporting automatic programming of system parameters for automatic configuration of the system in hands-on and hands-free modes of operation. The system comprises: an image formation and detection subsystem; an illumination subsystem; a digital image processing subsystem; a system control subsystem for managing system parameters, and controlling and/or coordinating operations of the system; and a configuration detection mechanism. The image formation and detection subsystem has the area-type image sensing array for detecting digital images of objects formed thereon by image formation optics providing a field of view (FOV) for the system. Within the FOV of the image formation and detection subsystem, the illumination subsystem produces a field of illumination that illuminates the object during the image capture mode of operation, and one or more digital images thereof are detected by an area-type image sensing array. When the hand-supportable housing is picked up from on a countertop surface or support stand and held in an operator's hand, the system parameters are automatically programmed so that the digital-imaging code symbol reading system is automatically configured into its hands-on mode of operation. When the hand-supportable is resting on the countertop surface or in the support stand, the system parameters are automatically programmed so that the digital-imaging code symbol reading system is automatically configured into its hands-free presentation mode of operation.

Abstract translation: 一种基于数字成像的代码符号读取系统，其具有动手模式操作和免提显示操作模式，并且支持用于以手动和免提操作模式自动配置系统的系统参数的自动编程 。 该系统包括：图像形成和检测子系统; 照明子系统; 数字图像处理子系统; 用于管理系统参数的系统控制子系统，以及控制和/或协调系统的操作; 以及配置检测机构。 图像形成和检测子系统具有区域型图像感测阵列，用于通过为系统提供视野（FOV）的图像形成光学器件来检测在其上形成的物体的数字图像。 在图像形成和检测子系统的FOV内，照明子系统产生在图像拍摄操作模式期间照亮物体的照明场，并且其一个或多个数字图像由区域型图像感测阵列检测。 当手持式外壳从台面或支撑架上拿起并保持在操作者的手中时，系统参数被自动编程，使得数字成像代码符号读取系统被自动配置成其动手模式 操作。 当手持式搁置在台面或支架上时，系统参数自动编程，使数字成像代码符号读取系统自动配置成其免提显示操作模式。

公开(公告)号：US07225989B2

公开(公告)日：2007-06-05

申请号：US10897389

申请日：2004-07-22

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G06K7/10

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: Method of performing autodiscrimination of 1D/2D bar code symbologies in a semi-automatic hand-supportable imaging-based bar code symbol reader having narrow-area and wide-area image capture modes of operation. The hand-supportable digital imaging-based bar code symbol reading device comprises: an automatic object presence and range detection subsystem; a multi-mode image formation and detection subsystem having narrow-area and wide area image capture modes of operation; a multi-mode LED-based illumination subsystem having narrow-area and wide area illumination modes of operation; an automatic light exposure measurement and illumination control subsystem; an image capturing and buffering subsystem; a multi-mode image-processing bar code symbol reading subsystem; an input/output subsystem; a manually-activatable trigger switch; and a system control subsystem integrated with each of the above-described subsystems.

Abstract translation: 在具有窄区域和广域图像捕获操作模式的半自动手持支持成像的条形码符号读取器中执行1D / 2D条形码符号自动识别的方法。 基于手持式数字成像的条形码符号读取装置包括：自动对象存在和范围检测子系统; 具有窄区域和广域图像捕捉模式的多模式图像形成和检测子系统; 具有窄区域和广域照明操作模式的多模式的基于LED的照明子系统; 自动曝光测量和照明控制子系统; 图像捕获和缓冲子系统; 多模式图像处理条码符号读取子系统; 输入/输出子系统; 一个手动启动的触发开关; 以及与上述每个子系统集成的系统控制子系统。

公开(公告)号：US07188770B2

公开(公告)日：2007-03-13

申请号：US10893797

申请日：2004-07-16

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G02B26/08

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: A hand-supportable Digital Imaging-Based Bar Code Symbol Reading Device comprises: an IR-based Object Presence and Range Detection Subsystem; A Multi-Mode Area-type Image Formation and Detection Subsystem having narrow-area and wide area image capture modes of operation; a Multi-Mode LED-based Illumination Subsystem having narrow-area and wide area illumination modes of operation; an Automatic Light Exposure Measurement and Illumination Control Subsystem; an Image Capturing and Buffering Subsystem; a Multi-Mode Image-Processing Bar Code Symbol Reading Subsystem; an Input/Output Subsystem; an manuallyactivatable trigger switch; a System Mode Configuration Parameter Table; and a System Control Subsystem integrated with each of the above-described subsystems. The bar code reading device can be configured and operated in numerous programmable modes of system operation to automatically read 1D and 2D bar code symbologies in a high-speed manner using advanced modes of image processing on captured images.

Abstract translation: 一种支持手持数字成像的条形码符号读取装置，包括：基于IR的对象存在和范围检测子系统; 具有窄区域和广域图像捕获模式的多模式区域型图像形成和检测子系统; 具有窄区域和广域照明操作模式的基于多模LED的照明子系统; 自动曝光测量和照明控制子系统; 图像捕获和缓冲子系统; 多模式图像处理条形码符号读取子系统; 输入/输出子系统; 可手动触发开关; 系统模式配置参数表; 以及与上述每个子系统集成的系统控制子系统。 条形码读取装置可以在多种系统操作的可编程模式下进行配置和操作，以高速方式自动读取1D和2D条形码符号，使用对捕获的图像进行高级模式的图像处理。