公开(公告)号：US08217138B2

公开(公告)日：2012-07-10

申请号：US13204919

申请日：2011-08-08

Applicant: Michael J. May ,  Sankar Ghosh

Inventor： Michael J. May ,  Sankar Ghosh

IPC: A61K38/00 ,  A61K38/04 ,  A01N1/02 ,  A01N25/00

CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K14/4747 ,  C12N9/1205

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

公开(公告)号：US20120101028A1

公开(公告)日：2012-04-26

申请号：US13204919

申请日：2011-08-08

Applicant: Michael J. May ,  Sankar Ghosh

Inventor： Michael J. May ,  Sankar Ghosh

IPC: A61K38/08 ,  A61P31/12 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P41/00 ,  A61P37/00 ,  A61P9/10 ,  A61P25/28

CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K14/4747 ,  C12N9/1205

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

公开(公告)号：US07812118B2

公开(公告)日：2010-10-12

申请号：US12421488

申请日：2009-04-09

Applicant: Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

Inventor： Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

IPC: C07K7/00 ,  A61K38/00

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

Abstract translation: 本发明提供抗炎化合物，其药物组合物及其用于治疗炎症性疾病的方法。 本发明还提供鉴定抗炎化合物的方法和抑制细胞中NF-和κ-依赖性靶基因表达的方法。

公开(公告)号：US20090286736A1

公开(公告)日：2009-11-19

申请号：US12424334

申请日：2009-04-15

Applicant: MICHAEL J. MAY ,  SANKAR GHOSH

Inventor： MICHAEL J. MAY ,  SANKAR GHOSH

IPC: A61K38/17 ,  C12N5/00 ,  A61P29/00 ,  A61P19/10 ,  A61P35/00 ,  A61P25/28 ,  A61P17/02 ,  A61P19/02 ,  A61P31/12 ,  A61P17/06

CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K14/4747 ,  C12N9/1205

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

公开(公告)号：US07534858B2

公开(公告)日：2009-05-19

申请号：US11439528

申请日：2006-05-22

Applicant: Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

Inventor： Michael J. May ,  Sankar Ghosh ,  Mark A. Findeis ,  Kathryn Phillips ,  Gerhard Hannig

IPC: C07K7/00 ,  A61K38/00

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.

公开(公告)号：US07428998B2

公开(公告)日：2008-09-30

申请号：US10901446

申请日：2004-07-27

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G06K7/10

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: A hand-supportable automatic digital imaging-based bar code symbol reading device comprises: an automatic object presence detection subsystem; an area-type image formation and detection subsystem having a narrow-area image-capture mode of operation; a LED-based illumination subsystem having narrow-area illumination mode of operation; an image capturing and buffering subsystem; and an image-processing bar code symbol reading subsystem. The automatic object presence detection subsystem automatically detects an object, and the LED-based illumination subsystem automatically illuminates the detected object in a field of narrow-area narrow-band illumination, while the area-type image formation and detection subsystem captures a narrow-area image thereof. The image-processing bar code symbol reading subsystem automatically and directly applies decode image processing operations on the captured image, in an outwardly-directed manner, referenced from the center of the captured narrow-area image, to automatically read a 1D bar code symbol on the detected object.

Abstract translation: 一种支持手持式自动数字成像的条形码符号读取装置，包括：自动对象存在检测子系统; 具有窄区域图像拍摄操作模式的区域型图像形成和检测子系统; 具有窄区域照明操作模式的基于LED的照明子系统; 图像捕获和缓冲子系统; 和图像处理条形码符号读取子系统。 自动对象存在检测子系统自动检测物体，并且基于LED的照明子系统在窄区域窄带照明领域中自动照亮检测到的物体，而区域型图像形成和检测子系统捕获窄区域 其图像。 图像处理条形码符号读取子系统以捕获的图像的中心为参照，以向外的方式自动地对拍摄的图像应用解码图像处理操作，以自动读取1D条形码符号 检测到的对象。

公开(公告)号：US20080128507A1

公开(公告)日：2008-06-05

申请号：US11980074

申请日：2007-10-30

Applicant: Constantine J. Tsikos ,  C. Harry Knowles ,  Xiaoxun Zhu ,  Micheal D. Schnee ,  Ka Man Au ,  Allan Wirth ,  Timothy A. Good ,  Andrew Jankevics ,  Sankar Ghosh ,  Charles A. Naylor ,  Thomas Amundsen ,  Robert Blake ,  William Svedas ,  Shawn Defoney ,  Edward Skypala ,  Pirooz Vatan ,  Russell Joseph Dobbs ,  George Kolis ,  Mark C. Schmidt ,  Jeffrey Yorsz ,  Patrick A. Giordano ,  Stephen J. Colavito ,  David W. Wilz ,  Barry E. Schwartz ,  Steven Y. Kim ,  Dale Fisher ,  Jon Van Tassell

Inventor： Constantine J. Tsikos ,  C. Harry Knowles ,  Xiaoxun Zhu ,  Micheal D. Schnee ,  Ka Man Au ,  Allan Wirth ,  Timothy A. Good ,  Andrew Jankevics ,  Sankar Ghosh ,  Charles A. Naylor ,  Thomas Amundsen ,  Robert Blake ,  William Svedas ,  Shawn Defoney ,  Edward Skypala ,  Pirooz Vatan ,  Russell Joseph Dobbs ,  George Kolis ,  Mark C. Schmidt ,  Jeffrey Yorsz ,  Patrick A. Giordano ,  Stephen J. Colavito ,  David W. Wilz ,  Barry E. Schwartz ,  Steven Y. Kim ,  Dale Fisher ,  Jon Van Tassell

IPC: G06K7/10

CPC classification number: G06K7/10732

Abstract: A tunnel-type digital imaging system for use within retail shopping environments such as supermarkets. The system includes a tunnel configuration arranged about a conveyor structure for transporting objects therethrough, and an image capturing and processing subsystem embodied within the tunnel configuration, for generating a 3D digital imaging volume above the conveyor structure and within the tunnel configuration, for capturing digital images of objects transported through the 3D imaging volume. The image capturing and processing subsystem includes a plurality of illumination and imaging stations. Each station includes a 2D imaging array having optics providing a 3D field of view (FOV) on the 2D imaging array that is projected and extends into the 3D imaging volume, and one or more light emitting devices configured together to produce a illumination beam that extends into the 3D FOV of the 2D imaging array. A digital image processing subsystem processing digital images of objects passing through the 3D imaging volume, and a system control subsystem controls and/or orchestrates the coplanar illumination and imaging subsystems during system operation.

Abstract translation: 一种隧道式数字成像系统，用于零售购物环境（如超市）。 该系统包括围绕用于输送物体的输送机结构布置的隧道结构，以及体现在隧道结构内的图像捕获和处理子系统，用于在输送机结构之上和隧道结构内生成用于捕获数字图像的3D数字成像体 的物体通过3D成像体积传输。 图像捕获和处理子系统包括多个照明和成像站。 每个站包括2D成像阵列，其具有在投影并延伸到3D成像体积的2D成像阵列上提供3D视场（FOV）的光学元件，以及配置在一起以产生延伸的照明光束的一个或多个发光器件 进入2D成像阵列的3D FOV。 处理通过3D成像体的物体的数字图像的数字图像处理子系统，以及系统控制子系统在系统操作期间控制和/或编排共面照明和成像子系统。

公开(公告)号：US20080128506A1

公开(公告)日：2008-06-05

申请号：US11978941

申请日：2007-10-30

Applicant: Constantine J. Tsikos ,  C. Harry Knowles ,  Xiaoxun Zhu ,  Michael D. Schnee ,  Ka Man Au ,  Allan Wirth ,  Timothy A. Good ,  Andrew Jankevics ,  Sankar Ghosh ,  Charles A. Naylor ,  Thomas Amundsen ,  Robert Blake ,  William Svedas ,  Shawn Defoney ,  Edward Skypala ,  Pirooz Vatan ,  Russell Joseph Dobbs ,  George Kolis ,  Mark C. Schmidt ,  Jeffrey Yorsz ,  Patrick A. Giordano ,  Stephen J. Colavito ,  David W. Wilz ,  Barry E. Schwartz ,  Steven Y. Kim ,  Dale Fisher ,  Jon Van Tassell

Inventor： Constantine J. Tsikos ,  C. Harry Knowles ,  Xiaoxun Zhu ,  Michael D. Schnee ,  Ka Man Au ,  Allan Wirth ,  Timothy A. Good ,  Andrew Jankevics ,  Sankar Ghosh ,  Charles A. Naylor ,  Thomas Amundsen ,  Robert Blake ,  William Svedas ,  Shawn Defoney ,  Edward Skypala ,  Pirooz Vatan ,  Russell Joseph Dobbs ,  George Kolis ,  Mark C. Schmidt ,  Jeffrey Yorsz ,  Patrick A. Giordano ,  Stephen J. Colavito ,  David W. Wilz ,  Barry E. Schwartz ,  Steven Y. Kim ,  Dale Fisher ,  Jon Van Tassell

IPC: G06K7/10

CPC classification number: G06K7/10732

Abstract: A hand-supportable planar laser illumination and imaging (PLIIM) based code symbol reader includes: a hand-supportable housing having light transmission aperture; a linear image formation and detection module having a linear image detection array; and a planar laser illumination beam (PLIB) producing device having at least one visible laser diode (VLD) for producing a planar light illumination beam (PLIB). The code symbol reader further includes image grabber for grabbing digital linear images formed and detected by the image formation and detection module, an image data buffer for buffering the digital linear images grabbed by the image grabber and constructing a two-dimensional image from a series of buffered linear digital images, and an image processing computer for processing the buffered two-dimensional digital image so as to read code symbols graphically represented in the two-dimensional digital linear image. During object illumination and imaging operations, a controller automatically controls the linear image formation and detection module, the PLIB producing device, the image frame grabber, and the image data buffer.

公开(公告)号：US07360706B2

公开(公告)日：2008-04-22

申请号：US10894477

申请日：2004-07-19

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G02B26/08

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: A hand-supportable digital imaging-based bar code symbol reading device comprises: an IR-based object presence and range detection subsystem; a multi-mode area-type image formation and detection subsystem having narrow-area and wide area image capture modes of operation; a multi-mode LED-based illumination subsystem having narrow-area and wide area illumination modes of operation; an automatic light exposure measurement and illumination control subsystem; an image capturing and buffering subsystem; a multi-mode image-processing bar code symbol reading subsystem; an input/output subsystem; a manually-activatable trigger switch; and a system control subsystem integrated with each of the above-described subsystems. The digital imaging-based bar code reading device employs a multi-mode bar code symbol reading image processor that is dynamically reconfigurable in response to real-time image analysis carried out upon captured narrow and wide area images.

Abstract translation: 一种基于手持式数字成像的条形码符号读取装置，包括：基于IR的对象存在和范围检测子系统; 具有窄区域和广域图像捕捉操作模式的多模式区域型图像形成和检测子系统; 具有窄区域和广域照明操作模式的多模式的基于LED的照明子系统; 自动曝光测量和照明控制子系统; 图像捕获和缓冲子系统; 多模式图像处理条码符号读取子系统; 输入/输出子系统; 一个手动启动的触发开关; 以及与上述每个子系统集成的系统控制子系统。 基于数字成像的条形码读取装置采用多模式条形码符号读取图像处理器，其响应于在捕获的窄和广域图像上执行的实时图像分析而被动态地重新配置。

公开(公告)号：US07320431B2

公开(公告)日：2008-01-22

申请号：US10901461

申请日：2004-07-28

Applicant: Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

Inventor： Xiaoxun Zhu ,  Yong Liu ,  Ka Man Au ,  Rui Hou ,  Hongpeng Yu ,  Xi Tao ,  Liang Liu ,  Wenhua Zhang ,  Anatoly Kotlarsky ,  Sankar Ghosh ,  Michael Schnee ,  Pasqual Spatafore ,  Thomas Amundsen ,  Sung Byun ,  Mark Schmidt ,  Garrett Russell ,  John Bonanno ,  C. Harry Knowles

IPC: G02B26/08

CPC classification number: G06K7/10851 ,  G06K7/10732 ,  G06K7/10881

Abstract: A digital imaging-based bar code symbol reading system which comprises: an automatic object presence and range detection subsystem; an image formation and detection subsystem having an area-type image sensing array with a field of view (FOV); a multi-mode LED-based illumination subsystem having LED illumination arrays for producing fields of narrow-band illumination in near and far portions of the FOV; an automatic light exposure measurement and illumination control subsystem; an image capturing and buffering subsystem; an image-processing bar code symbol reading subsystem; an input/output subsystem; and a system control subsystem for controlling the subsystems. The LED illumination arrays are automatically driven by the automatic light exposure measurement and illumination control subsystem in response to the generation of control activation signals by the automatic object presence and range detection subsystem.

Abstract translation: 一种基于数字成像的条形码符号读取系统，包括：自动对象存在和范围检测子系统; 具有具有视场（FOV）的区域型图像感测阵列的图像形成和检测子系统; 具有LED照明阵列的多模式的基于LED的照明子系统，用于在FOV的近部分和远端产生窄带照明领域; 自动曝光测量和照明控制子系统; 图像捕获和缓冲子系统; 图像处理条码符号读取子系统; 输入/输出子系统; 以及用于控制子系统的系统控制子系统。 响应于通过自动对象存在和范围检测子系统产生控制激活信号，LED照明阵列由自动曝光测量和照明控制子系统自动驱动。