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    Locally Diagnosing and Troubleshooting Service Issues
    81.
    发明申请
    Locally Diagnosing and Troubleshooting Service Issues 失效
    本地诊断和故障排除服务问题

    公开(公告)号：US20110228665A1

    公开(公告)日：2011-09-22

    申请号：US12727931

    申请日：2010-03-19

    Applicant: Shiv Kumar ,  Paritosh Bajpay ,  Jackson Liu ,  Narendra Ravi ,  Raghvendra G. Savoor

    Inventor： Shiv Kumar ,  Paritosh Bajpay ,  Jackson Liu ,  Narendra Ravi ,  Raghvendra G. Savoor

    IPC: G06F11/00

    CPC classification number: H04L12/2825 ,  G06Q10/06 ,  H04L12/2898 ,  H04L41/0631

    Abstract: A method includes detecting, at a customer premises equipment (CPE) device, a problem associated with a network device. The network device is communicatively coupled to the CPE device via a local area network. For example, the CPE device may include a residential gateway (RG). The method includes determining, at the CPE device, whether the problem associated with the network device is locally correctable. When the CPE device determines that the problem is locally correctable, the method includes initiating a corrective action to resolve the problem. When the CPE device determines that the problem is not locally correctable, the method includes sending data associated with the problem from the CPE device to a network system via a wide area network.

    Abstract translation: 一种方法包括在客户驻地设备（CPE）设备处检测与网络设备相关联的问题。 网络设备经由局域网通信地耦合到CPE设备。 例如，CPE设备可以包括住宅网关（RG）。 该方法包括在CPE设备处确定与网络设备相关联的问题是否是本地可校正的。 当CPE设备确定问题在本地可修正时，该方法包括启动纠正措施以解决问题。 当CPE设备确定问题不能在本地可修正时，该方法包括通过广域网从CPE设备向网络系统发送与问题相关的数据。

    FLUORESCENCE RESONANCE ENERGY TRANSFER ENZYME SUBSTRATES
    83.
    发明申请
    FLUORESCENCE RESONANCE ENERGY TRANSFER ENZYME SUBSTRATES 审中-公开
    荧光共振能量转移酶基质

    公开(公告)号：US20090162838A1

    公开(公告)日：2009-06-25

    申请号：US11568193

    申请日：2005-04-18

    Applicant: Shiv Kumar ,  Anup Sood

    Inventor： Shiv Kumar ,  Anup Sood

    IPC: C12Q1/68 ,  C12Q1/37 ,  C07H21/04 ,  C07K14/47

    CPC classification number: G01N33/542 ,  C12Q1/34

    Abstract: Disclosed are compounds of formula (I) wherein D1 is a first dye moiety whose fluorescence properties may be modulated so as to be suitable as a donor or an acceptor in an energy transfer arrangement; D2 is a second dye moiety suitable as an acceptor or a donor in an energy transfer arrangement with said first dye; L is a linking group comprises 2-200 linked atoms, wherein said linking group optionally includes an enzyme cleavage site; and M is an enzyme cleavable group chosen to modulate the fluorescence properties of D1. The compounds of formula (I) may be used as reporter molecules for detecting biochemical cleavage events in assays that employ fluorescence resonance energy transfer.

    Abstract translation: 公开了式（I）的化合物，其中D1是可以调节其荧光性质以适合作为能量转移装置中的给体或受体的第一染料部分; D2是第二染料部分，其适于作为与所述第一染料的能量转移装置中的受体或供体; L是包含2-200个连接原子的连接基团，其中所述连接基团任选地包括酶切割位点; M是选择调节D1荧光性质的酶切割基团。 式（I）的化合物可以用作用于检测采用荧光共振能量转移的测定中生化裂解事件的报道分子。

    Analyte detection
    86.
    发明授权
    Analyte detection 有权
    分析物检测

    公开(公告)号：US07244566B2

    公开(公告)日：2007-07-17

    申请号：US10651582

    申请日：2003-08-29

    Applicant: Anup Sood ,  Shiv Kumar ,  Carl Fuller ,  John Nelson

    Inventor： Anup Sood ,  Shiv Kumar ,  Carl Fuller ,  John Nelson

    IPC: C12Q1/68

    CPC classification number: C12P19/34 ,  C12Q1/68

    Abstract: A method of characterizing an analyte sample is provided that includes the steps of: (a) anchoring the analyte to a nucleic acid template of known sequence; (b) conducting a DNA polymerase reaction that includes the reaction of a template, a non-hydrolyzable primer, at least one terminal phosphate-labeled nucleotide, DNA polymerase, and an enzyme having 3′→5′ exonuclease activity which reaction results in the production of labeled polyphosphate; (c) permitting the labeled polyphosphate to react with a phosphatase to produce a detectable species characteristic of the sample; (d) detecting the detectable species. The method may include the step of characterizing the nucleic acid sample based on the detection. Also provided are methods of analyzing multiple analytes in a sample, and kits for characterizing analyte samples.

    Abstract translation: 提供表征分析物样品的方法，其包括以下步骤：（a）将分析物锚定到已知序列的核酸模板; （b）进行DNA聚合酶反应，其包括模板，不可水解的引物，至少一个末端磷酸酯标记的核苷酸，DNA聚合酶和具有3'→5'核酸外切酶活性的酶的反应，该反应导致 生产标记多磷酸盐; （c）允许标记的多磷酸酯与磷酸酶反应以产生样品的可检测物种特征; （d）检测可检测物种。 该方法可以包括基于检测来表征核酸样品的步骤。 还提供了分析样品中多种分析物的方法，以及用于表征分析物样品的试剂盒。

    Terminal-phosphate-labeled nucleotides and methods of use
    88.
    发明授权
    Terminal-phosphate-labeled nucleotides and methods of use 有权
    末端磷酸酯标记的核苷酸和使用方法

    公开(公告)号：US07223541B2

    公开(公告)日：2007-05-29

    申请号：US10358818

    申请日：2003-02-05

    Applicant: Carl Fuller ,  Shiv Kumar ,  Anup Sood ,  John Nelson

    Inventor： Carl Fuller ,  Shiv Kumar ,  Anup Sood ,  John Nelson

    IPC: C12Q1/68

    CPC classification number: C12Q1/6823 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/6816 ,  C12Q1/6851 ,  C12Q2521/525

    Abstract: The present invention relates to improved methods of detecting a target using a labeled substrate or substrate analog. The methods comprise reacting the substrate or substrate analog in an enzyme-catalyzed reaction which produces a labeled moiety with independently detectable signal only when such substrate or substrate analog reacts. The present invention, in particular, describes methods of detecting a nucleic acid in a sample, based on the use of terminal-phosphate-labeled nucleotides as substrates for nucleic acid polymerases. The methods provided by this invention utilize a nucleoside polyphosphate, dideoxynucleoside polyphosphate, or deoxynucleoside polyphosphate analogue which has a colorimetric dye, chemiluminescent, or fluorescent moiety, a mass tag or an electrochemical tag attached to the terminal-phosphate. When a nucleic acid polymerase uses this analogue as a substrate, an enzyme-activatable label would be present on the inorganic polyphosphate by-product of phosphoryl transfer. Cleavage of the polyphosphate product of phosphoryl transfer via phosphatase leads to a detectable change in the label attached thereon. When the polymerase assay is performed in the presence of a phosphatase, there is provided a convenient method for real-time monitoring of DNA or RNA synthesis and detection of a target nucleic acid.

    Abstract translation: 本发明涉及使用标记的底物或底物类似物检测靶的改进方法。 所述方法包括在酶催化的反应中使底物或底物类似物反应，其仅在这种底物或底物类似物反应时产生具有独立可检测信号的标记部分。 本发明特别地描述了基于使用末端磷酸酯标记的核苷酸作为核酸聚合酶的底物来检测样品中核酸的方法。 本发明提供的方法利用了具有比色染料，化学发光或荧光部分的核苷多磷酸，双脱氧核苷多聚磷酸酯或脱氧核苷多聚磷酸酯类似物，连接至末端磷酸酯的质量标签或电化学标签。 当核酸聚合酶使用该类似物作为底物时，酶活性标记将存在于磷酸转移的无机多磷酸盐副产物上。 通过磷酸酶切割磷酸转移的多磷酸盐产物导致附着在其上的标签的可检测的变化。 当在磷酸酶的存在下进行聚合酶测定时，提供了用于实时监测DNA或RNA合成和检测靶核酸的方便的方法。

    Energy transfer dyes
    89.
    发明授权
    Energy transfer dyes 失效
    能量转移染料

    公开(公告)号：US06967250B1

    公开(公告)日：2005-11-22

    申请号：US09386576

    申请日：1999-08-30

    Applicant: Shiv Kumar ,  Satyam Nampalli ,  Mahesh Khot

    Inventor： Shiv Kumar ,  Satyam Nampalli ,  Mahesh Khot

    IPC: C07D265/36 ,  G01N33/542

    CPC classification number: G01N33/542

    Abstract: Energy transfer dyes, their preparation, and their use as labels in biological systems is disclosed. The dyes are preferably in the form of cassettes which enable their attachment to a variety of biological materials. The dyes and the reagents that can be made from them offer a wide variety of fluorescent labels with large Stokes' shifts enabling their use in a variety of fluorescence applications over a wide range of the visible spectrum.

    Abstract translation: 公开了能量转移染料，它们的制备及其作为生物系统中的标记物的用途。 染料优选为使其能够附着于各种生物材料的盒的形式。 可以由其制成的染料和试剂提供了广泛的荧光标记，具有大的斯托克斯变化，使其能够在广泛的可见光谱范围内用于各种荧光应用。

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