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    ENHANCING CANCER THERAPY TREATMENT WITH BH3 MIMETICS
    84.
    发明申请
    ENHANCING CANCER THERAPY TREATMENT WITH BH3 MIMETICS 有权

    公开(公告)号：US20220347180A1

    公开(公告)日：2022-11-03

    申请号：US17764043

    申请日：2020-09-25

    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

    Inventor： Yiqun Shellman ,  Richard Tobin ,  Nabanita Mukherjee ,  David Norris ,  Martin D.` Carter

    IPC: A61K31/519 ,  A61K39/395 ,  A61K31/635 ,  A61P35/00

    Abstract: Disclosed herein are methods for using therapeutic compounds, for example BH3 mimetics such as MCL1 inhibitors, to treat patients that may have failed to respond to targeted or immunotherapy treatments. In several embodiments, methods for treating such patients include combining MCL1 inhibitors with immunotherapies to enhance immunotherapy treatment. For example, the combination of MCL1 inhibitors with immunotherapies is used to treat cancer, such as melanoma. In some embodiments, MCL1 inhibitory compounds and therapies may be useful in treating tissues or tumors having one or more MDSC cell expressing high levels of MCL1. In some embodiments, MCL1 and BCL2 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example cutaneous melanoma, melanoma subtypes selected from uveal, acral, and mucosal. In some embodiments, MCL1 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example uveal melanoma. In many embodiments the targeted cells or tissues may not have BRAF mutations.

    Wearable System for Automated, Objective and Continuous Quantification of Pain
    86.
    发明申请
    Wearable System for Automated, Objective and Continuous Quantification of Pain 有权

    公开(公告)号：US20220338801A1

    公开(公告)日：2022-10-27

    申请号：US17642317

    申请日：2020-09-11

    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE

    Inventor： Tam VU ,  Robin DETERDING ,  Hoang TRUONG

    IPC: A61B5/00 ,  A61B5/313 ,  A61B5/024 ,  A61B5/0533

    Abstract: A wearable objective pain measuring device includes a headband configured to be worn by a user on the user's head. The device includes one or more sensors in the headband, including one or more of: a sweep impedance profiling sensor to collect data reflective of activity of corrugator supercilia during a pain session; an electromyography sensor to collect data signals from a brain that reflects pain perception; a photoplethysmogram sensor configured to collect data regarding changes in hear rate and heart rate variability due to pain state; or a galvanic skin response sensor configured to collect data related to changes in sweat gland and skin conductance due to a pain state. The device includes a pain quantification pipeline to objectively quantify pain based on data from the one or more sensors. The device includes an output device configured to output an objective pain quantification based on quantifying pain.

    Mobile and augmented reality based depth and thermal fusion scan
    87.
    发明授权
    Mobile and augmented reality based depth and thermal fusion scan 有权

    公开(公告)号：US11481979B2

    公开(公告)日：2022-10-25

    申请号：US17049859

    申请日：2019-04-23

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Min-Hyung Choi ,  Shane Transue

    IPC: G06T19/00 ,  G06T3/40 ,  G06T7/20 ,  G06K9/00 ,  G06N3/08 ,  G06V20/10 ,  G06V40/10

    Abstract: Systems and methods are described for mobile and augmented reality-based depth and thermal fusion scan imaging. Some embodiments of the present technology use sophisticated techniques to fuse information from both thermal and depth imaging channels together to achieve synergistic effects for object recognition and personal identification. Hence, the techniques used in various embodiments provide a much better solution for, say, first responders, disaster relief agents, search and rescue, and law enforcement officials to gather more detailed forensic data. Some embodiments provide a series of unique features including small size, wearable devices, and ability to feed fused depth and thermal streams into AR glasses. In addition, some embodiments use a two-layer architecture for performing device local fusion and cloud-based platform for integration of data from multiple devices and cross-scene analysis and reconstruction.

    Fiber-to-chip coupler
    88.
    发明授权
    Fiber-to-chip coupler 有权

    公开(公告)号：US11480736B2

    公开(公告)日：2022-10-25

    申请号：US17144980

    申请日：2021-01-08

    Applicant: The Regents of the University of Colorado, a body corporate ,  Government of the United States of America as represented by the Secretary of Commerce

    Inventor： Saeed Khan ,  Jeffrey Shainline

    IPC: G02B6/30 ,  G02B6/42 ,  G02B6/293

    Abstract: A fiber-to-chip coupler includes a substrate, a waveguide on a top surface of the substrate, an optical fiber axially aligned to the waveguide, and a cap. The waveguide has a uniform region with uniform width and a tapered-waveguide region having a width that adiabatically increases from a minimum width to the uniform width. The optical fiber has a tapered fiber tip having a minimum core diameter, a cylindrical section having a maximum core diameter, and a tapered-fiber section therebetween. The optical fiber is located at least in part above the tapered-waveguide region, and has a core diameter that adiabatically decreases within a taper length of the tapered-fiber section. The cap extends from the tapered fiber tip toward the cylindrical section, is formed of a second material having a cap refractive index that exceeds a refractive index of the optical fiber, and includes a cap-region disposed on the tapered-waveguide region.

    Systems and methods for postural control of a multi-function prosthesis
    89.
    发明授权
    Systems and methods for postural control of a multi-function prosthesis 有权

    公开(公告)号：US11478367B2

    公开(公告)日：2022-10-25

    申请号：US16859122

    申请日：2020-04-27

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Jacob Segil ,  Richard Weir

    IPC: A61F2/72 ,  A61F2/58 ,  A61F2/70 ,  A61F2/76

    Abstract: Systems and methods for postural control of a multi-function prosthesis are provided. Various embodiments provide for a postural controller that use EMG signals to drive a point in a posture space and outputs continuously varying joint angles for a powered prosthetic hand. The postural controller can include an EMG signal processing unit to receive signals from electrodes for processing (e.g., band pass filtering, rectification, root mean square averaging, dynamic tuning, etc.). The processed EMG signals can then be combined or converted to produce a point in the postural control domain. The PC domain map defines the posture that corresponds to each PC cursor coordinate. This map can have limitless possible postures and limitless possible positions of the postures. The Joint Angle Transform converts the PC cursor coordinate into the joint angle array which is sent to the prosthetic hand thereby creating more natural movements.

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