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公开(公告)号:US11034750B2
公开(公告)日:2021-06-15
申请号:US16211538
申请日:2018-12-06
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Shimobi Onuoha , Simon Thomas
IPC分类号: C07K14/705 , C12N5/0783 , C07K14/725 , C07K16/28 , A61K39/00 , C07K14/735 , C07K16/30 , A61K35/17 , A61K38/17 , A61K35/00
摘要: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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公开(公告)号:US20210113618A1
公开(公告)日:2021-04-22
申请号:US17054670
申请日:2019-05-15
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Evangelia Kokalaki , Shaun Cordoba , Shimobi Onuoha , Simon Thomas , Biao Ma , Mathieu Ferrari
摘要: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.
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公开(公告)号:US10981970B2
公开(公告)日:2021-04-20
申请号:US16024445
申请日:2018-06-29
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Shimobi Onuoha , Simon Thomas
IPC分类号: C07K14/705 , C12N5/0783 , C07K14/725 , C07K16/28 , A61K39/00 , C07K14/735 , C07K16/30 , A61K35/17 , A61K38/17 , A61K35/00
摘要: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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公开(公告)号:US10954530B2
公开(公告)日:2021-03-23
申请号:US15554499
申请日:2016-03-01
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Leila Mekkaoui
IPC分类号: A61K39/00 , A61K35/17 , C12N5/0783 , A61K35/12 , A61K48/00 , C12N15/86 , C07K14/725 , C07K16/28 , A61K35/76 , A61K38/00 , C07K16/00 , C07K14/00
摘要: The present invention provides a retroviral or lentiviral vector having a viral envelope which comprises: (i) a mitogenic T-cell activating transmembrane protein which comprises a mitogenic domain and a transmembrane domain; and/or (ii) a cytokine-based T-cell activating transmembrane protein which comprises a cytokine domain and a transmembrane domain, wherein the mitogenic or cytokine-based T-cell activating transmembrane protein is not part of a viral envelope glycoprotein. When cells such as T-cells of Natural Killer cells are transduced by such a viral vector, they are simultaneously activated by the mitogenic T-cell activating transmembrane protein and/or the cytokine-based T-cell activating transmembrane protein.
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公开(公告)号:US20210040228A1
公开(公告)日:2021-02-11
申请号:US16999012
申请日:2020-08-20
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Matteo Righi , James Sillibourne , Shimobi Onuoha , Simon Thomas
IPC分类号: C07K16/30 , C07K14/46 , A61K39/00 , A61K35/17 , C07K14/715
摘要: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
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公开(公告)号:US20190330299A1
公开(公告)日:2019-10-31
申请号:US16076760
申请日:2017-02-10
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Simon Thomas , Shimobi Onuoha , Maria Stavrou
IPC分类号: C07K14/725 , C07K14/73 , C07K16/28 , A61K35/17
摘要: The present invention provides a chimeric antigen receptor (CAR) system comprising; (i) a receptor component comprising a antigen binding domain and a first binding domain; and (ii) a signalling component comprising a signalling domain and a second binding domain which binds the single domain binder of the first binding domain of the receptor component wherein either the first or second binding domains comprise a single domain binder, and wherein, binding of the first and second binding domains is disrupted by the presence of an agent, such that in the absence of the agent, the receptor component and the signalling component heterodimerize and binding of the antigen binding domain to antigen results in signalling through the signalling domain; whereas in the presence of the agent, the receptor component and the signalling component do not heterodimerize and binding of the antigen binding domain to antigen does not result in signalling through the signalling domain.
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公开(公告)号:US20190161531A1
公开(公告)日:2019-05-30
申请号:US16211538
申请日:2018-12-06
申请人: UCL BUSINESS PLC , AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Shimobi Onuoha , Simon Thomas
IPC分类号: C07K14/705 , C12N5/0783 , C07K16/28 , A61K39/00 , C07K14/725 , C07K16/30 , A61K35/17 , A61K38/17 , C07K14/735
摘要: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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公开(公告)号:US20190016820A1
公开(公告)日:2019-01-17
申请号:US16113224
申请日:2018-08-27
申请人: AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Matteo Righi , James Sillibourne , Shimobi Onuoha , Simon Thomas
IPC分类号: C07K16/30 , A61K39/00 , C07K14/715 , C07K14/46 , A61K35/17
摘要: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
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公开(公告)号:US10098926B2
公开(公告)日:2018-10-16
申请号:US15631948
申请日:2017-06-23
申请人: UCL BUSINESS PLC , AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Shimobi Onuoha , Simon Thomas
IPC分类号: A61K38/17 , C07K14/725 , C12N5/0783 , A61K35/17 , C07K14/705 , C07K16/28 , A61K39/00
摘要: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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公开(公告)号:US20170340705A1
公开(公告)日:2017-11-30
申请号:US15632119
申请日:2017-06-23
申请人: UCL BUSINESS PLC , AUTOLUS LIMITED
发明人: Martin Pulé , Shaun Cordoba , Shimobi Onuoha , Simon Thomas
IPC分类号: A61K38/17 , C07K14/705 , A61K35/17 , C12N5/0783 , C07K16/28 , A61K39/00
CPC分类号: A61K38/1774 , A61K35/00 , A61K35/17 , A61K39/0011 , A61K2039/505 , A61K2039/5158 , C07K14/7051 , C07K14/70521 , C07K14/70535 , C07K16/2803 , C07K16/2863 , C07K16/3061 , C07K2317/31 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N5/0636 , C12N5/0638 , C12N2501/505 , C12N2501/599 , C12N2510/02
摘要: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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