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    SYSTEM AND METHOD FOR RHYTHM IDENTIFICATION AND THERAPY DISCRIMINATION USING HEMODYNAMIC STATUS INFORMATION
    81.
    发明申请
    SYSTEM AND METHOD FOR RHYTHM IDENTIFICATION AND THERAPY DISCRIMINATION USING HEMODYNAMIC STATUS INFORMATION 审中-公开
    使用血液动力学状态信息进行RHYTHM识别和治疗分离的系统和方法

    公开(公告)号：US20100305635A1

    公开(公告)日：2010-12-02

    申请号：US12786074

    申请日：2010-05-24

    申请人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

    发明人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36564 ,  A61B5/02028 ,  A61B5/0452 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3962

    摘要： A system and method for controlling cardiac ventricular tachyarrhythmias by acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient. A CVP index is derived based on the pressure signal. The onset of a ventricular tachyarrhythmia episode is detected based on a cardiac rates signal. The CVP index and the rate signal are monitored and, responsive to the rate signal indicating a sustained tachycardia episode during the episode monitoring period, anti-tachycardia therapy selectively withheld and the episode monitoring period is extended based on the CVP index.

    摘要翻译： 一种用于通过从植入在患者的冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号来控制心室性心律失常的系统和方法。 基于压力信号导出CVP指数。 基于心率信号检测心室快速性心律失常事件的发作。 监测CVP指数和速率信号，并且响应于在发作监测期间指示持续性心动过速发作的速率信号，选择性地保留抗心动过速治疗，并且基于CVP指数扩大发作监测期。

    FABRICATION OF POLYANILINE NANOFIBER DISPERSIONS AND FILMS
    82.
    发明申请
    FABRICATION OF POLYANILINE NANOFIBER DISPERSIONS AND FILMS 有权
    聚氨酯纳米薄膜分散体和薄膜的制备

    公开(公告)号：US20100173076A1

    公开(公告)日：2010-07-08

    申请号：US12724252

    申请日：2010-03-15

    申请人： Richard B. Kaner ,  Dan Li ,  Jiaxing Huang

    发明人： Richard B. Kaner ,  Dan Li ,  Jiaxing Huang

    IPC分类号： B05D5/00 ,  B05D1/18 ,  B05D3/10 ,  C08L79/02

    CPC分类号： C08G73/0266 ,  D01D5/38 ,  D01D5/40 ,  D01F6/76

    摘要： A new method for forming stable polyaniline nanofiber colloids uses electrostatic repulsion to maintain dispersion of the nanofibers and prevent aggregation during synthesis of the nanofibers. The colloidal suspensions are formed directly from the reactants in solution maintained at a pH of about 1.0 to about 4.0 and a temperature of about 10° C. to about 100° C. with minimal or no stirring. Also set forth are new methods for forming ultrathin films of polyaniline nanofibers via self-assembly.

    摘要翻译： 用于形成稳定的聚苯胺纳米纤维胶体的新方法使用静电排斥来保持纳米纤维的分散并防止在纳米纤维合成期间的聚集。 胶体悬浮液直接由溶液中的反应物形成，保持在约1.0至约4.0的pH和约10℃至约100℃的温度，同时最小或不搅拌。 还阐述了通过自组装形成聚苯胺纳米纤维超薄膜的新方法。

    NEURAL STIMULATION FOR ARRHYTHMIA RECOGNITION AND THERAPY
    83.
    发明申请
    NEURAL STIMULATION FOR ARRHYTHMIA RECOGNITION AND THERAPY 有权
    神经刺激ARRHYTHMIA识别和治疗

    公开(公告)号：US20100036447A1

    公开(公告)日：2010-02-11

    申请号：US12535332

    申请日：2009-08-04

    申请人： Yunlong Zhang ,  Dan Li

    发明人： Yunlong Zhang ,  Dan Li

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36114 ,  A61N1/3622 ,  A61N1/37288 ,  A61N1/3787 ,  A61N1/3962

    摘要： A system and method can sense a tachyarrhythmia, compare the sensed tachyarrhythmia with a ventricular tachyarrhythmia criterion, provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia satisfies the ventricular tachyarrhythmia criterion, provide a neural stimulation when the sensed tachyarrhythmia does not satisfy the ventricular tachyarrhythmia criterion, determine whether the tachyarrhythmia continues during or after the neural stimulation when the tachyarrhythmia is sustained, compare the tachyarrhythmia sensed during or after the neural stimulation with a supraventricular tachyarrhythmia (SVT) criterion, and provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia does not satisfy the SVT criterion.

    摘要翻译： 系统和方法可以感觉到快速性心律失常，将感觉到的快速性心律失常与室性快速性心律失常标准进行比较，当感觉到的快速性心律失常满足心室快速性心律失常标准时，提供室性快速性心律失常治疗，当感觉到的快速性心律失常不满足心室快速性心律失常标准时提供神经刺激， 确定当紧张性心律失常持续时神经刺激期间或之后快速性心律失常是否持续，将神经刺激期间或之后感觉到的快速性心律失常与室上性快速性心律失常（SVT）标准进行比较，并且当感觉到的快速性心律不齐不满足时，提供室性快速性心律失常治疗 SVT标准。

    Extracts of Cranberry and Methods of Using Thereof
    84.
    发明申请
    Extracts of Cranberry and Methods of Using Thereof 审中-公开
    蔓越莓提取物及其使用方法

    公开(公告)号：US20100028469A1

    公开(公告)日：2010-02-04

    申请号：US12478431

    申请日：2009-06-04

    申请人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

    发明人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

    IPC分类号： A61K36/45 ,  A61K31/195 ,  A61K31/70 ,  A61K31/415 ,  A61P13/00

    CPC分类号： A61K9/0034 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/7023 ,  Y02A50/473 ,  A23V2250/21

    摘要： The present disclosure relates in part to extracts of cranberry (Vaccinium macrocarpon) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans. Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans. Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.

    摘要翻译： 本公开部分涉及包含富集量的某些具有抗感染活性的化合物的蔓越莓（牛痘macrocarpon）的提取物。 抗菌和/或抗真菌活性，例如 针对白色念珠菌的活性。 本公开的另一方面涉及组合的蔓越莓和肉桂提取物。 在某些实施方案中，这些组合的提取物已被优化以控制由大肠杆菌，金黄色葡萄球菌和白色念珠菌引起的尿路感染。 提取物的某些实施方案富含生物活性化合物，其已被证明能抑制白色念珠菌粘附和/或生物膜形成及其体外生长。 在本公开的另一方面，提取物富含衍生自蔓越莓和肉桂的生物活性物质，其已被证明可抑制普通尿道病原体如大肠杆菌，金黄色葡萄球菌和白色念珠菌的附着和生长。

    METHOD AND APPARATUS FOR CONTROLLING ANTI-TACHYARRHYTHMIA THERAPY USING HEMODYNAMIC TOLERABILITY
    86.
    发明申请
    METHOD AND APPARATUS FOR CONTROLLING ANTI-TACHYARRHYTHMIA THERAPY USING HEMODYNAMIC TOLERABILITY 有权
    使用HEMODYNAMIC耐受性控制抗TACHYARRHYTHMIA治疗的方法和装置

    公开(公告)号：US20090318985A1

    公开(公告)日：2009-12-24

    申请号：US12487251

    申请日：2009-06-18

    申请人： Allan C. Shuros ,  Dan Li

    发明人： Allan C. Shuros ,  Dan Li

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/4884 ,  A61B5/7264 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/37247 ,  A61N1/385

    摘要： A cardiac rhythm management system identifies a relationship between one or more hemodynamic parameters sensed from a patient and levels of hemodynamic tolerability of the patient. The identified relationship allows an implantable medical device to control delivery of anti-tachyarrhythmia therapy using the patient's hemodynamic tolerability during a detected tachyarrhythmia episode, in addition to classifying the detected tachyarrhythmia episode by its type and origin.

    摘要翻译： 心律管理系统识别从患者感测的一个或多个血液动力学参数与患者的血液动力学耐受性水平之间的关系。 所识别的关系允许可植入医疗装置在检测到的快速性心律失常发作期间使用患者的血液动力学耐受性来控制抗快速性心律失常治疗的递送，以及根据其类型和来源对检测到的快速性心律失常发作进行分类。

    Systems and Methods for Myocardial Ischemia Detection
    87.
    发明申请
    Systems and Methods for Myocardial Ischemia Detection 有权
    心肌缺血检测系统与方法

    公开(公告)号：US20090234211A1

    公开(公告)日：2009-09-17

    申请号：US12402224

    申请日：2009-03-11

    申请人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

    发明人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

    IPC分类号： A61B5/1468 ,  A61B5/04

    CPC分类号： A61B5/0402 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61N1/3627 ,  A61N1/36585

    摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

    摘要翻译： 本发明的实施方案涉及用于心肌缺血检测的装置和方法等。 在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心​​脏电场的信号。 可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。 控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。 本文还包括其它实施例。

    METHODS OF MONITORING HEMODYNAMIC STATUS FOR RHYTHM DISCRIMINATION WITHIN THE HEART
    88.
    发明申请
    METHODS OF MONITORING HEMODYNAMIC STATUS FOR RHYTHM DISCRIMINATION WITHIN THE HEART 有权
    监测心脏疾病分析的血液动力学状态的方法

    公开(公告)号：US20090204163A1

    公开(公告)日：2009-08-13

    申请号：US12366334

    申请日：2009-02-05

    申请人： Allan C. Shuros ,  Dan Li ,  Quan Ni

    发明人： Allan C. Shuros ,  Dan Li ,  Quan Ni

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/36578

    摘要： Systems and methods of performing rhythm discrimination within a patient's body using sensed hemodynamic signals are disclosed. The method can include the steps of receiving an electrical activity signal from an electrode located within or near the heart, detecting an event of the heart based on the received electrical activity signal, sensing one or more mechanical measurements using a sensor located within the body, analyzing a mechanical activity signal received from the sensor, and confirming the type of event based on the mechanical and electrical activity signals. The sensor can comprise a single pressure sensor configured to sense both atrial and ventricular activity within the heart.

    摘要翻译： 公开了使用感测到的血液动力学信号在患者体内进行节律辨别的系统和方法。 该方法可以包括以下步骤：从位于心脏内部或附近的电极接收电活动信号，基于接收到的电活动信号检测心脏的事件，使用位于体内的传感器感测一个或多个机械测量， 分析从传感器接收的机械活动信号，以及基于机械和电活动信号来确认事件的类型。 传感器可以包括构造成感测心脏内的心房和心室活动的单个压力传感器。

    Hemodynamic status assessment during tachycardia
    89.
    发明申请
    Hemodynamic status assessment during tachycardia 有权
    心动过速时的血液动力学状态评估

    公开(公告)号：US20090131999A1

    公开(公告)日：2009-05-21

    申请号：US12283234

    申请日：2008-09-10

    申请人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

    发明人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

    摘要： Systems and methods provide for sensing, during an event of tachycardia, hemodynamic signals concurrently from at least two spatially separated locations within a patient, and quantifying a spatial relationship between the hemodynamic signals. Hemodynamic stability or state of the patient during the tachycardia event is determine based at least in part on the quantified spatial relationship. One or more anti-tachycardia therapies to treat the tachycardia may be selected based at least in part on the determined stability or state of patient hemodynamics, and the selected one or more anti-tachycardia therapies may be delivered to treat the tachycardia. The hemodynamic signals may comprise at least two, or a mixed combination, of cardiac impedance signals, cardiac chamber pressure signals, arterial pressure signals, heart sounds; and acceleration signals.

    摘要翻译： 系统和方法提供在心动过速事件期间从患者内的至少两个空间上分离的位置同时感测血液动力学信号，并且量化血液动力学信号之间的空间关系。 至少部分地基于定量的空间关系确定在心动过速事件期间患者的血流动力学稳定性或状态。 可以至少部分地基于所确定的患者血液动力学的稳定性或状态来选择治疗心动过速的一种或多种抗心动过速疗法，并且可以递送所选择的一种或多种抗心动过速疗法以治疗心动过速。 血液动力学信号可以包括心脏阻抗信号，心室压力信号，动脉压信号，心音的至少两个或混合组合; 和加速度信号。