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    Extracts of Cranberry and Methods of Using Thereof
    81.
    发明申请
    Extracts of Cranberry and Methods of Using Thereof 审中-公开
    蔓越莓提取物及其使用方法

    公开(公告)号：US20100028469A1

    公开(公告)日：2010-02-04

    申请号：US12478431

    申请日：2009-06-04

    申请人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

    发明人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

    IPC分类号： A61K36/45 ,  A61K31/195 ,  A61K31/70 ,  A61K31/415 ,  A61P13/00

    CPC分类号： A61K9/0034 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/7023 ,  Y02A50/473 ,  A23V2250/21

    摘要： The present disclosure relates in part to extracts of cranberry (Vaccinium macrocarpon) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans. Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans. Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.

    摘要翻译： 本公开部分涉及包含富集量的某些具有抗感染活性的化合物的蔓越莓（牛痘macrocarpon）的提取物。 抗菌和/或抗真菌活性，例如 针对白色念珠菌的活性。 本公开的另一方面涉及组合的蔓越莓和肉桂提取物。 在某些实施方案中，这些组合的提取物已被优化以控制由大肠杆菌，金黄色葡萄球菌和白色念珠菌引起的尿路感染。 提取物的某些实施方案富含生物活性化合物，其已被证明能抑制白色念珠菌粘附和/或生物膜形成及其体外生长。 在本公开的另一方面，提取物富含衍生自蔓越莓和肉桂的生物活性物质，其已被证明可抑制普通尿道病原体如大肠杆菌，金黄色葡萄球菌和白色念珠菌的附着和生长。

    METHOD AND APPARATUS FOR CONTROLLING ANTI-TACHYARRHYTHMIA THERAPY USING HEMODYNAMIC TOLERABILITY
    83.
    发明申请
    METHOD AND APPARATUS FOR CONTROLLING ANTI-TACHYARRHYTHMIA THERAPY USING HEMODYNAMIC TOLERABILITY 有权
    使用HEMODYNAMIC耐受性控制抗TACHYARRHYTHMIA治疗的方法和装置

    公开(公告)号：US20090318985A1

    公开(公告)日：2009-12-24

    申请号：US12487251

    申请日：2009-06-18

    申请人： Allan C. Shuros ,  Dan Li

    发明人： Allan C. Shuros ,  Dan Li

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/4884 ,  A61B5/7264 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/37247 ,  A61N1/385

    摘要： A cardiac rhythm management system identifies a relationship between one or more hemodynamic parameters sensed from a patient and levels of hemodynamic tolerability of the patient. The identified relationship allows an implantable medical device to control delivery of anti-tachyarrhythmia therapy using the patient's hemodynamic tolerability during a detected tachyarrhythmia episode, in addition to classifying the detected tachyarrhythmia episode by its type and origin.

    摘要翻译： 心律管理系统识别从患者感测的一个或多个血液动力学参数与患者的血液动力学耐受性水平之间的关系。 所识别的关系允许可植入医疗装置在检测到的快速性心律失常发作期间使用患者的血液动力学耐受性来控制抗快速性心律失常治疗的递送，以及根据其类型和来源对检测到的快速性心律失常发作进行分类。

    Systems and Methods for Myocardial Ischemia Detection
    84.
    发明申请
    Systems and Methods for Myocardial Ischemia Detection 有权
    心肌缺血检测系统与方法

    公开(公告)号：US20090234211A1

    公开(公告)日：2009-09-17

    申请号：US12402224

    申请日：2009-03-11

    申请人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

    发明人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

    IPC分类号： A61B5/1468 ,  A61B5/04

    CPC分类号： A61B5/0402 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61N1/3627 ,  A61N1/36585

    摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

    摘要翻译： 本发明的实施方案涉及用于心肌缺血检测的装置和方法等。 在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心​​脏电场的信号。 可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。 控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。 本文还包括其它实施例。

    METHODS OF MONITORING HEMODYNAMIC STATUS FOR RHYTHM DISCRIMINATION WITHIN THE HEART
    85.
    发明申请
    METHODS OF MONITORING HEMODYNAMIC STATUS FOR RHYTHM DISCRIMINATION WITHIN THE HEART 有权
    监测心脏疾病分析的血液动力学状态的方法

    公开(公告)号：US20090204163A1

    公开(公告)日：2009-08-13

    申请号：US12366334

    申请日：2009-02-05

    申请人： Allan C. Shuros ,  Dan Li ,  Quan Ni

    发明人： Allan C. Shuros ,  Dan Li ,  Quan Ni

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/36578

    摘要： Systems and methods of performing rhythm discrimination within a patient's body using sensed hemodynamic signals are disclosed. The method can include the steps of receiving an electrical activity signal from an electrode located within or near the heart, detecting an event of the heart based on the received electrical activity signal, sensing one or more mechanical measurements using a sensor located within the body, analyzing a mechanical activity signal received from the sensor, and confirming the type of event based on the mechanical and electrical activity signals. The sensor can comprise a single pressure sensor configured to sense both atrial and ventricular activity within the heart.

    摘要翻译： 公开了使用感测到的血液动力学信号在患者体内进行节律辨别的系统和方法。 该方法可以包括以下步骤：从位于心脏内部或附近的电极接收电活动信号，基于接收到的电活动信号检测心脏的事件，使用位于体内的传感器感测一个或多个机械测量， 分析从传感器接收的机械活动信号，以及基于机械和电活动信号来确认事件的类型。 传感器可以包括构造成感测心脏内的心房和心室活动的单个压力传感器。

    Hemodynamic status assessment during tachycardia
    86.
    发明申请
    Hemodynamic status assessment during tachycardia 有权
    心动过速时的血液动力学状态评估

    公开(公告)号：US20090131999A1

    公开(公告)日：2009-05-21

    申请号：US12283234

    申请日：2008-09-10

    申请人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

    发明人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

    摘要： Systems and methods provide for sensing, during an event of tachycardia, hemodynamic signals concurrently from at least two spatially separated locations within a patient, and quantifying a spatial relationship between the hemodynamic signals. Hemodynamic stability or state of the patient during the tachycardia event is determine based at least in part on the quantified spatial relationship. One or more anti-tachycardia therapies to treat the tachycardia may be selected based at least in part on the determined stability or state of patient hemodynamics, and the selected one or more anti-tachycardia therapies may be delivered to treat the tachycardia. The hemodynamic signals may comprise at least two, or a mixed combination, of cardiac impedance signals, cardiac chamber pressure signals, arterial pressure signals, heart sounds; and acceleration signals.

    摘要翻译： 系统和方法提供在心动过速事件期间从患者内的至少两个空间上分离的位置同时感测血液动力学信号，并且量化血液动力学信号之间的空间关系。 至少部分地基于定量的空间关系确定在心动过速事件期间患者的血流动力学稳定性或状态。 可以至少部分地基于所确定的患者血液动力学的稳定性或状态来选择治疗心动过速的一种或多种抗心动过速疗法，并且可以递送所选择的一种或多种抗心动过速疗法以治疗心动过速。 血液动力学信号可以包括心脏阻抗信号，心室压力信号，动脉压信号，心音的至少两个或混合组合; 和加速度信号。

    Compositions and Methods Comprising Zingiber Species
    89.
    发明申请
    Compositions and Methods Comprising Zingiber Species 审中-公开
    组合和方法包括兴宁种

    公开(公告)号：US20080160116A1

    公开(公告)日：2008-07-03

    申请号：US11951948

    申请日：2007-12-06

    申请人： Dan Li ,  George W. Sypert ,  Robert T. Gow

    发明人： Dan Li ,  George W. Sypert ,  Robert T. Gow

    IPC分类号： A61K36/906 ,  A61K31/715 ,  A61K31/12 ,  A61P43/00

    CPC分类号： A61K36/9068 ,  A61K31/12 ,  A61K31/715

    摘要： An aspect of the present invention relates to compositions comprising a gingerol, for example, compositions comprising gingerol in an amount greater than about 2% by weight. In some aspects of the invention, the composition comprises 6-gingerol, 8-gingerol, 10-gingerol, 6-shagaol, or combinations thereof. Another aspect of the invention relates to a method for extracting a ginger species comprising, sequentially extracting a ginger species plant material to yield an essential oil fraction, a gingerol fraction, a phenolic fraction, and a polysaccharide fraction, wherein the essential oil and gingerol fractions are derived by extracting plant feedstock material by supercritical carbon dioxide extraction, the phenolic fraction is extracted from the plant feedstock material or from the remainder of the essential oil and gingerol extractions by hydroalcoholic extraction, and the polysaccharide fraction is derived by water extraction of the remainder of the phenolic extraction.

    摘要翻译： 本发明的一个方面涉及包含姜醇的组合物，例如包含量大于约2重量％的姜酚的组合物。 在本发明的某些方面，该组合物包含6-姜醇，8-姜醇，10-姜醇，6-莽草醇或其组合。 本发明的另一方面涉及一种用于提取生姜物种的方法，包括：依次提取姜种植物材料以产生精油​​馏分，姜油醇馏分，酚馏分和多糖级分，其中所述精油和姜醇馏分 通过超临界二氧化碳提取提取植物原料，通过水醇提取从植物原料或其余的精油和姜油中提取酚类成分，多糖级分是通过水提取其余部分得到的 的酚提取。

    Therapy delivery for identified tachyarrhythmia episode types
    90.
    发明申请
    Therapy delivery for identified tachyarrhythmia episode types 有权
    治疗确定快速性心律失常发作类型

    公开(公告)号：US20080125824A1

    公开(公告)日：2008-05-29

    申请号：US11715128

    申请日：2007-03-07

    申请人： William H. Sauer ,  Shelley Marie Cazares ,  Dan Li

    发明人： William H. Sauer ,  Shelley Marie Cazares ,  Dan Li

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3622 ,  A61N1/3627

    摘要： Methods and systems for identifying tachyarrhythmia episode types and delivering therapy to mitigate the identified tachyarrhythmia episode types are described. Electrogram signals of cardiac activity are sensed and stored by an implantable cardiac device. Tachyarrhythmia episodes are detected and tachyarrhythmia episode types are identified based on characteristics of the electrogram signals. In preparation for performing ablation, a tachyarrhythmia episode is induced. The features of the induced tachyarrhythmia episode are compared to characteristics of the identified episode types. A similarity between the induced tachyarrhythmia episode and at least one of the episode types identified from the stored electrogram signals is indicated to facilitate performing the ablation.

    摘要翻译： 描述了用于鉴定快速性心律失常发作类型并递送治疗以减轻所鉴定的快速性心律失常发作类型的方法和系统。 心脏活动的电图信号由可植入的心脏装置感测和储存。 检测到快速性心律失常发作，并根据电描记图信号的特征识别快速性心律失常发作类型。 为准备进行消融，诱发快速性心律失常发作。 将诱发的快速性心律失常发作的特征与鉴定的发作类型的特征进行比较。 指示诱导的快速性心律失常发作与从存储的电描记图信号识别的至少一种发作类型之间的相似性，以便于进行消融。