公开(公告)号：US20060267414A1

公开(公告)日：2006-11-30

申请号：US11133648

申请日：2005-05-20

Applicant: Bi Han ,  Daniel Chu ,  Mase Taub

Inventor： Bi Han ,  Daniel Chu ,  Mase Taub

IPC: H01H3/34

CPC classification number: G11C16/12 ,  G11C16/30 ,  Y10T307/964

Abstract: A double cascode protected switchable voltage source may be used to selectively provide positive or negative voltage sources, for example, to a flash memory. The positive supply may be connected through a PMOS pass device to a first cascode protection device. A negative supply may be connected through an NMOS pass device and an NMOS cascode protection device to an output. The circuits may be designed so that exceeding snapback limits and gate aided drain breakdown are less likely.

Abstract translation: 可以使用双共源共栅保护的可切换电压源来选择性地将正或负电压源例如提供给闪存。 正电源可以通过PMOS通道器件连接到第一共源共栅保护器件。 负电源可以通过NMOS通道器件和NMOS共源共栅保护器件连接到输出端。 这些电路可以被设计成使得超过回跳限制和栅极辅助漏极击穿不太可能。

公开(公告)号：US20060197386A1

公开(公告)日：2006-09-07

申请号：US11069175

申请日：2005-03-01

Applicant: Daniel Chu

Inventor： Daniel Chu

IPC: B23K11/24

CPC classification number: G11C16/30 ,  H03K17/102 ,  Y10T307/74

Abstract: A negative switch may enable switching of two different negative voltages. The switch may include a negative cascode bias generator which biases the gate of a cascade protection device. When the negative switch is passing a large negative voltage, the bias generator generates a lowered voltage to provide a cascade voltage for snapback protection of a passing transistor. When a relatively low negative voltage is to be switched, the bias generator may produce a positive voltage greater than the threshold voltage of the cascode protection device so that both high and low negative voltages may be switched by the same circuit without exposing the passing device to a voltage in excess of its snapback limit.

公开(公告)号：US06995269B2

公开(公告)日：2006-02-07

申请号：US10379397

申请日：2003-03-04

Applicant: Paul A. Renhowe ,  Daniel Chu ,  Rustum S. Boyce ,  David Duhl

Inventor： Paul A. Renhowe ,  Daniel Chu ,  Rustum S. Boyce ,  David Duhl

IPC: C07D211/72 ,  C07D295/20 ,  A61K31/44

CPC classification number: C07D233/64 ,  C07B2200/07 ,  C07B2200/09 ,  C07C279/18 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2603/74 ,  C07D209/16 ,  C07D215/12 ,  C07D241/08 ,  C07D241/42 ,  C07D295/215 ,  C07D307/24 ,  C07D309/14 ,  C07D333/20 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula IIA and IIB are novel guanidine compounds where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical formulations in conjunction with a pharmaceutically acceptable carrier.

Abstract translation: 式IIA和IIB的化合物是新的胍化合物，化学式id =“CHEM-US-00001”num =“000

公开(公告)号：US06638927B2

公开(公告)日：2003-10-28

申请号：US09945384

申请日：2001-08-31

Applicant: Paul A. Renhowe ,  Daniel Chu ,  Rustum S. Boyce ,  Zhi-Jie Ni ,  David Duhl ,  Effie Tozzo ,  Kirk Johnson ,  David C. Myles

Inventor： Paul A. Renhowe ,  Daniel Chu ,  Rustum S. Boyce ,  Zhi-Jie Ni ,  David Duhl ,  Effie Tozzo ,  Kirk Johnson ,  David C. Myles

IPC: C07D29520

CPC classification number: C07D233/64 ,  C07B2200/07 ,  C07B2200/09 ,  C07C279/18 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2603/74 ,  C07D209/16 ,  C07D215/12 ,  C07D241/08 ,  C07D241/42 ,  C07D295/215 ,  C07D307/24 ,  C07D309/14 ,  C07D333/20 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula IA and IB are new where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical formulations in conjunction with a pharmaceutically acceptable carrier.

Abstract translation: 式IA和IB的化合物是新的，其中变量R 1至R 10具有本文所述的值。 这些化合物可用于治疗诸如肥胖症和II型糖尿病的疾病，并且可以作为药物制剂与药学上可接受的载体一起提供。

公开(公告)号：US06624302B2

公开(公告)日：2003-09-23

申请号：US10331047

申请日：2002-12-27

Applicant: Daniel Chu ,  Maria Fardis ,  Chaitan Khosla ,  Christopher Reeves ,  Daniel Santi ,  Andreas Schirmer

Inventor： Daniel Chu ,  Maria Fardis ,  Chaitan Khosla ,  Christopher Reeves ,  Daniel Santi ,  Andreas Schirmer

IPC: C07D49816

CPC classification number: C07D498/18

Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include as part of their structure and bind to a FK binding protein wherein R4 and R5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R4 and R5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

Abstract translation: 本发明涉及新型聚酮化合物，产生新化合物的宿主细胞，以及使用它们的方法。 本发明的化合物是其部分结构并结合FK结合蛋白质的环状聚酮化合物（也称为“大环内酯类”或“大内酯”），其中R 4和R 5各自选自 由氢，甲基，乙基和甲氧基组成的基团，条件是R 4和R 5中的至少一个是氢，甲基或乙基。 如下面将更详细地解释的，本发明的化合物具有如使用这些化合物作为药物所希望的有利的P450酶活性曲线的性质。

公开(公告)号：US06569867B2

公开(公告)日：2003-05-27

申请号：US09853306

申请日：2001-05-10

Applicant: Daniel Chu ,  Maria Fardis ,  Chaitan Khosla ,  Christopher Reeves ,  Daniel Santi ,  Andreas Schirmer

Inventor： Daniel Chu ,  Maria Fardis ,  Chaitan Khosla ,  Christopher Reeves ,  Daniel Santi ,  Andreas Schirmer

IPC: C07D49816

CPC classification number: C07D498/18

Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include as part of their structure and bind to a FK binding protein wherein R4 and R5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R4 and R5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

Abstract translation: 本发明涉及新型聚酮化合物，产生新化合物的宿主细胞，以及使用它们的方法。 本发明的化合物是其部分结构并结合FK结合蛋白质的环状聚酮化合物（也称为“大环内酯类”或“大内酯”），其中R 4和R 5各自选自氢， 甲基，乙基和甲氧基，条件是R 4和R 5中的至少一个是氢，甲基或乙基。 如下面将更详细地解释的，本发明的化合物具有如使用这些化合物作为药物所希望的有利的P450酶活性曲线的性质。