摘要:
Compounds of formula IA and IB are new where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical formulations in conjunction with a pharmaceutically acceptable carrier.
摘要:
A method for delivering a melanocortin-4 receptor agonist to a mammalian subject, includes administering the melanocortin-4 receptor agonist to a tissue inside the nasal cavity or sinuses of the mammalian subject. In some instances, the melanocortin-4 receptor agonist includes a guanidine functional group.
摘要:
New pyridine-based compounds of Formula I, compositions, and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3-mediated disorders in vivo are provided. The methods, compounds, and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要:
New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要:
Content servers are directed to send messages to network nodes which are used to obtain IP addresses and to receive responses from the network nodes. The responses provide network service information. The content servers collect data based on the responses and feed the data to a routing server. Based on the data fed to the routing server, respective choices of content servers are selected and provided to the network nodes to respond to clients requesting content server addresses from the network nodes.
摘要:
The invention provides specific transgenic rice plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the rice genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.
摘要:
Server selection is optimized using randomness, feedback, and fanout. A central server maintains a vector of server selection probabilities and provides a subset of candidate servers from the vector for the client in response to receiving from a client a request for a server address to provide substantive service. An interrogating node (i.e., the client or DNS proxy) probes the candidate servers and selects a best server based on at least one criterion. The client accesses the selected server for the substantive data, and the selected server updates a counter used to keep track of the number of times the server is selected. The servers feedback the number of times selected to the central server, which, in turn, updates weightings in the vector of server selection probabilities.
摘要:
Methods and apparatuses of registering on a camera display separate fields of view of a visible light camera module and an infrared camera module by focusing the IR camera module. The fields of view can be displayed in several display modes including 1) full screen visible, infrared and/or blended, 2) picture-in-a-picture such as partial infrared image in a full screen visible image, and 3) infrared color alarms in visible-light images.
摘要:
A filter assembly for use in sidestream gas sampling assembly. The filter assembly of the present invention includes a hydrophilic The filter further includes a hydrophobic member positioned downstream of the hydrophilic liner. The hydrophobic disk acts as a second line of defense against moisture reaching the sensing mechanism member that is constructed from a porous material and is situated such that gas entering the filter assembly passes through at least a portion the hydrophilic member. In a further embodiment, the filter includes a hydrophobic member positioned downstream of the hydrophilic member. The hydrophobic member acts as a second line of defense against moisture reaching the sensing mechanism in the gas sampling assembly.
摘要:
A system and method for vacuum bag assembly fabrication via the vacuum bag method which reduces the amount of trapped air. The inventive system includes a chamber adapted to contain a vacuum bag and first and second evacuating mechanisms. The first evacuating mechanism serves to evacuate the bag and vent to atmosphere. The second evacuating mechanism serves to evacuate and vent the chamber to atmosphere. Thus, generally, the inventive method includes the steps of placing a vacuum bag lay up in an air tight chamber; and evacuating the vacuum bag lay up and the air tight chamber at the same time. In practice, the assembly would consist of at least two components and a heat curable composition. The components can be parts to be bonded together or layers of cloth to be made into a laminate. In this case, the heat curable composition would be a catalyzed adhesive or resin.