公开(公告)号：US4456754A

公开(公告)日：1984-06-26

申请号：US414946

申请日：1982-09-03

申请人： Masahiro Murakami ,  Masateru Kobayashi ,  Kimiyo Yamamoto ,  Chisei Shibuya

发明人： Masahiro Murakami ,  Masateru Kobayashi ,  Kimiyo Yamamoto ,  Chisei Shibuya

IPC分类号： C07D249/04 ,  C07D257/04 ,  C07D285/12 ,  C07D285/125 ,  C07D501/06 ,  C07D501/36

CPC分类号： C07D257/04 ,  C07D249/04 ,  C07D285/125

摘要： Novel thioesters effective as acylating agents for amines or hydrazines, especially effective as active esters in synthesis of cephalosporin compounds are disclosed. The novel thioester of the present invention can be prepared by reacting a thiol or a derivative thereof with an acetic acid derivative or a reactive derivative thereof. By reacting the thioester of the present invention with a 7-aminocephalosporin derivative or a salt thereof, cephalosporin derivatives or pharmacologically acceptable salts thereof which are excellent antibiotic substances having a high antimicrobial activity can be obtained in high yield very safely.

公开(公告)号：US4327211A

公开(公告)日：1982-04-27

申请号：US210746

申请日：1980-11-26

申请人： Masahiro Murakami ,  Masateru Kobayashi ,  Takanori Sone ,  Chisei Shibuya

发明人： Masahiro Murakami ,  Masateru Kobayashi ,  Takanori Sone ,  Chisei Shibuya

IPC分类号： C07D501/36 ,  C07D501/56

CPC分类号： C07D501/36

摘要： A method for preparing a cephalosporin compound represented by the general formula (III) ##STR1## (wherein R represents hydrogen or methyl group) or a pharmaceutically acceptable salt thereof, which is characterized by reacting 7-amino-3-(benzimidazol-2-yl)-thiomethyl-3-cephem-4-carboxylic acid represented by the general formula (I) ##STR2## or a salt thereof with a compound represented by general formula (II) ##STR3## wherein R represents hydrogen or methyl group.

摘要翻译： 制备由通式（III）表示的头孢菌素化合物（III）（其中R表示氢或甲基）或其药学上可接受的盐的方法，其特征在于使7-氨基-3-（苯并咪唑 （II）表示的化合物或其盐与通式（II）表示的化合物（II）表示的通式（I）表示的化合物 其中R表示氢或甲基。

公开(公告)号：US08601488B2

公开(公告)日：2013-12-03

申请号：US12954949

申请日：2010-11-29

申请人： Noriaki Asamoto ,  Masahiro Murakami

发明人： Noriaki Asamoto ,  Masahiro Murakami

IPC分类号： G06F9/46

CPC分类号： G06F9/461 ,  G06F9/4887

摘要： Ensuring real-time performance of multitask control and improving the processing efficiency of a system provided with a processor processing while switching between a plurality of tasks. The system includes an execution unit executing instructions on individual tasks while switching from one task to another, a distinguishing unit executing an instruction determined to be a predetermined instruction. The system further includes a determination unit set so that on condition that the instruction to be executed is the predetermined instruction, it determines whether to allow the execution unit to execute the predetermined instruction or to perform a task switching process without executing the predetermined instruction based on a predetermined condition.

摘要翻译： 确保多任务控制的实时性能，并且在多个任务之间切换时提高处理器处理的系统的处理效率。 该系统包括执行单元，其在从一个任务切换到另一个任务时执行关于各个任务的指令，执行确定为预定指令的指令的区分单元。 该系统还包括确定单元，使得在要执行的指令是预定指令的条件下，它确定是否允许执行单元执行预定指令或执行任务切换处理而不执行基于 预定条件。

公开(公告)号：US08588341B2

公开(公告)日：2013-11-19

申请号：US13267184

申请日：2011-10-06

申请人： Takashi Maeno ,  Masahiro Murakami

发明人： Takashi Maeno ,  Masahiro Murakami

IPC分类号： H03K9/00 ,  G06F3/038 ,  G06F1/04

CPC分类号： G06F13/4217

摘要： A circuit that transfers data between a first clock domain using a first clock and a second clock domain using a second clock synchronized with the first clock. The circuit comprises a data holding circuit operating at the first clock, an enable signal generation circuit connected to the data holding circuit. Preferably, the data transfer circuit includes an edge signal generation circuit connected to the data holding circuit, the edge signal generation circuit generating an edge signal allowing the data holding circuit to receive and send the data when edges of the first clock and the second clock align, and applying the edge signal to the data holding circuit.

摘要翻译： 使用与第一时钟同步的第二时钟，使用第一时钟和第二时钟域在第一时钟域之间传送数据的电路。 电路包括在第一时钟工作的数据保持电路，连接到数据保持电路的使能信号发生电路。 优选地，数据传送电路包括连接到数据保持电路的边沿信号产生电路，边沿信号产生电路产生边沿信号，允许数据保持电路在第一时钟和第二时钟的边缘对准时接收和发送数据 ，并将边沿信号应用于数据保持电路。

公开(公告)号：US20110104429A1

公开(公告)日：2011-05-05

申请号：US12832353

申请日：2010-07-08

申请人： Masahiko Kushino ,  Masahiro Murakami ,  Shinichi Tokuno

发明人： Masahiko Kushino ,  Masahiro Murakami ,  Shinichi Tokuno

IPC分类号： B32B3/02 ,  B32B3/30 ,  B29C65/00

CPC分类号： H01L21/565 ,  H01L21/561 ,  H01L23/13 ,  H01L23/3128 ,  H01L24/97 ,  H01L2224/83385 ,  H01L2924/01004 ,  H01L2924/01006 ,  H01L2924/01023 ,  H01L2924/01033 ,  H01L2924/014 ,  H01L2924/12041 ,  H01L2924/19041 ,  Y10T428/239 ,  Y10T428/24479 ,  Y10T428/24612

摘要： A substrate member is a manufacturing component of a module including electronic components mounted on a substrate and sealed with resin. The substrate member has substantially a plate-like shape and is to be the substrate later. A manufacturing process of the modules includes a mounting step of mounting electronic components on a component side of the substrate member, and a sealing step of supplying resin to flow on the component side so that the mounted electronic components are sealed with the resin. The mounting step includes mounting a first electronic component having substantially a flat mounting surface in a first mounting region specified on the component side so that a gap is formed between the mounting surface and the component side. The component side is provided with a first groove for boosting the resin to fill up the gap in the sealing step. Thus, insufficient filling of the resin in the gap between the substrate member and the electronic component is suppressed.

摘要翻译： 基板构件是包括安装在基板上并用树脂密封的电子部件的模块的制造部件。 基板构件基本上具有板状形状，并且稍后将成为基板。 模块的制造过程包括将电子部件安装在基板部件的部件侧的安装步骤以及供给树脂在部件侧流动从而将所安装的电子部件用树脂密封的密封工序。 安装步骤包括将具有基本上平坦的安装表面的第一电子部件安装在在部件侧指定的第一安装区域中，使得在安装表面和部件侧之间形成间隙。 部件侧设置有用于在密封步骤中增加树脂以填充间隙的第一凹槽。 因此，抑制了树脂在衬底构件和电子部件之间的间隙中的填充不充分。

公开(公告)号：US07855808B2

公开(公告)日：2010-12-21

申请号：US11902561

申请日：2007-09-24

申请人： Masahiro Murakami

发明人： Masahiro Murakami

IPC分类号： H04N1/60

CPC分类号： G06F3/1212 ,  G06F3/1204 ,  G06F3/1205 ,  G06F3/1256 ,  G06F3/1258 ,  G06F3/1284 ,  G06F3/1285

摘要： A printing system includes a processing device, a printing device and a display device. The processing device processes image data in accordance with a set image quality parameter. The printing device performs a printing process of an image represented by the image data processed by the processing device. The display device displays an adjustment screen for adjusting the image quality parameter after the printing process of the image by the printing device is started.

摘要翻译： 打印系统包括处理装置，打印装置和显示装置。 处理装置根据设定的图像质量参数处理图像数据。 打印装置执行由处理装置处理的图像数据表示的图像的打印处理。 显示装置在通过打印装置的图像的打印处理开始之后显示用于调整图像质量参数的调整画面。

公开(公告)号：US20100143321A1

公开(公告)日：2010-06-10

申请号：US12519437

申请日：2007-12-19

申请人： Kouji Shirai ,  Tatsuo Kawashima ,  Toshihisa Kuroda ,  Yutaka Mizushima ,  Ayako Mizushima ,  Masahiro Murakami ,  Tomoharu Fukuzaki

发明人： Kouji Shirai ,  Tatsuo Kawashima ,  Toshihisa Kuroda ,  Yutaka Mizushima ,  Ayako Mizushima ,  Masahiro Murakami ,  Tomoharu Fukuzaki

IPC分类号： A61K38/44 ,  A61P11/00

CPC分类号： A61K31/573 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/26 ,  A61K47/544 ,  C12N9/0089

摘要： A therapeutic agent for interstitial pneumonia is provided which effectively exploits the effect of superoxide dismutase (SOD). The therapeutic composition for interstitial pneumonia contains 10 to 100 mg of lecithinized superoxide dismutase represented by the following general formula (I): SOD′(Q-B)m   (I) (wherein SOD′ is a residue of superoxide dismutase; Q is a chemical crosslink; B is a residue of lysolecithin having the hydrogen atom of the hydroxyl group at position 2 of its glycerol moiety removed; and m is the average number of lysolecithin molecules bound to one molecule of the superoxide dismutase and is an integer of 1 or greater) and further contains sucrose to give it a stable form suitable for intravenous administration.

摘要翻译： 提供间质性肺炎治疗剂，有效利用超氧化物歧化酶（SOD）的作用。 间质性肺炎的治疗组合物含有10-100mg由以下通式（I）表示的卵磷脂化超氧化物歧化酶：SOD'（QB）m（I）（其中SOD'是超氧化物歧化酶的残基; Q是化学交联 ; B是除去其甘油部分的位置2处的羟基的氢原子的溶血卵磷脂的残基; m是与1分子超氧化物歧化酶结合的溶血卵磷脂分子的平均数，为1以上的整数） 并且还含有蔗糖以使其具有适于静脉内施用的稳定形式。

公开(公告)号：US07395107B2

公开(公告)日：2008-07-01

申请号：US11042202

申请日：2005-01-26

申请人： Atsushi Ishiyama ,  Yumie Ono ,  Masahiro Murakami

发明人： Atsushi Ishiyama ,  Yumie Ono ,  Masahiro Murakami

IPC分类号： A61B5/05

CPC分类号： A61B5/04007 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/743

摘要： In magnetocardiography, an assisting technique for a doctor diagnosing a heart disease will be provided. In the magnetocardiography, magnetism to be generated from a subject's heart is measured by a magnetic sensor, and from this measured data, a position of center of gravity of excitement wave front in a cardiac muscle excitement propagation process and a transition vector (wave front vector) is calculated by an analyzing computer. With this wave front vector as a feature parameter, the Mahalanobis' distance is calculated from a data base obtained by diagnosing in the past, a possibility (probability) of the subject having a heart disease is presumed on the basis of the Bayes' theorem for displaying. Also, by superimposing on a heart picture, the wave front vector position is displayed, and a cluster classification position in the wave front vector is displayed. Also, by the similar retrieval, another subject extremely similar to the subject in the feature parameter will be retrieved from the data base for screen displaying.

摘要翻译： 在磁心图中，将提供诊断心脏病的医生的辅助技术。 在磁心法中，通过磁传感器测量从受试者的心脏产生的磁性，并且根据该测量数据，在心肌兴奋传播过程中的兴奋波前的重心位置和过渡矢量（波前矢量 ）由分析计算机计算。 以该波前矢量作为特征参数，通过从过去的诊断获得的数据库计算马哈拉诺比斯距离，根据贝叶斯定理假设具有心脏病的受试者的可能性（概率） 显示。 此外，通过叠加在心脏图像上，显示波前矢量位置，并且显示波前矢量中的群集分类位置。 此外，通过类似的检索，将从用于屏幕显示的数据库中检索与特征参数中的主题非常相似的另一个对象。

公开(公告)号：US07354567B2

公开(公告)日：2008-04-08

申请号：US10503139

申请日：2003-02-25

申请人： Yasushi Arano ,  Emi Kaneko ,  Masahiro Murakami

发明人： Yasushi Arano ,  Emi Kaneko ,  Masahiro Murakami

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K51/1234

摘要： An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as 99mTc and CD is encapsulated, with radiochemical yield and purity enabling practical application. The present invention provides a method of producing a liposome wherein a complex of a short half-life metallic radioactive nuclide and ethylenedicysteine (CD) is encapsulated, which comprises mixing a complex of a short half-life metallic radioactive nuclide and N-[2-(1H-pyrrolylmethyl)]-N′-(4-penten-3-on-2)-ethane-1,2-diamine with an ethylenedicysteine (CD)-encapsulated liposome, and incubating the mixture.

摘要翻译： 本发明的一个目的是提供一种生产脂质体的方法，其中封装了半衰期短的金属放射性核素如99m Tc和CD的复合物，其放射化学产率和纯度使得实际应用 。 本发明提供了一种制备脂质体的方法，其中包含短半衰期金属放射性核素和乙基半胱氨酸（CD）的复合物，其包括将短半衰期金属放射性核素和N- [2- （1H-吡咯基甲基）] -N' - （4-戊烯-3-酮-2） - 乙烷-1,2-二胺与乙二
氨酸（CD）封装的脂质体混合，并温育该混合物。

公开(公告)号：US07340289B2

公开(公告)日：2008-03-04

申请号：US10634772

申请日：2003-08-06

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Masahiro Murakami ,  Kuniomi Ogata

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Masahiro Murakami ,  Kuniomi Ogata

IPC分类号： A61B5/05

CPC分类号： A61B5/04007 ,  A61B5/7239

摘要： A biomagnetic field measuring apparatus for performing (1) processes for removing a magnetic field waveform generated by a maternal heart from a waveform of a biomagnetic field measured, (2) processes for obtaining a template waveform of a magnetic field waveform generated by the fetal heart from a waveform, from which the magnetic field waveform generated by the maternal heart has been removed, (3) processes for obtaining a waveform of a cross correlation coefficient between the waveform, from which the magnetic field waveform generated by the mother's hears was removed, and the template waveform, and (4) a process for detecting peaks from a waveform of the cross correlation coefficient, and displaying times of appearance of the detected peaks on a display unit.

摘要翻译： 一种生物磁场测量装置，用于执行（1）从测量的生物磁场的波形中去除由母体心脏产生的磁场波形的处理，（2）用于获得由胎心产生的磁场波形的模板波形的处理 从母体心脏产生的磁场波形的波形从波形中除去，（3）获得从母体听到的磁场波形除去的波形之间的互相关系数的波形的处理， 和模板波形，以及（4）用于从互相关系数的波形检测峰值的处理以及在显示单元上显示检测到的峰值的出现次数。