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公开(公告)号：US09233151B2
公开(公告)日：2016-01-12
申请号：US13439829
申请日：2012-04-04
IPC分类号： A61K39/095 , A61K39/116 , A61K39/02 , A61K47/48 , A61K39/29 , A61K39/102 , A61K39/08 , A61K39/05 , C07H3/00 , A61K39/385 , A61K39/00
CPC分类号： A61K39/102 , A61K2039/545 , A61K2039/6037 , Y02A50/466 , Y02A50/484
摘要： A multi-valent vaccine composition is described comprising a conjugate of the capsular polysaccharide of H. influenzae b not adsorbed onto an aluminum adjuvant salt, and two or more further bacterial polysaccharides. A multi-valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.
摘要翻译： 描述了一种多价疫苗组合物，其包含未吸附到铝佐剂盐上的流感嗜血杆菌b的荚膜多糖的缀合物和两种或更多种其它细菌多糖。 还描述了一种多价疫苗组合物，其包括全细胞百日咳组分，破伤风类毒素，白喉类毒素，乙型肝炎表面抗原，流感嗜血杆菌b的荚膜多糖的缀合物和荚膜多糖的缀合物。 A型或C型脑膜炎（或两者）。 此外，描述了包含全细胞百日咳组分，破伤风类毒素，白喉类毒素和低剂量流感嗜血杆菌b的荚膜多糖的缀合物的多价疫苗组合物。
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82.发明申请IMMUNOGENIC COMPOSITION COMPRISING S. PNEUMONIAE POLYSACCHARIDES CONJUGATED TO CARRIER PROTEINS 审中-公开包含与载体蛋白结合的S. PNEUMONIAE多糖的免疫组合物公开(公告)号：US20120321658A1
公开(公告)日：2012-12-20
申请号：US13581686
申请日：2010-08-17
IPC分类号： C07K17/10 , A61P37/04 , A61K39/385
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/6068 , C07K16/1214
摘要： The present invention relates to an immunogenic composition comprising at least 2 different S. pneumoniae capsular saccharides, wherein one or more is/are selected from a first group consisting of serotypes 1, 3, 19A and 19F which is/are linked to a protein carrier(s) either directly or indirectly through a chemistry other than reductive amination, and one or more different saccharides is/are selected from a second group consisting of serotypes 4, 5, 6A, 6B, 7F, 9V, 14, 18C and 23F which is/are linked to a protein carrier(s) by reductive amination. Uses of such compositions are also disclosed.
摘要翻译： 本发明涉及包含至少2种不同的肺炎链球菌荚膜糖的免疫原性组合物，其中一种或多种选自与血清型1,3A，19A和19F组成的第一组，其与蛋白载体连接 直接或间接通过除还原胺化以外的化学物质，并且一种或多种不同的糖选自由血清型4,5,6A，6B，7F，9V，14,18C和23F组成的第二组，其中 通过还原胺化与蛋白质载体连接。 还公开了这些组合物的用途。
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公开(公告)号：US20110008419A1
公开(公告)日：2011-01-13
申请号：US12855734
申请日：2010-08-13
IPC分类号： A61K39/09 , A61K39/385 , A61K9/127 , A61P31/04
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular, the present invention relates to vaccines comprising a pneumococcal polysaccharide antigen, typically a pneumococcal polysaccharide conjugate antigen, formulated with a protein antigen from Streptococcus pneumoniae selected from the group consisting of PhtA, PhtD, PhtB, PhtE, SpsA, LytB, LytC, LytA, Sp125, Sp101, Sp128, Sp130 and Sp133, and optionally a Th1-inducing adjuvant
摘要翻译： 本发明涉及细菌多糖抗原疫苗领域。 特别地，本发明涉及包含肺炎球菌多糖抗原（通常为肺炎球菌多糖缀合物抗原）的疫苗，其通过选自PhtA，PhtD，PhtB，PhtE，SpsA，LytB，LytC， LytA，Sp125，Sp101，Sp128，Sp130和Sp133，以及任选的Th1诱导佐剂
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84.发明申请VACCINE COMPRISING STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDE CONJUGATES 有权包含结核分枝杆菌囊泡多糖聚合物的疫苗公开(公告)号：US20100209450A1
公开(公告)日：2010-08-19
申请号：US12665350
申请日：2008-06-24
IPC分类号： A61K39/385 , A61P31/04 , A61P37/04
CPC分类号： A61K39/092 , A61K39/09 , A61K39/116 , A61K47/646 , A61K2039/55 , A61K2039/55555 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
摘要： The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided with various conjugated capsular saccharides from different S. pneumoniae serotypes conjugated to 2 or more different carrier proteins, where the composition comprises serotype 19F capsular saccharide conjugated to diphtheria toxoid. Methods of making and uses thereof are also described.
摘要翻译： 本发明在肺炎球菌荚膜糖结合疫苗领域。 具体地说，将多价的肺炎链球菌免疫原性组合物与来自与2种或更多种不同载体蛋白缀合的不同肺炎链球菌血清型的各种共轭荚膜糖提供，其中组合物包含与白喉类毒素结合的血清型19F荚膜糖。 还描述了其制备和使用方法。
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公开(公告)号：US20080085289A1
公开(公告)日：2008-04-10
申请号：US11575694
申请日：2005-09-20
申请人： Cindy Castado , Nicolas Lecrenier , Cecile Neyt , Jan Poolman
发明人： Cindy Castado , Nicolas Lecrenier , Cecile Neyt , Jan Poolman
IPC分类号： A61K39/085 , A61K31/715 , A61P31/04 , A61K38/16
CPC分类号： A61K39/085 , A61K2039/505 , C07K16/1271
摘要： The present application relates to immunogenic compositions comprising a mixture of staphylococcal antigens which combines antigen having different functions, for instance, combinations including a staphylococcal extracellular component binding protein and a staphylococcal transporter protein or a staphylococcal extracellular component binding protein and a staphylococcal regulator of virulence or toxin or a staphylococcal transporter protein and a staphylococcal regulator of virulence or toxin. Vaccines, methods of treatment, uses of and processes to make a staphylococcal vaccine are also described.
摘要翻译： 本申请涉及包含葡萄球菌抗原的混合物的免疫原性组合物，其结合具有不同功能的抗原，例如包括葡萄球菌细胞外组分结合蛋白和葡萄球菌转运蛋白或葡萄球菌细胞外结合蛋白的组合，以及毒力的葡萄球菌调节剂或 毒素或葡萄球菌转运蛋白和毒素或毒素的葡萄球菌调节剂。 还描述了疫苗，治疗方法，葡萄球菌疫苗的使用和方法。
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公开(公告)号：US20070031449A1
公开(公告)日：2007-02-08
申请号：US10584362
申请日：2004-12-21
申请人： Martine Bos , Jan Poolman , Boris Tefsen , Johannes Tommassen
发明人： Martine Bos , Jan Poolman , Boris Tefsen , Johannes Tommassen
IPC分类号： A61K39/116
CPC分类号： C07K16/1217 , A61K35/74 , A61K2039/521 , C07K14/22 , C07K2317/34 , C07K2319/00
摘要： The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
摘要翻译： 本发明公开了一种革兰氏阴性细菌，其中参与LPS转运至外膜的蛋白质的表达在功能上被下调，使得与野生型革兰氏阴性细菌相比，外膜中的LPS水平降低。 Imp和MsbA蛋白的下调可导致这种细菌。 衍生自本发明的革兰氏阴性细菌的外膜囊泡制剂可用于疫苗中以提供针对细菌感染的保护。
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公开(公告)号：US20060110412A1
公开(公告)日：2006-05-25
申请号：US10529064
申请日：2003-06-10
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/52 , C07K14/22
摘要： The present invention relates to vaccine compositions for the effective prevention of neisserial, preferably meningococcal, disease. The vaccine of the invention comprise a multivalent meningococcal bled composition comprising at least one bleb with homologous bactericidal activity which is derived from a meningococcal strain with a serosubtype that is prevalent in a country of use, and at least one bleb with heterologous bacterial activity which is derived from a meningococcal strain which need not have a serosubtype that is prevalent in the country of use.
摘要翻译： 本发明涉及用于有效预防奈瑟氏球菌，优选脑膜炎球菌病的疫苗组合物。 本发明的疫苗包含多价脑膜炎球菌疫苗组合物，其包含至少一种具有同源杀菌活性的泡沫，其具有在使用国家中普遍存在的血清型的脑膜炎球菌菌株，以及至少一种具有异源细菌活性的泡沫， 衍生自不需要在使用国家普遍存在的血清型的脑膜炎球菌菌株。
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公开(公告)号：US20060093626A1
公开(公告)日：2006-05-04
申请号：US11240193
申请日：2005-09-30
申请人： Carine Capiau , Marguerite Deschamps , Pierre Desmons , Craig Laferriere , Jan Poolman , Jean-Paul Prieels
发明人： Carine Capiau , Marguerite Deschamps , Pierre Desmons , Craig Laferriere , Jan Poolman , Jean-Paul Prieels
IPC分类号： A61K39/09
CPC分类号： A61K39/155 , A61K39/092 , A61K39/095 , A61K39/102 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55572 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , A61K2039/70 , Y02A50/414 , Y02A50/484 , Y10S424/831
摘要： The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular the present invention relates to specific advantageous pneumococcal polysaccharide conjugates adjuvanted with 3D-MPL and substantially devoid of aluminium-based adjuvant.
摘要翻译： 本发明涉及细菌多糖抗原疫苗领域。 特别地，本发明涉及用3D-MPL佐剂化并且基本上不含铝基佐剂的特定有利的肺炎球菌多糖缀合物。
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公开(公告)号：US20060051361A1
公开(公告)日：2006-03-09
申请号：US10380575
申请日：2001-09-12
申请人： Craig Laferriere , Jan Poolman
发明人： Craig Laferriere , Jan Poolman
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular, the present invention relates to vaccines comprising a pneumococcal polysaccharide antigen, typically a pneumococcal polysaccharide conjugate antigen from Streptococcus pneumoniae selected from the group consisting of PhtA, PhtD, PhtB, PhtE, SpsA, LytB, LytC, LytA, Sp125, Sp101, Sp128, Sp130 and Sp133, and optionally a Th1-inducing adjuvant.
摘要翻译： 本发明涉及细菌多糖抗原疫苗领域。 特别地，本发明涉及包含肺炎球菌多糖抗原的疫苗，通常为肺炎链球菌的肺炎球菌多糖偶联抗原，其选自PhtA，PhtD，PhtB，PhtE，SpsA，LytB，LytC，LytA，Sp125，Sp101， Sp128，Sp130和Sp133，以及任选的Th1诱导佐剂。
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公开(公告)号：US20120207780A1
公开(公告)日：2012-08-16
申请号：US13439829
申请日：2012-04-04
IPC分类号： A61K39/385 , A61P37/04
CPC分类号： A61K39/102 , A61K2039/545 , A61K2039/6037 , Y02A50/466 , Y02A50/484
摘要： A multi-valent vaccine composition is described comprising a conjugate of the capsular polysaccharide of H. influenzae b not adsorbed onto an aluminium adjuvant salt, and two or more further bacterial polysaccharides. A multi-valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.
摘要翻译： 描述了一种多价疫苗组合物，其包含未吸附到铝佐剂盐上的流感嗜血杆菌b的荚膜多糖的缀合物和两种或更多种其它细菌多糖。 还描述了一种多价疫苗组合物，其包括全细胞百日咳组分，破伤风类毒素，白喉类毒素，乙型肝炎表面抗原，流感嗜血杆菌b的荚膜多糖的缀合物和荚膜多糖的缀合物。 A型或C型脑膜炎（或两者）。 此外，描述了包含全细胞百日咳组分，破伤风类毒素，白喉类毒素和低剂量流感嗜血杆菌b的荚膜多糖的缀合物的多价疫苗组合物。
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