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公开(公告)号：US20220056397A1
公开(公告)日：2022-02-24
申请号：US17414051
申请日：2019-02-01
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Alexander Govyadinov , Viktor Shkolnikov
Abstract: In one example in accordance with the present disclosure, a cell analysis system is described. The cell analysis system includes at least one cell analysis device. Each cell analysis device includes a channel to serially feed individual cells from a volume of cells into a lysing chamber. The cell analysis device also includes at least one feedback-controlled lysing element in the lysing chamber to agitate a cell. The cell analysis system also includes a controller to analyze the cell. The controller includes a lysate analyzer to analyze properties of the lysate and a rupture analyzer to analyze parameters of an agitation when a cell membrane ruptures.
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公开(公告)号：US11230692B2
公开(公告)日：2022-01-25
申请号：US16605985
申请日：2018-03-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
IPC: C12M1/00 , G01N33/543 , G01N33/569
Abstract: An example system includes an input channel to receive particles through a first end, a separation chamber, at least two output channels, an integrated pump to facilitate flow through the separation chamber and a cell analysis portion. The separation chamber is in fluid communication with a second end of the input channel. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of particles into at least two flow paths based on a size of the particles. The size associated with a first flow path of the at least two flow paths corresponds to a cell. A first output channel is to receive the first flow path corresponding to a cell. The cell analysis portion is coupled to the first output channel and is to perform at least one analysis associated with cells in the first output channel.
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公开(公告)号：US20220010359A1
公开(公告)日：2022-01-13
申请号：US17294041
申请日：2018-12-14
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
IPC: C12Q1/686
Abstract: Examples relate to conducting Polymerase Chain Reactions (PCR). An example device for conducting PCR includes a primer applicator to add a first multi-primer set of a primer library to a first test chamber of a test chamber array. The example device also includes an amplification analyzer to determine if amplification has occurred in the first test chamber. The example device includes a device controller to instruct the primer applicator to apply a second multi-primer set of the primer library to the first test chamber in response to a detection by the amplification analyzer that amplification has not occurred in the first test chamber. Example devices instruct the primer applicator to apply a first primer subset of the first multi-primer set to a second test chamber of the test chamber array in response to a detection by the amplification analyzer that amplification occurred in the first test chamber.
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公开(公告)号：US20210372925A1
公开(公告)日：2021-12-02
申请号：US17059732
申请日：2019-02-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Alexander Govyadinov , Brett E. Dahlgren
Abstract: A nucleic acid detection device includes a microfluidic opening and a sensor stack. The sensor stack includes an electrochemical electrode and a photodetector. The electrochemical electrode is formed of a conductive material that is transparent to a fluorescent emission, the electrochemical electrode including a first side and an opposite second side, wherein the first side is exposed to the microfluidic opening. The photodetector is positioned relative to the second side of the electrochemical electrode to optically receive the fluorescent emission when passed through the electrochemical electrode.
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公开(公告)号：US11162901B2
公开(公告)日：2021-11-02
申请号：US16074298
申请日：2016-04-20
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Ning Ge , Anita Rogacs , Viktor Shkolnikov , Alexander Govyadinov
Abstract: A surface enhanced Raman scattering (SERS) sensor may include a substrate, an electrically conductive layer having a first portion spaced from a second portion by a gap, an electrically resistive layer in contact with and extending between the first portion and the second portion of the electrically conductive layer to form an electrically resistive bridge across the gap that heats the nano fingers in response to electrical current flowing across the bridge from the first portion to the second portion and nano fingers extending upward from the bridge.
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Patent Agency Ranking
公开(公告)号：US20210277350A1
公开(公告)日：2021-09-09
申请号：US16605985
申请日：2018-03-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
IPC: C12M1/00 , G01N33/543 , G01N33/569
Abstract: An example system includes an input channel to receive particles through a first end, a separation chamber, at least two output channels, an integrated pump to facilitate flow through the separation chamber and a cell analysis portion. The separation chamber is in fluid communication with a second end of the input channel. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of particles into at least two flow paths based on a size of the particles. The size associated with a first flow path of the at least two flow paths corresponds to a cell. A first output channel is to receive the first flow path corresponding to a cell. The cell analysis portion is coupled to the first output channel and is to perform at least one analysis associated with cells in the first output channel.
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公开(公告)号：US11097270B2
公开(公告)日：2021-08-24
申请号：US16300115
申请日：2016-07-15
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Pavel Kornilovich , Alexander Govyadinov , David P. Markel , Erik D. Torniainen
Abstract: A microfluidic filtering system may include a first microfluidic channel, a first pump to move fluid along the first microfluidic channel in a first direction, a second microfluidic channel, a second pump to move fluid along the second microfluidic channel in a second direction opposite to the first direction and a filter channel extending between and interconnecting the first microfluidic channel and the second microfluidic channel.
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公开(公告)号：US20210178385A1
公开(公告)日：2021-06-17
申请号：US17268394
申请日：2018-11-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Daryl E. Anderson , George H. Corrigan III , Alexander Govyadinov
Abstract: In one example in accordance with the present disclosure, a microfluidic device is described. The microfluidic device includes a reservoir to contain a first thermally expandable fluid, a first heater to heat the thermally expandable fluid in the reservoir, a channel extending from the reservoir and connected to the reservoir at a first opening, and a liquid volume obstructing the channel.
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公开(公告)号：US20210154672A1
公开(公告)日：2021-05-27
申请号：US17047353
申请日：2018-08-10
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: In one example in accordance with the present disclosure, a cellular analytic system is described. The cellular analytic system includes a series of analytic devices. Each analytic device includes 1) a separator to separate a cellular particle from a surrounding fluid, 2) an analyzer coupled to a first outlet of the separator to analyze the surrounding fluid, and 3) at least one lysing device coupled to at least a second outlet of the separator to rupture a membrane of the cellular particle. An outlet of the lysing device is fluidly coupled to a separator of a downstream analytic device.
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公开(公告)号：US20210121883A1
公开(公告)日：2021-04-29
申请号：US16605927
申请日：2018-03-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: An example system includes an input channel to flow nucleic segments therethrough, a mixing portion coupled to the input channel, a separation chamber in fluid communication with the second end of the input channel, at least two output channels coupled to the chamber, and an integrated pump to facilitate flow through the separation chamber. The mixing portion is to include at least two different categories of beads having different sizes from each other and having a probe to attach to a corresponding nucleic acid segment. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of the different categories of beads and attached corresponding nucleic acid segment into at least two flow paths based on a size of the category of the beads. Each output channel is to receive separated categories of beads and attached nucleic acid segments.
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