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    Alkyl ether derivatives or salts thereof
    84.
    发明申请
    Alkyl ether derivatives or salts thereof 有权
    烷基醚衍生物或其盐

    公开(公告)号：US20060194781A1

    公开(公告)日：2006-08-31

    申请号：US11416321

    申请日：2006-05-03

    申请人： Akihito Saitoh ,  Noboru Iwakami ,  Tamotsu Takamatsu

    发明人： Akihito Saitoh ,  Noboru Iwakami ,  Tamotsu Takamatsu

    IPC分类号： A61K31/397 ,  A61K31/452 ,  A61K31/453 ,  A61K31/4025 ,  C07D405/02 ,  C07D409/02

    CPC分类号： C07D207/12 ,  C07D405/12 ,  C07D409/12

    摘要： An alkyl ether derivative represented by the general formula: wherein each of R1 and R2 represents one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an alkenyl group, an alkenyloxy group, an amino group, an alkylsulfonyl group, an arylsulfonyl group, a carbamoyl group, a heterocyclic group, a hydroxyl group, a carboxyl group, a nitro group, an oxo group and the like; R3 is an alkylamino group, an amino group, a hydroxyl group or the like; the ring A is a 5-membered or 6-membered heteroaromatic ring or a benzene ring; each of m and n is an integer of 1 to 6; and p is an integer of 1 to 3, or its salt has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite extension and hence is useful as a therapeutic agent for diseases in central and peripheral nerves.

    摘要翻译： 由以下通式表示的烷基醚衍生物：其中R 1和R 2各自表示一个或多个选自氢原子，卤素原子，烷基的基团 芳基，芳烷基，烷氧基，芳氧基，烷硫基，芳硫基，烯基，烯氧基，氨基，烷基磺酰基，芳基磺酰基，氨基甲酰基， 杂环基，羟基，羧基，硝基，氧代基等; R 3是烷基氨基，氨基，羟基等; 环A是5元或6元杂芳环或苯环; m和n各自为1至6的整数; p为1〜3的整数，或其盐具有保护神经元的活性，加速神经再生的活性和加速神经突延伸的活性，因此可用作中枢和外周神经疾病的治疗剂。