公开(公告)号：US20060041298A1

公开(公告)日：2006-02-23

申请号：US11254344

申请日：2005-10-20

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36542 ,  A61N2001/0585

摘要： Systems and methods for detecting and measuring cardiac contractile function of a heart using an acceleration sensor unit inserted within the heart, such as within a vein of the cardiac wall are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart by inserting and positioning an implantable lead having an electrode near a cardiac wall as well as detecting mechanical events within the patient's heart by then inserting and positioning a cardiac motion sensor unit through the inner lumen of the implantable lead. Furthermore, the systems and methods do not require dedicated leads and may be used with preexisting implantable leads.

公开(公告)号：US06980851B2

公开(公告)日：2005-12-27

申请号：US10001223

申请日：2001-11-15

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Bruce H. KenKnight ,  Jay A. Warren

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Bruce H. KenKnight ,  Jay A. Warren

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61B5/0402

CPC分类号： A61N1/3627 ,  A61N1/36585

摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.

摘要翻译： 一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹 患者的心力衰竭状态。 这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。

公开(公告)号：US20050283099A1

公开(公告)日：2005-12-22

申请号：US11203756

申请日：2005-08-15

申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

IPC分类号： A61N1/05 ,  A61N1/32 ,  A61H1/02

CPC分类号： A61N1/326 ,  A61N1/0587

摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

摘要翻译： 用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。 该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。 电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

公开(公告)号：US06915163B2

公开(公告)日：2005-07-05

申请号：US10634202

申请日：2003-08-05

申请人： Julio C. Spinelli ,  Qingsheng Zhu

发明人： Julio C. Spinelli ,  Qingsheng Zhu

IPC分类号： A61N1/362 ,  A61N1/37 ,  A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/371

摘要： A system and method for measuring the capture threshold of a bipolar lead in order to determine an appropriate value for the stimulus pulse energy to be used with the lead by a cardiac rhythm management device. An appropriate bipolar stimulating configuration can also be determined. The method is particularly useful in testing bipolar leads used to excite the left ventricle such as when delivering cardiac resynchronization therapy.

公开(公告)号：US20050137640A1

公开(公告)日：2005-06-23

申请号：US10952345

申请日：2004-09-28

申请人： Scott Freeberg ,  Michael Lyden ,  Qingsheng Zhu

发明人： Scott Freeberg ,  Michael Lyden ,  Qingsheng Zhu

IPC分类号： A61N1/362 ,  A61N1/37

CPC分类号： A61N1/3712

摘要： Methods and systems involve adjusting an energy used for safety pacing based on the capture threshold. The safety pacing energy may be adjusted prior to a capture threshold test. During the capture threshold test, backup safety paces are delivered using the adjusted pacing energy. Following suspension of automatic capture verification, the device may enter a suspension mode. During the suspension mode, safety pacing pulses are delivered using a pacing energy adjusted based on capture threshold.

摘要翻译： 方法和系统包括根据捕获阈值调整用于安全起搏的能量。 可以在捕获阈值测试之前调整安全起搏能量。 在捕获阈值测试期间，使用调整的起搏能量传送备用安全步伐。 在停止自动捕获验证之后，设备可能进入暂停模式。 在悬架模式下，使用基于捕获阈值调整的起搏能量来传送安全起搏脉冲。

公开(公告)号：US20050137490A1

公开(公告)日：2005-06-23

申请号：US11037276

申请日：2005-01-18

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur Olive ,  Don Villalta

IPC分类号： A61B5/00 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B7/02 ,  A61B5/02

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US06473649B1

公开(公告)日：2002-10-29

申请号：US09470269

申请日：1999-12-22

申请人： Mark Gryzwa ,  Qingsheng Zhu

发明人： Mark Gryzwa ,  Qingsheng Zhu

IPC分类号： A61N137

CPC分类号： A61N1/3712 ,  Y10S128/901

摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart and suitable for use during capture verification. The device of the present invention may operate in an automatic capture verification mode, wherein an electrocardiogram signal of a patient's heart is received and used by the device to determine whether a stimulation pulse evokes a response by the patient's heart. The device suspends the automatic capture verification mode and/or adjust the detection threshold dependent upon detected and/or measured noise, a determined amplitude of evoked response, a determined modulation in the evoked response, or detected and/or measured artifact. Further, the sensing circuit of the rhythm management device of the present invention reduces afterpotentials that result due to delivery of the stimulation pulses.

摘要翻译： 一种植入式心律管理装置，其能够自动检测患者心脏的内在和诱发反应并适于在捕获验证期间使用。 本发明的装置可以在自动捕获验证模式下操作，其中由装置接收并使用患者心脏的心电图信号，以确定刺激脉冲是否引起患者心脏的反应。 取决于检测到的和/或测量的噪声，所确定的诱发响应幅度，诱发响应中的确定调制，或检测到的和/或测量的伪影，该装置暂停自动捕获验证模式和/或调整检测阈值。 此外，本发明的节律管理装置的感测电路减少了由于刺激脉冲的传送而导致的后电位。

公开(公告)号：US06275731B1

公开(公告)日：2001-08-14

申请号：US09474193

申请日：1999-12-29

申请人： Qingsheng Zhu ,  Jungkuk Kim ,  Arthur Olive ,  Jan-Pieter Heemels

发明人： Qingsheng Zhu ,  Jungkuk Kim ,  Arthur Olive ,  Jan-Pieter Heemels

IPC分类号： A61N1365

CPC分类号： A61N1/3712

摘要： A method for reducing the affects of intrinsic detection latency in a cardiac rhythm management device, wherein said method is initiated immediately prior to delivering a stimulation pulse to the heart tissue. A coincidence of intrinsic and cardiac rhythm management initiated stimulus or the delivery of a stimulation pulse proximate the time of an intrinsic event due to intrinsic detection latency may results in delivery of unnecessary backup stimulus and/or imprecise determination of a pacing threshold. When stimulating the heart, the timing sequence for delivering a stimulation pulse typically depends upon the timing of a previous intrinsic or device initiated event. Further, the method of the present invention reduces the affects of intrinsic detection latency thereby facilitating improved detection of capture and determination of capture threshold for minimizing power consumption while assuring therapeutic efficacy.

摘要翻译： 一种减轻心律管理装置中内在检测延迟的影响的方法，其中所述方法在将刺激脉冲传递到心脏组织之前立即开始。 由于内在的检测潜伏期，固有和心律管理发起的刺激或接近内在事件时间的刺激脉冲的传递的巧合可能导致递送不必要的备份刺激和/或不精确地确定起搏阈值。 当刺激心脏时，用于递送刺激脉冲的定时序列通常取决于先前的固有或设备启动事件的时序。 此外，本发明的方法减少了内在检测潜能的影响，从而有助于提高捕获捕获阈值的检测和捕获阈值的确定，以最大限度地降低功耗，同时确保治疗效果。

公开(公告)号：US09265950B2

公开(公告)日：2016-02-23

申请号：US12152099

申请日：2008-05-12

申请人： Qingsheng Zhu ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Julio C. Spinelli

IPC分类号： A61N1/00 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.

摘要翻译： 心律管理系统检测水肿。 响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

公开(公告)号：US08812105B2

公开(公告)日：2014-08-19

申请号：US13282163

申请日：2011-10-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/362

CPC分类号： A61N1/3627

摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, an implantable pulse generator includes circuitry for generating pacing profiles, with signals of opposite polarities, specifically selected for delivery on electrodes at a site near the septal wall of a right ventricle of the heart.

摘要翻译： 工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。 某些方面涉及起搏和/或作图，通过产生用于递送到心脏部位的脉搏，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/ 压力或其组合。 在一个实施例中，可植入脉冲发生器包括用于产生具有相反极性的信号的起搏曲线的电路，其具体选择用于在靠近心脏右心室隔壁的位置处的电极上传送。