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    APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE
    82.
    发明申请
    APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE 有权
    用于密封血管内窥镜的装置和方法

    公开(公告)号：US20130066361A1

    公开(公告)日：2013-03-14

    申请号：US13610849

    申请日：2012-09-11

    申请人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    发明人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    IPC分类号： A61B17/03

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672

    摘要： Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.

    摘要翻译： 用于将穿过组织的穿刺密封到血管的装置包括：盒，其包括近端，尺寸适于插入穿刺的远端以及在其间延伸的内腔。 生物可吸收塞子设置在邻近远端的内腔内，并且锚定元件设置在靠近塞子的内腔内。 推动器构件设置在内腔内，用于将插塞和锚固元件从盒的远端伸出。 塞子可以由冻干的水凝胶形成，并且锚定元件可以由空气干燥的水凝胶形成，当暴露于水性环境时，锚定元件比塞子保持缓慢。 在使用过程中，插头和锚定元件被输送到穿刺部分中，塞子紧贴在血管壁上。 锚固元件上的突起接合穿刺周围的组织，以防止插塞的近端移动。

    Apparatus and methods for facilitating hemostasis within a vascular puncture
    84.
    发明授权
    Apparatus and methods for facilitating hemostasis within a vascular puncture 有权
    用于促进血管穿刺止血的装置和方法

    公开(公告)号：US08348971B2

    公开(公告)日：2013-01-08

    申请号：US10928744

    申请日：2004-08-27

    申请人： Puneet Khanna ,  Farhad Khosravi

    发明人： Puneet Khanna ,  Farhad Khosravi

    IPC分类号： A61B17/08

    CPC分类号： A61B17/08 ,  A61B17/0057 ,  A61B17/10 ,  A61B2017/00004 ,  A61B2017/00575 ,  A61B2017/00601 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00659

    摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a bioabsorbable sealing member secured to one end of a filament or other retaining member. The sealing member is delivered through the puncture into the vessel, and retracted against the wall of the vessel to provide temporary hemostasis. The sealing member is rapidly absorbed after exposure within the vessel, e.g., to an aqueous or heated physiological environment (e.g., exposure to blood or body temperature), immediately or shortly after completing a medical procedure via the puncture, e.g., within the time period that the patient is ambulatory. Optionally, extravascular sealing material is delivered into the puncture proximal to the sealing member. The retaining member and/or extravascular material may be bioabsorbable, being absorbed at a slower rate than the sealing member. Alternatively, the filament is removed from the puncture after hemostasis is established.

    摘要翻译： 用于密封与血管连通的穿刺的装置包括固定到细丝或其它保持构件的一端的生物可吸收密封构件。 密封构件通过穿刺输送到容器中，并且缩回到容器的壁上以提供临时止血。 在通过穿刺完成医疗程序之后立即或不久，例如在时间段内，密封构件在容器内暴露之后被快速吸收，例如，暴露于水或加热的生理环境（例如，暴露于血液或体温） 病人走路。 任选地，血管外密封材料被输送到靠近密封构件的穿刺中。 保持构件和/或血管外材料可以是生物可吸收的，以比密封构件更慢的速度被吸收。 或者，在建立止血后，从穿刺中除去细丝。

    Apparatus and methods for sealing a vascular puncture
    86.
    发明授权
    Apparatus and methods for sealing a vascular puncture 有权
    用于密封血管穿刺的装置和方法

    公开(公告)号：US08262693B2

    公开(公告)日：2012-09-11

    申请号：US10982385

    申请日：2004-11-05

    申请人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    发明人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    IPC分类号： A61B17/03

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672

    摘要： Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.

    摘要翻译： 用于将穿过组织的穿刺密封到血管的装置包括：盒，其包括近端，尺寸适于插入穿刺的远端以及在其间延伸的内腔。 生物可吸收塞子设置在邻近远端的内腔内，并且锚定元件设置在靠近塞子的内腔内。 推动器构件设置在内腔内，用于将插塞和锚固元件从盒的远端伸出。 塞子可以由冻干的水凝胶形成，并且锚定元件可以由空气干燥的水凝胶形成，当暴露于水性环境时，锚定元件比塞子保持缓慢。 在使用过程中，插头和锚定元件被输送到穿刺部分中，塞子紧贴在血管壁上。 锚固元件上的突起接合穿刺周围的组织，以防止插塞的近端移动。

    Flexible, stretchable coiled-sheet stent
    89.
    发明授权
    Flexible, stretchable coiled-sheet stent 失效
    弹性，伸缩性卷盘支架

    公开(公告)号：US07731745B2

    公开(公告)日：2010-06-08

    申请号：US10960328

    申请日：2004-10-06

    申请人： Yi Yang ,  Farhad Khosravi ,  Himanshu N. Patel

    发明人： Yi Yang ,  Farhad Khosravi ,  Himanshu N. Patel

    IPC分类号： A61F2/06 ,  A61M29/00

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/92 ,  A61F2002/91533 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2220/0016

    摘要： A coiled-sheet stent includes a tubular body having a longitudinal axis and a circumference, and a plurality of cylindrical bands formed in the tubular body, each band having a zig-zag pattern including a series of sequential diagonal elements connected to one another and extending about the circumference. A plurality of longitudinal connectors extend between and connect adjacent bands. The diagonal elements have an arcuate shape, all diagonal elements in each band being oriented in either a clockwise or counter-clockwise direction about the circumference. The tubular body is expandable between contracted and enlarged conditions, and the zig-zag pattern is expandable between unstretched and unstretched conditions, the zig-zag pattern being biased towards the stretched condition above a transition temperature, thereby at least partially defining the enlarged condition. A multi-cellular stent structure is also provided that includes a plurality of bat shaped cells formed in a tubular body, each cell defining a head region, a tail region and opposing curved wing regions, and a plurality of connectors extending between and connecting adjacent cells. The head and tail regions of adjacent cells are directly connected to one another, and connectors extend between adjacent wing regions of adjacent cells.

    摘要翻译： 螺旋片支架包括具有纵向轴线和圆周的管状体，以及形成在管状体中的多个圆柱形带，每个带具有包括一系列相互连接并延伸的顺序对角线元件的之字形图案 围绕圆周。 多个纵向连接器在相邻带之间延伸并连接相邻带。 对角元件具有弓形形状，每个带中的所有对角元件围绕圆周以顺时针或逆时针方向定向。 管状体在收缩和扩大的条件之间是可膨胀的，并且之字形图案可在未拉伸和未拉伸状态之间扩展，之字形图案被偏压到高于转变温度的拉伸状态，从而至少部分限定扩大状态。 还提供了一种多细胞支架结构，其包括形成在管状体中的多个蝙蝠形细胞，每个细胞限定头部区域，尾部区域和相对的弯曲翼状区域，以及在相邻细胞之间延伸并连接相邻细胞的多个连接器 。 相邻单元的头部和尾部区域彼此直接连接，并且连接器在相邻单元的相邻机翼区域之间延伸。

    Auto-injector apparatus and methods for sealing a vascular puncture
    90.
    发明授权
    Auto-injector apparatus and methods for sealing a vascular puncture 有权
    自动注射装置和密封血管穿刺的方法

    公开(公告)号：US07553319B2

    公开(公告)日：2009-06-30

    申请号：US10806934

    申请日：2004-03-22

    申请人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08 ,  A61M31/00

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61M25/10182 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a pair of syringe barrels having sealing components therein, and a plunger assembly biased to slide within the barrels from proximal to distal positions for injecting the components through outlets of the barrels. An auto-injector assembly is coupled to the plunger apparatus, and includes a spring mechanism locked in an inactive condition and an actuator activatable to release the spring mechanism, whereupon the spring mechanism automatically advances the plunger assembly towards the distal position to inject the components from the barrels. A valve coupled to the outlets and movable from a first position for mixing and/or reconstituting the sealing components from vials, a second position where the outlets communicate with a delivery line for delivering the sealing components into a puncture, and a third position for closing the outlets.

    摘要翻译： 用于密封与血管连通的穿刺的装置包括一对在其中具有密封部件的注射器筒，以及被偏置成在近端到远端位置在筒内滑动的柱塞组件，用于通过筒的出口喷射部件。 自动注射器组件联接到柱塞装置，并且包括锁定在不活动状态的弹簧机构和可激活以释放弹簧机构的致动器，于是弹簧机构自动地将柱塞组件前进到远侧位置以从 桶。 一个阀，其联接到所述出口并且可从第一位置移动，用于混合和/或重建来自小瓶的密封部件;第二位置，其中所述出口与用于将密封部件输送到穿刺部的输送管线连通;以及第三位置， 出口。