公开(公告)号：US20060276848A1

公开(公告)日：2006-12-07

申请号：US11149058

申请日：2005-06-06

申请人： Xiaoyi Min ,  Euljoon Park ,  Malin Ohlander

发明人： Xiaoyi Min ,  Euljoon Park ,  Malin Ohlander

IPC分类号： A61N1/365

CPC分类号： A61B5/0535 ,  A61B5/0402 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61N1/3601 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/371

摘要： An exemplary method includes acquiring impedance values over one or more respiratory cycles, determining an impedance span based on the impedance values and, based at least in part on the impedance span, determining cardiac condition or respiratory condition. Another exemplary method includes acquiring IEGMs over one or more respiratory cycles, determining evoked response measure values based on the IEGMs, determining an evoked response span based on the evoked response measure values and, based at least in part on the evoked response span, determining cardiac condition or respiratory condition. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括：通过一个或多个呼吸周期获取阻抗值，基于阻抗值确定阻抗跨度，并且至少部分地基于阻抗跨度，确定心脏状况或呼吸状况。 另一示例性方法包括通过一个或多个呼吸周期获取IEGM，基于IEGM确定诱发的应答测量值，基于诱发的响应测量值确定诱发的应答跨度，并且至少部分地基于诱发的响应跨度，确定心脏 病情或呼吸状况。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07139609B1

公开(公告)日：2006-11-21

申请号：US10346809

申请日：2003-01-17

申请人： Xiaoyi Min ,  Paul A. Levine ,  Euljoon Park

发明人： Xiaoyi Min ,  Paul A. Levine ,  Euljoon Park

IPC分类号： A61B5/02 ,  A61N1/365

CPC分类号： A61N1/36585 ,  A61B5/02 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/7239 ,  A61B7/04 ,  A61N1/3627

摘要： Techniques are provided for performing internal measurement of heart sounds to estimate patient cardiac function in terms of stroke volume, cardiac output, or a maximum rate of change of aortic pressure with time (max dP/dt). Control parameters of the medical device are then automatically adjusted so as to optimize overall cardiac function or to provide for ventricular resynchronization therapy. In one example, heart sound signals are derived from acceleration signals received from an accelerometer. The heart sound signals are analyzed to identify S1 and S2 heart sounds as well as ejection period and isovolumic interval (ISOV). Proxies for max dP/dt, stroke volume and cardiac output are then derived from the S1 and S2 heart sounds, the ejection period and the ISOV. Alternative techniques, not requiring detection of ISOV, are employed for use if the patient has heart value regurgitation.

摘要翻译： 提供技术用于进行心脏声音的内部测量，以根据中风量，心输出量或主动脉压随时间的最大变化率（最大dP / dt）来估计患者心脏功能。 然后自动调节医疗装置的控制参数，以便优化整体心脏功能或提供心室再同步治疗。 在一个示例中，从加速度计接收的加速度信号导出心音信号。 分析心音信号以识别S1和S2心音，以及射血期和等容间隔（ISOV）。 然后从S1和S2心脏声音，射血期和ISOV导出最大dP / dt，搏出量和心输出量的代理。 如果患者有心脏反流，则采用不需要检测ISOV的替代技术。

公开(公告)号：US5871530A

公开(公告)日：1999-02-16

申请号：US62373

申请日：1998-04-17

申请人： Terrell M. Williams ,  Peter M. J. Mulier ,  John G. Keimel ,  Timothy G. Laske ,  Gregory A. Boser ,  Mary M. Morris ,  Xiaoyi Min

发明人： Terrell M. Williams ,  Peter M. J. Mulier ,  John G. Keimel ,  Timothy G. Laske ,  Gregory A. Boser ,  Mary M. Morris ,  Xiaoyi Min

IPC分类号： A61N1/04 ,  A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/0563

摘要： A lead and a lead system for dispersion of a cardioversion/defibrillation electrode formed of one or more small diameter defibrillation electrodes in a heart chamber and for attaching a pace/sense electrode in contact with the heart. The small diameter defibrillation electrode or electrodes extend distally from the distal end of the lead body. If multiple electrodes are employed, they are preferably biased to spread apart when unrestrained and have a cross-section size small enough to be inserted into interstices of trabeculae in the ventricular chamber. The distal ends of the defibrillation electrodes may be free of attachment to the lead body or may be attached by a weak bond to the distal portion of the lead.

摘要翻译： 一种用于在心室中由一个或多个小直径除颤电极形成的复律/除颤电极的分散的引线和引导系统，并且用于附接与心脏接触的步调/感测电极。 小直径除颤电极或电极从引线体的远端向远端延伸。 如果使用多个电极，则它们优选地被偏置以在不受限制的情况下展开，并且具有足够小的横截面尺寸以插入心室中的小梁的间隙中。 除颤电极的远端可以没有附着到引线体，或者可以通过弱接合附着到引线的远端部分。

公开(公告)号：US5713924A

公开(公告)日：1998-02-03

申请号：US495251

申请日：1995-06-27

申请人： Xiaoyi Min ,  Luc R. Mongeon ,  Michael R. S. Hill

发明人： Xiaoyi Min ,  Luc R. Mongeon ,  Michael R. S. Hill

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/395

摘要： A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.

摘要翻译： 一种用于治疗纤维性颤动，特别是心房颤动的装置的方法。 响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。 低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。

公开(公告)号：US10369368B2

公开(公告)日：2019-08-06

申请号：US15172993

申请日：2016-06-03

申请人： Kyungmoo Ryu ,  Xiaoyi Min

发明人： Kyungmoo Ryu ,  Xiaoyi Min

IPC分类号： A61N1/05 ,  A61N1/37 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/372

摘要： An exemplary method for optimizing pacing configuration includes providing distances between electrodes of a series of three or more ventricular electrodes associated with a ventricle; selecting a ventricular electrode from the series; delivering energy to the ventricle via the selected ventricular electrode, the energy sufficient to cause an evoked response; acquiring signals of cardiac electrical activity associated with the evoked response via non-selected ventricular electrodes of the series; based on signals of cardiac electrical activity acquired via the non-selected ventricular electrodes and the distances, determining conduction velocities; based on the conduction velocities, deciding if the selected ventricular electrode is an optimal electrode for delivery of a cardiac pacing therapy; and, if the selected ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected ventricular electrode. Various other methods, devices, systems, etc., are also disclosed.

公开(公告)号：US09533158B2

公开(公告)日：2017-01-03

申请号：US12333176

申请日：2008-12-11

申请人： Xiaoyi Min

发明人： Xiaoyi Min

IPC分类号： A61N1/00 ,  A61N1/37 ,  A61B5/0452 ,  A61N1/368 ,  A61N1/362

CPC分类号： A61N1/37 ,  A61B5/0452 ,  A61N1/3627 ,  A61N1/368

摘要： A system and method for using an implantable cardiac stimulation device to monitor a patient for the progress of an existing condition and/or early detection of an emerging condition based, at least in part, on measuring and evaluating the timing characteristics of the patient's atrial activity. The atrial timing characteristics are used as indicators or predictors of conditions of interest, such as heart failure (HF) and atrial fibrillation (AF). In certain implementations, the system can determine discriminating indicators of a predominant underlying cause of a condition, such as between vagal and non-vagal AF, as an indicator of a suggested therapy. The system can store data corresponding to the observed atrial timing for trending analysis as well as transmit data for offline analysis, such as via an external device.

摘要翻译： 一种系统和方法，用于至少部分地基于测量和评估患者心房活动的时间特征来使用可植入心脏刺激装置来监测患者现有病症的进展和/或新出现的病症的早期检测 。 心房时间特征被用作心脏衰竭（HF）和房颤（AF）等感兴趣条件的指标或预测指标。 在某些实施方案中，系统可以确定病症的主要潜在原因（例如迷走神经与非迷走神经AF之间）的鉴别指标，作为建议治疗的指标。 系统可以存储对应于观察到的心房定时的数据，用于趋势分析，以及用于离线分析的传输数据，例如通过外部设备。

公开(公告)号：US09381363B2

公开(公告)日：2016-07-05

申请号：US12632519

申请日：2009-12-07

申请人： Kyungmoo Ryu ,  Xiaoyi Min

发明人： Kyungmoo Ryu ,  Xiaoyi Min

IPC分类号： A61N1/36 ,  A61N1/37 ,  A61N1/368 ,  A61N1/362 ,  A61N1/372

CPC分类号： A61N1/3684 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/371 ,  A61N1/37247

摘要： An exemplary method for optimizing pacing configuration includes providing distances between electrodes of a series of three or more ventricular electrodes associated with a ventricle; selecting a ventricular electrode from the series; delivering energy to the ventricle via the selected ventricular electrode, the energy sufficient to cause an evoked response; acquiring signals of cardiac electrical activity associated with the evoked response via non-selected ventricular electrodes of the series; based on signals of cardiac electrical activity acquired via the non-selected ventricular electrodes and the distances, determining conduction velocities; based on the conduction velocities, deciding if the selected ventricular electrode is an optimal electrode for delivery of a cardiac pacing therapy; and, if the selected ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected ventricular electrode. Various other methods, devices, systems, etc., are also disclosed.

摘要翻译： 用于优化起搏配置的示例性方法包括提供与心室相关联的一系列三个或更多个心室电极的电极之间的距离; 从该系列中选择一个心室电极; 通过选择的心室电极向心室输送能量，足以引起诱发反应的能量; 通过该系列的非选择性心室电极获取与诱发反应相关的心脏电活动的信号; 基于通过未选择的心室电极获取的心脏电活动的信号和距离，确定传导速度; 基于传导速度，确定所选择的心室电极是否是用于递送心脏起搏疗法的最佳电极; 并且如果所选择的心室电极包括用于递送心脏起搏治疗的最佳电极，则要求使用所选择的心室电极递送心脏起搏治疗。 还公开了各种其它方法，装置，系统等。

公开(公告)号：US09314634B2

公开(公告)日：2016-04-19

申请号：US12264077

申请日：2008-11-03

申请人： Xiaoyi Min

发明人： Xiaoyi Min

IPC分类号： A61N1/362 ,  A61N1/372

CPC分类号： A61N1/3627 ,  A61N1/37247

摘要： An exemplary system includes a programmer configured to instruct an implantable device and a qualification module with instructions to call for tests performed by an implantable device configured for delivery of CRT, to receive results from the tests, to analyze the results and to decide, based on the analysis, if the patient qualifies for automatic, implantable device-based optimization of one or more CRT parameters and, only if the patient qualifies for automatic, implantable device-based optimization of one or more CRT parameters, presenting a graphical user interface that comprises a selectable control to enable an algorithm of an implantable device to automatically optimize at least one of the one or more cardiac resynchronization therapy parameters. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性系统包括编程器，其被配置为指示可植入装置和鉴定模块，其具有用于调用由配置用于输送CRT的可植入装置执行的测试的指令，以接收来自测试的结果，以分析结果并基于 如果患者符合一个或多个CRT参数的自动植入式设备优化，并且仅当患者符合对一个或多个CRT参数进行自动可植入设备的优化时，呈现图形用户界面，该图形用户界面包括 可选择的控制以使可植入装置的算法能够自动优化所述一个或多个心脏再同步治疗参数中的至少一个。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US20150290461A1

公开(公告)日：2015-10-15

申请号：US14252546

申请日：2014-04-14

申请人： Xiaoyi Min ,  Timothy A. Fayram ,  Brad Maruca ,  Enri Zhulati ,  Kyle Pulley

发明人： Xiaoyi Min ,  Timothy A. Fayram ,  Brad Maruca ,  Enri Zhulati ,  Kyle Pulley

IPC分类号： A61N1/36 ,  A61N1/08 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/36135 ,  A61B5/407 ,  A61B5/4836 ,  A61N1/0553 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/37235 ,  A61N1/37247

摘要： The present disclosure provides systems and methods for neurostimulation. The method includes applying electrical stimulation to a patient using a paddle lead that includes a plurality of electrodes, acquiring evoked response data using at least some of the plurality of electrodes, wherein the evoked response data is indicative of a patient response to the electrical stimulation, transmitting the evoked response data to a computing device, and processing the evoked response data using the computing device to facilitate monitoring the applied electrical stimulation.

摘要翻译： 本公开提供了用于神经刺激的系统和方法。 该方法包括使用包括多个电极的桨导线向患者施加电刺激，使用多个电极中的至少一些来获取诱发的反应数据，其中所述诱发的反应数据指示患者对电刺激的反应， 将所述诱发响应数据发送到计算设备，以及使用所述计算设备处理所述诱发的响应数据，以便于监视所施加的电刺激。

公开(公告)号：US09017341B2

公开(公告)日：2015-04-28

申请号：US13352005

申请日：2012-01-17

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

IPC分类号： A61B19/00 ,  A61N1/05 ,  A61N1/375 ,  A61N1/372 ,  A61N1/365

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/36521 ,  A61N1/37288 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

摘要翻译： 无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。 电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。 该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。 壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。 该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。