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170 条记录 (耗时 0.051 秒)

    Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine
    81.
    发明授权
    Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine 失效
    含有二氢吡啶和吡咯并二氮杂的抗高血压组合产品

    公开(公告)号：US4859665A

    公开(公告)日：1989-08-22

    申请号：US937867

    申请日：1986-12-02

    申请人： Bernward Garthoff ,  Marcel Gerold ,  Fridolin Hefti ,  Stanislav Kazda ,  Andreas Knorr

    发明人： Bernward Garthoff ,  Marcel Gerold ,  Fridolin Hefti ,  Stanislav Kazda ,  Andreas Knorr

    IPC分类号： A61K31/50 ,  A61K31/55 ,  A61P9/12

    CPC分类号： A61K31/55 ,  Y10S514/929

    摘要： Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group ##STR2## R.sup.1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms,R.sup.2 is alkyl of 1 to 12 C atoms, which is optionally substituted by alkoxy of 1 to 3 C atoms, fluorine or N-methyl-N-benzylamino andR.sup.3 is alkyl of 1 to 4 C atoms, cyano or hydroxymethyl, and a pyridazodiazepine of the formula ##STR3## in which R.sup.4 is aralkyl,R.sup.5 is hydrogen or alkyl of 1 to 8 C atoms,R.sup.6 is hydrogen or alkyl of 1 to 8 C atoms andR.sup.7 and R.sup.8 are hydrogen, or together, an oxo group, are described.

    摘要翻译： 用于治疗高血压的组合物，其包含有效量的式“IMAGE”的二氢吡啶，其中X是与硝基，氯和三氟甲基相同或不同的取代基，或与苯环一起，组IMA IMA > R 1为1〜4个C原子的烷基，其任选被1〜4个C原子的烷氧基取代，R 2为1〜12个C原子的烷基，其任选被1〜3个C原子的烷氧基取代，氟或N - 甲基-N-苄基氨基，R3为1-4个C原子的烷基，氰基或羟甲基，以及其中R 4为芳烷基，R 5为氢或1至8个C原子的烷基的式“IMAGE”的吡咯并二氮杂为R6 氢或1〜8个碳原子的烷基，R7和R8为氢，或一起为氧代基。

    Certain nitratoalkyl ester dihydropyridines having antihypertensive properties
    82.
    发明授权
    Certain nitratoalkyl ester dihydropyridines having antihypertensive properties 失效
    某些具有抗高血压特性的硝基烷基酯二氢吡啶类

    公开(公告)号：US4565824A

    公开(公告)日：1986-01-21

    申请号：US550321

    申请日：1983-11-09

    申请人： Egbert Wehinger ,  Horst Meyer ,  Stanislav Kazda ,  Andreas Knorr

    发明人： Egbert Wehinger ,  Horst Meyer ,  Stanislav Kazda ,  Andreas Knorr

    IPC分类号： A61K31/455 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90

    CPC分类号： C07D211/90

    摘要： Dihydropyridines of the formula ##STR1## in which R is aryl or heterocyclic,R.sup.1, R.sup.2 and R.sup.3 each is hydrogen or various organic radicals,Y is oxygen, or optionally substituted --NH--,Z is --O--NO.sub.2 or --O--NO,X is --COR.sup.4, --COOR.sup.5 or --CO--Y--A--Z,R.sup.4 is alkyl, phenyl, benzyl or an amino radical, andR.sup.5 is an organic radical,or pharmaceutically acceptable acid addition salts thereof, exhibit circulation active properties, e.g. they can be used as antihypertensives, as peripheral and cerebral vasodilators and as coronary therapeutics.

    摘要翻译： 式中，R为芳基或杂环，R 1，R 2和R 3各自为氢或各种有机基团，Y为氧或任选取代的-NH-，Z为-O-NO 2或-O-NO X为-COR 4，-COOR 5或-CO-YAZ，R 4为烷基，苯基，苄基或氨基，R 5为有机基团或其药学上可接受的酸加成盐，具有循环活性，例如 它们可以作为抗高血压药物，作为外周血脑血管扩张剂和冠脉治疗药。

    1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid esters useful for treating renal insufficiency
    86.
    发明授权
    1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid esters useful for treating renal insufficiency 失效
    可用于治疗肾功能不全的1,4-二氢-2,6-二甲基-4-硝基苯基-3,5-吡啶二羧酸酯

    公开(公告)号：US4582840A

    公开(公告)日：1986-04-15

    申请号：US726879

    申请日：1985-04-25

    申请人： Bernward Garthoff ,  Stanislav Kazda ,  Andreas Knorr ,  Gunter Thomas

    发明人： Bernward Garthoff ,  Stanislav Kazda ,  Andreas Knorr ,  Gunter Thomas

    IPC分类号： C07D211/90 ,  A61K31/44 ,  A61K31/455 ,  A61P7/10 ,  C07D213/55

    CPC分类号： A61K31/44

    摘要： A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical.The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.

    摘要翻译： 一种防治患病患者的盐平衡紊乱的方法，其包括向所述患者施用盐平衡恢复有效量的式“IMAGE”的血管舒张性1,4-二氢吡啶，其中R 1和R 2各自独立地为烷基 具有1至4个碳原子，并且硝基在苯基的邻位或间位。 盐平衡障碍可伴随高血压疾病，或者也可通过向这样的患者施用高血压减轻剂而加重。