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    Circulation-active fluoromethoxyphenyl dihydropyridine compounds
    4.
    发明授权
    Circulation-active fluoromethoxyphenyl dihydropyridine compounds 失效
    循环活性氟甲氧基苯基二氢吡啶化合物

    公开(公告)号：US5008279A

    公开(公告)日：1991-04-16

    申请号：US263671

    申请日：1988-10-27

    Applicant: Gerhard Franckowiak ,  Jurgen Stoltefuss ,  Martin Bechem ,  Rainer Gross ,  Michael Kayser ,  Siegbert Hebisch ,  Matthias Schramm

    Inventor： Gerhard Franckowiak ,  Jurgen Stoltefuss ,  Martin Bechem ,  Rainer Gross ,  Michael Kayser ,  Siegbert Hebisch ,  Matthias Schramm

    IPC: A61K31/445 ,  A61K31/451 ,  A61P9/08 ,  C07D211/90 ,  C07D401/12

    CPC classification number: C07D401/12 ,  C07D211/90

    Abstract: Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine andR stands for straight-chain, branched or cyclic alkyl or alkenyl having 2 to 12 carbon atoms which can be interrupted by 1 to 2 oxygen and/or sulphur atoms in the chain, and which can be monosubstituted or polysubstituted(a) by hydroxyl, aryl having 6 to 12 carbon atoms, aryloxy having 6 to 12 carbon atoms, where the aryl radical is again substituted by alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms or halogen, the substituents being identical or different, or(b) by carboxyl, alkoxycarbonyl having up to 6 carbon atoms, pyridyl, piperidyl, pyrimidyl, acyloxy having up to 7 carbon atoms, sulphamoyl, carbamoyl, halogen or cyano, the substituents being identical or different, or(c) by an amino group, where the amino group can carry one or two identical or different substituents from the group consisting of alkyl having up to 6 carbon atoms, benzyl, phenyl or acyl having up to 7 carbon atoms,and salts thereof.

    Abstract translation: 式（I）的循环活性氟甲氧基苯基二氢吡啶，其中X代表氢或氟，R代表可被1至2个氧中断的具有2至12个碳原子的直链，支链或环状烷基或链烯基 和/或链中的硫原子，并且其可以被羟基，具有6至12个碳原子的芳基，具有6至12个碳原子的芳氧基单取代或多取代（a），其中芳基再次被具有至多 4个碳原子，具有至多4个碳原子的烷氧基或卤素，取代基相同或不同，或（b）由羧基，具有至多6个碳原子的烷氧基羰基，吡啶基，哌啶基，嘧啶基，具有至多7个碳原子的酰氧基， 氨基甲酰基，氨基甲酰基，卤素或氰基，取代基相同或不同，或（c）氨基，其中氨基可以带有一个或两个相同或不同的取代基，由至多6个碳原子的烷基 ms，苄基，苯基或具有至多7个碳原子的酰基及其盐。

    Benzylaminoaryl-dihydropyridinelactones and their use in medicaments
    5.
    发明授权
    Benzylaminoaryl-dihydropyridinelactones and their use in medicaments 失效
    苄基氨基芳基 - 二氢吡啶内酯及其在药物中的用途

    公开(公告)号：US4904665A

    公开(公告)日：1990-02-27

    申请号：US158184

    申请日：1988-02-18

    Applicant: Siegfried Goldmann ,  Rainer Gross ,  Martin Bechem ,  Michael Kayser ,  Matthias Schramm ,  Siegbert Hebisch

    Inventor： Siegfried Goldmann ,  Rainer Gross ,  Martin Bechem ,  Michael Kayser ,  Matthias Schramm ,  Siegbert Hebisch

    IPC: A61K31/44 ,  A61P3/08 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07D211/90 ,  C07D491/04 ,  C07D491/048

    CPC classification number: C07D491/04 ,  C07D211/90

    Abstract: A benzylaminoaryl-dihydropyridinelactone compound of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, halogen, cyano, nitro, C.sub.6 -C.sub.12 -aryl, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, di-C.sub.1 -C.sub.5 -alkylamino, C.sub.1 -C.sub.6 -alkoxycarboxyl or C.sub.1 -C.sub.6 -alkylsulphonyl,R.sup.2 represents hydrogen, or represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical having up to 10 carbon atoms which is optionally substituted by C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphonyl, halogen, cyano, hydroxyl, pyridyl, thienyl, pyrimidyl, piperidinyl, phenyl or an amino group, where the amino group carries two identical or different substituents from the series comprising C.sub.1 -C.sub.5 -alkyl, phenyl or benzyl,R.sup.3 represents C.sub.1 -C.sub.5 -alkyl, or represents cyano, hydroxymethyl or formyl, andR.sup.4 represents hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl or trifluoromethyl,and its isomers, isomeric mixtures, racemates or optical antipodes, and physiologically acceptable salts thereof. The compound being useful to improve the contractility of the heart and the tonus of the smooth muscles.

    Abstract translation: 式（I）的苄基氨基芳基 - 二氢吡啶内酯化合物其中R 1表示氢，卤素，氰基，硝基，C 6 -C 12 - 芳基，C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基，C 1 -C 6 - 烷硫基，三氟甲基，三氟甲氧基，三氟甲硫基，二氟甲氧基，二-C 1 -C 5烷基氨基，C 1 -C 6 - 烷氧基羧基或C 1 -C 6烷基磺酰基，R 2表示氢，或表示直链，支链或环状饱和或不饱和烃 具有至多10个碳原子的基团，其任选被C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷硫基，C 1 -C 6 - 烷基磺酰基，卤素，氰基，羟基，吡啶基，噻吩基，嘧啶基，哌啶基，苯基或氨基取代， 其中氨基从包含C 1 -C 5 - 烷基，苯基或苄基的系列中携带两个相同或不同的取代基，R 3表示C 1 -C 5 - 烷基，或表示氰基，羟甲基或甲酰基，R 4表示氢，卤素，C 1 -C 5 - 烷基或三氟甲基，及其异构体，异构体混合物，外消旋体或光学抗体 es及其生理上可接受的盐。 该化合物可用于改善心脏和平滑肌紧张的收缩性。

    [4-(6-Oxo-1,4,5,6-tetrahydro-3-pyridazinyl) anilino hexyl 1,4-dihydro-2,6 Di methyl 5 nitro 4 aryl pyridine 3-carboxylates
    6.
    发明授权
    [4-(6-Oxo-1,4,5,6-tetrahydro-3-pyridazinyl) anilino hexyl 1,4-dihydro-2,6 Di methyl 5 nitro 4 aryl pyridine 3-carboxylates 失效
    [4-（6-氧代-1,4,5,6-四氢-3-哒嗪基）苯胺基己基1,4-二氢-2,6-二甲基-5-硝基4芳基吡啶3-羧酸酯

    公开(公告)号：US4898865A

    公开(公告)日：1990-02-06

    申请号：US218759

    申请日：1988-07-13

    Applicant: Gerhard Franckowiak ,  Martin Bechem ,  Michael Kayser ,  Rainer Gross ,  Matthias Schramm ,  Friedel Seuter ,  Elisabeth Perzborn ,  Gunther Thomas

    Inventor： Gerhard Franckowiak ,  Martin Bechem ,  Michael Kayser ,  Rainer Gross ,  Matthias Schramm ,  Friedel Seuter ,  Elisabeth Perzborn ,  Gunther Thomas

    IPC: A61K31/50 ,  A61P3/00 ,  A61P3/08 ,  A61P9/00 ,  C07D237/04 ,  C07D401/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    CPC classification number: C07D401/12 ,  C07D237/04

    Abstract: Circulation active nitrodihydropyridines of the formula ##STR1## in which R represents aryl which has 6 to 12 carbon atoms and can be substituted up to 4 times, identically or differently, by halogen, nitro, cyano, alkyl, alkoxy, alkylthio, in each case having up to 6 carbon atoms, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio, difluoromethylenedioxy, trifluoroethylenedioxy or tetrafluoroethylenedioxy or by benzyl, benzyloxy or benzylthio, each of which is optionally substituted by halogen, nitro, cyano, trifuoromethyl, alkyl having up to 4 carbon atoms or alkoxy having up to 4 carbon atoms, or represents a heterocycle which is optionally substituted by halogen, phenyl or alkyl having up to 4 carbon atoms and is from the group consisting of pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyrimidyl, pyridazinyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl, andn represents a number from 1 to 12,and physiologically acceptable salts thereof.

    Abstract translation: 具有式“IMAGE”的循环活性硝基二氢吡啶，其中R表示具有6至12个碳原子并且可以相同或不同地被卤素，硝基，氰基，烷基，烷氧基，烷硫基取代至多4次的芳基， 具有至多6个碳原子，三氟甲基，三氟甲氧基，二氟甲氧基，三氟甲硫基，二氟亚甲二氧基，三氟亚乙二氧基或四氟亚乙二氧基或苄基，苄氧基或苄硫基，其各自任选被卤素，硝基，氰基，三氟甲基，具有至多4个碳原子的烷基 或具有至多4个碳原子的烷氧基，或表示任选被卤素，苯基或具有至多4个碳原子的烷基取代的杂环，并且是由吡咯基，噻吩基，呋喃基，吡唑基，咪唑基，恶唑基，噻唑基， 吡啶基，嘧啶基，哒嗪基，喹啉基，苯并二唑基，苯并二唑基，色烯基或硫代色烯基，n表示1〜12的数，生理学上可接受的 其盐。

    A GROUND-BASED SOFTWARE TOOL FOR CONTROLLING REDUNDANCY MANAGEMENT SWITCHING OPERATIONS
    9.
    发明申请
    A GROUND-BASED SOFTWARE TOOL FOR CONTROLLING REDUNDANCY MANAGEMENT SWITCHING OPERATIONS 有权
    一种基于地面的软件工具，用于控制冗余管理切换操作

    公开(公告)号：US20060156053A1

    公开(公告)日：2006-07-13

    申请号：US10905608

    申请日：2005-01-12

    Applicant: Thomas Judd ,  Michael Kayser

    Inventor： Thomas Judd ,  Michael Kayser

    IPC: G06F11/00

    CPC classification number: G06F11/2023 ,  G06F11/2038 ,  G06F11/2048

    Abstract: Systems, methods, and computer program products for easily altering redundancy management data values associated with redundancy management logic that is executed by redundant data processing systems. The redundancy management data values are altered on a computer device remote from the system that includes the redundant data processing systems.

    Abstract translation: 用于容易地改变由冗余数据处理系统执行的冗余管理逻辑相关联的冗余管理数据值的系统，方法和计算机程序产品。 冗余管理数据值在远离包括冗余数据处理系统的系统的计算机设备上被改变。

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