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81.发明申请MODULATION OF TRANSTHYRETIN EXPRESSION FOR THE TREATMENT OF CNS RELATED DISORDERS 审中-公开用于治疗CNS相关疾病的TRANSTHYRETIN表达调控公开(公告)号：US20110237646A1
公开(公告)日：2011-09-29
申请号：US13056295
申请日：2009-08-07
申请人： Richard Alan Smith , Brett P. Monia
发明人： Richard Alan Smith , Brett P. Monia
IPC分类号： A61K31/7088 , A61K31/7125 , A61K31/712 , A61K31/7115 , A61P25/00 , A61P25/28
CPC分类号： A61K31/7125
摘要： Compounds, compositions and methods are provided for modulating the expression of transthyretin in the brain, specifically the choroid plexus. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.
摘要翻译： 提供化合物，组合物和方法用于调节脑中转甲状腺激素的表达，特别是脉络丛。 组合物包含针对核酸编码转甲状腺素蛋白的寡核苷酸。 提供了使用这些化合物调节转甲状腺素蛋白表达和用于诊断和治疗与转甲状腺素蛋白表达相关的疾病和病症的方法。
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公开(公告)号：US07148204B2
公开(公告)日：2006-12-12
申请号：US10302262
申请日：2002-11-21
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
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公开(公告)号：US06884787B2
公开(公告)日：2005-04-26
申请号：US09906158
申请日：2001-07-14
申请人： Brett P. Monia , Susan M. Freier
发明人： Brett P. Monia , Susan M. Freier
IPC分类号： A61K38/00 , C12N15/113 , A01N43/04 , A61K31/70
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of transforming growth factor-beta 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding transforming growth factor-beta 3. Methods of using these compounds for modulation of transforming growth factor-beta 3 expression and for treatment of diseases associated with expression of transforming growth factor-beta 3 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节转化生长因子-β3的表达。组合物包含靶向编码转化生长因子-β3的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节 提供转化生长因子-β3表达和治疗与转化生长因子-β3表达相关的疾病。
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公开(公告)号：US06806258B2
公开(公告)日：2004-10-19
申请号：US10057550
申请日：2002-01-25
申请人： Brett P. Monia
发明人： Brett P. Monia
IPC分类号： C07H2100
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3517 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating or preventing conditions, including hyperproliferative conditions, associated with raf expression.
摘要翻译： 提供寡核苷酸，其靶向编码人raf的核酸并能够抑制raf表达。 寡核苷酸可以在一个或多个位置具有化学修饰，并且可以是嵌合寡核苷酸。 还提供了使用本发明的寡核苷酸抑制人raf表达的方法。 本发明还包括抑制细胞过度增殖的方法以及治疗或预防与raf表达相关的病症（包括过度增殖病症）的方法。
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公开(公告)号：US06656688B1
公开(公告)日：2003-12-02
申请号：US09856747
申请日：2001-05-24
申请人： C. Frank Bennett , Brett P. Monia , Lex M. Cowsert
发明人： C. Frank Bennett , Brett P. Monia , Lex M. Cowsert
IPC分类号： C07H2100
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of NF-kappa-B p65 subunit. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding NF-kappa-B p65 subunit. Methods of using these compounds for modulation of NF-kappa-B p65 subunit expression and for treatment of diseases associated with expression of NF-kappa-B p65 subunit are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节NF-κBp65亚基的表达。 组合物包含靶向编码NF-κBp65亚基的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节NF-κBp65亚基表达和治疗与NF-κBp65亚基表达相关的疾病的方法。
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公开(公告)号：US06492171B2
公开(公告)日：2002-12-10
申请号：US09733294
申请日：2000-12-07
IPC分类号： C07H2104
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/07049 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TERT. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TERT. Methods of using these compounds for modulation of TERT expression and for treatment of diseases associated with expression of TERT are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节TERT的表达。 组合物包含靶向编码TERT的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TERT表达和治疗与TERT表达相关的疾病的方法。
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公开(公告)号：US06383808B1
公开(公告)日：2002-05-07
申请号：US09659791
申请日：2000-09-11
申请人： Brett P. Monia , Susan M. Freier
发明人： Brett P. Monia , Susan M. Freier
IPC分类号： C12N500
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of clusterin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding clusterin. Methods of using these compounds for modulation of clusterin expression and for treatment of diseases associated with expression of clusterin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节聚集蛋白的表达。 组合物包含靶向编码簇蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节簇蛋白表达和治疗与簇蛋白表达有关的疾病的方法。
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公开(公告)号：US06184212B2
公开(公告)日：2001-02-06
申请号：US09280805
申请日：1999-03-26
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
摘要翻译： 提供化合物，组合物和方法用于抑制人mdm2的表达。 组合物包括靶向编码mdm2的核酸的反义化合物。 提供了使用这些寡核苷酸抑制mdm2表达和治疗诸如与mdm2过度表达相关的癌症的疾病的方法。
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公开(公告)号：US06172216B2
公开(公告)日：2001-01-09
申请号：US09167921
申请日：1998-10-07
IPC分类号： C07H2102
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided.
摘要翻译： 提供组合物和方法用于调节bcl-x的表达。 优选靶向编码bcl-x的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节bcl-x表达和治疗与bcl-x表达有关的疾病的方法。
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公开(公告)号：US06168950A
公开(公告)日：2001-01-02
申请号：US09359756
申请日：1999-07-23
申请人： Brett P. Monia , William Gaarde , Donna T. Ward , Lex M. Cowsert
发明人： Brett P. Monia , William Gaarde , Donna T. Ward , Lex M. Cowsert
IPC分类号： C07T2104
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/3341 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK1. Methods of using these compounds for modulation of MEKK1 expression and for treatment of diseases associated with expression of MEKK1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节MEKK1的表达。 组合物包含靶向编码MEKK1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MEKK1表达和治疗与MEKK1表达相关的疾病的方法。
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