5′-modified bicyclic nucleic acid analogs
    81.
    发明授权
    5′-modified bicyclic nucleic acid analogs 有权
    5'-修饰的双环核酸类似物

    公开(公告)号:US07547684B2

    公开(公告)日:2009-06-16

    申请号:US11747057

    申请日:2007-05-10

    IPC分类号: A01N43/04 A61K31/70

    CPC分类号: C07H19/04 C07H21/00

    摘要: The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

    摘要翻译: 本发明提供了包含这些核苷类似物中的至少一种的5'-修饰的双环核苷类似物和寡聚化合物。 在优选的实施方案中,核苷类似物在5'-碳上具有(R)或(S) - 亲和性。 这些双环核苷类似物可用于增强低聚化合物的性质,包括例如增强的核酸酶抗性。

    Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
    90.
    发明授权
    Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom 有权
    由其制备的碱改性的双环核苷和寡聚化合物

    公开(公告)号:US08779118B2

    公开(公告)日:2014-07-15

    申请号:US13519287

    申请日:2011-01-06

    IPC分类号: C07H19/00 C07H21/04 C12Q1/68

    CPC分类号: C07H21/00

    摘要: Provided herein are novel base modified bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, novel pyrimidine bicyclic nucleosides are provided wherein each pyrimidine base is substituted at the 5 position with an optionally substituted, aromatic or heteroaromatic ring system comprising from 5 to 7 ring atoms selected from C, N, O and S. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

    摘要翻译: 本文提供了新的碱改性双环核苷,由其制备的低聚化合物和使用低聚化合物的方法。 更具体地,提供新的嘧啶双环核苷,其中每个嘧啶碱基在5位被具有任选取代的芳族或杂芳族环系统取代,所述环系包含5至7个选自C,N,O和S的环原子。在某些实施方案中, 本文提供的寡聚化合物与目标RNA的一部分杂交导致靶RNA的正常功能丧失。