公开(公告)号：US20130229708A1

公开(公告)日：2013-09-05

申请号：US13847393

申请日：2013-03-19

申请人： Triantafyllos Tafas ,  Michael Thomas

发明人： Triantafyllos Tafas ,  Michael Thomas

IPC分类号： G02B26/00 ,  G02B21/06

CPC分类号： G02B26/008 ,  G02B7/006 ,  G02B21/06

摘要： An improved filter wheel is disclosed, through embodiments, that comprises a plurality of reflector support structures formed as a unitized structure with a circular base member. In some embodiments, the filter wheel further comprises a plurality of light sources mounted on the filter wheel.

摘要翻译： 通过实施例公开了一种改进的滤光轮，其包括形成为具有圆形基底构件的组合结构的多个反射器支撑结构。 在一些实施例中，滤光轮还包括安装在滤光轮上的多个光源。

公开(公告)号：US08484733B2

公开(公告)日：2013-07-09

申请号：US11563730

申请日：2006-11-28

申请人： Shamim Pirzada ,  Anup Rao ,  Michael Thomas ,  James L. Fenton ,  Bailey G. Szeto ,  Sanjay Pol ,  Ashok Ramaswami

发明人： Shamim Pirzada ,  Anup Rao ,  Michael Thomas ,  James L. Fenton ,  Bailey G. Szeto ,  Sanjay Pol ,  Ashok Ramaswami

IPC分类号： G06F11/00

CPC分类号： H04L63/1408 ,  G06F21/554 ,  G06F21/562

摘要： In one embodiment, a system can comprise an interface that receives data related to a communication session and a messaging security device component that evaluates the data and enables a security measure for preventative monitoring of a threat based on the evaluation, the security measure can be universally applied to two or more messaging formats.

公开(公告)号：US20120301955A1

公开(公告)日：2012-11-29

申请号：US13584410

申请日：2012-08-13

申请人： Michael Thomas ,  Gloria Erichsen ,  William Widner

发明人： Michael Thomas ,  Gloria Erichsen ,  William Widner

IPC分类号： C12N15/113 ,  C12N15/63

CPC分类号： C07K14/32 ,  C12N15/75

摘要： The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to a polynucleotide sequence encoding the polypeptide and a modified mRNA processing/stabilizing sequence located downstream of the promoter region and upstream of the ribosome binding site of the polynucleotide sequence encoding the polypeptide, wherein the modified mRNA processing/stabilizing sequence promotes higher expression of the polynucleotide sequence compared to an unmodified mRNA processing/stabilizing sequence; and (b) isolating the polypeptide having biological activity from the cultivation medium. The present invention also relates to such modified mRNA processing/stabilizing sequences, nucleic acid constructs, and bacterial host cells and to methods of obtaining such bacterial host cells.

公开(公告)号：US08268586B2

公开(公告)日：2012-09-18

申请号：US12520072

申请日：2007-12-19

申请人： Michael Thomas ,  Gloria Erichsen ,  William Widner

发明人： Michael Thomas ,  Gloria Erichsen ,  William Widner

IPC分类号： C12P21/02

CPC分类号： C07K14/32 ,  C12N15/75

摘要： The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to a polynucleotide sequence encoding the polypeptide and a modified mRNA processing/stabilizing sequence located downstream of the promoter region and upstream of the ribosome binding site of the polynucleotide sequence encoding the polypeptide, wherein the modified mRNA processing/stabilizing sequence promotes higher expression of the polynucleotide sequence compared to an unmodified mRNA processing/stabilizing sequence; and (b) isolating the polypeptide having biological activity from the cultivation medium. The present invention also relates to such modified mRNA processing/stabilizing sequences, nucleic acid constructs, and bacterial host cells and to methods of obtaining such bacterial host cells.

摘要翻译： 本发明涉及生产在细菌细胞中具有生物活性的多肽的方法，包括：（a）在有助于产生多肽的培养基中培养细菌宿主细胞，其中细菌宿主细胞包含核酸构建体，其包含 与编码多肽的多核苷酸序列可操作地连接的启动子区和位于编码多肽的多核苷酸序列的启动子区域的下游和修饰的mRNA加工/稳定序列的修饰的mRNA加工/稳定序列，其中修饰的mRNA加工/稳定序列促进更高 与未修饰的mRNA加工/稳定序列相比，多核苷酸序列的表达; 和（b）从培养基中分离具有生物活性的多肽。 本发明还涉及这种修饰的mRNA加工/稳定序列，核酸构建体和细菌宿主细胞以及获得这种细菌宿主细胞的方法。

公开(公告)号：US08088715B2

公开(公告)日：2012-01-03

申请号：US12270820

申请日：2008-11-13

申请人： Sir Walter Bodmer ,  Triantafyllos Tafas ,  Michael Kilpatrick ,  Petros Tsipouras ,  Xiuzhong Wang ,  Youngmin Kim ,  Michael Thomas ,  Antti Seppo ,  Triantafyllia Ntouroupi ,  Changhua Yu ,  Charles Climer

发明人： Sir Walter Bodmer ,  Triantafyllos Tafas ,  Michael Kilpatrick ,  Petros Tsipouras ,  Xiuzhong Wang ,  Youngmin Kim ,  Michael Thomas ,  Antti Seppo ,  Triantafyllia Ntouroupi ,  Changhua Yu ,  Charles Climer

IPC分类号： C40B30/04

CPC分类号： G06K9/00127 ,  G01N21/6458

摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.

摘要翻译： 一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。

公开(公告)号：US20110239670A1

公开(公告)日：2011-10-06

申请号：US13133675

申请日：2009-11-23

申请人： Carinne Kempen ,  Helmut Henrich ,  Franz Lurken ,  Serge Morel-Jean ,  Michael Thomas ,  Richard Soula

发明人： Carinne Kempen ,  Helmut Henrich ,  Franz Lurken ,  Serge Morel-Jean ,  Michael Thomas ,  Richard Soula

IPC分类号： F25D29/00

CPC分类号： F25D29/001 ,  F25D3/105

摘要： A method for managing access to a confined space which is cooled by the direct injection of a cryogenic fluid, comprising at least one system for closing the confined space, which can prevent access to said confined space and can be opened/closed to a variable and controllable degree, and a data acquisition and processing device. The device can: control the open or closed state of the closure system; set and control the degree to which the closure system is open/closed; ensure that a time delay (TP) is respected every time the closure system is closed, after which time delay the injection of cryogenic fluid into the space resumes; and, at the request of a user, implement the cycle for opening the closure system. The device determines the time that has elapsed (TE) in the closed position since the last closure cycle of the closure system and compares TE to TP. If TE=TP the device immediately authorizes the opening of the closure system. If TE>TP the device authorizes the opening of the closure system after a predefined waiting time.

摘要翻译： 一种用于管理通过直接注入低温流体而被冷却的密闭空间的通路的方法，该方法包括至少一个闭合密闭空间的系统，该系统可防止进入所述约束空间，并能够打开/关闭变量， 可控程度，以及数据采集和处理设备。 该装置可以：控制关闭系统的打开或关闭状态; 设置和控制关闭系统打开/关闭的程度; 确保每次关闭系统关闭时延时间（TP），之后延迟将低温液体注入空间中恢复; 并且根据用户的要求，实施打开关闭系统的循环。 该设备确定自闭合系统的最后一个闭合周期以来关闭位置的时间（TE），并将TE与TP进行比较。 如果TE = TP，设备立即授权关闭系统的打开。 如果TE> TP，设备将在预定义的等待时间后授权关闭系统的打开。

公开(公告)号：US20110160728A1

公开(公告)日：2011-06-30

申请号：US12651371

申请日：2009-12-31

申请人： Neal Blitz ,  Michael Thomas ,  David Crook ,  Paul Vasta

发明人： Neal Blitz ,  Michael Thomas ,  David Crook ,  Paul Vasta

IPC分类号： A61B17/58

CPC分类号： A61B17/7225 ,  A61B17/1725 ,  A61B17/1775 ,  A61B17/725 ,  A61B17/7291 ,  A61B17/861 ,  A61B17/862 ,  A61B17/8875 ,  A61B17/8883 ,  A61B17/921 ,  A61B2090/037

摘要： An intramedullary fixation device and related method for treatment of a Jones fracture. An exemplary device may comprise a rod having a distal section and a threaded proximal section, and means for securing the distal section within a first bone portion on a distal side of a fracture site. The device may also comprise a compression collar threadably received over the proximal section for providing compression to the fracture site, the compression collar comprising a threaded portion on its exterior surface configured to engage an interior of a second bone portion on a proximal side of the fracture site. In addition, the device includes an anti-rotational system engaging the compression collar to prevent rotation of the compression collar from its position providing the compression to the fracture site.

摘要翻译： 一种用于治疗琼斯骨折的髓内固定装置及相关方法。 示例性装置可以包括具有远端部分和螺纹近端部分的杆，以及用于将远侧部分固定在骨折部位的远侧上的第一骨部内的装置。 所述装置还可以包括可螺纹地容纳在所述近端部分上以用于向所述骨折部位提供压缩的压缩套环，所述压缩套环包括在其外表面上的螺纹部分，所述螺纹部分被构造成接合所述骨折的近侧上的第二骨部分的内部 现场。 此外，该装置包括接合压缩套环的防旋转系统，以防止压缩套环从提供压缩的位置到骨折部位的旋转。

公开(公告)号：US20110122492A1

公开(公告)日：2011-05-26

申请号：US12833887

申请日：2010-07-09

申请人： Michael Thomas ,  Charles Climer ,  Richard Schlueter ,  Triantafyllos P. Tafas ,  Michael Kilpatrick ,  Antti Seppo

发明人： Michael Thomas ,  Charles Climer ,  Richard Schlueter ,  Triantafyllos P. Tafas ,  Michael Kilpatrick ,  Antti Seppo

IPC分类号： G02B21/34 ,  B01D35/02 ,  B01D29/085

CPC分类号： G02B21/34

摘要： An filter, apparatus and method for preparing microscope slides is presented. After filtration of the specimen is performed, the filter containing the filtrand is configured to be microscopically examined. The filter may either be affixed to a microscope slide or, in an embodiment, the filter may be incorporated into a microscope slide.

摘要翻译： 提出了一种用于制备显微镜载片的过滤器，设备和方法。 过滤样品后，将含有过滤物的过滤器配置为进行显微镜检查。 过滤器可以被固定到显微镜载玻片上，或者在一个实施例中，过滤器可以结合到显微镜载片中。

公开(公告)号：US20110118738A1

公开(公告)日：2011-05-19

申请号：US12618514

申请日：2009-11-13

申请人： Paul Vasta ,  David Crook ,  Michael Thomas

发明人： Paul Vasta ,  David Crook ,  Michael Thomas

IPC分类号： A61B17/00

CPC分类号： A61B17/62

摘要： An orthopedic fixation system having two rings or other base/frame elements separated by a plurality of struts. The struts are attached to the rings by a combination of a attachment mechanism having at least two degrees of movement each, and at least one connecting mechanism. The connecting mechanisms may be moveably or non-moveably connected to one or more tracks located on either or both rings of base elements. A combination of these elements provides a fixation device that allows for six degrees of freedom of movement between the rings or other base elements.

摘要翻译： 一种矫形固定系统，具有由多个支柱分开的两个环或其他基部/框架元件。 支柱通过具有至少两个运动方向的连接机构和至少一个连接机构的组合而附接到环上。 连接机构可以可移动地或不可移动地连接到位于基座元件的一个或两个环上的一个或多个轨道。 这些元件的组合提供了一种固定装置，其允许环或其它基本元件之间的六个自由度的移动。

公开(公告)号：US20090152097A1

公开(公告)日：2009-06-18

申请号：US12063328

申请日：2006-08-09

申请人： Marko Eichler ,  Michael Thomas ,  Eugen Schlittenhardt

发明人： Marko Eichler ,  Michael Thomas ,  Eugen Schlittenhardt

IPC分类号： H05H1/24 ,  C23C16/00 ,  H05H1/34

CPC分类号： H05H1/2406 ,  H05H2001/2418

摘要： The present invention relates to a plasma generating device having a first and a second electrode (3, 4) which are at a spacing from each other for generating a plasma (13) between the two electrodes (3, 4), a dielectric (8) which is disposed between the two electrodes (3, 4), a gas inlet (10) in the space between the two electrodes (3, 4) for supply of a plasma generating gas (12), one of the two electrodes (3, 4) having at least one opening (5) as gas outlet from the space between the two electrodes (3, 4), through which the plasma (13), which can be generated between the two electrodes (3, 4), can be expelled parallel to the direction of the electrical field which can be produced by the two electrodes (3, 4) between the two electrodes (3, 4), a grating, net and/or fabric (1) being disposed across the cross-section of the at least one opening (5).

摘要翻译： 本发明涉及一种等离子体产生装置，其具有彼此间隔开的第一和第二电极（3,4），用于在两个电极（3,4）之间产生等离子体（13），电介质（8） ），设置在两个电极（3,4）之间，在两个电极（3,4）之间的空间中的气体入口（10），用于供应等离子体产生气体（12），两个电极（3）中的一个 ，4）具有至少一个开口（5）作为从两个电极（3,4）之间的空间排出的气体，通过该开口可以在两个电极（3,4）之间产生的等离子体（13）可以 被平行于可由两个电极（3,4）之间的两个电极（3,4）产生的电场的方向排出，格栅，网和/或织物（1）横跨横截面布置， 所述至少一个开口（5）的截面。