公开(公告)号：US20100298901A1

公开(公告)日：2010-11-25

申请号：US12771217

申请日：2010-04-30

申请人： John Louis Sommer ,  Scott J. Brabec ,  Jon Frederic Urban ,  Yong-Fu Xiao ,  Xiaohong Zhou

发明人： John Louis Sommer ,  Scott J. Brabec ,  Jon Frederic Urban ,  Yong-Fu Xiao ,  Xiaohong Zhou

IPC分类号： A61N1/362 ,  A61N1/36

CPC分类号： A61N1/3621 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0452 ,  A61B5/0456 ,  A61N1/3627 ,  A61N1/3702

摘要： A method and apparatus for reducing a patient's heart rate or blood pressure. The apparatus provides stimulation to the patient's atrial and/or nodal tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial an/or nodal tissue, responsive to detecting an occurrence of a ventricular depolarization following a preceding atrial depolarization.The apparatus may define a time window following the ventricular depolarization, following the atrial depolarization or determined based upon the timing of both the atrial and ventricular depolarizations. The stimulus may be delivered during or on expiration of the defined time window. The duration of the time window may be pre-set or determined based upon measurements of the patient's refractory periods.

摘要翻译： 一种减轻患者心率或血压的方法和装置。 该装置响应于检测在前面的心室去极化的发生之后，在心室的相关不应期内但在受刺激的心房和/或淋巴结组织的相关不应期之外对患者的心房和/或淋巴结组织提供刺激。 心房去极化。 该装置可以在心房去极化之后定义心室去极化之后的时间窗口，或者基于心房和心室去极化的时间确定。 刺激可以在定义的时间窗口期间或期满时传送。 时间窗口的持续时间可以基于患者的不应期的测量来预先确定或确定。

公开(公告)号：US20100114200A1

公开(公告)日：2010-05-06

申请号：US12362814

申请日：2009-01-30

申请人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke

发明人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke

IPC分类号： A61N1/37 ,  A61N1/362

CPC分类号： A61N1/08 ,  A61N1/36114 ,  A61N1/37 ,  A61N1/37258 ,  A61N1/37288

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US20100114199A1

公开(公告)日：2010-05-06

申请号：US12362809

申请日：2009-01-30

申请人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke ,  Timothy Davis

发明人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke ,  Timothy Davis

IPC分类号： A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/36114 ,  A61N1/36185 ,  A61N1/3686 ,  A61N1/3688

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US20100114197A1

公开(公告)日：2010-05-06

申请号：US12362773

申请日：2009-01-30

申请人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  James D. Reinke ,  Timothy Davis

发明人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  James D. Reinke ,  Timothy Davis

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3605 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/37 ,  A61N1/37258 ,  A61N1/37288

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US20100114196A1

公开(公告)日：2010-05-06

申请号：US12362768

申请日：2009-01-30

申请人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  James D. Reinke ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  Timothy Davis

发明人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  James D. Reinke ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  Timothy Davis

IPC分类号： A61N1/365

CPC分类号： A61N1/36114 ,  A61N1/3622 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/3962 ,  A61N2001/083

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US20100114195A1

公开(公告)日：2010-05-06

申请号：US12362662

申请日：2009-01-30

申请人： John E. Burnes ,  Chris Zillmer ,  Paul G. Krause ,  Gerald P. Arne ,  Timothy Davis ,  David J. Peichel ,  James D. Reinke ,  William T. Donofrio ,  Xiaohong Zhou

发明人： John E. Burnes ,  Chris Zillmer ,  Paul G. Krause ,  Gerald P. Arne ,  Timothy Davis ,  David J. Peichel ,  James D. Reinke ,  William T. Donofrio ,  Xiaohong Zhou

IPC分类号： A61N1/39 ,  A61N1/36 ,  A61N1/362

CPC分类号： A61N1/0504 ,  A61B5/046 ,  A61N1/0587 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/365 ,  A61N1/3962

摘要： An implantable medical device may deliver pacing, cardioversion, and/or defibrillation stimulation to a heart of a patient via extravascular electrodes and delivers electrical stimulation to a nonmyocardial tissue site to modulate the autonomic nervous system of the patient. The implantable medical device may include a cardiac therapy module that generates and delivers at least one of pacing, cardioversion, or defibrillation therapy to a patient via an extravascular electrode, and a neurostimulation therapy module that generates and delivers a neurostimulation signal to the patient via a neurostimulation electrode. The cardiac therapy module and neurostimulation therapy module may be disposed in a common housing of the medical device. In some examples, at least one common lead may electrically couple the neurostimulation electrode and the extravascular electrode to the neurostimulation and cardiac therapy modules, respectively.

摘要翻译： 可植入医疗装置可以通过血管外电极向患者的心脏递送起搏，心脏复律和/或除颤刺激，并将电刺激递送至非心肌组织部位以调节患者的自主神经系统。 可植入医疗装置可以包括心脏治疗模块，该心脏治疗模块通过血管外电极产生并向患者提供起搏，心脏复律或除颤疗法中的至少一种，以及神经刺激治疗模块，其通过以下方式产生并递送神经刺激信号给患者 神经刺激电极。 心脏治疗模块和神经刺激治疗模块可以设置在医疗装置的公共壳体中。 在一些示例中，至少一个共同的引线可以将神经刺激电极和血管外电极分别电耦合到神经刺激和心脏治疗模块。

公开(公告)号：US20090269410A1

公开(公告)日：2009-10-29

申请号：US12429650

申请日：2009-04-24

申请人： James F. McGinnis ,  Lily L. Wong ,  Xiaohong Zhou

发明人： James F. McGinnis ,  Lily L. Wong ,  Xiaohong Zhou

IPC分类号： A61K33/24 ,  A61K9/14 ,  A61P29/00 ,  A61P27/02 ,  A61P9/00 ,  A61P19/02 ,  A61P1/00 ,  A61P17/00

CPC分类号： A61K9/14 ,  A61K33/24

摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.

摘要翻译： 本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。 本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上 在滑膜组织中 在肠组织中 或在骨头。 此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。 因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

公开(公告)号：US20080269819A1

公开(公告)日：2008-10-30

申请号：US11740565

申请日：2007-04-26

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61N1/36114 ,  A61N1/3962

摘要： An implantable medical device and associated method discriminate between ventricular tachycardia and supraventricular tachycardia. Cardiac signals are sensed for detecting ventricular intervals corresponding to a tachycardia. Electrical stimulation pulses are delivered to cardiac neural tissue and verified as being effective in exciting the cardiac neural tissue. If the ventricular intervals corresponding to the tachycardia are increased in response to delivering stimulation pulses to the cardiac neural tissue, the tachycardia is detected as a supraventricular tachycardia.

摘要翻译： 植入式医疗装置和相关方法区分室性心动过速和室上性心动过速。 感测心脏信号以检测对应于心动过速的心室间隔。 电刺激脉冲被递送到心脏神经组织并被证实是有效激励心脏神经组织。 如果对应于心动过速的心室间隔响应于向心脏神经组织递送刺激脉冲而增加，则将心动过速检测为室上性心动过速。

公开(公告)号：US20080082133A1

公开(公告)日：2008-04-03

申请号：US11536946

申请日：2006-09-29

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： A61N1/00

CPC分类号： A61B5/0456 ,  A61B5/0452 ,  A61N1/365 ,  G16H40/63

摘要： An implantable medical device and associated method assesses T-wave alternans. The method includes sensing a cardiac signal from implanted electrodes subsequent to a premature contraction; measuring a T-wave parameter from the sensed cardiac signal for a plurality of cardiac cycles; and determining a T-wave alternans metric corresponding to the measured T-wave parameter.

摘要翻译： 可植入医疗器械和相关方法评估T波交替。 该方法包括在过早收缩之后感测来自植入电极的心脏信号; 从感测的心脏信号中测量多个心动周期的T波参数; 以及确定对应于所测量的T波参数的T波交替量度。

公开(公告)号：US07232435B2

公开(公告)日：2007-06-19

申请号：US10773965

申请日：2004-02-06

申请人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

发明人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

IPC分类号： A61K9/22

CPC分类号： A61M5/142 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3523 ,  A61M2230/00 ,  A61M2230/04 ,  A61M2230/63 ,  A61N1/3962

摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms and otherwise treat heart failure (HF) and pathologies associated with HF. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with HF (or pathologies associated with HF) and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist, e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine.

摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解症状，另外治疗与HF有关的心力衰竭（HF）和病理学。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与HF相关的生理学参数（或与HF相关的病理学）和触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂组成的组之一，例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫西康定，甲基多巴，甲苯噻嗪，胍法辛， 右美托咪定。