公开(公告)号：US07313433B2

公开(公告)日：2007-12-25

申请号：US10780794

申请日：2004-02-18

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Aurichio

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Aurichio

IPC分类号： A61B5/04

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

摘要翻译： 公开了用于预测心脏再同步治疗的急性反应的方法和装置。 该方法可以包括在本征收缩周期期间测量第一间隔并且在刺激的收缩期期间测量第二间隔。 可以通过将第一间隔和第二间隔之间的持续时间的百分比变化与预定阈值进行比较来预测急性反应。 第一和第二时间间隔可以使用例如表面ECG或者心内电描记图来测量。 在一个实施例中，第一间隔可以是在非刺激的收缩期期间测量的固有QRS复合物的持续时间。 类似地，第二间隔可以是在刺激的收缩期期间测量的受激QRS复合物的持续时间。

公开(公告)号：US20070179546A1

公开(公告)日：2007-08-02

申请号：US11567933

申请日：2006-12-07

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20070129781A1

公开(公告)日：2007-06-07

申请号：US11549676

申请日：2006-10-16

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US07215997B2

公开(公告)日：2007-05-08

申请号：US10744900

申请日：2003-12-22

申请人： Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

发明人： Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

IPC分类号： A61N1/365

CPC分类号： A61N1/365

摘要： A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.

摘要翻译： 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行后重建控制。

公开(公告)号：US07184835B2

公开(公告)日：2007-02-27

申请号：US10735267

申请日：2003-12-12

申请人： Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli

发明人： Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/365 ,  A61N1/3682

摘要： A pacing system provides for optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal. A look-up table relating the timing of such electrical or mechanical events to atrio-ventricular delay time intervals is provided for programming the pacing system.

摘要翻译： 起搏系统提供用于参数的最佳血液动力学心脏功能，例如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）或行程体积（主动脉脉压），用于计算房室延迟的系统 心室起搏脉冲的最佳时机。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。 提供了将这种电气或机械事件的时间与心房延迟时间间隔相关联的查找表，用于对起搏系统进行编程。

公开(公告)号：US20060161209A1

公开(公告)日：2006-07-20

申请号：US11037309

申请日：2005-01-18

申请人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

发明人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61N1/36592

摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

摘要翻译： 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

公开(公告)号：US20060041279A1

公开(公告)日：2006-02-23

申请号：US11113809

申请日：2005-04-25

申请人： Yinghong Yu ,  Jiang Ding ,  Milton Morris

发明人： Yinghong Yu ,  Jiang Ding ,  Milton Morris

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and system for identifying and assessing inter-atrial conduction delays in patients is disclosed. Patients who are so identified and are also in need of ventricular resynchronization therapy may then be treated with left atrial pacing and ventricular resynchronization pacing. Certain patients may alternatively be treated with ventricular resynchronization therapy delivered with a conservatively selected atrio-ventricular delay interval and without left atrial pacing.

摘要翻译： 公开了一种用于识别和评估患者心房间传导延迟的方法和系统。 那些如此确定并且也需要心室再同步治疗的患者然后可以用左心房起搏和心室再同步起搏治疗。 某些患者可以替代地以具有保守选择的心房延迟间隔并且没有左心房起搏的心室再同步治疗进行治疗。

公开(公告)号：US06937901B2

公开(公告)日：2005-08-30

申请号：US09999255

申请日：2001-10-31

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/37 ,  A61N1/18

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

公开(公告)号：US06923772B2

公开(公告)日：2005-08-02

申请号：US10236714

申请日：2002-09-06

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61B5/11 ,  A61B5/02

CPC分类号： A61B5/1107 ,  A61B5/6869 ,  A61B5/7242 ,  A61B2562/0219

摘要： A device for measuring a synchronicity of contraction of a heart to determine if an individual would be a responder to cardiac resynchronization therapy. The device may include a first electrode positioned at a first ventricular wall location to measure movement of the first ventricular wall location and generate a first signal, as well as a second electrode positioned at a second ventricular wall location to measure movement of the second ventricular wall location and generate a second signal. A processing module may process the first and second signals, for example, integrate the signals multiple times, and generate an output based on the processed signals. Based on this output, an individual can be labeled a responder or non-responder to cardiac resynchronization therapy. The electrodes may each include an accelerometer to measure acceleration of the heart wall.

摘要翻译： 用于测量心脏收缩的同步性的装置，以确定个体是否是心脏再同步治疗的应答​​者。 该装置可以包括位于第一心室壁位置处的第一电极，以测量第一心室壁位置的运动并产生第一信号，以及定位在第二心室壁位置处的第二电极，以测量第二心室壁的运动 位置并产生第二个信号。 处理模块可以处理第一和第二信号，例如，多次对信号进行积分，并且基于处理的信号生成输出。 基于该输出，个体可以被标记为心脏再同步治疗的应答​​者或非应答者。 电极可以各自包括用于测量心脏壁的加速度的加速度计。

公开(公告)号：US06360127B1

公开(公告)日：2002-03-19

申请号：US09492911

申请日：2000-01-20

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

IPC分类号： A61N1365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.