公开(公告)号：US20060111626A1

公开(公告)日：2006-05-25

申请号：US11322841

申请日：2005-12-29

申请人： Martin Rossing ,  Robert Kieval ,  Mary Cole

发明人： Martin Rossing ,  Robert Kieval ,  Mary Cole

IPC分类号： A61M5/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/306

摘要： Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.

摘要翻译： 用于植入的电极结构包括电极，附着到电极的弹性背衬和背衬或电极上的螯合药物，其被释放以控制和/或限制瘢痕组织的生长。 弹性背衬包括接触组织结构的组织接触侧和远离组织接触侧的暴露侧。 电极结构可用于激活压力感受器，并且背衬是弹性的并且可以与组织结构例如颈动脉窦一起伸展和缩回。 电极和螯合药物可以定位在组织接触侧，因此药物在电极附近释放。 背衬可以由绝缘材料制成并且限制药物朝向暴露侧的扩散，允许瘢痕组织在暴露侧附近生长以保持电极的定位。

公开(公告)号：US20060074453A1

公开(公告)日：2006-04-06

申请号：US10958694

申请日：2004-10-04

申请人： Robert Kieval ,  Martin Rossing ,  Eric Irwin ,  John Brintnall

发明人： Robert Kieval ,  Martin Rossing ,  Eric Irwin ,  John Brintnall

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/3627

摘要： A method for treating heart failure in a patient involves activating a baroreflex system of the patient with at least one baroreflex activation device and resynchronizing the patient's heart with a cardiac resynchronization device. Activating the baroreflex system and resynchronizing the heart may be performed simultaneously or sequentially, in various embodiments. In some embodiments, one or more patient conditions are sensed, and such condition(s) may be used for setting and/or modifying the baroreflex activation and/or heart resynchronization. A device for treating heart failure includes a baroreflex activation member coupled with a cardiac resynchronization member. Some embodiments further include one or more sensors and a processor. In some embodiments, the device is fully implantable.

摘要翻译： 用于治疗患者心力衰竭的方法包括用至少一个压力反射激活装置激活患者的压力反射系统，并用心脏再同步装置重新同步患者的心脏。 在各种实施例中，激活压力反射系统和重新同步心脏可以同时或顺序地执行。 在一些实施例中，感测到一个或多个患者状况，并且这种状况可用于设置和/或修改压力反射激活和/或心脏再同步。 用于治疗心力衰竭的装置包括与心脏再同步构件连接的压力反射激活构件。 一些实施例还包括一个或多个传感器和处理器。 在一些实施例中，该装置是完全可植入的。

公开(公告)号：US20060004430A1

公开(公告)日：2006-01-05

申请号：US11168753

申请日：2005-06-27

申请人： Martin Rossing ,  Stephen Bolea ,  David Mayer ,  Aaron Hjelle ,  Tom Crowley ,  Eric Irwin

发明人： Martin Rossing ,  Stephen Bolea ,  David Mayer ,  Aaron Hjelle ,  Tom Crowley ,  Eric Irwin

IPC分类号： A61N1/05

CPC分类号： A61N1/3752 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/0558 ,  H01R4/14 ,  H01R4/4863 ,  H01R13/5224 ,  H01R13/5804 ,  H01R2201/12

摘要： Connection structures on an extra-vascular electrode lead body improve strain relief and strengthen the transition region where electrical conductors carried by the lead body are joined to individual electrodes at the distal end of the lead. The electrodes include structure or mechanisms for externally securing the electrode assembly to a body part. A first connection structure is located on the lead body proximal the electrodes to anchor the lead body to a first anchor location in the body that generally moves in concert with the body part. A second connection structure is located on the lead body proximal to the first connection structure to anchor the lead body to a second anchor location that is at least partially independent of movement of the body part. The first and second anchor location are offset by a distance that is less than a distance between the first and second connection structures to provide strain relief for the electrodes.

摘要翻译： 超血管电极引线体上的连接结构改善了应变消除，并且加强了由引线体承载的电导体连接到引线远端处的各个电极的过渡区域。 电极包括用于将电极组件外部固定到主体部分的结构或机构。 第一连接结构位于靠近电极的引线体上，以将引线主体锚固到主体中与身体部分一致移动的第一锚定位置。 第二连接结构位于靠近第一连接结构的引线体上，以将引线主体锚固到至少部分地与主体部分的运动无关的第二锚定位置。 第一和第二锚定位置偏移小于第一和第二连接结构之间的距离的距离，以为电极提供应变消除。

公开(公告)号：US06850801B2

公开(公告)日：2005-02-01

申请号：US09963991

申请日：2001-09-26

申请人： Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith

发明人： Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith

IPC分类号： A61N1/08

CPC分类号： A61N1/36117

摘要： Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. A mapping method permits the baroreceptor activation device to be precisely located to maximize therapeutic efficacy.

摘要翻译： 通过激活压力感受器可以选择性地和可控地降低血压，神经系统活性和神经激素活性的装置，系统和方法。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦内。 映射方法允许压力感受器激活装置精确定位以最大化治疗功效。

公开(公告)号：US20040019364A1

公开(公告)日：2004-01-29

申请号：US10402393

申请日：2003-03-27

申请人： CVRX, Inc.

发明人： Robert S. Kieval ,  Bruce J. Persson ,  David J. Serdar ,  Peter T. Keith ,  Martin A. Rossing

IPC分类号： A61N001/36

CPC分类号： A61N1/08 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36007 ,  A61N1/36117 ,  A61N1/37229

摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

公开(公告)号：US20230355170A1

公开(公告)日：2023-11-09

申请号：US18175279

申请日：2023-02-27

申请人： CVRx, Inc.

发明人： Dimitrios Georgakopoulos ,  Ivana Stojanovic ,  Nadim Yared

IPC分类号： A61B5/00 ,  A61B5/0205

CPC分类号： A61B5/4836 ,  A61B5/0205 ,  A61B5/7282 ,  A61B5/6822

摘要： Devices, systems and methods for non-invasive modulation of the baroreflex system of a patient. In embodiments, the present disclosure may be used to measure and monitor baroreflex function for diagnostic purposes in patients acutely or chronically to inform and guide medical treatment, assess disease severity, or assess morbidity/mortality risk. In embodiments, the present disclosure may be used to provide non-invasive baroreflex activation therapy acutely or chronically to treat a variety of disease conditions through rebalancing of the sympathetic and parasympathetic limbs of the autonomic nervous system and their connections to higher brain centers.

公开(公告)号：USD1000461S1

公开(公告)日：2023-10-03

申请号：US29821362

申请日：2021-12-29

申请人： CVRx, Inc.

设计人： John Stroebel ,  Morgan Beeson ,  Yifei Yao ,  Robert L. Davidson ,  Bart Carey ,  Cliff Rockwell ,  Al Crouse

摘要： The FIGURE is a front view of a display screen or a portion thereof with graphical user interface.
The outer broken line, showing the display screen or portion thereof, and all other broken lines, showing portions of the graphical user interface, illustrate portions of the article of manufacture. None of the aforementioned broken-line subject matter forms part of the claimed design.

公开(公告)号：US20230201580A1

公开(公告)日：2023-06-29

申请号：US18090996

申请日：2022-12-29

申请人： CVRx, Inc.

发明人： Luke PARKER ,  Gregory SUNDBERG ,  Paul PIGNATO

IPC分类号： A61N1/05 ,  A61N1/375

CPC分类号： A61N1/059 ,  A61N1/3752

摘要： Devices and methods of use for introduction and implantation of an electrode structure for baroreflex activation therapy, as part of a minimally invasive implant technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. One or more of the electrical lead or electrode structure may include elements to improve fixation at a target implant location. Improvements to delivery tools associated with implant are also described.

公开(公告)号：US11458304B2

公开(公告)日：2022-10-04

申请号：US16818484

申请日：2020-03-13

申请人： CVRx, Inc.

发明人： Paul Pignato ,  Vance Kesler ,  Adam Cates ,  Bart Carey ,  Greg Sundberg ,  Joe DuPay ,  Luis Miguel Rodriguez

IPC分类号： A61N1/375 ,  A61N1/05 ,  A61N1/36

摘要： Embodiments of the present invention generally pertain to devices and methods for use in conjunction with implanting a baroreflex therapy system which includes an implantable pulse generator and associated circuitry contained within a hermetically sealed housing, an elongate flexible electrical lead connectable to the housing, and a monopolar electrode structure coupled with the electrical lead. More specifically, the devices and methods of the present invention allow for a mapping procedure to be conducted as part of the implant procedure prior to fully implanting the baroreflex therapy system.

公开(公告)号：US20210316135A1

公开(公告)日：2021-10-14

申请号：US17268192

申请日：2019-08-15

申请人： CVRx, Inc.

发明人： Paul Pignato ,  Seth Wilks ,  Vance Kesler ,  James E. Johnson ,  James Anderson Smith ,  Peter James Meinz ,  William Thomas Hartsig ,  Caleb Ole Vainikka

IPC分类号： A61N1/05 ,  A61N1/36

摘要： Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. A system includes an introducer tool including a dilator portion, a carrier portion and a release mechanism, the dilator portion selectively engageable with the carrier portion. The system further includes a lead including a lead body and an electrode structure, the electrode structure including an active side with an electrode disposed thereon, and an inactive side with an element disposed thereon. The introducer tool is configured to be temporarily inserted into a patient over a guidewire, and a portion of the release mechanism is selectively engageable with the element of the electrode structure to retain the electrode structure to the introducer tool.