公开(公告)号：US10457652B2

公开(公告)日：2019-10-29

申请号：US16219648

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/5513 ,  C07D243/14 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D413/06 ,  C07D417/06 ,  C07D267/14 ,  C07D413/12 ,  C07D413/04 ,  C07D291/08 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10407419B2

公开(公告)日：2019-09-10

申请号：US15568072

申请日：2015-09-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, Jr. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A61P35/00

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where Y1, X1, X2, Y2, W1, W2, W3, and R1-R5 are described herein.

公开(公告)号：US10407418B2

公开(公告)日：2019-09-10

申请号：US16199489

申请日：2018-11-26

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr.

IPC: C07D245/06 ,  C07D471/04 ,  C07D487/04 ,  C07D413/06 ,  C07D267/22

Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10266487B2

公开(公告)日：2019-04-23

申请号：US15925559

申请日：2018-03-19

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, Jr. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  C07D209/46 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D317/68 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D241/12 ,  C07D417/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D401/14 ,  C07D487/04 ,  C07D487/08 ,  C07D307/68 ,  C07D213/65 ,  C07D295/192 ,  C07D211/58 ,  C07D211/16 ,  C07D513/10 ,  C07D491/10 ,  C07D209/42 ,  C07D277/56 ,  C07D209/08 ,  C07D498/04 ,  C07D207/267 ,  C07D493/08 ,  C07D207/10 ,  A61K31/407 ,  A61K31/5377 ,  C07D495/10 ,  A61K31/185 ,  A61K31/438 ,  A61K31/277 ,  C07D209/44 ,  A61K31/4035 ,  C07D295/155 ,  A61K31/451 ,  C07D471/10 ,  A61K31/435 ,  C07D487/10 ,  C07D221/20 ,  A61K31/397 ,  C07D235/14 ,  A61K31/4184 ,  C07D233/68 ,  A61K31/417 ,  C07D213/56 ,  A61K31/44 ,  C07D241/08 ,  A61K31/495 ,  C07D417/04 ,  A61K31/4439 ,  C07D471/04

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US20190092762A1

公开(公告)日：2019-03-28

申请号：US16199489

申请日：2018-11-26

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR.

IPC: C07D413/06 ,  C07D267/22

CPC classification number: C07D413/06 ,  C07D267/22

Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10239845B2

公开(公告)日：2019-03-26

申请号：US15013816

申请日：2016-02-02

Applicant: Forma Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/553 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10208052B1

公开(公告)日：2019-02-19

申请号：US15926236

申请日：2018-03-20

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Neal Green ,  Gary Gustafson ,  David R. Lancia, Jr. ,  Lorna Mitchell ,  Tatiana Shelekhin

IPC: C07D487/04 ,  A61K9/00

Abstract: Compositions for the activation of PKR are provided, as well as therapeutic administration of the compositions for the treatment of pyruvate kinase-related medical conditions, such as pyruvate kinase deficiency (PKD).

公开(公告)号：US10189841B2

公开(公告)日：2019-01-29

申请号：US15355887

申请日：2016-11-18

Applicant: Forma Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: A61K31/522 ,  C07D473/00

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US20180141910A1

公开(公告)日：2018-05-24

申请号：US15568051

申请日：2015-09-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, Jr. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D215/227 ,  C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D417/12 ,  C07D413/12 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D519/00 ,  A61P35/00

CPC classification number: C07D215/227 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.

公开(公告)号：US09932351B2

公开(公告)日：2018-04-03

申请号：US15015563

申请日：2016-02-04

Applicant: Forma Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David Lancia, Jr.

IPC: A61K31/519 ,  C07D495/04

CPC classification number: C07D495/04 ,  A61K31/519

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.