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公开(公告)号：US11655453B2
公开(公告)日：2023-05-23
申请号：US16610398
申请日：2018-05-03
发明人： Richard Beatson , Adrian Hayday , Oliver Nussbaumer , Richard Woolf , Maria Luisa Iannitto , Natalie Mount
IPC分类号： C12N5/0783 , A61K35/17 , A61K45/06
CPC分类号： C12N5/0636 , A61K35/17 , A61K45/06 , C12N2500/90 , C12N2501/21 , C12N2501/2301 , C12N2501/2302 , C12N2501/2304 , C12N2501/2309 , C12N2501/2312 , C12N2501/2315 , C12N2501/2318 , C12N2501/2321 , C12N2501/2333
摘要： The present invention provides methods of expanding γδ T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded γδ T cells and methods of using the expanded γδ T cells (e.g., apart of an adoptive T cell therapy).
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82.发明申请公开(公告)号：US20230099491A1
公开(公告)日：2023-03-30
申请号：US17936811
申请日：2022-09-29
申请人： CANCER RESEARCH TECHNOLOGY LIMITED , KING'S COLLEGE LONDON , THE FRANCIS CRICK INSTITUTE LIMITED
发明人： Adrian HAYDAY , Oliver NUSSBAUMER , Richard WOOLF
IPC分类号： C12N5/0783
摘要： This invention relates to the expansion of non-haematopoietic tissue-resident γδ T cells in vitro by culturing lympho-cytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or inter-leukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident γδ T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident γδ T cells and uses thereof.
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公开(公告)号：US20230074749A1
公开(公告)日：2023-03-09
申请号：US16479511
申请日：2018-01-18
发明人： Anatoly ZAYATS , Pan WANG , Mazhar NASIR , Wayne DICKSON , Alexey KRASAVIN
摘要： Aspects and embodiments relate to a plasmonic metamaterial structure, applications and devices including that plasmonic metamaterial structure, and a method of forming that plasmonic metamaterial structure. Aspects and embodiments provide a plasmonic metamaterial structure which comprises: a plurality of optical antenna elements. The plurality of optical antenna elements comprise: a first electrode, a second electrode and a plasmonic nanostructure element located between the first and second electrode to form an electron tunnelling junction between the first and second electrodes. The plurality of optical antenna elements are configured such that the electromagnetic field of one optical antenna element spatially overlaps that of adjacent optical antenna elements and adjacent optical antenna elements are electromagnetically coupled to allow the plurality of optical antenna elements to act as a plasmonic metamaterial. Aspects and embodiments also provide devices including that plasmonic metamaterial structure, and a method of forming that plasmonic metamaterial structure. Aspects and embodiments recognise that the sensitivity of an electron tunnelling junction, coupled with provision of a plurality of optical antenna elements may provide a practical structure which can provide sensing platforms, modulation, light source and nanoscale light source devices and applications.
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公开(公告)号：US20230069012A1
公开(公告)日：2023-03-02
申请号：US17797135
申请日：2021-02-08
摘要： Disclosed is a patch or bandage for tissue regeneration and/or repair. The bandage comprises i) one or more proteins from the Wnt family, or an agonist of the Wnt signalling pathway; and ii) a scaffold, wherein the one or more Wnt proteins or Wnt agonist is immobilised on the scaffold, and wherein the scaffold is formed from a functionalised biocompatible polymer.
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公开(公告)号：US11543478B2
公开(公告)日：2023-01-03
申请号：US16783531
申请日：2020-02-06
发明人： Rene Botnar , Radhouene Neji , Claudia Prieto , Giorgia Milotta
IPC分类号： G01R33/50 , G01R33/48 , G01R33/56 , G01R33/567 , G06T7/00
摘要： A method and apparatus for generating a T1 or T2 map for a three-dimensional (3D) image volume of a subject. The method includes acquiring first, second, and third 3D images of the image volume of the subject. Signal evolutions of voxels through the first to third 3D images by comparing voxel intensity levels of corresponding voxel locations in the first, second, and third 3D images. A simulation dictionary representing the signal evolutions for a number of different tissue parameter combinations is obtained. The T1 or T2 map is generated by comparing the determined signal evolutions to entries in the dictionary and by finding, for each of the determined signal evolutions, the entry in the dictionary that best matches the determined signal evolution.
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86.发明申请公开(公告)号：US20220064451A1
公开(公告)日：2022-03-03
申请号：US17366550
申请日：2021-07-02
发明人： Ingvar HELGASON , Dusko ILIC
摘要： Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
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公开(公告)号：US11187768B2
公开(公告)日：2021-11-30
申请号：US16500515
申请日：2018-04-06
发明人： Rui Pedro Azeredo Gomes Teixeira , Joseph Vilmos Hajnal , Shaihan Jalal Malik , Daniel John West
IPC分类号： G01V3/00 , G01R33/50 , G01R33/483 , G01R33/56 , G01R33/561
摘要： The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored multi-band RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.
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公开(公告)号：US11169368B2
公开(公告)日：2021-11-09
申请号：US16959346
申请日：2018-12-21
发明人： Richard Marsh , Susan Cox
摘要： Embodiments of the present invention provide a method and system for processing microscopy images to enable localisation analysis of high density raw data, and thereby achieve higher spatial resolution than would otherwise be the case. This is achieved by exploiting temporal redundancies in the image data resulting from close-to emitters that would otherwise be resolved as a single emitter were they to emit or fluoresce at the same time, but which, by virtue of emitting or fluorescing at slightly different (yet potentially overlapping) times, can be subject to temporal filtering by different filters of different temporal bandwidth to resolve the two emitters. Effectively, the different temporal filters have different time constants which work together to effectively highlight the different emission or fluorescence times of the two emitters, to thereby allow the two close-to emitters to be separately resolved.
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89.发明授权公开(公告)号：US11169154B2
公开(公告)日：2021-11-09
申请号：US16043525
申请日：2018-07-24
IPC分类号： G01N33/574 , C07K16/28
摘要： Methods and products are provided for determining if a subject having a tumor is at risk of metastasis of the tumor. Specifically, the methods comprise detecting phosphorylated cofilin, and both phosphorylated and non-phosphorylated cofilin; quantifying the phosphorylated cofilin, and the total of phosphorylated and nonphosphorylated cofilin; and determining if a subject having the tumor is likely to experience metastasis of the tumor, based on the ratio of the amount of detected phosphorylated cofilin:total amount of phosphorylated and non-phosphorylated cofilin detected. Further disclosed are the types of tumor metastases that can be determined using the methods provided.
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公开(公告)号：US11154205B2
公开(公告)日：2021-10-26
申请号：US16085258
申请日：2017-03-14
摘要： Embodiments and aspects described herein provide a method of determining pressure difference across a tube arising from fluid flow within the tube, comprising: obtaining three-dimensional time dependent fluid velocity data at a plurality of points along the tube; processing the three-dimensional time dependent fluid velocity data to determine: i) a flow rate (Q) of the fluid through the tube; ii) the kinetic energy (K) of the fluid flow through the tube; iii) an advective energy rate (A) of the fluid flow through the tube; and iv) a viscous dissipation rate (V) pertaining to the fluid flow; and calculating the pressure difference in dependence on all of the flow rate (Q), kinetic energy (K), advective energy rate (A), and viscous dissipation rate (V). Further embodiments and aspects are also described.
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