公开(公告)号：US20230072937A1

公开(公告)日：2023-03-09

申请号：US17782814

申请日：2020-12-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Yi LI ,  Ning LIU ,  Tao YU ,  Chengde WU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D513/04 ,  A61P35/00

摘要： Provided are a thiazololactam compound, and the use thereof in the preparation of a drug for treating ERK-related diseases. Specially, the present invention provides a compound as shown in formula (III) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230055321A1

公开(公告)日：2023-02-23

申请号：US17778533

申请日：2020-11-20

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Shanghua XIA ,  Zhaoguo CHEN ,  Zuhao GUO ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Li ZHANG ,  Fen JIANG ,  Jingjing WANG ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： A61K31/519 ,  C07D519/00 ,  A61K45/06 ,  A61K31/55

摘要： Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.

公开(公告)号：US11578081B1

公开(公告)日：2023-02-14

申请号：US17781839

申请日：2020-12-04

申请人： ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Fei Hong ,  Jinming Huang ,  Jinxia Lin ,  Yichao Zhuang ,  Zhiyi Luo ,  Xiaoping Zheng ,  Zhigan Jiang ,  Haiying He

IPC分类号： C07D495/04

摘要： Disclosed are a crystal form (I) as an inhibitor of ACC1 and ACC2, a preparation method therefor, and the use thereof in the preparation of a drug as an inhibitor of ACC1 and ACC2.

公开(公告)号：US20230017858A1

公开(公告)日：2023-01-19

申请号：US17779310

申请日：2020-11-27

申请人： MEDSHINE DISCOVERY INC.

发明人： Yonggang LIAO ,  Wenyuan QIAN ,  Changqing WEI ,  Yao XIAO ,  Zhengying XI ,  Chen ZHANG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D487/04 ,  A61P35/00

摘要： Disclosed are a diazaindole derivative as shown in formula I and the use thereof in the preparation of a drug for treating Chk1-related diseases.

公开(公告)号：US20220372001A1

公开(公告)日：2022-11-24

申请号：US17624462

申请日：2020-07-03

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi LEI ,  Yunfu LUO

IPC分类号： C07D235/26

摘要： A crystal form of compound 1, a solvate thereof, a crystal form of the solvate thereof, and a preparation method therefor. Further comprised is an application of the crystal forms in the preparation of a medicament for treating diseases related to TNFα.

公开(公告)号：US20220324848A1

公开(公告)日：2022-10-13

申请号：US17641759

申请日：2020-09-11

申请人： Medshine Discovery Inc. ,  Shanghaitech University

发明人： Yunfu LUO ,  Yong CANG ,  Bo PENG ,  Maoyi LEI ,  Yu XU ,  Shuhui CHEN

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D413/04

摘要： The present disclosure discloses a compound shown in formula (II) and a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the compound as an active ingredient, and use thereof in the preparation of medicaments for protein degradation.

公开(公告)号：US11466024B2

公开(公告)日：2022-10-11

申请号：US16635916

申请日：2018-07-27

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Kevin X Chen ,  Kai Zhou ,  Yanxin Yu ,  Boyu Hu ,  Linghui Wu ,  Xiaoyuan Chen ,  Jiangfeng Lin ,  Haomin Chen ,  Xiangjian Wang ,  Xiquan Zhang ,  Xin Tian ,  Hongjiang Xu

IPC分类号： C07D495/04

摘要： A bicyclic compound acting as a RORγ inhibitor. Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof, the compound having a structure as represented by formula (I-A) or formula (I-B). The provided compound of formula (I-A) or formula (I-B) or pharmaceutically acceptable salt thereof has good RORγ inhibitory activities, being expected to be used for treating diseases mediated by RORγ receptors in a mammal.

公开(公告)号：US11459323B2

公开(公告)日：2022-10-04

申请号：US16965086

申请日：2019-01-29

申请人： MEDSHINE DISCOVERY INC.

发明人： Lianghu Gu ,  Wei Luo ,  Zhigang Huang ,  Charles Z. Ding ,  Cheng Li ,  Shuhui Chen

IPC分类号： C07D417/14 ,  A61P31/04

摘要： Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating diseases associated with bacterial infection. Specifically disclosed are the compounds as shown in formula (I′) and formula (II′), isomers thereof or pharmaceutically acceptable salts thereof.

公开(公告)号：US20220281868A1

公开(公告)日：2022-09-08

申请号：US17629117

申请日：2020-07-23

申请人： MEDSHINE DISCOVERY INC.

发明人： Yaxian CAI ,  Xiaobing YAN ,  Zhe CAI ,  Guoping HU ,  Charles Z. DING ,  Kevin X CHEN ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D471/18 ,  A61P7/02

摘要： Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof.

公开(公告)号：US20220267324A1

公开(公告)日：2022-08-25

申请号：US17629566

申请日：2020-07-24

申请人： MEDSHINE DISCOVERY INC.

发明人： Zhengxia CHEN ,  Meibi DAI ,  Yang ZHANG ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  A61P35/00

摘要： FGFR and VEGFR dual inhibitors, specifically being a compound represented by formula (I) or a pharmaceutically acceptable salt.