公开(公告)号：US20090207413A1

公开(公告)日：2009-08-20

申请号：US12293501

申请日：2007-03-22

申请人： Michael A. Carpenter ,  George Sirinakis

发明人： Michael A. Carpenter ,  George Sirinakis

IPC分类号： G01N21/00

CPC分类号： G01N21/783 ,  G01N21/31 ,  G01N21/7703 ,  G01N33/0036 ,  G01N33/0037 ,  G01N33/004 ,  G01N33/0047 ,  G01N33/005 ,  Y02A50/243 ,  Y02A50/245 ,  Y10T436/205831

摘要： A method for detecting a gas phase constituent such as carbon monoxide, nitrogen dioxide, hydrogen, or hydrocarbons in a gas comprising oxygen such as air, includes providing a sensing material or film having a metal embedded in a catalytically active matrix such as gold embedded in a yttria stabilized zirconia (YSZ) matrix. The method may include annealing the sensing material at about 900° C., exposing the sensing material and gas to a temperature above 400° C., projecting light onto the sensing material, and detecting a change in the absorption spectrum of the sensing material due to the exposure of the sensing material to the gas in air at the temperature which causes a chemical reaction in the sensing material compared to the absorption spectrum of the sensing material in the absence of the gas. Systems employing such a method are also disclosed.

摘要翻译： 一种用于检测包括氧气如气体的气体中的一氧化碳，二氧化氮，氢气或烃类的气相成分的方法包括提供一种感测材料或膜，该感测材料或膜具有埋入催化活性基质中的金属， 氧化钇稳定氧化锆（YSZ）基体。 该方法可以包括在约900℃退火感测材料，将感测材料和气体暴露于高于400℃的温度，将光投射到感测材料上，并检测感应材料的吸收光谱的变化 在感测材料中与在不存在气体的情况下与感测材料的吸收光谱相比，在感测材料中引起化学反应的温度下感测材料暴露于空气中的气体。 还公开了采用这种方法的系统。

公开(公告)号：US07544774B2

公开(公告)日：2009-06-09

申请号：US11003951

申请日：2004-12-03

申请人： Jonathan L. Miller ,  Vicki A. Lyle

发明人： Jonathan L. Miller ,  Vicki A. Lyle

IPC分类号： C07K5/00

CPC分类号： C07K14/705 ,  C07K14/001 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2317/34

摘要： The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.

摘要翻译： 本发明涉及功能上模拟单克隆抗体的结合位点的分离的肽，该单克隆抗体识别人血小板糖蛋白Ib / IX复合物内的表位。 该肽被称为模拟表位。 本发明还提供能够结合肽或模拟表位的分离的分子，该分子可以是抗体，第二肽，碳水化合物，DNA分子，RNA分子或其它天然或化学合成的分子。 这种分离的分子称为抗模拟表位。 具体提供了模拟单克隆抗体C-34和SZ-2的结合位点的模拟表位，以及C-34模拟表位的抗模拟表位。

公开(公告)号：US07521252B2

公开(公告)日：2009-04-21

申请号：US11049833

申请日：2005-02-03

申请人： Michael A. Carpenter ,  Zhouying Zhao

发明人： Michael A. Carpenter ,  Zhouying Zhao

IPC分类号： G01N33/00 ,  C22F1/14

CPC分类号： G01N21/783 ,  Y10T436/22

摘要： Methods for forming hydrogen sensing materials include forming a palladium alloy thin film having less than about 83 atomic percent of palladium, and annealing the palladium alloy thin film to relieve residual stress and increase atomic intermixing of the nanorystaline lattice, while maintaining a grain size close to the grain size of the nonannealed palladium alloy thin film. For example, the sensing material may include a palladium-gold alloy thin film having about 60 atomic percent of palladium and about 40 atomic percent of gold. The palladium-gold alloy thin film is then annealed at a temperature of about 200 degrees Celsius for 1 hour. Methods for detecting hydrogen containing gas in which the hydrogen sensing material is maintained in a single phase when exposed to the hydrogen containing gas, and optical hydrogen sensors are also disclosed.

摘要翻译： 用于形成氢感测材料的方法包括形成具有小于约83原子百分比的钯的钯合金薄膜，并且退火钯合金薄膜以减轻残余应力并增加纳米晶格的原子混合，同时保持晶粒尺寸接近 未退火的钯合金薄膜的晶粒尺寸。 例如，感测材料可以包括具有约60原子百分比的钯和约40原子％的金的钯 - 金合金薄膜。 然后钯 - 金合金薄膜在约200摄氏度的温度下退火1小时。 还公开了当暴露于含氢气体时氢传感材料保持在单相中的含氢气体的检测方法和光学氢传感器。

公开(公告)号：US20090062205A1

公开(公告)日：2009-03-05

申请号：US12204922

申请日：2008-09-05

申请人： Sathyamangalam V. Balasubramanian

发明人： Sathyamangalam V. Balasubramanian

IPC分类号： A61K38/16 ,  A61P43/00

CPC分类号： A61K9/127 ,  A61K38/37 ,  A61K38/47 ,  A61K47/10

摘要： Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties.

摘要翻译： 提供了可用于重构含有蛋白质/肽药物的浓缩制剂的组合物。 组合物通常包括一种或多种脂质，以及促进和稳定（a）具有更大蛋白质包封的脂质分子组装形成的一种或多种醇; （b）蛋白质 - 脂质复合物和（c）蛋白质和脂质溶液。 重建培养基改善了蛋白质 - 脂质缔合，从而改变药物性质。

公开(公告)号：US20090046883A1

公开(公告)日：2009-02-19

申请号：US12162992

申请日：2007-01-25

申请人： Miles N. Ronald

发明人： Miles N. Ronald

IPC分类号： H04R17/02 ,  C23F1/00

CPC分类号： H04R19/005 ,  H04R1/38 ,  H04R19/04 ,  H04R31/00 ,  Y10T29/43 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/4908

摘要： A differential microphone having a perimeter slit formed around the microphone diaphragm that replaces the backside hole previously required in conventional silicon, micromachined microphones. The differential microphone is formed using silicon fabrication techniques applied only wafer. The backside holes of prior art microphones typically require that a secondary machining operation be performed on the rear surface of the silicon wafer during fabrication. This secondary operation adds complexity and cost to the micromachined microphones so fabricated. Comb fingers forming a portion of a capacitive arrangement may be fabricated as part of the differential microphone diaphragm.

摘要翻译： 差分麦克风具有围绕麦克风隔膜形成的周边狭缝，其替代了传统硅，微机械麦克风以前需要的背面孔。 差分麦克风使用仅使用晶片的硅制造技术来形成。 现有技术的麦克风的背面孔通常要求在制造期间在硅晶片的后表面上进行二次加工操作。 这种二次操作为如此制造的微加工麦克风增加了复杂性和成本。 形成电容布置的一部分的梳形手指可以制造为差分麦克风隔膜的一部分。

公开(公告)号：US20090023953A1

公开(公告)日：2009-01-22

申请号：US12033545

申请日：2008-02-19

申请人： John T. WELCH

发明人： John T. WELCH

IPC分类号： C07C229/30

CPC分类号： C07C381/00

摘要： There are provided SF5-containing amino acids of the general formulas and processes for preparing same. Other embodiments are also disclosed.

摘要翻译： 提供了含有通式的含SF5的氨基酸及其制备方法。 还公开了其他实施例。

公开(公告)号：US07471975B2

公开(公告)日：2008-12-30

申请号：US11232847

申请日：2005-09-22

申请人： Randall L. Barbour

发明人： Randall L. Barbour

IPC分类号： A61B6/00

CPC分类号： A61B5/0066 ,  A61B5/0073 ,  A61B5/0095 ,  A61B5/02007 ,  A61B5/1455 ,  A61B5/14551

摘要： A method of measuring local and propagating pulsatile behavior of a vasculature system provides a way to non-invasively measure vascular dynamics and, in particular, allows for objective measurement of the propagating expansion-contraction waves. The method includes capturing a time-series of optical images, and analyzing the images to produce a time-series of vector field maps based on measurements of local displacement of hemoglobin contrast. The method further includes obtaining a resulting time-dependent tensor field image and analyzing the resulting time-dependent tensor field image to obtain metrics of local and propagating oscillatory behavior.

摘要翻译： 测量脉管系统的局部和传播脉动行为的方法提供了非侵入性地测量血管动力学的方式，并且特别地允许客观测量传播的扩张 - 收缩波。 该方法包括捕获时间序列的光学图像，并且基于血红蛋白对比的局部位移测量，分析图像以产生时间序列的矢量场地图。 该方法还包括获得所得到的时间依赖张量场图像并分析所得到的时间依赖张量场图像以获得局部和传播振荡行为的度量。

公开(公告)号：US20080281818A1

公开(公告)日：2008-11-13

申请号：US12026048

申请日：2008-02-05

申请人： Scott A. TENENBAUM ,  Christopher ZALESKI ,  Francis DOYLE ,  Ajish GEORGE

发明人： Scott A. TENENBAUM ,  Christopher ZALESKI ,  Francis DOYLE ,  Ajish GEORGE

IPC分类号： G06F7/06 ,  G06F17/30

CPC分类号： G16B40/00 ,  G16B20/00

摘要： Processing of genomic data is facilitated by providing a storage device with a database having a segmented sequence table. The table has a plurality of data subsets of common nucleotide sequence size n, wherein≧2, and each data subset of common nucleotide sequence n is separately indexed within the table. A database manager associated with the database retrieves a selected nucleotide sequence locus from the table. The selected nucleotide sequence locus is sized differently from the common nucleotide sequence size n, and the retrieving includes identifying each data subset of the segmented sequence table containing at least a portion of the selected nucleotide sequence locus, and retrieving the identified data subsets. The database manager processes the retrieved, identified data subsets to remove genomic data mapped to the nucleotide positions outside the selected nucleotide sequence locus, and outputs the selected nucleotide sequence locus.

摘要翻译： 通过向存储设备提供具有分段序列表的数据库来促进基因组数据的处理。 该表具有多个共同核苷酸序列大小为n的数据子集，其中> = 2，并且公共核苷酸序列n的每个数据子集在表内分开索引。 与数据库相关联的数据库管理器从表中检索选定的核苷酸序列基因座。 所选择的核苷酸序列基因座的大小不同于公共核苷酸序列大小n，并且检索包括识别包含所选择的核苷酸序列基因座的至少一部分的分割序列表的每个数据子集，以及检索所识别的数据子集。 数据库管理者处理检索到的识别数据子集以去除映射到所选择的核苷酸序列基因座外的核苷酸位置的基因组数据，并输出所选择的核苷酸序列位点。

公开(公告)号：US20080281181A1

公开(公告)日：2008-11-13

申请号：US11587467

申请日：2005-05-13

申请人： James V. Manzione ,  Jerome Liang

发明人： James V. Manzione ,  Jerome Liang

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： A61B6/504 ,  A61B6/032 ,  A61B6/037 ,  A61B6/466 ,  A61B6/481 ,  A61B6/507 ,  A61B6/583 ,  A61B34/30 ,  A61B90/10

摘要： Different applications for multiple imaging technologies are provided to advance patient care. In one aspect, a 3-D imaging device is used to identify the location of target region in a patient, such as a tumor or aneurysm, for instance. The location information is then used to control a device used in performing a surgical or other intervention, further imaging or a diagnostic or therapeutic procedure (920). The device can operate fully automatically, as a robot, or can assist a manual procedure performed by a physician. In another aspect, the invention provides a technique for obtaining an improved image of the vasculature in a patient (1020). In another aspect, images from multiple imaging technologies are combined or fused (1120) to achieve synergistic benefits.

摘要翻译： 提供了多种成像技术的不同应用，以促进患者护理。 在一个方面，使用3-D成像装置来识别患者（例如肿瘤或动脉瘤）中的目标区域的位置。 然后使用位置信息来控制用于执行手术或其他干预，进一步成像或诊断或治疗过程的设备（920）。 该装置可以作为机器人完全自动地操作，或者可以帮助由医师执行的手动过程。 在另一方面，本发明提供了一种用于在患者（1020）中获得血管系统的改进图像的技术。 另一方面，来自多个成像技术的图像被组合或融合（1120）以实现协同效益。

公开(公告)号：US07449578B1

公开(公告)日：2008-11-11

申请号：US11087236

申请日：2005-03-23

申请人： Qingdong Zheng ,  Paras N. Prasad ,  Guang S. He

发明人： Qingdong Zheng ,  Paras N. Prasad ,  Guang S. He

IPC分类号： C07F15/04 ,  C07D471/02

CPC分类号： C07D471/04 ,  B82Y10/00 ,  G11B2007/24624

摘要： The present invention provides substituted phenanthroline compounds with high two photon absorption cross sections, as well as substituted phenanthroline compounds which additionally have quenched fluorescence emission upon two photon absorption.

摘要翻译： 本发明提供了具有高双光子吸收横截面的取代菲咯啉化合物，以及在两光子吸收时另外具有骤冷荧光发射的取代菲咯啉化合物。