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公开(公告)号：US20060096348A1
公开(公告)日：2006-05-11
申请号：US10986400
申请日：2004-11-10
申请人： Attilio Difiore
发明人： Attilio Difiore
IPC分类号： G01L27/00
CPC分类号： A61M1/3653 , A61M1/3658 , A61M1/3659 , A61M1/3661 , A61M2209/02
摘要： A system and method for measuring recirculation of blood in a catheter designed for implantation in a human is described. In one variation, the system comprises an artificial circulatory system and an ultrasonic detection device for measuring and comparing the density of a circulated blood simulant with a later introduced bolus saline. The system may be configured to simulate a human heart by providing the flow, pressure and dimensions of a typical human heart. In addition to simulating the circulatory system of a normal human heart, the system may also be configured to simulate particular negative conditions of a patient, such as stenotic condition, which would affect the recirculation measurement.
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82.发明授权公开(公告)号：US06926838B2
公开(公告)日：2005-08-09
申请号：US10355944
申请日：2003-01-31
IPC分类号： A61B5/0275 , A61M1/16 , A61M1/36 , A61B5/026 , A61B8/06
CPC分类号： A61M1/3653 , A61B5/0275 , A61M1/16 , A61M1/3655 , A61M1/3658 , A61M1/3663 , A61M1/3669 , A61M1/367
摘要： The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.
摘要翻译： 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。
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公开(公告)号：US20050096578A1
公开(公告)日：2005-05-05
申请号：US10977995
申请日：2004-10-28
CPC分类号： A61M1/3663 , A61M1/16 , A61M1/3639 , A61M1/3658 , A61M2205/3334 , A61M2205/3344 , A61M2205/50
摘要： A method and a device for determining the blood flow QF in a vascular access (F) during an extracorporeal blood treatment is described, where the blood enters the blood treatment unit (3) of the blood treatment machine through an arterial branch (19) of an extracorporeal circulation loop (2) which is in fluid connection with the vascular access at an arterial connection. The blood is returned through a venous branch (21) of the extracorporeal circulation, which is in fluid connection with the vascular access at a venous connection (13). The blood flow in the vascular access is determined by measuring the pressure part, pven, in the arterial and/or venous branch of the extracorporeal circulation when the vascular access is open and interrupted, while the extracorporeal blood flow QB is varied. Then the fistula flow QF is determined from the measured values for the arterial and/or venous pressure while the vascular access is open and interrupted.
摘要翻译： 描述了在体外血液处理期间用于确定血管通路（F）中的血流量Q F的方法和装置，其中血液进入血液处理机的血液处理单元（3） 通过与动脉连接处的血管通路流体连接的体外循环回路（2）的动脉分支（19）。 血液通过体外循环的静脉分支（21）返回，体液循环与静脉连接处的血管通路流体连通（13）。 血管通路中的血流通过测量体外循环的动脉和/或静脉分支中的压力，即血管通路是否为压力P 开放和中断，而体外血流量Q B 是变化的。 然后根据动脉和/或静脉压的测量值确定瘘流QΨ，同时血管通路打开和中断。
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84.发明申请公开(公告)号：US20050085761A1
公开(公告)日：2005-04-21
申请号：US10924150
申请日：2004-08-23
CPC分类号： A61M25/0029 , A61M1/3653 , A61M1/3658 , A61M1/3659 , A61M25/0026 , A61M25/0032 , A61M25/0068 , A61M2025/0024 , A61M2025/0031 , A61M2025/0035
摘要： The present invention provides an apparatus, system, and method of use of a simple, less invasive, self-expandable percutaneous double lumen cannula assembly for VV ECMO that overcomes the limitations and obstacles of the techniques described above. The present invention achieves near theoretical total venous blood drainage, total extracorporeal gas exchange, and prevents recirculation and multiple cannulation, thereby simplifying VV ECMO, decreasing surgical and blood trauma, and expanding its application.
摘要翻译： 本发明提供了一种用于VV ECMO的简单的，较少侵入性的，可自膨胀的经皮双腔插管组件的装置，系统和方法，其克服了上述技术的限制和障碍。 本发明实现近理论总静脉血液排出，总体外气体交换，并防止再循环和多次插管，从而简化VV ECMO，减少手术和血液创伤，扩大其应用。
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公开(公告)号：US06827698B1
公开(公告)日：2004-12-07
申请号：US09549364
申请日：2000-04-14
IPC分类号： A61M3700
CPC分类号： A61M1/3663 , A61M1/16 , A61M1/3639 , A61M1/3658 , A61M2205/3334 , A61M2205/3344 , A61M2205/50
摘要： A method and a device for determining the blood flow QF in a vascular access (F) during an extracorporeal blood treatment is described, where the blood enters the blood treatment unit (3) of the blood treatment machine through an arterial branch (19) of an extracorporeal circulation loop (2) which is in fluid connection with the vascular access at an arterial connection. The blood is returned through a venous branch (21) of the extracorporeal circulation, which is in fluid connection with the vascular access at a venous connection (13). The blood flow in the vascular access is determined by measuring the pressure Part, Pven, in the arterial and/or venous branch of the extracorporeal circulation when the vascular access is open and interrupted, while the extracorporeal blood flow QB is varied. Then the fistula flow QF is determined from the measured values for the arterial and/or venous pressure while the vascular access is open and interrupted.
摘要翻译： 描述了一种用于在体外血液处理期间确定血管通路（F）中的血流QF的方法和装置，其中血液通过血液处理机的血液处理单元（3）通过动脉分支（19）进入血液处理单元 在动脉连接处与血管通路流体连接的体外循环回路（2）。 血液通过体外循环的静脉分支（21）返回，体液循环与静脉连接处的血管通路流体连通（13）。 通过测量血管通路打开和中断时体外循环的动脉和/或静脉分支中的压力Part，Pven，同时体外血流量QB变化来确定血管通路中的血流量。 然后根据动脉和/或静脉压的测量值确定瘘流QF，同时血管通路打开和中断。
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公开(公告)号：US06695807B2
公开(公告)日：2004-02-24
申请号：US10051465
申请日：2002-01-18
IPC分类号： A61M3700
CPC分类号： A61M1/367 , A61M1/3658 , A61M39/223 , A61M39/28
摘要： A tubular set portion for circulating blood between a patient and an extracorporeal blood treatment device. The set portion has: an arterial tube for conveying blood from a patient toward the blood treatment device; a venous tube for conveying blood from the blood treatment device back towards the patient; and a pair of spaced, transverse tubes that each connect between the arterial tube and the venous tube, each of the tubes being capable of clamp sealing. The arterial and venous tubes are clamp sealable between the spaced, transverse tubes. Flow reversal on the patient's side of this device is possible by appropriate clamping of two opposed tube sections of the rectangular array which may be formed by the joined tube sections, while flow remains unchanged on the side of the tubular set portion that is connected to the extracorporeal blood treatment device.
摘要翻译： 一种用于在患者和体外血液处理装置之间循环血液的管状固定部分。 设置部分具有：用于将血液从患者输送到血液处理装置的动脉管; 用于将血液从血液处理装置输送回患者的静脉管; 以及一对间隔开的横向管，每个管连接在动脉管和静脉管之间，每个管能够夹紧密封。 动脉和静脉管可夹紧在间隔开的横向管之间。 可以通过适当地夹紧矩形阵列的两个相对的管部分，这可以由连接的管部分形成，而在该装置的患者侧的流动反转是可能的，同时流体在连接到管状部分的管状部分的一侧保持不变 体外血液处理装置。
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公开(公告)号：US20040017201A1
公开(公告)日：2004-01-29
申请号：US10630004
申请日：2003-07-29
IPC分类号： G01N027/02
CPC分类号： A61M1/16 , A61M1/361 , A61M1/3612 , A61M1/3653 , A61M1/3655 , A61M1/3658 , A61M1/3659 , A61M1/3661 , A61M1/3669 , G01F1/7046 , G01F1/708 , G01F1/7088
摘要： Methods and apparatuses for determining a fluid parameter in a vessel by altering a property of the fluid, sensing the difference in the property after the fluid is altered, particularly as related to the property in an unaltered portion of the fluid.
摘要翻译： 用于通过改变流体的性质来确定容器中的流体参数的方法和装置，感测流体改变后特性的差异，特别是与流体的未改变部分中的性质有关。
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88.发明申请Method and apparatus to measure blood flow and recirculation in hemodialysis shunts 失效测量血液透析分流中血流和再循环的方法和装置公开(公告)号：US20010050256A1
公开(公告)日：2001-12-13
申请号：US09734352
申请日：2000-12-11
发明人： Nikolai M. Krivitski
IPC分类号： A61B005/026
CPC分类号： A61M1/3653 , A61B5/0275 , A61M1/16 , A61M1/3655 , A61M1/3658 , A61M1/3663 , A61M1/3669 , A61M1/367
摘要： The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.
摘要翻译： 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。
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89.发明授权System and method for determining the flow rate of blood in a vessel using doppler frequency signals 有权使用多普勒频率信号确定血管中血液流量的系统和方法公开(公告)号：US06167765A
公开(公告)日：2001-01-02
申请号：US09160685
申请日：1998-09-25
申请人： William F. Weitzel
发明人： William F. Weitzel
IPC分类号： G01F120
CPC分类号： A61M1/3663 , A61M1/3658
摘要： A system and method are provided for determining the flow rate of blood in a vessel, such as a hemodialysis access. The system includes a conduit, such as an external dialysis circuit or an intravascular catheter, in communication with the blood in the vessel and having a diversion point for diverting the blood from the vessel into the conduit. As such, the vessel has a flow rate (QA) upstream from the diversion point and a flow rate (QD) downstream from the diversion point. A pump is connected to the conduit for diverting the blood into the conduit using a pump flow rate. An ultrasonic sensor is provided in communication with the blood in the vessel downstream from the diversion point. The ultrasonic sensor senses the downstream flow rate (QD) and generates at least two downstream Doppler frequency signals including a first downstream Doppler frequency signal when the pump has a first pump flow rate and a second downstream Doppler frequency signal when the pump has a second pump flow rate. A processor connected to the ultrasonic sensor and the pump then determines the upstream flow rate (QA) when the pump has a selected pump flow rate from the first and second downstream Doppler frequency signals and the selected pump flow rate.
摘要翻译： 提供了一种系统和方法，用于确定血管中血液的流速，例如血液透析通路。 该系统包括与容器中的血液连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。 因此，容器具有从转向点上游的流量（QA）和从转向点下游的流量（QD）。 泵连接到管道，以使用泵流量将血液转入管道。 提供超声波传感器，其与转移点下游的血管中的血液连通。 超声波传感器感测下游流量（QD）并且当泵具有第一泵流量时产生包括第一下游多普勒频率信号的至少两个下行多普勒频率信号，当泵具有第二下游多普勒频率信号时，该泵具有第二泵 流量。 连接到超声波传感器和泵的处理器随后确定当泵具有来自第一和第二下游多普勒频率信号的选定的泵流量和所选择的泵流量时的上游流量（QA）。
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90.发明授权
公开(公告)号：US06153109A
公开(公告)日：2000-11-28
申请号：US10697
申请日：1998-01-22
申请人： Nikolai Krivitski
发明人： Nikolai Krivitski
CPC分类号： A61M1/367 , A61M1/3653 , A61M1/3658 , A61M1/3663 , A61M1/16 , A61M1/3669
摘要： A device for determining shunt flow in a hemodialysis shunt connected between two points in a cardiovascular-hemodialysis system includes a flow sensor connected to either the hemodialysis inflow (arterial) line or the outflow (venous) line. An indicator is preferably introduced into the system that is sensed by first and second sensors that are spaced apart and disposed effective for sensing the indicator at two locations in the cardiovascular-hemodialysis system. Natural indicators produced by the body, such as density variations in the blood caused by rhythmic breathing, are optionally used instead of an introduced indicator. A detector connected to the flow sensor and the first and second sensors determines, at a first flow rate, a first time a first indicator takes to move between the two locations, and at a second flow rate, a second time a second indicator takes to move between the two locations. The shunt flow is then calculated from the first and second times and the first and second flow rates.
摘要翻译： 用于确定连接在心血管血液透析系统的两个点之间的血液透析分流器中的分路流的装置包括连接到血液透析流入（动脉）线或流出（静脉）线的流量传感器。 指示器优选地被引入系统中，该第一和第二传感器被间隔开并设置成有效用于在心血管血液透析系统的两个位置处感测指示器。 任选地使用身体产生的自然指标，例如由节律呼吸引起的血液中的密度变化，而不是引入的指示剂。 连接到流量传感器和第一和第二传感器的检测器以第一流量第一时间确定第一指示器在两个位置之间移动，并且以第二流量第二时间确定第二指示器 在两个位置之间移动。 然后从第一次和第二次以及第一和第二流速计算并联流量。
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