公开(公告)号：US09750864B2

公开(公告)日：2017-09-05

申请号：US15163300

申请日：2016-05-24

申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

发明人： Pascal Kopperschimdt

IPC分类号： B01D21/24 ,  B01D24/38 ,  A61M1/34 ,  A61M1/36 ,  A61M1/16 ,  A61B5/021 ,  A61B5/00

CPC分类号： A61M1/342 ,  A61B5/02141 ,  A61B5/7225 ,  A61B5/7257 ,  A61M1/1601 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3658 ,  A61M2205/3355 ,  A61M2205/702 ,  A61M2230/30

摘要： The invention relates to a process for monitoring the supply of substitution fluid upstream or downstream of a dialyzer or filter arranged in an extracorporeal blood stream. One embodiment provides, for the detection of predilution or postdilution, for measuring the pressure in the blood stream downstream of the dialyzer or filter, predilution or postdilution being recognized on the basis of the change in pressure following the shutting off and/or starting up of the substituate pump provided for conveying the substitution fluid. Another embodiment provides for recognizing predilution or postdilution on the basis of the comparison of the oscillating pressure signal attributable to the substituate pump to a characteristic reference signal. The characteristic reference signal to which the pressure signal of the substituate pump is compared is preferably the oscillating pressure signal of a blood pump arranged in the blood stream for conveying the blood upstream of the dialyzer or filter. In addition, the invention relates to an extracorporeal blood treatment device with a facility for detecting predilution or postdilution, which device operates according to the processes detailed above.

公开(公告)号：US20150366530A1

公开(公告)日：2015-12-24

申请号：US14312916

申请日：2014-06-24

申请人： MediaTek Inc.

发明人： Po-Wen KU

IPC分类号： A61B7/04 ,  A61B5/00 ,  A61B5/02 ,  A61M1/36 ,  A61B5/0402

CPC分类号： A61B7/04 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/0402 ,  A61B5/04028 ,  A61B5/7282 ,  A61M1/3658 ,  A61M2205/3375 ,  A61M2210/12 ,  A61M2230/04

摘要： A device for detecting fistula stenosis is provided. The device includes a physiological signal sensor, an acoustic receiver and a processing circuit. The physiological signal sensor is configured for providing a physiological signal of a user. The acoustic receiver is configured for detecting a sound from a fistula of the user to generate a sound signal. The processing circuit is configured for providing a degree of fistula stenosis according to the physiological signal of the user and the sound signal.

摘要翻译： 提供了一种用于检测瘘管狭窄的装置。 该装置包括生理信号传感器，声学接收器和处理电路。 生理信号传感器被配置用于提供用户的生理信号。 声学接收器被配置用于检测来自用户的瘘的声音以产生声音信号。 处理电路被配置为根据用户的生理信号和声音信号提供一定程度的瘘管狭窄。

公开(公告)号：US08858486B2

公开(公告)日：2014-10-14

申请号：US12744281

申请日：2008-11-22

申请人： Wei Zhang ,  Elke Schulte ,  Christoph Bardorz

发明人： Wei Zhang ,  Elke Schulte ,  Christoph Bardorz

IPC分类号： A61M37/00 ,  A61M1/36 ,  A61M1/16

CPC分类号： A61M1/16 ,  A61M1/1617 ,  A61M1/3658 ,  A61M2205/13

摘要： A method for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part during an extracorporeal blood treatment is disclosed, where the blood to be treated flows in an extracorporeal blood circuit through a blood chamber of a dialyzer split by a semi-permeable membrane into the blood chamber and a liquid chamber, and dialysis liquid flows in a dialysis liquid path through the dialysis liquid chamber of the dialyzer. A device for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part, and a blood treatment device including such a device are also disclosed. The method and device are based on the fact that the sum of the fistula recirculation and the cardiopulmonary recirculation part, i.e. the total recirculation, is determined for two blood flow rates which differ from each other. The fistula recirculation and/or the cardiopulmonary recirculation part are then determined from the recirculation for the two blood flow rates.

摘要翻译： 公开了一种用于在体外血液处理期间确定瘘管和/或心肺再循环部分中的再循环的方法，其中待治疗的血液通过半透膜分离的透析器的血室在体外血液回路中流动 进入血液室和液体室，并且透析液体在透析液体路径中流过透析器的透析液体室。 还公开了一种用于确定瘘管和/或心肺再循环部分中的再循环的装置，以及包括这种装置的血液处理装置。 该方法和装置基于以下事实：对于彼此不同的两个血液流速，确定瘘再循环和心肺再循环部分的总和，即总再循环。 然后从两次血流速率的再循环中确定瘘再循环和/或心肺再循环部分。

公开(公告)号：US20140296766A1

公开(公告)日：2014-10-02

申请号：US14202727

申请日：2014-03-10

申请人： B. BRAUN AVITUM AG

发明人： SILVIE KRAUSE ,  CHRISTOF STROHHOEFER ,  JOERN AHRENS ,  ALEX CASTELLARNAU ,  SOEREN WEYER

IPC分类号： A61M1/36

CPC分类号： A61M1/3658 ,  A61M1/1609 ,  A61M1/1615 ,  A61M2205/3313 ,  A61M2205/3331 ,  A61M2205/3334

摘要： Control methods of a dialysis machine for allowing the dialysate-side detection of a recirculation in an arteriovenous shunt of a patient during ongoing hemodialysis are described. A sensor is arranged downstream of a dialyser and detects a change of a physicochemical parameter PD of outflowing dialysis fluid. Control elements are provided to guide the dialysis fluid in a selected manner through the dialyser or pass it by. Recirculation may be determined by passing the dialysis fluid by the dialyser so that the dialysis fluid is guided unchanged along the sensor for calibration, switching the control elements after optional sensor calibration such that the dialysis fluid flows through the dialyser, and adjusting a desired first blood flow value BF1 in the blood-side extracorporeal circulatory branch so that between an inlet of the extracorporeal circulatory branch and an outlet a recirculation R and, a first clearance K1 are adjusted and the parameter detected by the sensor adopts a corresponding value PD1, changing the first blood flow value BF1 to a second blood flow value BF2, wherein a second clearance K2 is adjusted, and accordingly at the sensor a new parameter value PD2 is provided and detected, and determining the recirculation R by the course of change from the parameter value PD1 to the parameter value PD2.

摘要翻译： 描述了透析机的控制方法，用于在持续血液透析期间允许透析液侧检测患者的静脉分流中的再循环。 传感器布置在透析器的下游，并检测流出的透析液的物理化学参数PD的变化。 提供控制元件以通过透析器以选定的方式引导透析液体或使其透过。 可以通过使透析器通过透析液来确定再循环，使得透析流体沿着传感器不变地被引导用于校准，在可选的传感器校准之后切换控制元件，使得透析流体流过透析器，并且调节期望的第一血液 血液侧体循环分支中的流量值BF1，使得在体外循环分支的入口与出口之间的再循环R和第一间隙K1被调整，并且由传感器检测的参数采用相应的值PD1， 第一血流值BF1到第二血流值BF2，其中调整第二间隙K2，并且相应地在传感器处提供和检测新的参数值PD2，并且根据参数值的变化过程来确定再循环R PD1到参数值PD2。

公开(公告)号：US20140291534A1

公开(公告)日：2014-10-02

申请号：US14217991

申请日：2014-03-18

申请人： B. BRAUN AVITUM AG

发明人： JOERN AHRENS

IPC分类号： A61M1/16 ,  G01N21/59

CPC分类号： A61M1/1694 ,  A61M1/1617 ,  A61M1/3658 ,  A61M1/3664 ,  A61M2205/3313 ,  G01N21/59

摘要： Methods and devices implementing, for detecting a recirculation, at the side of a dialysis solution, by a blood-sided administration of a bolus are disclosed. Recirculation may be detected by: measuring a first light absorbance value (ad) of a dialysis solution (d) draining off a dialyzer using a spectrometer, prior to the administration of the bolus; venous administration of the bolus having a predefined volume (QBven) at the venous access; measuring a second light absorbance value (bd) of the draining dialysis solution using a spectrometer, after the administration of the bolus; and determining a change in the absorbance value between the first (ad) and second (bd) measured absorbance values due to the presence of a bolus in the dialysis solution during recirculation as a basis for the recirculation quantification.

摘要翻译： 公开了用于通过血液侧面施用大丸剂在透析溶液侧实现再循环的方法和装置。 可以通过以下方式检测再循环：在施用推注之前，测量使用光谱仪从透析器排出的透析溶液（d）的第一光吸收值（ad） 在静脉通路时静脉内施用具有预定体积（QBven）的推注; 在施用推注之后，使用光谱仪测量排泄透析溶液的第二光吸收值（bd）; 并且由于在再循环期间在透析溶液中存在推注作为再循环定量的基础，确定第一（ad）和第二（bd）测量的吸光度值之间的吸光度值的变化。

公开(公告)号：US20140100549A1

公开(公告)日：2014-04-10

申请号：US14106326

申请日：2013-12-13

申请人： GAMBRO LUNDIA AB

发明人： Bernard BENE

IPC分类号： A61M1/36

CPC分类号： A61M1/3656 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3658 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/30

摘要： The invention relates to a calculation and control system for the determination of the state of a vascular access of a patient intended to follow successive sessions of extracorporeal blood treatment by extraction and return of the blood via the vascular access, the system comprising: means for determining the value of at least one hemodynamic extracorporeal parameter of the patient for at least two sessions; means for determining the value of the purification effectiveness of the treatment for at least two sessions; programmed means for determining a risk score relating to the state of the vascular access of the patient as a function of at least two values of the hemodynamic extracorporeal parameter and of at least two determined values of the purification effectiveness.

摘要翻译： 本发明涉及一种计算和控制系统，用于通过经由血管通路提取和返回血液来确定旨在跟随体外血液处理的连续阶段的患者的血管通路的状态，所述系统包括：用于确定 至少一次患者的血液动力学体外参数的值至少两次; 用于确定治疗至少两次的净化效力的价值的手段; 用于根据血液动力学体外参数和至少两个确定的净化效力的值的至少两个值来确定与患者的血管通路状态相关的风险评分的程序化手段。

公开(公告)号：US20140083943A1

公开(公告)日：2014-03-27

申请号：US14032922

申请日：2013-09-20

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Thomas Nuernberger

IPC分类号： A61M1/36 ,  A61M1/16

CPC分类号： A61M1/3403 ,  A61M1/1656 ,  A61M1/1672 ,  A61M1/342 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3658 ,  A61M1/3663 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50 ,  B01D61/28 ,  B01D61/30

摘要： A device and method for detecting recirculation for an extracorporeal blood treatment apparatus and an apparatus with a device for detecting recirculation are based on targeted haemodilution by administration of a substituate bolus, causing a pressure change in venous and arterial branches of the extracorporeal circuit due to a viscosity change of flowing fluid.Recirculation is detected based on detection of the pressure change. The device includes a control unit cooperating with a device for conveying blood and a device for supplying substituate. The control unit provides an operating mode for detecting recirculation, in which blood flow rate is reduced during administration of a substituate bolus. With simultaneous substituate bolus administration and reduction of blood flow rate, the composition of fluid flow is optimised for detection of recirculation, so that fairly large pressure changes result in venous and arterial branches, thereby improving sensitivity and reliability of the measurement method.

摘要翻译： 用于检测体外血液处理装置的再循环的装置和方法以及具有用于检测再循环的装置的装置基于通过施用取代弹丸的目标血液稀释，导致体外循环的静脉和动脉分支中的压力变化，由于 流动液体的粘度变化。 基于压力变化的检测来检测循环。 该装置包括与用于输送血液的装置配合的控制单元和用于提供取代物的装置。 控制单元提供用于检测再循环的操作模式，其中在给药代谢团期间血流速度降低。 通过同时取代推注给药和降低血液流速，优化流体流动的组成，用于检测再循环，从而使相当大的压力变化导致静脉和动脉分支，从而提高测量方法的灵敏度和可靠性。

公开(公告)号：US20120150090A1

公开(公告)日：2012-06-14

申请号：US13372860

申请日：2012-02-14

申请人： Balazs Szamosfalvi ,  Stanley Frinak ,  Jerry Yee

发明人： Balazs Szamosfalvi ,  Stanley Frinak ,  Jerry Yee

IPC分类号： A61M1/36 ,  A61M1/34

CPC分类号： A61M1/3672 ,  A61M1/3406 ,  A61M1/3413 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3455 ,  A61M1/3458 ,  A61M1/3609 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3658 ,  A61M1/3675 ,  A61M2202/0486 ,  A61M2205/3306

摘要： The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable solutes.

摘要翻译： 本发明包括用于向体外血液回路输送局部柠檬酸抗凝（RCA）的综合替代液体系统和方法，其中所述系统可以包括在线间隙监测器（OCM）和用于 连续测定超滤溶质的患者血浆含量。

公开(公告)号：US20120143123A1

公开(公告)日：2012-06-07

申请号：US13310014

申请日：2011-12-02

申请人： Charles W. Agnew

发明人： Charles W. Agnew

IPC分类号： A61M25/14

CPC分类号： A61M25/0075 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/3659 ,  A61M1/3661 ,  A61M25/04 ,  A61M2025/0025 ,  A61M2025/0031 ,  A61M2025/0035 ,  A61M2025/0039 ,  A61M2025/0079

摘要： A catheter assembly used for extracorporeal treatment, such as dialysis, of blood or other body fluid, includes an outer and inner catheter in a coaxial relationship. A fluid path is provided by a passageway defined between the catheters and a distal end of the outer catheter, and another fluid path is provided through a lumen and a distal end of the inner catheter. A sealing member is coupled to one of the catheters. The member in a first position is configured to permit the distal ends of the catheters to transport fluid, while in a second position the member is configured to inhibit at least one of the distal ends from transporting fluid. The sealing member may include a flared portion for enhance sealing. The sealing member may also have a portion extending outward from the catheters to position the distal ends away from vessel contact.

摘要翻译： 用于体外治疗（例如透析，血液或其他体液）的导管组件包括同轴关系的外导管和内导管。 流体通道由限定在导管和外导管的远端之间的通道提供，并且另一流体路径通过内导管和内导管的远端提供。 密封构件联接到导管之一。 第一位置的构件构造成允许导管的远端输送流体，而在第二位置，构件被构造成阻止远端中的至少一个输送流体。 密封构件可以包括用于增强密封的扩口部分。 密封构件还可以具有从导管向外延伸的部分，以将远端远离血管接触。

公开(公告)号：US20110004141A1

公开(公告)日：2011-01-06

申请号：US12744281

申请日：2007-11-22

申请人： Wei Zhang ,  Elke Schulte ,  Christoph Bardorz

发明人： Wei Zhang ,  Elke Schulte ,  Christoph Bardorz

IPC分类号： A61M1/16 ,  A61M1/36

CPC分类号： A61M1/16 ,  A61M1/1617 ,  A61M1/3658 ,  A61M2205/13

摘要： A method for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part during an extracorporeal blood treatment is disclosed, where the blood to be treated flows in an extracorporeal blood circuit through a blood chamber of a dialyzer split by a semi-permeable membrane into the blood chamber and a liquid chamber, and dialysis liquid flows in a dialysis liquid path through the dialysis liquid chamber of the dialyzer. A device for determining the recirculation in a fistula and/or the cardio-pulmonary recirculation part, and a blood treatment device including such a device are also disclosed. The method and device are based on the fact that the sum of the fistula recirculation and the cardiopulmonary recirculation part, i.e. the total recirculation, is determined for two blood flow rates which differ from each other. The fistula recirculation and/or the cardiopulmonary recirculation part are then determined from the recirculation for the two blood flow rates.

摘要翻译： 公开了一种用于在体外血液处理期间确定瘘管和/或心肺再循环部分中的再循环的方法，其中待治疗的血液通过半透膜分离的透析器的血室在体外血液回路中流动 进入血液室和液体室，并且透析液体在透析液体路径中流过透析器的透析液体室。 还公开了一种用于确定瘘管和/或心肺再循环部分中的再循环的装置，以及包括这种装置的血液处理装置。 该方法和装置基于以下事实：对于彼此不同的两个血液流速，确定瘘再循环和心肺再循环部分的总和，即总再循环。 然后从两次血流速率的再循环中确定瘘再循环和/或心肺再循环部分。